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Items: 41


Super-Resolution Imaging of G Protein-Coupled Receptors Using Ground State Depletion Microscopy.

Caetano Crowley FA, Heit B, Ferguson SSG.

Methods Mol Biol. 2019;1947:323-336. doi: 10.1007/978-1-4939-9121-1_18.


CD36 mediates albumin transcytosis by dermal but not lung microvascular endothelial cells: role in fatty acid delivery.

Raheel H, Ghaffari S, Khosraviani N, Mintsopoulos V, Auyeung D, Wang C, Kim YH, Mullen B, Sung HK, Ho M, Fairn G, Neculai D, Febbraio M, Heit B, Lee WL.

Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L740-L750. doi: 10.1152/ajplung.00127.2018. Epub 2019 Jan 31.


Soluble CD93 is an apoptotic cell opsonin recognized by αx β2.

Blackburn JWD, Lau DHC, Liu EY, Ellins J, Vrieze AM, Pawlak EN, Dikeakos JD, Heit B.

Eur J Immunol. 2019 Apr;49(4):600-610. doi: 10.1002/eji.201847801. Epub 2019 Feb 7.


PACS-1 and adaptor protein-1 mediate ACTH trafficking to the regulated secretory pathway.

Dirk BS, End C, Pawlak EN, Van Nynatten LR, Jacob RA, Heit B, Dikeakos JD.

Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):519-525. doi: 10.1016/j.bbrc.2018.11.085. Epub 2018 Nov 17.


Quantification of Efferocytosis by Single-cell Fluorescence Microscopy.

Taruc K, Yin C, Wootton DG, Heit B.

J Vis Exp. 2018 Aug 18;(138). doi: 10.3791/58149.


Membrane Diffusion Occurs by Continuous-Time Random Walk Sustained by Vesicular Trafficking.

Goiko M, de Bruyn JR, Heit B.

Biophys J. 2018 Jun 19;114(12):2887-2899. doi: 10.1016/j.bpj.2018.04.024.


Armed for destruction: formation, function and trafficking of neutrophil granules.

Yin C, Heit B.

Cell Tissue Res. 2018 Mar;371(3):455-471. doi: 10.1007/s00441-017-2731-8. Epub 2017 Nov 29. Review.


Human-Specific Mutations and Positively Selected Sites in MARCO Confer Functional Changes.

Novakowski KE, Yap NVL, Yin C, Sakamoto K, Heit B, Golding GB, Bowdish DME.

Mol Biol Evol. 2018 Feb 1;35(2):440-450. doi: 10.1093/molbev/msx298.


SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1.

Fung KY, Wang C, Nyegaard S, Heit B, Fairn GD, Lee WL.

Front Physiol. 2017 Oct 30;8:841. doi: 10.3389/fphys.2017.00841. eCollection 2017.


Rab17 mediates intermixing of phagocytosed apoptotic cells with recycling endosomes.

Yin C, Argintaru D, Heit B.

Small GTPases. 2019 May;10(3):218-226. doi: 10.1080/21541248.2017.1308852. Epub 2017 May 4.


Antagonistic Coevolution of MER Tyrosine Kinase Expression and Function.

Evans AL, Blackburn JWD, Taruc K, Kipp A, Dirk BS, Hunt NR, Barr SD, Dikeakos JD, Heit B.

Mol Biol Evol. 2017 Jul 1;34(7):1613-1628. doi: 10.1093/molbev/msx102.


Rab17 mediates differential antigen sorting following efferocytosis and phagocytosis.

Yin C, Kim Y, Argintaru D, Heit B.

Cell Death Dis. 2016 Dec 22;7(12):e2529. doi: 10.1038/cddis.2016.431.


HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling.

Dirk BS, Pawlak EN, Johnson AL, Van Nynatten LR, Jacob RA, Heit B, Dikeakos JD.

Sci Rep. 2016 Nov 14;6:37021. doi: 10.1038/srep37021.


Quantitative Efferocytosis Assays.

Evans AL, Blackburn JW, Yin C, Heit B.

Methods Mol Biol. 2017;1519:25-41.


Short-Lived Cages Restrict Protein Diffusion in the Plasma Membrane.

Goiko M, de Bruyn JR, Heit B.

Sci Rep. 2016 Oct 11;6:34987. doi: 10.1038/srep34987.


82-kDa choline acetyltransferase and SATB1 localize to β-amyloid induced matrix attachment regions.

Winick-Ng W, Caetano FA, Winick-Ng J, Morey TM, Heit B, Rylett RJ.

Sci Rep. 2016 Apr 7;6:23914. doi: 10.1038/srep23914.


PSD-95 regulates CRFR1 localization, trafficking and β-arrestin2 recruitment.

Dunn HA, Chahal HS, Caetano FA, Holmes KD, Yuan GY, Parikh R, Heit B, Ferguson SSG.

Cell Signal. 2016 May;28(5):531-540. doi: 10.1016/j.cellsig.2016.02.013. Epub 2016 Feb 17.


MIiSR: Molecular Interactions in Super-Resolution Imaging Enables the Analysis of Protein Interactions, Dynamics and Formation of Multi-protein Structures.

Caetano FA, Dirk BS, Tam JH, Cavanagh PC, Goiko M, Ferguson SS, Pasternak SH, Dikeakos JD, de Bruyn JR, Heit B.

PLoS Comput Biol. 2015 Dec 11;11(12):e1004634. doi: 10.1371/journal.pcbi.1004634. eCollection 2015 Dec.


Antimicrobial Mechanisms of Macrophages and the Immune Evasion Strategies of Staphylococcus aureus.

Flannagan RS, Heit B, Heinrichs DE.

Pathogens. 2015 Nov 27;4(4):826-68. doi: 10.3390/pathogens4040826. Review.


Intracellular replication of Staphylococcus aureus in mature phagolysosomes in macrophages precedes host cell death, and bacterial escape and dissemination.

Flannagan RS, Heit B, Heinrichs DE.

Cell Microbiol. 2016 Apr;18(4):514-35. doi: 10.1111/cmi.12527. Epub 2015 Oct 26.


A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis.

Armstrong SM, Sugiyama MG, Fung KY, Gao Y, Wang C, Levy AS, Azizi P, Roufaiel M, Zhu SN, Neculai D, Yin C, Bolz SS, Seidah NG, Cybulsky MI, Heit B, Lee WL.

Cardiovasc Res. 2015 Nov 1;108(2):268-77. doi: 10.1093/cvr/cvv218. Epub 2015 Sep 2.


Endothelial LSP1 Modulates Extravascular Neutrophil Chemotaxis by Regulating Nonhematopoietic Vascular PECAM-1 Expression.

Hossain M, Qadri SM, Xu N, Su Y, Cayabyab FS, Heit B, Liu L.

J Immunol. 2015 Sep 1;195(5):2408-16. doi: 10.4049/jimmunol.1402225. Epub 2015 Aug 3.


Visualizing Interactions Between HIV-1 Nef and Host Cellular Proteins Using Ground-State Depletion Microscopy.

Dirk BS, Heit B, Dikeakos JD.

AIDS Res Hum Retroviruses. 2015 Jul;31(7):671-2. doi: 10.1089/aid.2014.0333. Epub 2015 May 18. No abstract available.


Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promote monocyte adhesion and impair insulin transcytosis.

Pillon NJ, Azizi PM, Li YE, Liu J, Wang C, Chan KL, Hopperton KE, Bazinet RP, Heit B, Bilan PJ, Lee WL, Klip A.

Am J Physiol Endocrinol Metab. 2015 Jul 1;309(1):E35-44. doi: 10.1152/ajpendo.00611.2014. Epub 2015 May 5.


Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells.

Azizi PM, Zyla RE, Guan S, Wang C, Liu J, Bolz SS, Heit B, Klip A, Lee WL.

Mol Biol Cell. 2015 Feb 15;26(4):740-50. doi: 10.1091/mbc.E14-08-1307. Epub 2014 Dec 24.


Cytoskeletal confinement of CX3CL1 limits its susceptibility to proteolytic cleavage by ADAM10.

Wong HS, Jaumouillé V, Heit B, Doodnauth SA, Patel S, Huang YW, Grinstein S, Robinson LA.

Mol Biol Cell. 2014 Dec 1;25(24):3884-99. doi: 10.1091/mbc.E13-11-0633. Epub 2014 Sep 24.


Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization.

Heit B, Kim H, Cosío G, Castaño D, Collins R, Lowell CA, Kain KC, Trimble WS, Grinstein S.

Dev Cell. 2013 Feb 25;24(4):372-83. doi: 10.1016/j.devcel.2013.01.007. Epub 2013 Feb 7.


Changes in mitochondrial surface charge mediate recruitment of signaling molecules during apoptosis.

Heit B, Yeung T, Grinstein S.

Am J Physiol Cell Physiol. 2011 Jan;300(1):C33-41. doi: 10.1152/ajpcell.00139.2010. Epub 2010 Oct 6.


Molecular regulators of leucocyte chemotaxis during inflammation.

Wong CH, Heit B, Kubes P.

Cardiovasc Res. 2010 May 1;86(2):183-91. doi: 10.1093/cvr/cvq040. Epub 2010 Feb 2. Review.


Contribution of phosphatidylserine to membrane surface charge and protein targeting during phagosome maturation.

Yeung T, Heit B, Dubuisson JF, Fairn GD, Chiu B, Inman R, Kapus A, Swanson M, Grinstein S.

J Cell Biol. 2009 Jun 1;185(5):917-28. doi: 10.1083/jcb.200903020.


Vav1 is essential for mechanotactic crawling and migration of neutrophils out of the inflamed microvasculature.

Phillipson M, Heit B, Parsons SA, Petri B, Mullaly SC, Colarusso P, Gower RM, Neely G, Simon SI, Kubes P.

J Immunol. 2009 Jun 1;182(11):6870-8. doi: 10.4049/jimmunol.0803414.


PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils.

Heit B, Robbins SM, Downey CM, Guan Z, Colarusso P, Miller BJ, Jirik FR, Kubes P.

Nat Immunol. 2008 Jul;9(7):743-52. doi: 10.1038/ni.1623. Epub 2008 Jun 8.


PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP.

Heit B, Liu L, Colarusso P, Puri KD, Kubes P.

J Cell Sci. 2008 Jan 15;121(Pt 2):205-14. doi: 10.1242/jcs.020412.


Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade.

Phillipson M, Heit B, Colarusso P, Liu L, Ballantyne CM, Kubes P.

J Exp Med. 2006 Nov 27;203(12):2569-75. Epub 2006 Nov 20.


Fundamentally different roles for LFA-1, Mac-1 and alpha4-integrin in neutrophil chemotaxis.

Heit B, Colarusso P, Kubes P.

J Cell Sci. 2005 Nov 15;118(Pt 22):5205-20. Epub 2005 Oct 25.


Lipopolysaccharide: a p38 MAPK-dependent disrupter of neutrophil chemotaxis.

Khan AI, Heit B, Andonegui G, Colarusso P, Kubes P.

Microcirculation. 2005 Jul-Aug;12(5):421-32.


Role of CD44 and hyaluronan in neutrophil recruitment.

Khan AI, Kerfoot SM, Heit B, Liu L, Andonegui G, Ruffell B, Johnson P, Kubes P.

J Immunol. 2004 Dec 15;173(12):7594-601.


In vivo impairment of neutrophil recruitment during lentivirus infection.

Kubes P, Heit B, van Marle G, Johnston JB, Knight D, Khan A, Power C.

J Immunol. 2003 Nov 1;171(9):4801-8.


Measuring chemotaxis and chemokinesis: the under-agarose cell migration assay.

Heit B, Kubes P.

Sci STKE. 2003 Feb 18;2003(170):PL5.


An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients.

Heit B, Tavener S, Raharjo E, Kubes P.

J Cell Biol. 2002 Oct 14;159(1):91-102. Epub 2002 Oct 7.

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