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Items: 35


Innovative approaches to track lymph node germinal center responses to evaluate development of broadly neutralizing antibodies in human HIV vaccine trials.

Patricia D'Souza M, Allen MA, Baumblatt JAG, Boggiano C, Crotty S, Grady C, Havenar-Daughton C, Heit A, Hu DJ, Kunwar N, McElrath MJ; Lymph Node Webinar Contributors.

Vaccine. 2018 Sep 11;36(38):5671-5677. doi: 10.1016/j.vaccine.2018.07.071. Epub 2018 Aug 7.


Functional characterization of the bovine foamy virus miRNA expression cassette and its dumbbell-shaped pri-miRNA.

Cao W, Heit A, Hotz-Wagenblatt A, Löchelt M.

Virus Genes. 2018 Aug;54(4):550-560. doi: 10.1007/s11262-018-1574-z. Epub 2018 May 31.


Quantitative mass spectrometry analysis reveals a panel of nine proteins as diagnostic markers for colon adenocarcinomas.

Atak A, Khurana S, Gollapalli K, Reddy PJ, Levy R, Ben-Salmon S, Hollander D, Donyo M, Heit A, Hotz-Wagenblatt A, Biran H, Sharan R, Rane S, Shelar A, Ast G, Srivastava S.

Oncotarget. 2018 Feb 5;9(17):13530-13544. doi: 10.18632/oncotarget.24418. eCollection 2018 Mar 2.


Vaccination establishes clonal relatives of germinal center T cells in the blood of humans.

Heit A, Schmitz F, Gerdts S, Flach B, Moore MS, Perkins JA, Robins HS, Aderem A, Spearman P, Tomaras GD, De Rosa SC, McElrath MJ.

J Exp Med. 2017 Jul 3;214(7):2139-2152. doi: 10.1084/jem.20161794. Epub 2017 Jun 21.


CXCL13 is a plasma biomarker of germinal center activity.

Havenar-Daughton C, Lindqvist M, Heit A, Wu JE, Reiss SM, Kendric K, Bélanger S, Kasturi SP, Landais E, Akondy RS, McGuire HM, Bothwell M, Vagefi PA, Scully E; IAVI Protocol C Principal Investigators, Tomaras GD, Davis MM, Poignard P, Ahmed R, Walker BD, Pulendran B, McElrath MJ, Kaufmann DE, Crotty S.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2702-7. doi: 10.1073/pnas.1520112113. Epub 2016 Feb 23.


Optimization of a whole blood phenotyping assay for enumeration of peripheral blood leukocyte populations in multicenter clinical trials.

Hensley-McBain T, Heit A, De Rosa SC, McElrath MJ, Andersen-Nissen E.

J Immunol Methods. 2014 Sep;411:23-36. doi: 10.1016/j.jim.2014.06.002. Epub 2014 Jun 9.


Enumeration of major peripheral blood leukocyte populations for multicenter clinical trials using a whole blood phenotyping assay.

Hensley TR, Easter AB, Gerdts SE, De Rosa SC, Heit A, McElrath MJ, Andersen-Nissen E.

J Vis Exp. 2012 Sep 16;(67):e4302. doi: 10.3791/4302.


Profiling immunity to HIV vaccines with systems biology.

Andersen-Nissen E, Heit A, McElrath MJ.

Curr Opin HIV AIDS. 2012 Jan;7(1):32-7. doi: 10.1097/COH.0b013e32834ddcd9. Review.


Immunostimulatory CpG-DNA and PSA-peptide vaccination elicits profound cytotoxic T cell responses.

Maurer T, Pournaras C, Aguilar-Pimentel JA, Thalgott M, Horn T, Heck M, Heit A, Kuebler H, Gschwend JE, Nawroth R.

Urol Oncol. 2013 Oct;31(7):1395-401. doi: 10.1016/j.urolonc.2011.09.002. Epub 2011 Oct 7.


Toll-like receptor 3 mediates expression of clusterin/apolipoprotein J in vascular smooth muscle cells stimulated with RNA released from necrotic cells.

Baiersdörfer M, Schwarz M, Seehafer K, Lehmann C, Heit A, Wagner H, Kirschning CJ, Koch-Brandt C.

Exp Cell Res. 2010 Dec 10;316(20):3489-500. doi: 10.1016/j.yexcr.2010.07.022. Epub 2010 Aug 5.


Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation.

Werninghaus K, Babiak A, Gross O, Hölscher C, Dietrich H, Agger EM, Mages J, Mocsai A, Schoenen H, Finger K, Nimmerjahn F, Brown GD, Kirschning C, Heit A, Andersen P, Wagner H, Ruland J, Lang R.

J Exp Med. 2009 Jan 16;206(1):89-97. doi: 10.1084/jem.20081445. Epub 2009 Jan 12.


Sequence independent interferon-alpha induction by multimerized phosphodiester DNA depends on spatial regulation of Toll-like receptor-9 activation in plasmacytoid dendritic cells.

Haas T, Schmitz F, Heit A, Wagner H.

Immunology. 2009 Feb;126(2):290-8. doi: 10.1111/j.1365-2567.2008.02897.x. Epub 2008 Nov 15.


Zinc signals are essential for lipopolysaccharide-induced signal transduction in monocytes.

Haase H, Ober-Blöbaum JL, Engelhardt G, Hebel S, Heit A, Heine H, Rink L.

J Immunol. 2008 Nov 1;181(9):6491-502.


Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells.

Schmitz F, Heit A, Dreher S, Eisenächer K, Mages J, Haas T, Krug A, Janssen KP, Kirschning CJ, Wagner H.

Eur J Immunol. 2008 Nov;38(11):2981-92. doi: 10.1002/eji.200838761.


Circumvention of regulatory CD4(+) T cell activity during cross-priming strongly enhances T cell-mediated immunity.

Heit A, Gebhardt F, Lahl K, Neuenhahn M, Schmitz F, Anderl F, Wagner H, Sparwasser T, Busch DH, Kastenmüller K.

Eur J Immunol. 2008 Jun;38(6):1585-97. doi: 10.1002/eji.200737966.


The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation.

Haas T, Metzger J, Schmitz F, Heit A, Müller T, Latz E, Wagner H.

Immunity. 2008 Mar;28(3):315-23. doi: 10.1016/j.immuni.2008.01.013.


TLR9 contributes to antiviral immunity during gammaherpesvirus infection.

Guggemoos S, Hangel D, Hamm S, Heit A, Bauer S, Adler H.

J Immunol. 2008 Jan 1;180(1):438-43.


Protective cancer immunotherapy: what can the innate immune system contribute?

Schmitz F, Heit A.

Expert Opin Biol Ther. 2008 Jan;8(1):31-43. Review.


Vaccine protocols for enhanced immunogenicity of exogenous antigens.

Heit A, Busch DH, Wagner H, Schmitz F.

Int J Med Microbiol. 2008 Jan;298(1-2):27-32. Epub 2007 Sep 20. Review.


Polylactide-coglycolide microspheres co-encapsulating recombinant tandem prion protein with CpG-oligonucleotide break self-tolerance to prion protein in wild-type mice and induce CD4 and CD8 T cell responses.

Kaiser-Schulz G, Heit A, Quintanilla-Martinez L, Hammerschmidt F, Hess S, Jennen L, Rezaei H, Wagner H, Schätzl HM.

J Immunol. 2007 Sep 1;179(5):2797-807.


Antigen co-encapsulated with adjuvants efficiently drive protective T cell immunity.

Heit A, Schmitz F, Haas T, Busch DH, Wagner H.

Eur J Immunol. 2007 Aug;37(8):2063-74.


NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs.

Schleicher U, Liese J, Knippertz I, Kurzmann C, Hesse A, Heit A, Fischer JA, Weiss S, Kalinke U, Kunz S, Bogdan C.

J Exp Med. 2007 Apr 16;204(4):893-906. Epub 2007 Mar 26.


Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo.

Hamm S, Heit A, Koffler M, Huster KM, Akira S, Busch DH, Wagner H, Bauer S.

Int Immunol. 2007 Mar;19(3):297-304. Epub 2007 Feb 7.


Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells.

Schmitz F, Heit A, Guggemoos S, Krug A, Mages J, Schiemann M, Adler H, Drexler I, Haas T, Lang R, Wagner H.

Eur J Immunol. 2007 Feb;37(2):315-27.


CpG motif-independent activation of TLR9 upon endosomal translocation of "natural" phosphodiester DNA.

Yasuda K, Rutz M, Schlatter B, Metzger J, Luppa PB, Schmitz F, Haas T, Heit A, Bauer S, Wagner H.

Eur J Immunol. 2006 Feb;36(2):431-6.


Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO.

Wingender G, Garbi N, Schumak B, Jüngerkes F, Endl E, von Bubnoff D, Steitz J, Striegler J, Moldenhauer G, Tüting T, Heit A, Huster KM, Takikawa O, Akira S, Busch DH, Wagner H, Hämmerling GJ, Knolle PA, Limmer A.

Eur J Immunol. 2006 Jan;36(1):12-20.


Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways.

Yasuda K, Yu P, Kirschning CJ, Schlatter B, Schmitz F, Heit A, Bauer S, Hochrein H, Wagner H.

J Immunol. 2005 May 15;174(10):6129-36.


Protective CD8 T cell immunity triggered by CpG-protein conjugates competes with the efficacy of live vaccines.

Heit A, Schmitz F, O'Keeffe M, Staib C, Busch DH, Wagner H, Huster KM.

J Immunol. 2005 Apr 1;174(7):4373-80.


Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes.

Kalis C, Gumenscheimer M, Freudenberg N, Tchaptchet S, Fejer G, Heit A, Akira S, Galanos C, Freudenberg MA.

J Immunol. 2005 Apr 1;174(7):4295-300.


Targeting split vaccines to the endosome improves vaccination.

Wagner H, Heit A, Schmitz F, Bauer S.

Curr Opin Biotechnol. 2004 Dec;15(6):538-42. Review.


CpG-DNA aided cross-priming by cross-presenting B cells.

Heit A, Huster KM, Schmitz F, Schiemann M, Busch DH, Wagner H.

J Immunol. 2004 Feb 1;172(3):1501-7.


Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice.

Spies B, Hochrein H, Vabulas M, Huster K, Busch DH, Schmitz F, Heit A, Wagner H.

J Immunol. 2003 Dec 1;171(11):5908-12.


CpG-DNA aided cross-presentation of soluble antigens by dendritic cells.

Maurer T, Heit A, Hochrein H, Ampenberger F, O'Keeffe M, Bauer S, Lipford GB, Vabulas RM, Wagner H.

Eur J Immunol. 2002 Aug;32(8):2356-64.

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