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PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma.

Rataj F, Kraus FBT, Chaloupka M, Grassmann S, Heise C, Cadilha BL, Duewell P, Endres S, Kobold S.

Front Immunol. 2018 Aug 30;9:1955. doi: 10.3389/fimmu.2018.01955. eCollection 2018.


Optimized arylomycins are a new class of Gram-negative antibiotics.

Smith PA, Koehler MFT, Girgis HS, Yan D, Chen Y, Chen Y, Crawford JJ, Durk MR, Higuchi RI, Kang J, Murray J, Paraselli P, Park S, Phung W, Quinn JG, Roberts TC, Rougé L, Schwarz JB, Skippington E, Wai J, Xu M, Yu Z, Zhang H, Tan MW, Heise CE.

Nature. 2018 Sep;561(7722):189-194. doi: 10.1038/s41586-018-0483-6. Epub 2018 Sep 12.


Heterogeneity of Cell Surface Glutamate and GABA Receptor Expression in Shank and CNTN4 Autism Mouse Models.

Heise C, Preuss JM, Schroeder JC, Battaglia CR, Kolibius J, Schmid R, Kreutz MR, Kas MJH, Burbach JPH, Boeckers TM.

Front Mol Neurosci. 2018 Jun 19;11:212. doi: 10.3389/fnmol.2018.00212. eCollection 2018.


A common CHRNE mutation in Brazilian patients with congenital myasthenic syndrome.

Estephan EP, Sobreira CFDR, Dos Santos ACJ, Tomaselli PJ, Marques W Jr, Ortega RPM, Costa MCM, da Silva AMS, Mendonça RH, Caldas VM, Zambon AA, Abath Neto O, Marchiori PE, Heise CO, Reed UC, Azuma Y, Töpf A, Lochmüller H, Zanoteli E.

J Neurol. 2018 Mar;265(3):708-713. doi: 10.1007/s00415-018-8736-8. Epub 2018 Jan 30.


Spine magnetic resonance imaging with dynamic flexion sequences for evaluation of mini-polymyoclonus.

Grativvol RS, Cavalcante WCP, Caldas VM, Pimentel GA, Heise CO, Gutierrez LG, Lucato LT, Nitrini R.

Arq Neuropsiquiatr. 2017 Oct;75(10):760. doi: 10.1590/0004-282X20170131. No abstract available.


Good sensory recovery of the hand in brachial plexus surgery using the intercostobrachial nerve as the donor.

Foroni L, Siqueira MG, Martins RS, Heise CO, Sterman H Neto, Imamura AY.

Arq Neuropsiquiatr. 2017 Nov;75(11):796-800. doi: 10.1590/0004-282X20170148.


Cancer cells induce interleukin-22 production from memory CD4+ T cells via interleukin-1 to promote tumor growth.

Voigt C, May P, Gottschlich A, Markota A, Wenk D, Gerlach I, Voigt S, Stathopoulos GT, Arendt KAM, Heise C, Rataj F, Janssen KP, Königshoff M, Winter H, Himsl I, Thasler WE, Schnurr M, Rothenfußer S, Endres S, Kobold S.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12994-12999. doi: 10.1073/pnas.1705165114. Epub 2017 Nov 17.


Elective amputation of the upper limb is an option in the treatment of traumatic injuries of the brachial plexus?

Siqueira MG, Martins RS, Heise CO, Foroni L.

Arq Neuropsiquiatr. 2017 Sep;75(9):667-670. doi: 10.1590/0004-282X20170096. Review.


Clinical predictors of tissue necrosis following rattlesnake envenomation.

Heise CW, Ruha AM, Padilla-Jones A, Truitt Hayek C, Gerkin RD.

Clin Toxicol (Phila). 2018 Apr;56(4):281-284. doi: 10.1080/15563650.2017.1371311. Epub 2017 Sep 8.


A tertiary care hospital's 10 years' experience with rectal ultrasound in early rectal cancer.

Akhter A, Walker A, Heise CP, Kennedy GD, Benson ME, Pfau PR, Johnson EA, Frick TJ, Gopal DV.

Endosc Ultrasound. 2018 May-Jun;7(3):191-195. doi: 10.4103/eus.eus_15_17.

11. What does it offer?

Woosley RL, Black K, Heise CW, Romero K.

Trends Cardiovasc Med. 2018 Feb;28(2):94-99. doi: 10.1016/j.tcm.2017.07.010. Epub 2017 Aug 1. Review.


Distal nerve transfer versus supraclavicular nerve grafting: comparison of elbow flexion outcome in neonatal brachial plexus palsy with C5-C7 involvement.

Heise CO, Siqueira MG, Martins RS, Foroni LH, Sterman-Neto H.

Childs Nerv Syst. 2017 Sep;33(9):1571-1574. doi: 10.1007/s00381-017-3492-0. Epub 2017 Jun 24.


A review of vilazodone exposures with focus on serotonin syndrome effects.

Heise CW, Malashock H, Brooks DE.

Clin Toxicol (Phila). 2017 Nov;55(9):1004-1007. doi: 10.1080/15563650.2017.1332369. Epub 2017 Jun 8.


Facial and bulbar muscle atrophy in acetylcholine receptor antibody-positive myasthenia gravis.

Grativvol RS, Silva AM, Guedes BF, Estephan EP, Mendonça RH, Zambon AA, Heise CO, Zanoteli E.

Arq Neuropsiquiatr. 2017 Mar;75(3):197-198. doi: 10.1590/0004-282X20160192. No abstract available.


Adverse Drug Event Causality Analysis (ADECA): A Process for Evaluating Evidence and Assigning Drugs to Risk Categories for Sudden Death.

Woosley RL, Romero K, Heise CW, Gallo T, Tate J, Woosley RD, Ward S.

Drug Saf. 2017 Jun;40(6):465-474. doi: 10.1007/s40264-017-0519-0. Review.


Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission.

Zapata J, Moretto E, Hannan S, Murru L, Longatti A, Mazza D, Benedetti L, Fossati M, Heise C, Ponzoni L, Valnegri P, Braida D, Sala M, Francolini M, Hildebrand J, Kalscheuer V, Fanelli F, Sala C, Bettler B, Bassani S, Smart TG, Passafaro M.

Nat Commun. 2017 Mar 6;8:14536. doi: 10.1038/ncomms14536.


Associations of Specific Postoperative Complications With Outcomes After Elective Colon Resection: A Procedure-Targeted Approach Toward Surgical Quality Improvement.

Scarborough JE, Schumacher J, Kent KC, Heise CP, Greenberg CC.

JAMA Surg. 2017 Feb 15;152(2):e164681. doi: 10.1001/jamasurg.2016.4681. Epub 2017 Feb 15.


Adaptive Optimal Control Using Frequency Selective Information of the System Uncertainty With Application to Unmanned Aircraft.

Maity A, Hocht L, Heise C, Holzapfel F.

IEEE Trans Cybern. 2018 Jan;48(1):165-177. doi: 10.1109/TCYB.2016.2627030. Epub 2016 Nov 28.


Ayahuasca Exposure: Descriptive Analysis of Calls to US Poison Control Centers from 2005 to 2015.

Heise CW, Brooks DE.

J Med Toxicol. 2017 Sep;13(3):245-248. doi: 10.1007/s13181-016-0593-1. Epub 2016 Nov 28.


Nonlethal CHRNA1-Related Congenital Myasthenic Syndrome with a Homozygous Null Mutation.

Abath Neto O, Heise CO, Moreno CA, Estephan EP, Mesrob L, Lechner D, Boland A, Deleuze JF, Oliveira AS, Reed UC, Biancalana V, Laporte J, Zanoteli E.

Can J Neurol Sci. 2017 Jan;44(1):125-127. doi: 10.1017/cjn.2016.322. Epub 2016 Oct 17. No abstract available.


The differential role of cortical protein synthesis in taste memory formation and persistence.

Levitan D, Gal-Ben-Ari S, Heise C, Rosenberg T, Elkobi A, Inberg S, Sala C, Rosenblum K.

NPJ Sci Learn. 2016;1:16001. Epub 2016 May 11.


A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase.

Morisaki JH, Smith PA, Date SV, Kajihara KK, Truong CL, Modrusan Z, Yan D, Kang J, Xu M, Shah IM, Mintzer R, Kofoed EM, Cheung TK, Arnott D, Koehler MF, Heise CE, Brown EJ, Tan MW, Hazenbos WL.

MBio. 2016 Sep 6;7(5). pii: e00412-16. doi: 10.1128/mBio.00412-16.


Short-term outcomes of minimally invasive versus open colectomy for colon cancer.

Papageorge CM, Zhao Q, Foley EF, Harms BA, Heise CP, Carchman EH, Kennedy GD.

J Surg Res. 2016 Jul;204(1):83-93. doi: 10.1016/j.jss.2016.04.020. Epub 2016 Apr 22.


Superior therapeutic efficacy of nab-paclitaxel over cremophor-based paclitaxel in locally advanced and metastatic models of human pancreatic cancer.

Rajeshkumar NV, Yabuuchi S, Pai SG, Tong Z, Hou S, Bateman S, Pierce DW, Heise C, Von Hoff DD, Maitra A, Hidalgo M.

Br J Cancer. 2016 Aug 9;115(4):442-53. doi: 10.1038/bjc.2016.215. Epub 2016 Jul 21.


Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors.

Lee W, Crawford JJ, Aliagas I, Murray LJ, Tay S, Wang W, Heise CE, Hoeflich KP, La H, Mathieu S, Mintzer R, Ramaswamy S, Rouge L, Rudolph J.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3518-24. doi: 10.1016/j.bmcl.2016.06.031. Epub 2016 Jun 15.


Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus.

Heise C, Schroeder JC, Schoen M, Halbedl S, Reim D, Woelfle S, Kreutz MR, Schmeisser MJ, Boeckers TM.

Front Cell Neurosci. 2016 Apr 26;10:106. doi: 10.3389/fncel.2016.00106. eCollection 2016.


Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window.

Rudolph J, Murray LJ, Ndubaku CO, O'Brien T, Blackwood E, Wang W, Aliagas I, Gazzard L, Crawford JJ, Drobnick J, Lee W, Zhao X, Hoeflich KP, Favor DA, Dong P, Zhang H, Heise CE, Oh A, Ong CC, La H, Chakravarty P, Chan C, Jakubiak D, Epler J, Ramaswamy S, Vega R, Cain G, Diaz D, Zhong Y.

J Med Chem. 2016 Jun 9;59(11):5520-41. doi: 10.1021/acs.jmedchem.6b00638. Epub 2016 May 24.


Substance-specific importance of EGFR for vascular smooth muscle cells motility in primary culture.

Schreier B, Schwerdt G, Heise C, Bethmann D, Rabe S, Mildenberger S, Gekle M.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt A):1519-33. doi: 10.1016/j.bbamcr.2016.03.017. Epub 2016 Mar 21.


eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures.

Heise C, Taha E, Murru L, Ponzoni L, Cattaneo A, Guarnieri FC, Montani C, Mossa A, Vezzoli E, Ippolito G, Zapata J, Barrera I, Ryazanov AG, Cook J, Poe M, Stephen MR, Kopanitsa M, Benfante R, Rusconi F, Braida D, Francolini M, Proud CG, Valtorta F, Passafaro M, Sala M, Bachi A, Verpelli C, Rosenblum K, Sala C.

Cereb Cortex. 2017 Mar 1;27(3):2226-2248. doi: 10.1093/cercor/bhw075.


Two Cases of Refractory Cardiogenic Shock Secondary to Bupropion Successfully Treated with Veno-Arterial Extracorporeal Membrane Oxygenation.

Heise CW, Skolnik AB, Raschke RA, Owen-Reece H, Graeme KA.

J Med Toxicol. 2016 Sep;12(3):301-4. doi: 10.1007/s13181-016-0539-7. Epub 2016 Feb 8.


Graves' Disease Pharmacotherapy in Women of Reproductive Age.

Prunty JJ, Heise CD, Chaffin DG.

Pharmacotherapy. 2016 Jan;36(1):64-83. doi: 10.1002/phar.1676. Review.


Assessing nerves in leprosy.

Garbino JA, Heise CO, Marques W Jr.

Clin Dermatol. 2016 Jan-Feb;34(1):51-8. doi: 10.1016/j.clindermatol.2015.10.018. Epub 2015 Nov 6.


Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.

Ndubaku CO, Crawford JJ, Drobnick J, Aliagas I, Campbell D, Dong P, Dornan LM, Duron S, Epler J, Gazzard L, Heise CE, Hoeflich KP, Jakubiak D, La H, Lee W, Lin B, Lyssikatos JP, Maksimoska J, Marmorstein R, Murray LJ, O'Brien T, Oh A, Ramaswamy S, Wang W, Zhao X, Zhong Y, Blackwood E, Rudolph J.

ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6. doi: 10.1021/acsmedchemlett.5b00398. eCollection 2015 Dec 10.


Does Anastomotic Leak Contribute to High Failure-to-rescue Rates?

Tevis SE, Carchman EH, Foley EF, Heise CP, Harms BA, Kennedy GD.

Ann Surg. 2016 Jun;263(6):1148-51. doi: 10.1097/SLA.0000000000001409.


Consequences of postnatal vascular smooth muscle EGFR deletion on acute angiotensin II action.

Schreier B, Hünerberg M, Rabe S, Mildenberger S, Bethmann D, Heise C, Sibilia M, Offermanns S, Gekle M.

Clin Sci (Lond). 2016 Jan;130(1):19-33. doi: 10.1042/CS20150503. Epub 2015 Oct 5.


Neonatal brachial plexus palsy: a permanent challenge.

Heise CO, Martins R, Siqueira M.

Arq Neuropsiquiatr. 2015 Sep;73(9):803-8. doi: 10.1590/0004-282X20150105. Review.


Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors.

Burdick DJ, Wang S, Heise C, Pan B, Drummond J, Yin J, Goeser L, Magnuson S, Blaney J, Moffat J, Wang W, Chen H.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4728-4732. doi: 10.1016/j.bmcl.2015.08.048. Epub 2015 Aug 22.


SPARC Expression Did Not Predict Efficacy of nab-Paclitaxel plus Gemcitabine or Gemcitabine Alone for Metastatic Pancreatic Cancer in an Exploratory Analysis of the Phase III MPACT Trial.

Hidalgo M, Plaza C, Musteanu M, Illei P, Brachmann CB, Heise C, Pierce D, Lopez-Casas PP, Menendez C, Tabernero J, Romano A, Wei X, Lopez-Rios F, Von Hoff DD.

Clin Cancer Res. 2015 Nov 1;21(21):4811-8. doi: 10.1158/1078-0432.CCR-14-3222. Epub 2015 Jul 13. Erratum in: Clin Cancer Res. 2016 Dec 15;22(24):6302.


Postoperative Ileus--More than Just Prolonged Length of Stay?

Tevis SE, Carchman EH, Foley EF, Harms BA, Heise CP, Kennedy GD.

J Gastrointest Surg. 2015 Sep;19(9):1684-90. doi: 10.1007/s11605-015-2877-1. Epub 2015 Jun 24.


Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series.

Rudolph J, Aliagas I, Crawford JJ, Mathieu S, Lee W, Chao Q, Dong P, Rouge L, Wang W, Heise C, Murray LJ, La H, Liu Y, Manning G, Diederich F, Hoeflich KP.

ACS Med Chem Lett. 2015 May 20;6(6):711-5. doi: 10.1021/acsmedchemlett.5b00151. eCollection 2015 Jun 11.


Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.

Crawford JJ, Lee W, Aliagas I, Mathieu S, Hoeflich KP, Zhou W, Wang W, Rouge L, Murray L, La H, Liu N, Fan PW, Cheong J, Heise CE, Ramaswamy S, Mintzer R, Liu Y, Chao Q, Rudolph J.

J Med Chem. 2015 Jun 25;58(12):5121-36. doi: 10.1021/acs.jmedchem.5b00572. Epub 2015 Jun 12.


Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors.

Therrien E, Larouche G, Nguyen N, Rahil J, Lemieux AM, Li Z, Fournel M, Yan TP, Landry AJ, Lefebvre S, Wang JJ, MacBeth K, Heise C, Nguyen A, Besterman JM, Déziel R, Wahhab A.

Bioorg Med Chem Lett. 2015 Jun 15;25(12):2514-8. doi: 10.1016/j.bmcl.2015.04.068. Epub 2015 Apr 28.


Accidental pediatric ingestions of medical marijuana: a 4-year poison center experience.

Lovecchio F, Heise CW.

Am J Emerg Med. 2015 Jun;33(6):844-5. doi: 10.1016/j.ajem.2015.03.030. Epub 2015 Mar 23. No abstract available.


Characterizing readmission in ulcerative colitis patients undergoing restorative proctocolectomy.

Hanzlik TP, Tevis SE, Suwanabol PA, Carchman EH, Harms BA, Heise CP, Foley EF, Kennedy GD.

J Gastrointest Surg. 2015 Mar;19(3):564-9. doi: 10.1007/s11605-014-2734-7. Epub 2015 Jan 6.


Interdigital direct neurorrhaphy for treatment of painful neuroma due to finger amputation.

Martins RS, Siqueira MG, Heise CO, Yeng LT, de Andrade DC, Teixeira MJ.

Acta Neurochir (Wien). 2015 Apr;157(4):667-71. doi: 10.1007/s00701-014-2288-1. Epub 2014 Dec 24.


Coloring [Formula: see text]-Embeddable [Formula: see text]-Uniform Hypergraphs.

Heise CG, Panagiotou K, Pikhurko O, Taraz A.

Discrete Comput Geom. 2014;52(4):663-679. Epub 2014 Oct 17.


Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity.

Valenzuela JC, Heise C, Franken G, Singh J, Schweitzer B, Seidenbecher CI, Frischknecht R.

Philos Trans R Soc Lond B Biol Sci. 2014 Oct 19;369(1654):20130606. doi: 10.1098/rstb.2013.0606.


Massive Atenolol, Lisinopril, and Chlorthalidone Overdose Treated with Endoscopic Decontamination, Hemodialysis, Impella Percutaneous Left Ventricular Assist Device, and ECMO.

Heise CW, Beutler D, Bosak A, Orme G, Loli A, Graeme K.

J Med Toxicol. 2015 Mar;11(1):110-4. doi: 10.1007/s13181-014-0419-y.


An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin.

Carrancio S, Markovics J, Wong P, Leisten J, Castiglioni P, Groza MC, Raymon HK, Heise C, Daniel T, Chopra R, Sung V.

Br J Haematol. 2014 Jun;165(6):870-82. doi: 10.1111/bjh.12838. Epub 2014 Mar 18.


Elongation factor-2 phosphorylation in dendrites and the regulation of dendritic mRNA translation in neurons.

Heise C, Gardoni F, Culotta L, di Luca M, Verpelli C, Sala C.

Front Cell Neurosci. 2014 Feb 10;8:35. doi: 10.3389/fncel.2014.00035. eCollection 2014. Review.

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