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Immune predictors of mortality following RNA virus infection.

Graham JB, Swarts JL, Menachery VD, Gralinski LE, Schäfer A, Plante KS, Morrison CR, Voss KM, Green R, Choonoo G, Jeng S, Miller DR, Mooney MA, McWeeney SK, Ferris MT, Pardo-Manuel de Villena F, Gale M, Heise MT, Baric RS, Lund JM.

J Infect Dis. 2019 Oct 17. pii: jiz531. doi: 10.1093/infdis/jiz531. [Epub ahead of print]


Mouse Models as Resources for Studying Infectious Diseases.

Sarkar S, Heise MT.

Clin Ther. 2019 Oct;41(10):1912-1922. doi: 10.1016/j.clinthera.2019.08.010. Epub 2019 Sep 18.


Studies on Dibenzylamines as Inhibitors of Venezuelan Equine Encephalitis Virus.

Nguyen TH, Haese NN, Madadi N, Sarkar S, Bonin K, Streblow CE, Taft-Benz S, Tower NA, Rasmussen L, Bostwick R, Augelli-Szafran CE, Suto MJ, Morrison TE, DeFilippis V, Heise MT, Streblow DN, Pathak AK.

ACS Infect Dis. 2019 Dec 13;5(12):2014-2028. doi: 10.1021/acsinfecdis.9b00035. Epub 2019 Jul 11.


The Collaborative Cross: A Systems Genetics Resource for Studying Host-Pathogen Interactions.

Noll KE, Ferris MT, Heise MT.

Cell Host Microbe. 2019 Apr 10;25(4):484-498. doi: 10.1016/j.chom.2019.03.009. Review.


Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs.

Broeckel R, Sarkar S, May NA, Totonchy J, Kreklywich CN, Smith P, Graves L, DeFilippis VR, Heise MT, Morrison TE, Moorman N, Streblow DN.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02325-18. doi: 10.1128/AAC.02325-18. Print 2019 Apr.


Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis.

Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Leist SR, Whitmore A, Heise MT, Baric RS.

mBio. 2018 Oct 9;9(5). pii: e01753-18. doi: 10.1128/mBio.01753-18.


Genetic control of alphavirus pathogenesis.

Baxter VK, Heise MT.

Mamm Genome. 2018 Aug;29(7-8):408-424. doi: 10.1007/s00335-018-9776-1. Epub 2018 Aug 27. Review.


Development of a Broadly Accessible Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Platform.

Agnihothram S, Menachery VD, Yount BL Jr.,, Lindesmith LC, Scobey T, Whitmore A, Schäfer A, Heise MT, Baric RS.

J Virol. 2018 May 14;92(11). pii: e00027-18. doi: 10.1128/JVI.00027-18. Print 2018 Jun 1.


Structural divergence creates new functional features in alphavirus genomes.

Kutchko KM, Madden EA, Morrison C, Plante KS, Sanders W, Vincent HA, Cruz Cisneros MC, Long KM, Moorman NJ, Heise MT, Laederach A.

Nucleic Acids Res. 2018 Apr 20;46(7):3657-3670. doi: 10.1093/nar/gky012.


Ross River virus envelope glycans contribute to disease through activation of the host complement system.

Gunn BM, Jones JE, Shabman RS, Whitmore AC, Sarkar S, Blevins LK, Morrison TE, Heise MT.

Virology. 2018 Feb;515:250-260. doi: 10.1016/j.virol.2017.12.022. Epub 2018 Jan 8.


Bayesian Diallel Analysis Reveals Mx1-Dependent and Mx1-Independent Effects on Response to Influenza A Virus in Mice.

Maurizio PL, Ferris MT, Keele GR, Miller DR, Shaw GD, Whitmore AC, West A, Morrison CR, Noll KE, Plante KS, Cockrell AS, Threadgill DW, Pardo-Manuel de Villena F, Baric RS, Heise MT, Valdar W.

G3 (Bethesda). 2018 Feb 2;8(2):427-445. doi: 10.1534/g3.117.300438.


Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology.

Jones JE, Long KM, Whitmore AC, Sanders W, Thurlow LR, Brown JA, Morrison CR, Vincent H, Peck KM, Browning C, Moorman N, Lim JK, Heise MT.

mBio. 2017 Nov 14;8(6). pii: e01456-17. doi: 10.1128/mBio.01456-17.


Permissivity of Dipeptidyl Peptidase 4 Orthologs to Middle East Respiratory Syndrome Coronavirus Is Governed by Glycosylation and Other Complex Determinants.

Peck KM, Scobey T, Swanstrom J, Jensen KL, Burch CL, Baric RS, Heise MT.

J Virol. 2017 Sep 12;91(19). pii: e00534-17. doi: 10.1128/JVI.00534-17. Print 2017 Oct 1.


Complete Genome Sequences of 15 Chikungunya Virus Isolates from Puerto Rico.

Sanders WA, Long K, Rivera B, Vincent HA, Heise MT, Rodriguez-Orengo JF, Moorman NJ.

Genome Announc. 2017 Jul 6;5(27). pii: e00561-17. doi: 10.1128/genomeA.00561-17.


A Reverse Genetics Platform That Spans the Zika Virus Family Tree.

Widman DG, Young E, Yount BL, Plante KS, Gallichotte EN, Carbaugh DL, Peck KM, Plante J, Swanstrom J, Heise MT, Lazear HM, Baric RS.

mBio. 2017 Mar 7;8(2). pii: e02014-16. doi: 10.1128/mBio.02014-16.


Animal Models of Chikungunya Virus Infection and Disease.

Haese NN, Broeckel RM, Hawman DW, Heise MT, Morrison TE, Streblow DN.

J Infect Dis. 2016 Dec 15;214(suppl 5):S482-S487. Review.


A mouse model for MERS coronavirus-induced acute respiratory distress syndrome.

Cockrell AS, Yount BL, Scobey T, Jensen K, Douglas M, Beall A, Tang XC, Marasco WA, Heise MT, Baric RS.

Nat Microbiol. 2016 Nov 28;2:16226. doi: 10.1038/nmicrobiol.2016.226.


Transcriptional profiles of WNV neurovirulence in a genetically diverse Collaborative Cross population.

Green R, Wilkins C, Thomas S, Sekine A, Ireton RC, Ferris MT, Hendrick DM, Voss K, Pardo-Manuel de Villena F, Baric RS, Heise MT, Gale M Jr.

Genom Data. 2016 Oct 14;10:137-140. eCollection 2016 Dec.


A Universal Next-Generation Sequencing Protocol To Generate Noninfectious Barcoded cDNA Libraries from High-Containment RNA Viruses.

Moser LA, Ramirez-Carvajal L, Puri V, Pauszek SJ, Matthews K, Dilley KA, Mullan C, McGraw J, Khayat M, Beeri K, Yee A, Dugan V, Heise MT, Frieman MB, Rodriguez LL, Bernard KA, Wentworth DE, Stockwell TB, Shabman RS.

mSystems. 2016 Jun 7;1(3). pii: e00039-15. eCollection 2016 May-Jun.


Dengue Virus Envelope Dimer Epitope Monoclonal Antibodies Isolated from Dengue Patients Are Protective against Zika Virus.

Swanstrom JA, Plante JA, Plante KS, Young EF, McGowan E, Gallichotte EN, Widman DG, Heise MT, de Silva AM, Baric RS.

mBio. 2016 Jul 19;7(4). pii: e01123-16. doi: 10.1128/mBio.01123-16.


Chikungunya Virus: Current Perspectives on a Reemerging Virus.

Morrison CR, Plante KS, Heise MT.

Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.EI10-0017-2016. Review.


Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives.

Peck KM, Burch CL, Heise MT, Baric RS.

Annu Rev Virol. 2015 Nov;2(1):95-117. doi: 10.1146/annurev-virology-100114-055029. Epub 2015 Aug 7. Review.


CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection.

Jiang C, Zhou Z, Quan Y, Zhang S, Wang T, Zhao X, Morrison C, Heise MT, He W, Miller MS, Lin X.

Cell Rep. 2016 Mar 15;14(10):2389-401. doi: 10.1016/j.celrep.2016.02.031. Epub 2016 Mar 3.


γδ T Cells Play a Protective Role in Chikungunya Virus-Induced Disease.

Long KM, Ferris MT, Whitmore AC, Montgomery SA, Thurlow LR, McGee CE, Rodriguez CA, Lim JK, Heise MT.

J Virol. 2015 Oct 21;90(1):433-43. doi: 10.1128/JVI.02159-15. Print 2016 Jan 1.


Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.

Gralinski LE, Ferris MT, Aylor DL, Whitmore AC, Green R, Frieman MB, Deming D, Menachery VD, Miller DR, Buus RJ, Bell TA, Churchill GA, Threadgill DW, Katze MG, McMillan L, Valdar W, Heise MT, Pardo-Manuel de Villena F, Baric RS.

PLoS Genet. 2015 Oct 9;11(10):e1005504. doi: 10.1371/journal.pgen.1005504. eCollection 2015 Oct.


Protective and Pathogenic Responses to Chikungunya Virus Infection.

Long KM, Heise MT.

Curr Trop Med Rep. 2015 Mar;2(1):13-21.


Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus.

Smith SA, Silva LA, Fox JM, Flyak AI, Kose N, Sapparapu G, Khomandiak S, Ashbrook AW, Kahle KM, Fong RH, Swayne S, Doranz BJ, McGee CE, Heise MT, Pal P, Brien JD, Austin SK, Diamond MS, Dermody TS, Crowe JE Jr.

Cell Host Microbe. 2015 Jul 8;18(1):86-95. doi: 10.1016/j.chom.2015.06.009. Erratum in: Cell Host Microbe. 2015 Sep 9;18(3):382. Khomadiak, Solomiia [corrected to Khomandiak, Solomiia].


Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection.

Totura AL, Whitmore A, Agnihothram S, Schäfer A, Katze MG, Heise MT, Baric RS.

mBio. 2015 May 26;6(3):e00638-15. doi: 10.1128/mBio.00638-15.


Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection.

Peck KM, Cockrell AS, Yount BL, Scobey T, Baric RS, Heise MT.

J Virol. 2015 Apr;89(8):4696-9. doi: 10.1128/JVI.03445-14. Epub 2015 Feb 4.


Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance.

Rasmussen AL, Okumura A, Ferris MT, Green R, Feldmann F, Kelly SM, Scott DP, Safronetz D, Haddock E, LaCasse R, Thomas MJ, Sova P, Carter VS, Weiss JM, Miller DR, Shaw GD, Korth MJ, Heise MT, Baric RS, de Villena FP, Feldmann H, Katze MG.

Science. 2014 Nov 21;346(6212):987-91. doi: 10.1126/science.1259595. Epub 2014 Oct 30.


A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner.

Donohoe DR, Holley D, Collins LB, Montgomery SA, Whitmore AC, Hillhouse A, Curry KP, Renner SW, Greenwalt A, Ryan EP, Godfrey V, Heise MT, Threadgill DS, Han A, Swenberg JA, Threadgill DW, Bultman SJ.

Cancer Discov. 2014 Dec;4(12):1387-97. doi: 10.1158/2159-8290.CD-14-0501. Epub 2014 Sep 29.


Residue 82 of the Chikungunya virus E2 attachment protein modulates viral dissemination and arthritis in mice.

Ashbrook AW, Burrack KS, Silva LA, Montgomery SA, Heise MT, Morrison TE, Dermody TS.

J Virol. 2014 Nov;88(21):12180-92. doi: 10.1128/JVI.01672-14. Epub 2014 Aug 20.


Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.

Yamane D, McGivern DR, Wauthier E, Yi M, Madden VJ, Welsch C, Antes I, Wen Y, Chugh PE, McGee CE, Widman DG, Misumi I, Bandyopadhyay S, Kim S, Shimakami T, Oikawa T, Whitmire JK, Heise MT, Dittmer DP, Kao CC, Pitson SM, Merrill AH Jr, Reid LM, Lemon SM.

Nat Med. 2014 Aug;20(8):927-35. doi: 10.1038/nm.3610. Epub 2014 Jul 27.


Editorial overview: viral pathogenesis: dealing with complexity in virus-induced disease.

Heise MT.

Curr Opin Virol. 2014 Jun;6:v-vii. doi: 10.1016/j.coviro.2014.05.002. Epub 2014 Jun 2. No abstract available.


Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice.

Lykken JM, DiLillo DJ, Weimer ET, Roser-Page S, Heise MT, Grayson JM, Weitzmann MN, Tedder TF.

J Immunol. 2014 Jul 15;193(2):746-56. doi: 10.4049/jimmunol.1302848. Epub 2014 Jun 13.


Annotation of long non-coding RNAs expressed in collaborative cross founder mice in response to respiratory virus infection reveals a new class of interferon-stimulated transcripts.

Josset L, Tchitchek N, Gralinski LE, Ferris MT, Eisfeld AJ, Green RR, Thomas MJ, Tisoncik-Go J, Schroth GP, Kawaoka Y, Manuel de Villena FP, Baric RS, Heise MT, Peng X, Katze MG.

RNA Biol. 2014;11(7):875-90. doi: 10.4161/rna.29442. Epub 2014 Jun 12.


Genomic profiling of collaborative cross founder mice infected with respiratory viruses reveals novel transcripts and infection-related strain-specific gene and isoform expression.

Xiong H, Morrison J, Ferris MT, Gralinski LE, Whitmore AC, Green R, Thomas MJ, Tisoncik-Go J, Schroth GP, Pardo-Manuel de Villena F, Baric RS, Heise MT, Peng X, Katze MG.

G3 (Bethesda). 2014 Jun 5;4(8):1429-44. doi: 10.1534/g3.114.011759.


Mouse dipeptidyl peptidase 4 is not a functional receptor for Middle East respiratory syndrome coronavirus infection.

Cockrell AS, Peck KM, Yount BL, Agnihothram SS, Scobey T, Curnes NR, Baric RS, Heise MT.

J Virol. 2014 May;88(9):5195-9. doi: 10.1128/JVI.03764-13. Epub 2014 Feb 26.


Quantitative genetics in the study of virus-induced disease.

Ferris MT, Heise MT.

Adv Virus Res. 2014;88:193-225. doi: 10.1016/B978-0-12-800098-4.00004-0. Review.


A single-amino-acid polymorphism in Chikungunya virus E2 glycoprotein influences glycosaminoglycan utilization.

Silva LA, Khomandiak S, Ashbrook AW, Weller R, Heise MT, Morrison TE, Dermody TS.

J Virol. 2014 Mar;88(5):2385-97. doi: 10.1128/JVI.03116-13. Epub 2013 Dec 26.


Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus.

Pal P, Dowd KA, Brien JD, Edeling MA, Gorlatov S, Johnson S, Lee I, Akahata W, Nabel GJ, Richter MK, Smit JM, Fremont DH, Pierson TC, Heise MT, Diamond MS.

PLoS Pathog. 2013;9(4):e1003312. doi: 10.1371/journal.ppat.1003312. Epub 2013 Apr 18.


Dendritic cell immunoreceptor regulates Chikungunya virus pathogenesis in mice.

Long KM, Whitmore AC, Ferris MT, Sempowski GD, McGee C, Trollinger B, Gunn B, Heise MT.

J Virol. 2013 May;87(10):5697-706. doi: 10.1128/JVI.01611-12. Epub 2013 Mar 13.


Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.

Ferris MT, Aylor DL, Bottomly D, Whitmore AC, Aicher LD, Bell TA, Bradel-Tretheway B, Bryan JT, Buus RJ, Gralinski LE, Haagmans BL, McMillan L, Miller DR, Rosenzweig E, Valdar W, Wang J, Churchill GA, Threadgill DW, McWeeney SK, Katze MG, Pardo-Manuel de Villena F, Baric RS, Heise MT.

PLoS Pathog. 2013 Feb;9(2):e1003196. doi: 10.1371/journal.ppat.1003196. Epub 2013 Feb 28.


Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice.

Horikawa M, Weimer ET, DiLillo DJ, Venturi GM, Spolski R, Leonard WJ, Heise MT, Tedder TF.

J Immunol. 2013 Feb 1;190(3):1158-68. doi: 10.4049/jimmunol.1201427. Epub 2012 Dec 28.


The viral interferon regulatory factors of kaposi's sarcoma-associated herpesvirus differ in their inhibition of interferon activation mediated by toll-like receptor 3.

Jacobs SR, Gregory SM, West JA, Wollish AC, Bennett CL, Blackbourn DJ, Heise MT, Damania B.

J Virol. 2013 Jan;87(2):798-806. doi: 10.1128/JVI.01851-12. Epub 2012 Oct 31.


An attenuating mutation in a neurovirulent Sindbis virus strain interacts with the IPS-1 signaling pathway in vivo.

Wollish AC, Ferris MT, Blevins LK, Loo YM, Gale M Jr, Heise MT.

Virology. 2013 Jan 20;435(2):269-80. doi: 10.1016/j.virol.2012.09.008. Epub 2012 Oct 17.


Myd88-dependent toll-like receptor 7 signaling mediates protection from severe Ross River virus-induced disease in mice.

Neighbours LM, Long K, Whitmore AC, Heise MT.

J Virol. 2012 Oct;86(19):10675-85. doi: 10.1128/JVI.00601-12. Epub 2012 Jul 25.


Chikungunya virus transmission--more than meets the eye.

Long KM, Heise MT.

J Infect Dis. 2012 Sep 15;206(6):806-7. doi: 10.1093/infdis/jis297. Epub 2012 Jun 15. No abstract available.


Mannose binding lectin is required for alphavirus-induced arthritis/myositis.

Gunn BM, Morrison TE, Whitmore AC, Blevins LK, Hueston L, Fraser RJ, Herrero LJ, Ramirez R, Smith PN, Mahalingam S, Heise MT.

PLoS Pathog. 2012;8(3):e1002586. doi: 10.1371/journal.ppat.1002586. Epub 2012 Mar 22.


Chikungunya: a re-emerging virus.

Burt FJ, Rolph MS, Rulli NE, Mahalingam S, Heise MT.

Lancet. 2012 Feb 18;379(9816):662-71. doi: 10.1016/S0140-6736(11)60281-X. Epub 2011 Nov 17. Review.


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