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Items: 1 to 50 of 96

1.

Virulence of Agrobacterium tumefaciens requires lipid homeostasis mediated by the lysyl-phosphatidylglycerol hydrolase AcvB.

Groenewold MK, Hebecker S, Fritz C, Czolkoss S, Wiesselmann M, Heinz DW, Jahn D, Narberhaus F, Aktas M, Moser J.

Mol Microbiol. 2019 Jan;111(1):269-286. doi: 10.1111/mmi.14154. Epub 2018 Nov 14.

PMID:
30353924
2.

A phosphatidic acid-binding protein is important for lipid homeostasis and adaptation to anaerobic biofilm conditions in Pseudomonas aeruginosa.

Groenewold MK, Massmig M, Hebecker S, Danne L, Magnowska Z, Nimtz M, Narberhaus F, Jahn D, Heinz DW, Jänsch L, Moser J.

Biochem J. 2018 Jun 6;475(11):1885-1907. doi: 10.1042/BCJ20180257.

PMID:
29717024
3.

Dimerization of the plant molybdenum insertase Cnx1E is required for synthesis of the molybdenum cofactor.

Krausze J, Probst C, Curth U, Reichelt J, Saha S, Schafflick D, Heinz DW, Mendel RR, Kruse T.

Biochem J. 2017 Jan 1;474(1):163-178. doi: 10.1042/BCJ20160846. Epub 2016 Nov 1.

PMID:
27803248
4.

Structures of two bacterial resistance factors mediating tRNA-dependent aminoacylation of phosphatidylglycerol with lysine or alanine.

Hebecker S, Krausze J, Hasenkampf T, Schneider J, Groenewold M, Reichelt J, Jahn D, Heinz DW, Moser J.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10691-6. doi: 10.1073/pnas.1511167112. Epub 2015 Aug 10.

5.

Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins.

Kling A, Lukat P, Almeida DV, Bauer A, Fontaine E, Sordello S, Zaburannyi N, Herrmann J, Wenzel SC, König C, Ammerman NC, Barrio MB, Borchers K, Bordon-Pallier F, Brönstrup M, Courtemanche G, Gerlitz M, Geslin M, Hammann P, Heinz DW, Hoffmann H, Klieber S, Kohlmann M, Kurz M, Lair C, Matter H, Nuermberger E, Tyagi S, Fraisse L, Grosset JH, Lagrange S, Müller R.

Science. 2015 Jun 5;348(6239):1106-12. doi: 10.1126/science.aaa4690.

PMID:
26045430
6.

The crystal structure of siroheme decarboxylase in complex with iron-uroporphyrin III reveals two essential histidine residues.

Haufschildt K, Schmelz S, Kriegler TM, Neumann A, Streif J, Arai H, Heinz DW, Layer G.

J Mol Biol. 2014 Sep 23;426(19):3272-3286. doi: 10.1016/j.jmb.2014.07.021. Epub 2014 Jul 30.

PMID:
25083922
7.

Secrets of a secretin.

Heinz DW.

Structure. 2013 Dec 3;21(12):2098-9. doi: 10.1016/j.str.2013.11.002.

8.

Wound healing potential of a dimeric InlB variant analyzed by in vitro experiments on re-epithelialization of human skin models.

Kolditz F, Krausze J, Heinz DW, Niemann HH, Müller-Goymann CC.

Eur J Pharm Biopharm. 2014 Feb;86(2):277-83. doi: 10.1016/j.ejpb.2013.10.003. Epub 2013 Oct 15.

PMID:
24140590
9.

In situ structural analysis of the Yersinia enterocolitica injectisome.

Kudryashev M, Stenta M, Schmelz S, Amstutz M, Wiesand U, Castaño-Díez D, Degiacomi MT, Münnich S, Bleck CK, Kowal J, Diepold A, Heinz DW, Dal Peraro M, Cornelis GR, Stahlberg H.

Elife. 2013 Jul 30;2:e00792. doi: 10.7554/eLife.00792.

10.

Structure of ADP-aluminium fluoride-stabilized protochlorophyllide oxidoreductase complex.

Moser J, Lange C, Krausze J, Rebelein J, Schubert WD, Ribbe MW, Heinz DW, Jahn D.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2094-8. doi: 10.1073/pnas.1218303110. Epub 2013 Jan 22.

11.

Structural characterization of Spinacia oleracea trypsin inhibitor III (SOTI-III).

Glotzbach B, Schmelz S, Reinwarth M, Christmann A, Heinz DW, Kolmar H.

Acta Crystallogr D Biol Crystallogr. 2013 Jan;69(Pt 1):114-20. doi: 10.1107/S0907444912043880. Epub 2012 Dec 20.

PMID:
23275169
12.

Arranged sevenfold: structural insights into the C-terminal oligomerization domain of human C4b-binding protein.

Hofmeyer T, Schmelz S, Degiacomi MT, Dal Peraro M, Daneschdar M, Scrima A, van den Heuvel J, Heinz DW, Kolmar H.

J Mol Biol. 2013 Apr 26;425(8):1302-17. doi: 10.1016/j.jmb.2012.12.017. Epub 2012 Dec 28.

PMID:
23274142
13.

High affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants.

Kügler J, Schmelz S, Gentzsch J, Haid S, Pollmann E, van den Heuvel J, Franke R, Pietschmann T, Heinz DW, Collins J.

J Biol Chem. 2012 Nov 9;287(46):39224-32. doi: 10.1074/jbc.M112.393843. Epub 2012 Sep 10.

14.

Structural basis for intrinsic thermosensing by the master virulence regulator RovA of Yersinia.

Quade N, Mendonca C, Herbst K, Heroven AK, Ritter C, Heinz DW, Dersch P.

J Biol Chem. 2012 Oct 19;287(43):35796-803. doi: 10.1074/jbc.M112.379156. Epub 2012 Aug 30.

15.

Engineered variants of InlB with an additional leucine-rich repeat discriminate between physiologically relevant and packing contacts in crystal structures of the InlB:MET complex.

Niemann HH, Gherardi E, Bleymüller WM, Heinz DW.

Protein Sci. 2012 Oct;21(10):1528-39. doi: 10.1002/pro.2142. Epub 2012 Sep 17.

16.

Braces for the peptide backbone: insights into structure-activity relationships of protease inhibitor mimics with locked amide conformations.

Tischler M, Nasu D, Empting M, Schmelz S, Heinz DW, Rottmann P, Kolmar H, Buntkowsky G, Tietze D, Avrutina O.

Angew Chem Int Ed Engl. 2012 Apr 10;51(15):3708-12. doi: 10.1002/anie.201108983. Epub 2012 Feb 28. No abstract available.

PMID:
22374650
17.

Streamlining homogeneous glycoprotein production for biophysical and structural applications by targeted cell line development.

Wilke S, Groebe L, Maffenbeier V, Jäger V, Gossen M, Josewski J, Duda A, Polle L, Owens RJ, Wirth D, Heinz DW, van den Heuvel J, Büssow K.

PLoS One. 2011;6(12):e27829. doi: 10.1371/journal.pone.0027829. Epub 2011 Dec 9.

18.

Unusual carbon fixation gives rise to diverse polyketide extender units.

Quade N, Huo L, Rachid S, Heinz DW, Müller R.

Nat Chem Biol. 2011 Dec 4;8(1):117-24. doi: 10.1038/nchembio.734.

PMID:
22138621
19.

Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli.

de Groot JC, Schlüter K, Carius Y, Quedenau C, Vingadassalom D, Faix J, Weiss SM, Reichelt J, Standfuss-Gabisch C, Lesser CF, Leong JM, Heinz DW, Büssow K, Stradal TE.

Structure. 2011 Sep 7;19(9):1294-306. doi: 10.1016/j.str.2011.06.015.

20.

Crystal structure of the heme d1 biosynthesis enzyme NirE in complex with its substrate reveals new insights into the catalytic mechanism of S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferases.

Storbeck S, Saha S, Krausze J, Klink BU, Heinz DW, Layer G.

J Biol Chem. 2011 Jul 29;286(30):26754-67. doi: 10.1074/jbc.M111.239855. Epub 2011 May 31.

21.

Polysaccharide synthesis of the levansucrase SacB from Bacillus megaterium is controlled by distinct surface motifs.

Strube CP, Homann A, Gamer M, Jahn D, Seibel J, Heinz DW.

J Biol Chem. 2011 May 20;286(20):17593-600. doi: 10.1074/jbc.M110.203166. Epub 2011 Mar 25.

22.

Structure of the effector-binding domain of the LysR-type transcription factor RovM from Yersinia pseudotuberculosis.

Quade N, Dieckmann M, Haffke M, Heroven AK, Dersch P, Heinz DW.

Acta Crystallogr D Biol Crystallogr. 2011 Feb;67(Pt 2):81-90. doi: 10.1107/S0907444910049681. Epub 2011 Jan 8.

PMID:
21245528
23.

Structures of the nucleotide-binding domain of the human ABCB6 transporter and its complexes with nucleotides.

Haffke M, Menzel A, Carius Y, Jahn D, Heinz DW.

Acta Crystallogr D Biol Crystallogr. 2010 Sep;66(Pt 9):979-87. doi: 10.1107/S0907444910028593. Epub 2010 Aug 13.

PMID:
20823549
24.

Highlight: of systems and structures.

Heinz DW, Betzel C, Wilmanns M.

Biol Chem. 2010 Jul;391(7):717-8. doi: 10.1515/BC.2010.095. No abstract available.

PMID:
20623997
25.

Crystal structure of the nitrogenase-like dark operative protochlorophyllide oxidoreductase catalytic complex (ChlN/ChlB)2.

Bröcker MJ, Schomburg S, Heinz DW, Jahn D, Schubert WD, Moser J.

J Biol Chem. 2010 Aug 27;285(35):27336-45. doi: 10.1074/jbc.M110.126698. Epub 2010 Jun 17.

26.

Structure and function of enzymes in heme biosynthesis.

Layer G, Reichelt J, Jahn D, Heinz DW.

Protein Sci. 2010 Jun;19(6):1137-61. doi: 10.1002/pro.405. Review.

27.

Structure of Shigella IpgB2 in complex with human RhoA: implications for the mechanism of bacterial guanine nucleotide exchange factor mimicry.

Klink BU, Barden S, Heidler TV, Borchers C, Ladwein M, Stradal TE, Rottner K, Heinz DW.

J Biol Chem. 2010 May 28;285(22):17197-208. doi: 10.1074/jbc.M110.107953. Epub 2010 Apr 2.

28.

The oxygen-independent coproporphyrinogen III oxidase HemN utilizes harderoporphyrinogen as a reaction intermediate during conversion of coproporphyrinogen III to protoporphyrinogen IX.

Rand K, Noll C, Schiebel HM, Kemken D, Dülcks T, Kalesse M, Heinz DW, Layer G.

Biol Chem. 2010 Jan;391(1):55-63. doi: 10.1515/BC.2010.006.

PMID:
19919179
29.

Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB.

Ferraris DM, Gherardi E, Di Y, Heinz DW, Niemann HH.

J Mol Biol. 2010 Jan 22;395(3):522-32. doi: 10.1016/j.jmb.2009.10.074. Epub 2009 Nov 6.

PMID:
19900460
30.

Structure of the heme biosynthetic Pseudomonas aeruginosa porphobilinogen synthase in complex with the antibiotic alaremycin.

Heinemann IU, Schulz C, Schubert WD, Heinz DW, Wang YG, Kobayashi Y, Awa Y, Wachi M, Jahn D, Jahn M.

Antimicrob Agents Chemother. 2010 Jan;54(1):267-72. doi: 10.1128/AAC.00553-09. Epub 2009 Oct 12.

31.

Crystal structure and catalytic mechanism of 4-methylmuconolactone methylisomerase.

Marín M, Heinz DW, Pieper DH, Klink BU.

J Biol Chem. 2009 Nov 20;284(47):32709-16. doi: 10.1074/jbc.M109.024604. Epub 2009 Sep 29.

32.

Structural basis for autoinhibition and activation of Auto, a virulence-associated peptidoglycan hydrolase of Listeria monocytogenes.

Bublitz M, Polle L, Holland C, Heinz DW, Nimtz M, Schubert WD.

Mol Microbiol. 2009 Mar;71(6):1509-22. doi: 10.1111/j.1365-2958.2009.06619.x. Epub 2009 Jan 23.

33.

The absolute configuration of rhizopodin and its inhibition of actin polymerization by dimerization.

Hagelueken G, Albrecht SC, Steinmetz H, Jansen R, Heinz DW, Kalesse M, Schubert WD.

Angew Chem Int Ed Engl. 2009;48(3):595-8. doi: 10.1002/anie.200802915. No abstract available.

PMID:
19035596
34.

Structure of the type III secretion recognition protein YscU from Yersinia enterocolitica.

Wiesand U, Sorg I, Amstutz M, Wagner S, van den Heuvel J, Lührs T, Cornelis GR, Heinz DW.

J Mol Biol. 2009 Jan 23;385(3):854-66. doi: 10.1016/j.jmb.2008.10.034. Epub 2008 Oct 19.

PMID:
18976663
35.

Crystal structure and standardized geometric analysis of InlJ, a listerial virulence factor and leucine-rich repeat protein with a novel cysteine ladder.

Bublitz M, Holland C, Sabet C, Reichelt J, Cossart P, Heinz DW, Bierne H, Schubert WD.

J Mol Biol. 2008 Apr 18;378(1):87-96. doi: 10.1016/j.jmb.2008.01.100. Epub 2008 Feb 20.

PMID:
18343406
36.

X-ray and neutron small-angle scattering analysis of the complex formed by the Met receptor and the Listeria monocytogenes invasion protein InlB.

Niemann HH, Petoukhov MV, Härtlein M, Moulin M, Gherardi E, Timmins P, Heinz DW, Svergun DI.

J Mol Biol. 2008 Mar 21;377(2):489-500. doi: 10.1016/j.jmb.2008.01.027. Epub 2008 Jan 16.

PMID:
18262542
37.

ATP-driven reduction by dark-operative protochlorophyllide oxidoreductase from Chlorobium tepidum mechanistically resembles nitrogenase catalysis.

Bröcker MJ, Virus S, Ganskow S, Heathcote P, Heinz DW, Schubert WD, Jahn D, Moser J.

J Biol Chem. 2008 Apr 18;283(16):10559-67. doi: 10.1074/jbc.M708010200. Epub 2008 Feb 5.

38.

Structures and diseases.

Wendt KU, Weiss MS, Cramer P, Heinz DW.

Nat Struct Mol Biol. 2008 Feb;15(2):117-20. doi: 10.1038/nsmb0208-117. No abstract available.

PMID:
18250627
39.

Structure of the Yersinia enterocolitica type III secretion translocator chaperone SycD.

Büttner CR, Sorg I, Cornelis GR, Heinz DW, Niemann HH.

J Mol Biol. 2008 Jan 25;375(4):997-1012. Epub 2007 Nov 12.

PMID:
18054956
40.

Thermodynamically reengineering the listerial invasion complex InlA/E-cadherin.

Wollert T, Heinz DW, Schubert WD.

Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):13960-5. Epub 2007 Aug 22.

41.

Glutamate recognition and hydride transfer by Escherichia coli glutamyl-tRNA reductase.

Lüer C, Schauer S, Virus S, Schubert WD, Heinz DW, Moser J, Jahn D.

FEBS J. 2007 Sep;274(17):4609-14. Epub 2007 Aug 14.

42.

Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB.

Niemann HH, Jäger V, Butler PJ, van den Heuvel J, Schmidt S, Ferraris D, Gherardi E, Heinz DW.

Cell. 2007 Jul 27;130(2):235-46.

43.

Crystal structure of the electron transfer complex rubredoxin rubredoxin reductase of Pseudomonas aeruginosa.

Hagelueken G, Wiehlmann L, Adams TM, Kolmar H, Heinz DW, Tümmler B, Schubert WD.

Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12276-81. Epub 2007 Jul 16.

44.

Extending the host range of Listeria monocytogenes by rational protein design.

Wollert T, Pasche B, Rochon M, Deppenmeier S, van den Heuvel J, Gruber AD, Heinz DW, Lengeling A, Schubert WD.

Cell. 2007 Jun 1;129(5):891-902.

45.

Crystal structure of a non-discriminating glutamyl-tRNA synthetase.

Schulze JO, Masoumi A, Nickel D, Jahn M, Jahn D, Schubert WD, Heinz DW.

J Mol Biol. 2006 Sep 1;361(5):888-97. Epub 2006 Jul 5.

PMID:
16876193
46.

Probing the active site of Pseudomonas aeruginosa porphobilinogen synthase using newly developed inhibitors.

Frère F, Nentwich M, Gacond S, Heinz DW, Neier R, Frankenberg-Dinkel N.

Biochemistry. 2006 Jul 11;45(27):8243-53.

PMID:
16819823
47.

The crystal structure of SdsA1, an alkylsulfatase from Pseudomonas aeruginosa, defines a third class of sulfatases.

Hagelueken G, Adams TM, Wiehlmann L, Widow U, Kolmar H, Tümmler B, Heinz DW, Schubert WD.

Proc Natl Acad Sci U S A. 2006 May 16;103(20):7631-6. Epub 2006 May 9. Erratum in: Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10824.

48.

The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains.

Frese S, Schubert WD, Findeis AC, Marquardt T, Roske YS, Stradal TE, Heinz DW.

J Biol Chem. 2006 Jun 30;281(26):18236-45. Epub 2006 Apr 24.

49.

The substrate radical of Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN.

Layer G, Pierik AJ, Trost M, Rigby SE, Leech HK, Grage K, Breckau D, Astner I, Jänsch L, Heathcote P, Warren MJ, Heinz DW, Jahn D.

J Biol Chem. 2006 Jun 9;281(23):15727-34. Epub 2006 Apr 9.

50.

Evolutionary relationship between initial enzymes of tetrapyrrole biosynthesis.

Schulze JO, Schubert WD, Moser J, Jahn D, Heinz DW.

J Mol Biol. 2006 May 19;358(5):1212-20. Epub 2006 Mar 10.

PMID:
16564539

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