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Items: 1 to 50 of 177

1.

Anatomy 101 for AI-driven robotics: Explanatory, ethical and legal frameworks for development of cadaveric skills training standards in autonomous robotic surgery/autopsy.

O'Sullivan S, Leonard S, Holzinger A, Allen C, Battaglia F, Nevejans N, van Leeuwen FWB, Sajid MI, Friebe M, Ashrafian H, Heinsen H, Wichmann D, Hartnett M.

Int J Med Robot. 2019 May 30:e2020. doi: 10.1002/rcs.2020. [Epub ahead of print] Review.

PMID:
31144777
2.

Teaching NeuroImages: In vivo visualization of Edinger comb and Wilson pencils.

Horn A, Ewert S, Alho EJL, Axer M, Heinsen H, Fonoff ET, Polimeni JR, Herrington TM.

Neurology. 2019 Apr 2;92(14):e1663-e1664. doi: 10.1212/WNL.0000000000007252. No abstract available.

PMID:
30936236
3.

Neuroanatomy of the equine brain as revealed by high-field (3Tesla) magnetic-resonance-imaging.

Schmidt MJ, Knemeyer C, Heinsen H.

PLoS One. 2019 Apr 1;14(4):e0213814. doi: 10.1371/journal.pone.0213814. eCollection 2019.

4.

The role of artificial intelligence and machine learning in harmonization of high-resolution post-mortem MRI (virtopsy) with respect to brain microstructure.

O'Sullivan S, Heinsen H, Grinberg LT, Chimelli L, Amaro E Jr, do Nascimento Saldiva PH, Jeanquartier F, Jean-Quartier C, da Graça Morais Martin M, Sajid MI, Holzinger A.

Brain Inform. 2019 Mar 7;6(1):3. doi: 10.1186/s40708-019-0096-3.

5.

Astrocyte- and Microglia-Specific Mitochondrial DNA Deletions Levels in Sporadic Alzheimer's Disease.

Strobel S, Grünblatt E, Heinsen H, Riederer P, Espach T, Meder M, Monoranu CM.

J Alzheimers Dis. 2019;67(1):149-157. doi: 10.3233/JAD-180661.

PMID:
30475765
6.

Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive-compulsive disorder.

de Oliveira KC, Grinberg LT, Hoexter MQ, Brentani H, Suemoto CK, Nery FG, Lima LC, Alho ATDL, Farfel JM, Ferretti-Rebustini REL, Leite REP, Moretto AC, da Silva AV, Lafer B, Miguel EC, Nitrini R, Jacob-Filho W, Heinsen H, Pasqualucci CA.

Brain Struct Funct. 2019 Jan;224(1):191-203. doi: 10.1007/s00429-018-1752-8. Epub 2018 Oct 8.

PMID:
30298291
7.

Distribution of magnetic remanence carriers in the human brain.

Gilder SA, Wack M, Kaub L, Roud SC, Petersen N, Heinsen H, Hillenbrand P, Milz S, Schmitz C.

Sci Rep. 2018 Jul 27;8(1):11363. doi: 10.1038/s41598-018-29766-z.

8.

On the origin of tau seeding activity in Alzheimer's disease.

Heinsen H, Grinberg LT.

Acta Neuropathol. 2018 Nov;136(5):815-817. doi: 10.1007/s00401-018-1890-3. Epub 2018 Jul 23. No abstract available.

9.

Pathoarchitectonics of the cerebral cortex in chorea-acanthocytosis and Huntington's disease.

Liu J, Heinsen H, Grinberg LT, Alho E, Amaro E Jr, Pasqualucci CA, Rüb U, Seidel K, den Dunnen W, Arzberger T, Schmitz C, Kiessling MC, Bader B, Danek A.

Neuropathol Appl Neurobiol. 2019 Apr;45(3):230-243. doi: 10.1111/nan.12495. Epub 2018 Jun 10.

PMID:
29722054
10.

Impaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF.

Pfeiffer V, Götz R, Camarero G, Heinsen H, Blum R, Rapp UR.

PLoS One. 2018 Mar 28;13(3):e0192067. doi: 10.1371/journal.pone.0192067. eCollection 2018.

11.

Corrigendum to "LMD proteomics provides evidence for hippocampus field-specific motor protein abundance changes with relevance to Alzheimer's disease" [BBAPAP 1865 (6) (2017) 703-714].

Schrötter A, Oberhaus A, Kolbe K, Seger S, Mastalski T, El Magraoui F, Hoffmann-Posorske E, Bohnert M, Deckert J, Braun C, Graw M, Schmitz C, Arzberger T, Loosse C, Heinsen H, Meyer HE, Müller T.

Biochim Biophys Acta Proteins Proteom. 2018 Apr;1866(4):580. doi: 10.1016/j.bbapap.2018.01.008. Epub 2018 Feb 9. No abstract available.

PMID:
29429852
12.

Subcortical neurodegeneration in chorea: Similarities and differences between chorea-acanthocytosis and Huntington's disease.

Liu J, Heinsen H, Grinberg LT, Alho E, Amaro E Jr, Pasqualucci CA, Rüb U, den Dunnen W, Arzberger T, Schmitz C, Kiessling M, Bader B, Danek A.

Parkinsonism Relat Disord. 2018 Apr;49:54-59. doi: 10.1016/j.parkreldis.2018.01.009. Epub 2018 Jan 10.

PMID:
29402698
13.

Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study.

Eser RA, Ehrenberg AJ, Petersen C, Dunlop S, Mejia MB, Suemoto CK, Walsh CM, Rajana H, Oh J, Theofilas P, Seeley WW, Miller BL, Neylan TC, Heinsen H, Grinberg LT.

J Neuropathol Exp Neurol. 2018 Feb 1;77(2):149-161. doi: 10.1093/jnen/nlx113.

14.

High thickness histological sections as alternative to study the three-dimensional microscopic human sub-cortical neuroanatomy.

Alho EJL, Alho ATDL, Grinberg L, Amaro E Jr, Dos Santos GAB, da Silva RE, Neves RC, Alegro M, Coelho DB, Teixeira MJ, Fonoff ET, Heinsen H.

Brain Struct Funct. 2018 Apr;223(3):1121-1132. doi: 10.1007/s00429-017-1548-2. Epub 2017 Nov 1.

15.

Light at the beginning of the tunnel? Investigating early mechanistic changes in Alzheimer's disease.

Grinberg LT, Heinsen H.

Brain. 2017 Nov 1;140(11):2770-2773. doi: 10.1093/brain/awx261. No abstract available.

PMID:
29088348
16.

Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans.

Theofilas P, Ehrenberg AJ, Nguy A, Thackrey JM, Dunlop S, Mejia MB, Alho AT, Paraizo Leite RE, Rodriguez RD, Suemoto CK, Nascimento CF, Chin M, Medina-Cleghorn D, Cuervo AM, Arkin M, Seeley WW, Miller BL, Nitrini R, Pasqualucci CA, Filho WJ, Rueb U, Neuhaus J, Heinsen H, Grinberg LT.

Neurobiol Aging. 2018 Jan;61:1-12. doi: 10.1016/j.neurobiolaging.2017.09.007. Epub 2017 Sep 20.

17.

Subthalamic Nucleus Deep Brain Stimulation: Basic Concepts and Novel Perspectives.

Hamani C, Florence G, Heinsen H, Plantinga BR, Temel Y, Uludag K, Alho E, Teixeira MJ, Amaro E, Fonoff ET.

eNeuro. 2017 Sep 22;4(5). pii: ENEURO.0140-17.2017. doi: 10.1523/ENEURO.0140-17.2017. eCollection 2017 Sep-Oct. Review.

18.

LMD proteomics provides evidence for hippocampus field-specific motor protein abundance changes with relevance to Alzheimer's disease.

Schrötter A, Oberhaus A, Kolbe K, Seger S, Mastalski T, El Magraoui F, Hoffmann-Posorske E, Bohnert M, Deckert J, Braun C, Graw M, Schmitz C, Arzberger T, Loosse C, Heinsen H, Meyer HE, Müller T.

Biochim Biophys Acta Proteins Proteom. 2017 Jun;1865(6):703-714. doi: 10.1016/j.bbapap.2017.03.013. Epub 2017 Apr 2. Erratum in: Biochim Biophys Acta. 2018 Feb 8;:.

PMID:
28377147
19.

Magnetic resonance diffusion tensor imaging for the pedunculopontine nucleus: proof of concept and histological correlation.

Alho ATDL, Hamani C, Alho EJL, da Silva RE, Santos GAB, Neves RC, Carreira LL, Araújo CMM, Magalhães G, Coelho DB, Alegro MC, Martin MGM, Grinberg LT, Pasqualucci CA, Heinsen H, Fonoff ET, Amaro E Jr.

Brain Struct Funct. 2017 Aug;222(6):2547-2558. doi: 10.1007/s00429-016-1356-0. Epub 2017 Mar 10.

20.

Alzheimer's Disease: Characterization of the Brain Sites of the Initial Tau Cytoskeletal Pathology Will Improve the Success of Novel Immunological Anti-Tau Treatment Approaches.

Rüb U, Stratmann K, Heinsen H, Seidel K, Bouzrou M, Korf HW.

J Alzheimers Dis. 2017;57(3):683-696. doi: 10.3233/JAD-161102. Review.

PMID:
28269779
21.

Automating cell detection and classification in human brain fluorescent microscopy images using dictionary learning and sparse coding.

Alegro M, Theofilas P, Nguy A, Castruita PA, Seeley W, Heinsen H, Ushizima DM, Grinberg LT.

J Neurosci Methods. 2017 Apr 15;282:20-33. doi: 10.1016/j.jneumeth.2017.03.002. Epub 2017 Mar 4.

22.

Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease.

Ehrenberg AJ, Nguy AK, Theofilas P, Dunlop S, Suemoto CK, Di Lorenzo Alho AT, Leite RP, Diehl Rodriguez R, Mejia MB, Rüb U, Farfel JM, de Lucena Ferretti-Rebustini RE, Nascimento CF, Nitrini R, Pasquallucci CA, Jacob-Filho W, Miller B, Seeley WW, Heinsen H, Grinberg LT.

Neuropathol Appl Neurobiol. 2017 Aug;43(5):393-408. doi: 10.1111/nan.12387. Epub 2017 Mar 31.

23.

Huntington's disease (HD): the neuropathology of a multisystem neurodegenerative disorder of the human brain.

Rüb U, Seidel K, Heinsen H, Vonsattel JP, den Dunnen WF, Korf HW.

Brain Pathol. 2016 Nov;26(6):726-740. doi: 10.1111/bpa.12426. Review.

PMID:
27529157
24.

Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery.

Theofilas P, Ehrenberg AJ, Dunlop S, Di Lorenzo Alho AT, Nguy A, Leite REP, Rodriguez RD, Mejia MB, Suemoto CK, Ferretti-Rebustini REL, Polichiso L, Nascimento CF, Seeley WW, Nitrini R, Pasqualucci CA, Jacob Filho W, Rueb U, Neuhaus J, Heinsen H, Grinberg LT.

Alzheimers Dement. 2017 Mar;13(3):236-246. doi: 10.1016/j.jalz.2016.06.2362. Epub 2016 Aug 8.

25.

Argyrophilic Grain Disease: Demographics, Clinical, and Neuropathological Features From a Large Autopsy Study.

Rodriguez RD, Suemoto CK, Molina M, Nascimento CF, Leite RE, de Lucena Ferretti-Rebustini RE, Farfel JM, Heinsen H, Nitrini R, Ueda K, Pasqualucci CA, Jacob-Filho W, Yaffe K, Grinberg LT.

J Neuropathol Exp Neurol. 2016 Jul;75(7):628-35. doi: 10.1093/jnen/nlw034. Epub 2016 Jun 9.

26.
27.

Parallel Atrophy of Cortex and Basal Forebrain Cholinergic System in Mild Cognitive Impairment.

Kilimann I, Hausner L, Fellgiebel A, Filippi M, Würdemann TJ, Heinsen H, Teipel SJ.

Cereb Cortex. 2017 Mar 1;27(3):1841-1848. doi: 10.1093/cercor/bhw019.

PMID:
26879092
28.

The Neuropathology of Huntington´s disease: classical findings, recent developments and correlation to functional neuroanatomy.

Rüb U, Vonsattel JP, Heinsen H, Korf HW.

Adv Anat Embryol Cell Biol. 2015;217:1-146. Review.

PMID:
26767207
29.

Three-dimensional and stereological characterization of the human substantia nigra during aging.

Di Lorenzo Alho AT, Suemoto CK, Polichiso L, Tampellini E, de Oliveira KC, Molina M, Santos GA, Nascimento C, Leite RE, de Lucena Ferreti-Rebustini RE, da Silva AV, Nitrini R, Pasqualucci CA, Jacob-Filho W, Heinsen H, Grinberg LT.

Brain Struct Funct. 2016 Sep;221(7):3393-403. doi: 10.1007/s00429-015-1108-6. Epub 2015 Sep 19.

30.

A Long Journey from Childhood to Senility: The 23rd HUPO BPP Workshop: 16-17 April 2015, São Paulo, Brazil.

Magraoui FE, Schrötter A, Heinsen H, Leite R, Park YM, Meyer HE, Grinberg LT.

Proteomics. 2015 Sep;15(17):2895-7. doi: 10.1002/pmic.201570154.

PMID:
26331911
31.

Precortical Phase of Alzheimer's Disease (AD)-Related Tau Cytoskeletal Pathology.

Stratmann K, Heinsen H, Korf HW, Del Turco D, Ghebremedhin E, Seidel K, Bouzrou M, Grinberg LT, Bohl J, Wharton SB, den Dunnen W, Rüb U.

Brain Pathol. 2016 May;26(3):371-86. doi: 10.1111/bpa.12289. Epub 2015 Aug 24.

32.

Enrichment of single neurons and defined brain regions from human brain tissue samples for subsequent proteome analysis.

Molina M, Steinbach S, Park YM, Yun SY, Di Lorenzo Alho AT, Heinsen H, Grinberg LT, Marcus K, Leite RE, May C.

J Neural Transm (Vienna). 2015 Jul;122(7):993-1005. doi: 10.1007/s00702-015-1414-4. Epub 2015 Jun 30.

PMID:
26123835
33.

Proteome-wide characterization of signalling interactions in the hippocampal CA4/DG subfield of patients with Alzheimer's disease.

Ho Kim J, Franck J, Kang T, Heinsen H, Ravid R, Ferrer I, Hee Cheon M, Lee JY, Shin Yoo J, Steinbusch HW, Salzet M, Fournier I, Mok Park Y.

Sci Rep. 2015 Jun 10;5:11138. doi: 10.1038/srep11138.

34.

Oncostatic effects of fluoxetine in experimental colon cancer models.

Kannen V, Garcia SB, Silva WA Jr, Gasser M, Mönch R, Alho EJ, Heinsen H, Scholz CJ, Friedrich M, Heinze KG, Waaga-Gasser AM, Stopper H.

Cell Signal. 2015 Sep;27(9):1781-8. doi: 10.1016/j.cellsig.2015.05.008. Epub 2015 May 22.

PMID:
26004136
35.

Cognitive Correlates of Basal Forebrain Atrophy and Associated Cortical Hypometabolism in Mild Cognitive Impairment.

Grothe MJ, Heinsen H, Amaro E Jr, Grinberg LT, Teipel SJ.

Cereb Cortex. 2016 Jun;26(6):2411-2426. doi: 10.1093/cercor/bhv062. Epub 2015 Apr 2.

36.

Proteogenomics of the human hippocampus: The road ahead.

Kang MG, Byun K, Kim JH, Park NH, Heinsen H, Ravid R, Steinbusch HW, Lee B, Park YM.

Biochim Biophys Acta. 2015 Jul;1854(7):788-97. doi: 10.1016/j.bbapap.2015.02.010. Epub 2015 Mar 12. Review.

PMID:
25770686
37.

Turning on the Light Within: Subcortical Nuclei of the Isodentritic Core and their Role in Alzheimer's Disease Pathogenesis.

Theofilas P, Dunlop S, Heinsen H, Grinberg LT.

J Alzheimers Dis. 2015;46(1):17-34. doi: 10.3233/JAD-142682. Review.

38.

Changes in the expression of genes related to neuroinflammation over the course of sporadic Alzheimer's disease progression: CX3CL1, TREM2, and PPARγ.

Strobel S, Grünblatt E, Riederer P, Heinsen H, Arzberger T, Al-Sarraj S, Troakes C, Ferrer I, Monoranu CM.

J Neural Transm (Vienna). 2015 Jul;122(7):1069-76. doi: 10.1007/s00702-015-1369-5. Epub 2015 Jan 18.

PMID:
25596843
39.

Cholinergic basal forebrain structure influences the reconfiguration of white matter connections to support residual memory in mild cognitive impairment.

Ray NJ, Metzler-Baddeley C, Khondoker MR, Grothe MJ, Teipel S, Wright P, Heinsen H, Jones DK, Aggleton JP, O'Sullivan MJ.

J Neurosci. 2015 Jan 14;35(2):739-47. doi: 10.1523/JNEUROSCI.3617-14.2015.

40.

Huntington's Disease (HD): Neurodegeneration of Brodmann's Primary Visual Area 17 (BA17).

Rüb U, Seidel K, Vonsattel JP, Lange HW, Eisenmenger W, Götz M, Del Turco D, Bouzrou M, Korf HW, Heinsen H.

Brain Pathol. 2015 Nov;25(6):701-11. doi: 10.1111/bpa.12237. Epub 2015 Jan 27.

PMID:
25495445
41.

Large-scale analysis of posttranslational modifications in the hippocampus of patients with Alzheimer's disease using pI shift and label-free quantification without enrichment.

Kang T, Kim JH, Hong I, Park NH, Heinsen H, Lee JY, Ravid R, Ferrer I, Yoo JS, Kwon KH, Park YM.

Anal Bioanal Chem. 2014 Sep;406(22):5433-46. doi: 10.1007/s00216-014-7933-2. Epub 2014 Aug 15. Erratum in: Anal Bioanal Chem. 2014 Nov;406(28):7411. Park, Nanhyun [corrected to Park, Nam Hyun].

PMID:
25120180
42.

Neuropathology of the anterior midcingulate cortex in young children with autism.

Uppal N, Wicinski B, Buxbaum JD, Heinsen H, Schmitz C, Hof PR.

J Neuropathol Exp Neurol. 2014 Sep;73(9):891-902. doi: 10.1097/NEN.0000000000000108.

PMID:
25101703
43.

Atrophy of the cholinergic basal forebrain in dementia with Lewy bodies and Alzheimer's disease dementia.

Grothe MJ, Schuster C, Bauer F, Heinsen H, Prudlo J, Teipel SJ.

J Neurol. 2014 Oct;261(10):1939-48. doi: 10.1007/s00415-014-7439-z. Epub 2014 Jul 25.

PMID:
25059393
44.

The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies.

Seidel K, Mahlke J, Siswanto S, Krüger R, Heinsen H, Auburger G, Bouzrou M, Grinberg LT, Wicht H, Korf HW, den Dunnen W, Rüb U.

Brain Pathol. 2015 Mar;25(2):121-35. doi: 10.1111/bpa.12168. Epub 2014 Sep 12.

45.

Frontiers in neurodegeneration--new insights and prospects--20th HUPO BPP Workshop: 15 September 2013, Yokohama, Japan.

Schrötter A, El Magraoui F, Gröttrup B, Heinsen H, Marcus K, Meyer HE, Park YM, Grinberg LT.

Proteomics. 2014 Jun;14(11):1305-7. doi: 10.1002/pmic.201470084.

PMID:
24903697
46.

Huntington's disease (HD): degeneration of select nuclei, widespread occurrence of neuronal nuclear and axonal inclusions in the brainstem.

Rüb U, Hentschel M, Stratmann K, Brunt E, Heinsen H, Seidel K, Bouzrou M, Auburger G, Paulson H, Vonsattel JP, Lange H, Korf HW, den Dunnen W.

Brain Pathol. 2014 Apr;24(3):247-60. doi: 10.1111/bpa.12115. Epub 2014 Mar 3.

47.

Developing new methods to answer old and new questions in neurodegenerative diseases: 21(st) Workshop of the HUPO Brain Proteome Project (HBPP) 23-24 January 2014, Honolulu, Hawaii.

El Magraoui F, Eisenacher M, Schrötter A, Kuhlmann K, Heinsen H, Andrén P, Nilsson P, Häggmark A, Schmitz G, Verhaert P, Borchers C, Yoo JS, Lee BH, Meyer HE, Grinberg LT.

Proteomics. 2014 Jun;14(11):1308-10. doi: 10.1002/pmic.201470083. Epub 2014 Apr 22.

48.

Neuropathology of the posteroinferior occipitotemporal gyrus in children with autism.

Uppal N, Gianatiempo I, Wicinski B, Schmeidler J, Heinsen H, Schmitz C, Buxbaum JD, Hof PR.

Mol Autism. 2014 Feb 24;5(1):17. doi: 10.1186/2040-2392-5-17.

49.

Subregional basal forebrain atrophy in Alzheimer's disease: a multicenter study.

Kilimann I, Grothe M, Heinsen H, Alho EJ, Grinberg L, Amaro E Jr, Dos Santos GA, da Silva RE, Mitchell AJ, Frisoni GB, Bokde AL, Fellgiebel A, Filippi M, Hampel H, Klöppel S, Teipel SJ.

J Alzheimers Dis. 2014;40(3):687-700. doi: 10.3233/JAD-132345.

50.

A novel approach for integrative studies on neurodegenerative diseases in human brains.

Theofilas P, Polichiso L, Wang X, Lima LC, Alho ATL, Leite REP, Suemoto CK, Pasqualucci CA, Jacob-Filho W, Heinsen H; Brazilian Aging Brain Study Group, Grinberg LT.

J Neurosci Methods. 2014 Apr 15;226:171-183. doi: 10.1016/j.jneumeth.2014.01.030. Epub 2014 Feb 3.

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