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Items: 1 to 50 of 441


Discovery of an Experimental Model of Unicuspid Aortic Valve.

Weiss RM, Chu Y, Brooks RM, Lund DD, Cheng J, Zimmerman KA, Kafa MK, Sistla P, Doshi H, Shao JQ, El Accaoui RN, Otto CM, Heistad DD.

J Am Heart Assoc. 2018 Jun 30;7(13). pii: e006908. doi: 10.1161/JAHA.117.006908.


Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice.

Chu Y, Lund DD, Doshi H, Keen HL, Knudtson KL, Funk ND, Shao JQ, Cheng J, Hajj GP, Zimmerman KA, Davis MK, Brooks RM, Chapleau MW, Sigmund CD, Weiss RM, Heistad DD.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):466-74. doi: 10.1161/ATVBAHA.115.306912. Epub 2016 Jan 14.


Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification.

Huk DJ, Austin BF, Horne TE, Hinton RB, Ray WC, Heistad DD, Lincoln J.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):328-38. doi: 10.1161/ATVBAHA.115.306091. Epub 2015 Dec 3.


Atherosclerosis stabilization with PCSK-9 inhibition: An evolving concept for cardiovascular prevention.

Robinson JG, Heistad DD, Fox KA.

Atherosclerosis. 2015 Dec;243(2):593-7. doi: 10.1016/j.atherosclerosis.2015.10.023. Epub 2015 Oct 23.


Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin.

Peña Silva RA, Mitchell IJ, Kung DK, Pewe LL, Granja MF, Harty JT, Faraci FM, Heistad DD, Hasan DM.

Neurosurgery. 2015 Oct;77(4):613-20. doi: 10.1227/NEU.0000000000000883.


Spontaneous Aortic Regurgitation and Valvular Cardiomyopathy in Mice.

Hajj GP, Chu Y, Lund DD, Magida JA, Funk ND, Brooks RM, Baumbach GL, Zimmerman KA, Davis MK, El Accaoui RN, Hameed T, Doshi H, Chen B, Leinwand LA, Song LS, Heistad DD, Weiss RM.

Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1653-62. doi: 10.1161/ATVBAHA.115.305729. Epub 2015 May 21.


Stages in Discovery: Angiotensin-Converting Enzyme Type 2 and Stroke.

Peña-Silva RA, Heistad DD.

Hypertension. 2015 Jul;66(1):15-6. doi: 10.1161/HYPERTENSIONAHA.115.05278. Epub 2015 May 4. No abstract available.


Myeloperoxidase is increased in human cerebral aneurysms and increases formation and rupture of cerebral aneurysms in mice.

Chu Y, Wilson K, Gu H, Wegman-Points L, Dooley SA, Pierce GL, Cheng G, Pena Silva RA, Heistad DD, Hasan D.

Stroke. 2015 Jun;46(6):1651-6. doi: 10.1161/STROKEAHA.114.008589. Epub 2015 Apr 28.


Smooth Muscle Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo.

Hasan DM, Starke RM, Gu H, Wilson K, Chu Y, Chalouhi N, Heistad DD, Faraci FM, Sigmund CD.

Hypertension. 2015 Jul;66(1):211-20. doi: 10.1161/HYPERTENSIONAHA.115.05332. Epub 2015 Apr 27.


Multimodality and molecular imaging of matrix metalloproteinase activation in calcific aortic valve disease.

Jung JJ, Razavian M, Challa AA, Nie L, Golestani R, Zhang J, Ye Y, Russell KS, Robinson SP, Heistad DD, Sadeghi MM.

J Nucl Med. 2015 Jun;56(6):933-8. doi: 10.2967/jnumed.114.152355. Epub 2015 Apr 23.


Angiotensin 1-7 reduces mortality and rupture of intracranial aneurysms in mice.

Peña Silva RA, Kung DK, Mitchell IJ, Alenina N, Bader M, Santos RA, Faraci FM, Heistad DD, Hasan DM.

Hypertension. 2014 Aug;64(2):362-8. doi: 10.1161/HYPERTENSIONAHA.114.03415. Epub 2014 May 5.


Aortic valve sclerosis in mice deficient in endothelial nitric oxide synthase.

El Accaoui RN, Gould ST, Hajj GP, Chu Y, Davis MK, Kraft DC, Lund DD, Brooks RM, Doshi H, Zimmerman KA, Kutschke W, Anseth KS, Heistad DD, Weiss RM.

Am J Physiol Heart Circ Physiol. 2014 May;306(9):H1302-13. doi: 10.1152/ajpheart.00392.2013. Epub 2014 Mar 7.


Promising neuroprotective effects of the angiotensin-(1-7)-angiotensin-converting enzyme 2-Mas axis in stroke.

Peña Silva RA, Heistad DD.

Exp Physiol. 2014 Feb;99(2):342-3. doi: 10.1113/expphysiol.2013.076836. No abstract available.


The role of valvular endothelial cell paracrine signaling and matrix elasticity on valvular interstitial cell activation.

Gould ST, Matherly EE, Smith JN, Heistad DD, Anseth KS.

Biomaterials. 2014 Apr;35(11):3596-606. doi: 10.1016/j.biomaterials.2014.01.005. Epub 2014 Jan 24.


Two ways to make great contributions.

Heistad DD.

Circ Res. 2013 Jul 19;113(3):249-51. doi: 10.1161/CIRCRESAHA.113.301831. Review. No abstract available.


Fibrocalcific aortic valve disease: opportunity to understand disease mechanisms using mouse models.

Weiss RM, Miller JD, Heistad DD.

Circ Res. 2013 Jul 5;113(2):209-22. doi: 10.1161/CIRCRESAHA.113.300153. Review.


Introduction to the Compendium on calcific aortic valve disease.

Heistad DD, Shanahan C, Demer LL.

Circ Res. 2013 Jul 5;113(2):176-8. doi: 10.1161/CIRCRESAHA.113.301833. No abstract available.


Osteoprotegerin inhibits aortic valve calcification and preserves valve function in hypercholesterolemic mice.

Weiss RM, Lund DD, Chu Y, Brooks RM, Zimmerman KA, El Accaoui R, Davis MK, Hajj GP, Zimmerman MB, Heistad DD.

PLoS One. 2013 Jun 6;8(6):e65201. doi: 10.1371/journal.pone.0065201. Print 2013.


Response to letter regarding article, "Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging".

Pena-Silva RA, Faraci FM, Heistad DD.

Stroke. 2013 Apr;44(4):e35. No abstract available.


Vascular function during prolonged progression and regression of atherosclerosis in mice.

Miller JD, Chu Y, Castaneda LE, Serrano KM, Brooks RM, Heistad DD.

Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):459-65. doi: 10.1161/ATVBAHA.112.252700. Epub 2013 Jan 10.


Pioglitazone attenuates valvular calcification induced by hypercholesterolemia.

Chu Y, Lund DD, Weiss RM, Brooks RM, Doshi H, Hajj GP, Sigmund CD, Heistad DD.

Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):523-32. doi: 10.1161/ATVBAHA.112.300794. Epub 2013 Jan 3.


Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging.

Peña Silva RA, Chu Y, Miller JD, Mitchell IJ, Penninger JM, Faraci FM, Heistad DD.

Stroke. 2012 Dec;43(12):3358-63. doi: 10.1161/STROKEAHA.112.667063. Epub 2012 Nov 15.


Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.

Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O'Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM.

Circulation. 2011 Oct 18;124(16):1783-91. doi: 10.1161/CIRCULATIONAHA.110.006767. Review. No abstract available.


Calcific aortic valve stenosis: methods, models, and mechanisms.

Miller JD, Weiss RM, Heistad DD.

Circ Res. 2011 May 27;108(11):1392-412. doi: 10.1161/CIRCRESAHA.110.234138. Review.


No answer to Alzheimer's disease?

Chu Y, Heistad DD.

Circ Res. 2010 Dec 10;107(12):1400-2. doi: 10.1161/CIRCRESAHA.110.234450. Epub 2010 Dec 2. No abstract available.


Evidence for active regulation of pro-osteogenic signaling in advanced aortic valve disease.

Miller JD, Weiss RM, Serrano KM, Castaneda LE, Brooks RM, Zimmerman K, Heistad DD.

Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2482-6. doi: 10.1161/ATVBAHA.110.211029. Epub 2010 Sep 23. Erratum in: Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):e2.


MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure.

Miller JD, Peotta VA, Chu Y, Weiss RM, Zimmerman K, Brooks RM, Heistad DD.

Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1600-7. doi: 10.1152/ajpheart.01108.2009. Epub 2010 Mar 19.


EP1c times for angiotensin: EP1 receptors facilitate angiotensin II-induced vascular dysfunction.

Pena-Silva RA, Heistad DD.

Hypertension. 2010 Apr;55(4):846-8. doi: 10.1161/HYPERTENSIONAHA.109.148346. Epub 2010 Mar 1. No abstract available.


Critical role for copper/zinc-superoxide dismutase in preventing spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice.

Wakisaka Y, Chu Y, Miller JD, Rosenberg GA, Heistad DD.

Stroke. 2010 Apr;41(4):790-7. doi: 10.1161/STROKEAHA.109.569616. Epub 2010 Feb 11.


Spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice.

Wakisaka Y, Chu Y, Miller JD, Rosenberg GA, Heistad DD.

J Cereb Blood Flow Metab. 2010 Jan;30(1):56-69. doi: 10.1038/jcbfm.2009.183. Epub 2009 Sep 2.


Biventricular adaptation to volume overload in mice with aortic regurgitation.

Berry CJ, Miller JD, McGroary K, Thedens DR, Young SG, Heistad DD, Weiss RM.

J Cardiovasc Magn Reson. 2009 Aug 11;11:27. doi: 10.1186/1532-429X-11-27.


Serotonin produces monoamine oxidase-dependent oxidative stress in human heart valves.

Peña-Silva RA, Miller JD, Chu Y, Heistad DD.

Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1354-60. doi: 10.1152/ajpheart.00570.2009. Epub 2009 Aug 7.


Lowering plasma cholesterol levels halts progression of aortic valve disease in mice.

Miller JD, Weiss RM, Serrano KM, Brooks RM 2nd, Berry CJ, Zimmerman K, Young SG, Heistad DD.

Circulation. 2009 May 26;119(20):2693-701. doi: 10.1161/CIRCULATIONAHA.108.834614. Epub 2009 May 11.


Protective effect of extracellular superoxide dismutase on endothelial function during aging.

Lund DD, Chu Y, Miller JD, Heistad DD.

Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1920-5. doi: 10.1152/ajpheart.01342.2008. Epub 2009 Apr 17.


Remodelling of small cerebral arteries in human hypertension: structural and functional alterations.

Grassi G, Heistad DD.

J Hypertens. 2009 Apr;27(4):709-11. doi: 10.1097/HJH.0b013e3283295dd4. No abstract available.


Novel aspects of oxidative stress in cardiovascular diseases.

Heistad DD, Wakisaka Y, Miller J, Chu Y, Pena-Silva R.

Circ J. 2009 Feb;73(2):201-7. Epub 2008 Dec 26. Review.


Endothelial function in the time of the giants.

Heistad DD.

J Cardiovasc Pharmacol. 2008 Nov;52(5):385-92. doi: 10.1097/FJC.0b013e31818a403b. Review.


Superoxide dismutase gene transfer reduces portal pressure in CCl4 cirrhotic rats with portal hypertension.

Laviña B, Gracia-Sancho J, Rodríguez-Vilarrupla A, Chu Y, Heistad DD, Bosch J, García-Pagán JC.

Gut. 2009 Jan;58(1):118-25. doi: 10.1136/gut.2008.149880. Epub 2008 Oct 1.


Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans.

Miller JD, Chu Y, Brooks RM, Richenbacher WE, Peña-Silva R, Heistad DD.

J Am Coll Cardiol. 2008 Sep 2;52(10):843-50. doi: 10.1016/j.jacc.2008.05.043.


Gene transfer after subarachnoid hemorrhage: a tool and potential therapy.

Heistad DD, Watanabe Y, Chu Y.

Acta Neurochir Suppl. 2008;104:157-9.


Shear stress influences spatial variations in vascular Mn-SOD expression: implication for LDL nitration.

Ai L, Rouhanizadeh M, Wu JC, Takabe W, Yu H, Alavi M, Li R, Chu Y, Miller J, Heistad DD, Hsiai TK.

Am J Physiol Cell Physiol. 2008 Jun;294(6):C1576-85. doi: 10.1152/ajpcell.00518.2007. Epub 2008 Apr 23.


Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage.

Wakisaka Y, Miller JD, Chu Y, Baumbach GL, Wilson S, Faraci FM, Sigmund CD, Heistad DD.

J Cereb Blood Flow Metab. 2008 Jun;28(6):1175-85. doi: 10.1038/jcbfm.2008.7. Epub 2008 Feb 27.


Role of angiotensin II in endothelial dysfunction induced by lipopolysaccharide in mice.

Lund DD, Brooks RM, Faraci FM, Heistad DD.

Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3726-31. Epub 2007 Oct 26.


Effects of a common human gene variant of extracellular superoxide dismutase on endothelial function after endotoxin in mice.

Lund DD, Chu Y, Brooks RM, Faraci FM, Heistad DD.

J Physiol. 2007 Oct 15;584(Pt 2):583-90. Epub 2007 Aug 23.


Central gene transfer of interleukin-10 reduces hypothalamic inflammation and evidence of heart failure in rats after myocardial infarction.

Yu Y, Zhang ZH, Wei SG, Chu Y, Weiss RM, Heistad DD, Felder RB.

Circ Res. 2007 Aug 3;101(3):304-12. Epub 2007 Jun 14.


Cerebral vascular dysfunction during hypercholesterolemia.

Kitayama J, Faraci FM, Lentz SR, Heistad DD.

Stroke. 2007 Jul;38(7):2136-41. Epub 2007 May 24.


Two views on plaque rupture.

Hansson GK, Heistad DD.

Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):697. No abstract available.


Gene therapy for stroke: 2006 overview.

Chu Y, Miller JD, Heistad DD.

Curr Hypertens Rep. 2007 Mar;9(1):19-24. Review.


Vascular endothelium summary statement I: Health promotion and chronic disease prevention.

Hooper WC, Catravas JD, Heistad DD, Sessa WC, Mensah GA.

Vascul Pharmacol. 2007 May;46(5):315-7. Epub 2006 Nov 22.


Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression.

Tsimikas S, Aikawa M, Miller FJ Jr, Miller ER, Torzewski M, Lentz SR, Bergmark C, Heistad DD, Libby P, Witztum JL.

Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):175-81. Epub 2006 Nov 2.


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