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Items: 1 to 50 of 65

1.

Specific subpopulations of hypothalamic leptin receptor-expressing neurons mediate the effects of early developmental leptin receptor deletion on energy balance.

Rupp AC, Allison MB, Jones JC, Patterson CM, Faber CL, Bozadjieva N, Heisler LK, Seeley RJ, Olson DP, Myers MG Jr.

Mol Metab. 2018 Jun 6. pii: S2212-8778(18)30432-0. doi: 10.1016/j.molmet.2018.06.001. [Epub ahead of print]

2.

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice.

Meakin PJ, Jalicy SM, Montagut G, Allsop DJP, Cavellini DL, Irvine SW, McGinley C, Liddell MK, McNeilly AD, Parmionova K, Liu YR, Bailey CLS, Dale JK, Heisler LK, McCrimmon RJ, Ashford MLJ.

Sci Rep. 2018 Jan 8;8(1):55. doi: 10.1038/s41598-017-18388-6.

3.

An appetite for life: brain regulation of hunger and satiety.

Heisler LK, Lam DD.

Curr Opin Pharmacol. 2017 Dec;37:100-106. doi: 10.1016/j.coph.2017.09.002. Epub 2017 Nov 5. Review.

PMID:
29107871
4.

Lorcaserin improves glycemic control via a melanocortin neurocircuit.

Burke LK, Ogunnowo-Bada E, Georgescu T, Cristiano C, de Morentin PBM, Valencia Torres L, D'Agostino G, Riches C, Heeley N, Ruan Y, Rubinstein M, Low MJ, Myers MG, Rochford JJ, Evans ML, Heisler LK.

Mol Metab. 2017 Oct;6(10):1092-1102. doi: 10.1016/j.molmet.2017.07.004. Epub 2017 Jul 21.

5.

Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite.

Garfield AS, Davies JR, Burke LK, Furby HV, Wilkinson LS, Heisler LK, Isles AR.

Mol Brain. 2016 Dec 8;9(1):95.

6.

Activation of Ventral Tegmental Area 5-HT2C Receptors Reduces Incentive Motivation.

Valencia-Torres L, Olarte-Sánchez CM, Lyons DJ, Georgescu T, Greenwald-Yarnell M, Myers MG Jr, Bradshaw CM, Heisler LK.

Neuropsychopharmacology. 2017 Jun;42(7):1511-1521. doi: 10.1038/npp.2016.264. Epub 2016 Nov 24.

7.

Intracerebroventricular Catalase Reduces Hepatic Insulin Sensitivity and Increases Responses to Hypoglycemia in Rats.

Pauliina Markkula S, Lyons D, Yueh CY, Riches C, Hurst P, Fielding B, Heisler LK, Evans ML.

Endocrinology. 2016 Dec;157(12):4669-4676. Epub 2016 Oct 14.

8.

Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala.

Marcinkiewcz CA, Mazzone CM, D'Agostino G, Halladay LR, Hardaway JA, DiBerto JF, Navarro M, Burnham N, Cristiano C, Dorrier CE, Tipton GJ, Ramakrishnan C, Kozicz T, Deisseroth K, Thiele TE, McElligott ZA, Holmes A, Heisler LK, Kash TL.

Nature. 2016 Sep 1;537(7618):97-101. doi: 10.1038/nature19318. Epub 2016 Aug 24.

9.

Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice.

Xu P, He Y, Cao X, Valencia-Torres L, Yan X, Saito K, Wang C, Yang Y, Hinton A Jr, Zhu L, Shu G, Myers MG Jr, Wu Q, Tong Q, Heisler LK, Xu Y.

Biol Psychiatry. 2017 May 1;81(9):737-747. doi: 10.1016/j.biopsych.2016.06.005. Epub 2016 Jun 9.

10.

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.

Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, Tóth M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian H.

Cell Metab. 2016 May 10;23(5):821-36. doi: 10.1016/j.cmet.2016.04.003. Epub 2016 Apr 28.

11.

Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons.

Burke LK, Doslikova B, D'Agostino G, Greenwald-Yarnell M, Georgescu T, Chianese R, Martinez de Morentin PB, Ogunnowo-Bada E, Cansell C, Valencia-Torres L, Garfield AS, Apergis-Schoute J, Lam DD, Speakman JR, Rubinstein M, Low MJ, Rochford JJ, Myers MG, Evans ML, Heisler LK.

Mol Metab. 2016 Jan 22;5(3):245-252. doi: 10.1016/j.molmet.2016.01.005. eCollection 2016 Mar.

12.

Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit.

D'Agostino G, Lyons DJ, Cristiano C, Burke LK, Madara JC, Campbell JN, Garcia AP, Land BB, Lowell BB, Dileone RJ, Heisler LK.

Elife. 2016 Mar 14;5. pii: e12225. doi: 10.7554/eLife.12225.

13.

5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats.

Martin-Gronert MS, Stocker CJ, Wargent ET, Cripps RL, Garfield AS, Jovanovic Z, D'Agostino G, Yeo GS, Cawthorne MA, Arch JR, Heisler LK, Ozanne SE.

Dis Model Mech. 2016 Apr;9(4):401-12. doi: 10.1242/dmm.023903. Epub 2016 Jan 14.

14.

Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice.

D'Agostino G, Cristiano C, Lyons DJ, Citraro R, Russo E, Avagliano C, Russo R, Raso GM, Meli R, De Sarro G, Heisler LK, Calignano A.

Mol Metab. 2015 May 2;4(7):528-36. doi: 10.1016/j.molmet.2015.04.005. eCollection 2015 Jul.

15.

5-hydroxytryptamine medications for the treatment of obesity.

Burke LK, Heisler LK.

J Neuroendocrinol. 2015 Jun;27(6):389-98. doi: 10.1111/jne.12287. Review.

PMID:
25925636
16.

A parabrachial-hypothalamic cholecystokinin neurocircuit controls counterregulatory responses to hypoglycemia.

Garfield AS, Shah BP, Madara JC, Burke LK, Patterson CM, Flak J, Neve RL, Evans ML, Lowell BB, Myers MG Jr, Heisler LK.

Cell Metab. 2014 Dec 2;20(6):1030-7. doi: 10.1016/j.cmet.2014.11.006.

17.

Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance.

Flak JN, Patterson CM, Garfield AS, D'Agostino G, Goforth PB, Sutton AK, Malec PA, Wong JT, Germani M, Jones JC, Rajala M, Satin L, Rhodes CJ, Olson DP, Kennedy RT, Heisler LK, Myers MG Jr.

Nat Neurosci. 2014 Dec;17(12):1744-1750. doi: 10.1038/nn.3861. Epub 2014 Nov 10.

18.

5-HT obesity medication efficacy via POMC activation is maintained during aging.

Burke LK, Doslikova B, D'Agostino G, Garfield AS, Farooq G, Burdakov D, Low MJ, Rubinstein M, Evans ML, Billups B, Heisler LK.

Endocrinology. 2014 Oct;155(10):3732-8. doi: 10.1210/en.2014-1223. Epub 2014 Jul 22.

19.

Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup.

Cowley M, Garfield AS, Madon-Simon M, Charalambous M, Clarkson RW, Smalley MJ, Kendrick H, Isles AR, Parry AJ, Carney S, Oakey RJ, Heisler LK, Moorwood K, Wolf JB, Ward A.

PLoS Biol. 2014 Feb 25;12(2):e1001799. doi: 10.1371/journal.pbio.1001799. eCollection 2014 Feb.

20.

Distribution of cells responsive to 5-HT₆ receptor antagonist-induced hypophagia.

Garfield AS, Burke LK, Shaw J, Evans ML, Heisler LK.

Behav Brain Res. 2014 Jun 1;266:201-6. doi: 10.1016/j.bbr.2014.02.018. Epub 2014 Feb 21.

21.

5-HT2C receptor agonist anorectic efficacy potentiated by 5-HT1B receptor agonist coapplication: an effect mediated via increased proportion of pro-opiomelanocortin neurons activated.

Doslikova B, Garfield AS, Shaw J, Evans ML, Burdakov D, Billups B, Heisler LK.

J Neurosci. 2013 Jun 5;33(23):9800-4. doi: 10.1523/JNEUROSCI.4326-12.2013.

22.

Neuroanatomical characterisation of the expression of the lipodystrophy and motor-neuropathy gene Bscl2 in adult mouse brain.

Garfield AS, Chan WS, Dennis RJ, Ito D, Heisler LK, Rochford JJ.

PLoS One. 2012;7(9):e45790. doi: 10.1371/journal.pone.0045790. Epub 2012 Sep 25.

23.

Unraveling the brain regulation of appetite: lessons from genetics.

Yeo GS, Heisler LK.

Nat Neurosci. 2012 Oct;15(10):1343-9. doi: 10.1038/nn.3211. Epub 2012 Sep 25. Review.

PMID:
23007189
24.

Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract.

Garfield AS, Patterson C, Skora S, Gribble FM, Reimann F, Evans ML, Myers MG Jr, Heisler LK.

Endocrinology. 2012 Oct;153(10):4600-7. Epub 2012 Aug 6.

25.

Recurrent hypoglycemia is associated with loss of activation in rat brain cingulate cortex.

Hurst P, Garfield AS, Marrow C, Heisler LK, Evans ML.

Endocrinology. 2012 Apr;153(4):1908-14. doi: 10.1210/en.2011-1827. Epub 2012 Mar 6.

26.

Melanocortin-3 receptors are involved in adaptation to restricted feeding.

Begriche K, Marston OJ, Rossi J, Burke LK, McDonald P, Heisler LK, Butler AA.

Genes Brain Behav. 2012 Apr;11(3):291-302. doi: 10.1111/j.1601-183X.2012.00766.x. Epub 2012 Feb 6.

27.

Brain glucose sensors play a significant role in the regulation of pancreatic glucose-stimulated insulin secretion.

Osundiji MA, Lam DD, Shaw J, Yueh CY, Markkula SP, Hurst P, Colliva C, Roda A, Heisler LK, Evans ML.

Diabetes. 2012 Feb;61(2):321-8. doi: 10.2337/db11-1050. Epub 2011 Dec 30.

28.

Setting the tone: reactive oxygen species and the control of appetitive melanocortin neurons.

Rochford JJ, Myers MG Jr, Heisler LK.

Cell Metab. 2011 Nov 2;14(5):573-4. doi: 10.1016/j.cmet.2011.10.004.

29.

Neuropeptide Y cells represent a distinct glucose-sensing population in the lateral hypothalamus.

Marston OJ, Hurst P, Evans ML, Burdakov DI, Heisler LK.

Endocrinology. 2011 Nov;152(11):4046-52. doi: 10.1210/en.2011-1307. Epub 2011 Sep 13.

30.

Leptin does not directly affect CNS serotonin neurons to influence appetite.

Lam DD, Leinninger GM, Louis GW, Garfield AS, Marston OJ, Leshan RL, Scheller EL, Christensen L, Donato J Jr, Xia J, Evans ML, Elias C, Dalley JW, Burdakov DI, Myers MG Jr, Heisler LK.

Cell Metab. 2011 May 4;13(5):584-91. doi: 10.1016/j.cmet.2011.03.016.

31.

Glucokinase inhibitor glucosamine stimulates feeding and activates hypothalamic neuropeptide Y and orexin neurons.

Zhou L, Yueh CY, Lam DD, Shaw J, Osundiji M, Garfield AS, Evans M, Heisler LK.

Behav Brain Res. 2011 Sep 12;222(1):274-8. doi: 10.1016/j.bbr.2011.03.043. Epub 2011 Apr 1.

32.

Role of central serotonin and melanocortin systems in the control of energy balance.

Marston OJ, Garfield AS, Heisler LK.

Eur J Pharmacol. 2011 Jun 11;660(1):70-9. doi: 10.1016/j.ejphar.2010.12.024. Epub 2011 Jan 7. Review.

PMID:
21216242
33.

A serotonin and melanocortin circuit mediates D-fenfluramine anorexia.

Xu Y, Jones JE, Lauzon DA, Anderson JG, Balthasar N, Heisler LK, Zinn AR, Lowell BB, Elmquist JK.

J Neurosci. 2010 Nov 3;30(44):14630-4. doi: 10.1523/JNEUROSCI.5412-09.2010.

34.

Brain serotonin system in the coordination of food intake and body weight.

Lam DD, Garfield AS, Marston OJ, Shaw J, Heisler LK.

Pharmacol Biochem Behav. 2010 Nov;97(1):84-91. doi: 10.1016/j.pbb.2010.09.003. Epub 2010 Sep 17. Review.

PMID:
20837046
35.

Recurrent hypoglycemia increases hypothalamic glucose phosphorylation activity in rats.

Osundiji MA, Hurst P, Moore SP, Markkula SP, Yueh CY, Swamy A, Hoashi S, Shaw JS, Riches CH, Heisler LK, Evans ML.

Metabolism. 2011 Apr;60(4):550-6. doi: 10.1016/j.metabol.2010.05.009. Epub 2010 Jul 29.

36.

Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically.

Stanley S, Pinto S, Segal J, Pérez CA, Viale A, DeFalco J, Cai X, Heisler LK, Friedman JM.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7024-9. doi: 10.1073/pnas.1002790107. Epub 2010 Mar 29.

37.

Brain glucosamine boosts protective glucoprivic feeding.

Osundiji MA, Zhou L, Shaw J, Moore SP, Yueh CY, Sherwin R, Heisler LK, Evans ML.

Endocrinology. 2010 Apr;151(4):1499-508. doi: 10.1210/en.2009-0989. Epub 2010 Feb 23.

38.

Transgenic mice expressing green fluorescent protein under the control of the corticotropin-releasing hormone promoter.

Alon T, Zhou L, Pérez CA, Garfield AS, Friedman JM, Heisler LK.

Endocrinology. 2009 Dec;150(12):5626-32. doi: 10.1210/en.2009-0881. Epub 2009 Oct 23.

39.

Nutritional state influences Nociceptin/Orphanin FQ peptide receptor expression in the dorsal raphe nucleus.

Przydzial MJ, Garfield AS, Lam DD, Moore SP, Evans ML, Heisler LK.

Behav Brain Res. 2010 Jan 20;206(2):313-7. doi: 10.1016/j.bbr.2009.09.017. Epub 2009 Sep 16.

40.

Role of central melanocortin pathways in energy homeostasis.

Garfield AS, Lam DD, Marston OJ, Przydzial MJ, Heisler LK.

Trends Endocrinol Metab. 2009 Jul;20(5):203-15. doi: 10.1016/j.tem.2009.02.002. Epub 2009 Jun 21. Review.

PMID:
19541496
41.

Targeting the serotonin 2C receptor for the treatment of obesity and type 2 diabetes.

Marston OJ, Heisler LK.

Neuropsychopharmacology. 2009 Jan;34(1):252-3. doi: 10.1038/npp.2008.169. Review. No abstract available.

42.

Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism.

Kumar KG, Trevaskis JL, Lam DD, Sutton GM, Koza RA, Chouljenko VN, Kousoulas KG, Rogers PM, Kesterson RA, Thearle M, Ferrante AW Jr, Mynatt RL, Burris TP, Dong JZ, Halem HA, Culler MD, Heisler LK, Stephens JM, Butler AA.

Cell Metab. 2008 Dec;8(6):468-81. doi: 10.1016/j.cmet.2008.10.011.

43.

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis.

Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK.

Neuron. 2008 Nov 26;60(4):582-9. doi: 10.1016/j.neuron.2008.09.033.

44.

Pharmacological targeting of the serotonergic system for the treatment of obesity.

Garfield AS, Heisler LK.

J Physiol. 2009 Jan 15;587(1):49-60. doi: 10.1113/jphysiol.2008.164152. Epub 2008 Nov 24. Review.

45.

Distribution and neurochemical characterization of neurons within the nucleus of the solitary tract responsive to serotonin agonist-induced hypophagia.

Lam DD, Zhou L, Vegge A, Xiu PY, Christensen BT, Osundiji MA, Yueh CY, Evans ML, Heisler LK.

Behav Brain Res. 2009 Jan 3;196(1):139-43. doi: 10.1016/j.bbr.2008.07.039. Epub 2008 Aug 13.

46.

Nociceptin/orphanin FQ peptide receptor as a therapeutic target for obesity.

Przydzial MJ, Heisler LK.

Mini Rev Med Chem. 2008 Jul;8(8):796-811. Review.

PMID:
18673136
47.

Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors.

Lam DD, Przydzial MJ, Ridley SH, Yeo GS, Rochford JJ, O'Rahilly S, Heisler LK.

Endocrinology. 2008 Mar;149(3):1323-8. Epub 2007 Nov 26.

48.

Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways.

Zhou L, Sutton GM, Rochford JJ, Semple RK, Lam DD, Oksanen LJ, Thornton-Jones ZD, Clifton PG, Yueh CY, Evans ML, McCrimmon RJ, Elmquist JK, Butler AA, Heisler LK.

Cell Metab. 2007 Nov;6(5):398-405.

49.

Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation.

Heisler LK, Pronchuk N, Nonogaki K, Zhou L, Raber J, Tung L, Yeo GS, O'Rahilly S, Colmers WF, Elmquist JK, Tecott LH.

J Neurosci. 2007 Jun 27;27(26):6956-64.

50.

Melanocortin receptors as targets in the treatment of obesity.

Lam DD, Farooqi IS, Heisler LK.

Curr Top Med Chem. 2007;7(11):1085-1097.

PMID:
17584129

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