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Items: 1 to 50 of 170

1.

Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.

Wang Z, Watt W, Brooks NA, Harris MS, Urban J, Boatman D, McMillan M, Kahn M, Heinrikson RL, Finzel BC, Wittwer AJ, Blinn J, Kamtekar S, Tomasselli AG.

Biochim Biophys Acta. 2010 Sep;1804(9):1817-31. doi: 10.1016/j.bbapap.2010.05.007. Epub 2010 May 24.

PMID:
20580860
2.

Activity of recombinant cysteine-rich domain proteins derived from the membrane-bound MUC17/Muc3 family mucins.

Ho SB, Luu Y, Shekels LL, Batra SK, Kandarian B, Evans DB, Zaworski PG, Wolfe CL, Heinrikson RL.

Biochim Biophys Acta. 2010 Jul;1800(7):629-38. doi: 10.1016/j.bbagen.2010.03.010. Epub 2010 Mar 20.

3.

Human intestinal MUC17 mucin augments intestinal cell restitution and enhances healing of experimental colitis.

Luu Y, Junker W, Rachagani S, Das S, Batra SK, Heinrikson RL, Shekels LL, Ho SB.

Int J Biochem Cell Biol. 2010 Jun;42(6):996-1006. doi: 10.1016/j.biocel.2010.03.001. Epub 2010 Mar 6.

4.

Large scale refolding and purification of the catalytic domain of human BACE-2 produced in E. coli.

Emmons TL, Mildner AM, Lull JM, Leone JW, Fischer HD, Heinrikson RL, Tomasselli AG.

Protein Pept Lett. 2009;16(2):121-31.

PMID:
19200034
5.

High yield expression of human BACE constructs in Eschericia coli for refolding, purification, and high resolution diffracting crystal forms.

Tomasselli AG, Paddock DJ, Emmons TL, Mildner AM, Leone JW, Lull JM, Cialdella JI, Prince DB, Fischer HD, Heinrikson RL, Benson TE.

Protein Pept Lett. 2008;15(2):131-43.

PMID:
18289105
6.

Large-scale purification of human BACE expressed in mammalian cells and removal of the prosegment with HIV-1 protease to improve crystal diffraction.

Emmons TL, Shuck ME, Babcock MS, Holloway JS, Leone JW, Durbin JD, Paddock DJ, Prince DB, Heinrikson RL, Fischer HD, Bienkowski MJ, Benson TE, Tomasselli AG.

Protein Pept Lett. 2008;15(2):119-30.

PMID:
18289104
7.

An efficient method to express and refold a truncated human procaspase-9: a caspase with activity toward Glu-X bonds.

Sadhukhan R, Leone JW, Lull J, Wang Z, Kletzien RF, Heinrikson RL, Tomasselli AG.

Protein Expr Purif. 2006 Apr;46(2):299-308. Epub 2005 Oct 6.

PMID:
16256367
8.

Human beta-secretase (BACE) and BACE inhibitors.

John V, Beck JP, Bienkowski MJ, Sinha S, Heinrikson RL.

J Med Chem. 2003 Oct 23;46(22):4625-30. Review. No abstract available.

PMID:
14561080
9.

Heterodimer formation is essential for heparanase enzymatic activity.

Levy-Adam F, Miao HQ, Heinrikson RL, Vlodavsky I, Ilan N.

Biochem Biophys Res Commun. 2003 Sep 5;308(4):885-91.

PMID:
12927802
10.

Employing a superior BACE1 cleavage sequence to probe cellular APP processing.

Tomasselli AG, Qahwash I, Emmons TL, Lu Y, Leone JW, Lull JM, Fok KF, Bannow CA, Smith CW, Bienkowski MJ, Heinrikson RL, Yan R.

J Neurochem. 2003 Mar;84(5):1006-17.

11.

[W206R]-procaspase 3: an inactivatable substrate for caspase 8.

Rank KB, Mildner AM, Leone JW, Koeplinger KA, Chou KC, Tomasselli AG, Heinrikson RL, Sharma SK.

Protein Expr Purif. 2001 Jul;22(2):258-66.

PMID:
11437602
12.

Intrasteric inhibition of ATP binding is not required to prevent unregulated autophosphorylation or signaling by the insulin receptor.

Frankel M, Ablooglu AJ, Leone JW, Rusinova E, Ross JB, Heinrikson RL, Kohanski RA.

Mol Cell Biol. 2001 Jul;21(13):4197-207.

13.

Cleaved high molecular weight kininogen binds directly to the integrin CD11b/CD18 (Mac-1) and blocks adhesion to fibrinogen and ICAM-1.

Sheng N, Fairbanks MB, Heinrikson RL, Canziani G, Chaiken IM, Mosser DM, Zhang H, Colman RW.

Blood. 2000 Jun 15;95(12):3788-95.

PMID:
10845911
14.

Neurobiology. Stay the executioner's hand.

Gurney ME, Tomasselli AG, Heinrikson RL.

Science. 2000 Apr 14;288(5464):283-4. No abstract available.

PMID:
10777410
15.

Prediction of the tertiary structure of a caspase-9/inhibitor complex.

Chou KC, Tomasselli AG, Heinrikson RL.

FEBS Lett. 2000 Mar 31;470(3):249-56.

16.

Caspase 8: an efficient method for large-scale autoactivation of recombinant procaspase 8 by matrix adsorption and characterization of the active enzyme.

Koeplinger KA, Mildner AM, Leone JW, Wheeler JS, Heinrikson RL, Tomasselli AG.

Protein Expr Purif. 2000 Apr;18(3):378-87.

PMID:
10733893
17.

Targeting the HIV-protease in AIDS therapy: a current clinical perspective.

Tomasselli AG, Heinrikson RL.

Biochim Biophys Acta. 2000 Mar 7;1477(1-2):189-214. Review.

PMID:
10708858
18.

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.

Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME.

Nature. 1999 Dec 2;402(6761):533-7.

PMID:
10591213
19.

Processing of the human heparanase precursor and evidence that the active enzyme is a heterodimer.

Fairbanks MB, Mildner AM, Leone JW, Cavey GS, Mathews WR, Drong RF, Slightom JL, Bienkowski MJ, Smith CW, Bannow CA, Heinrikson RL.

J Biol Chem. 1999 Oct 15;274(42):29587-90.

20.

The atomic-resolution structure of human caspase-8, a key activator of apoptosis.

Watt W, Koeplinger KA, Mildner AM, Heinrikson RL, Tomasselli AG, Watenpaugh KD.

Structure. 1999 Sep 15;7(9):1135-43.

21.

Mechanism, structure-activity studies, and potential applications of glutathione S-transferase-catalyzed cleavage of sulfonamides.

Zhao Z, Koeplinger KA, Peterson T, Conradi RA, Burton PS, Suarato A, Heinrikson RL, Tomasselli AG.

Drug Metab Dispos. 1999 Sep;27(9):992-8.

PMID:
10460797
22.

Activated sulfonamides are cleaved by glutathione-S-transferases.

Koeplinger KA, Zhao Z, Peterson T, Leone JW, Schwende FS, Heinrikson RL, Tomasselli AG.

Drug Metab Dispos. 1999 Sep;27(9):986-91.

PMID:
10460796
23.

Production of chemokines CTAPIII and NAP/2 by digestion of recombinant ubiquitin-CTAPIII with yeast ubiquitin C-terminal hydrolase and human immunodeficiency virus protease.

Mildner AM, Paddock DJ, LeCureux LW, Leone JW, Anderson DC, Tomasselli AG, Heinrikson RL.

Protein Expr Purif. 1999 Jul;16(2):347-54.

PMID:
10419831
24.

A model of the complex between cyclin-dependent kinase 5 and the activation domain of neuronal Cdk5 activator.

Chou KC, Watenpaugh KD, Heinrikson RL.

Biochem Biophys Res Commun. 1999 Jun 7;259(2):420-8.

PMID:
10362524
25.

Cation binding to the integrin CD11b I domain and activation model assessment.

Baldwin ET, Sarver RW, Bryant GL Jr, Curry KA, Fairbanks MB, Finzel BC, Garlick RL, Heinrikson RL, Horton NC, Kelley LL, Mildner AM, Moon JB, Mott JE, Mutchler VT, Tomich CS, Watenpaugh KD, Wiley VH.

Structure. 1998 Jul 15;6(7):923-35.

26.

Prediction of the tertiary structure and substrate binding site of caspase-8.

Chou KC, Jones D, Heinrikson RL.

FEBS Lett. 1997 Dec 8;419(1):49-54.

27.

Prediction of the tertiary structure of the complement control protein module.

Chou KC, Heinrikson RL.

J Protein Chem. 1997 Nov;16(8):765-73.

PMID:
9365925
28.

Use of the HIV-1 protease for excision of growth-hormone-releasing factor from synthetic and recombinant peptide precursors.

Tomasselli AG, Mildner AA, Paddock DJ, Wheeler JS, Kubiak TM, Martin RA, Moseley WM, Mott JE, White MC, Leone JW, Heinrikson RL.

Biotechnol Appl Biochem. 1997 Aug;26(1):39-49.

PMID:
9262002
29.

Identification of signal-induced IkappaB-alpha kinases in human endothelial cells.

Bennett BL, Lacson RG, Chen CC, Cruz R, Wheeler JS, Kletzien RF, Tomasselli AG, Heinrikson RL, Manning AM.

J Biol Chem. 1996 Aug 16;271(33):19680-8.

30.

Predicting human immunodeficiency virus protease cleavage sites in proteins by a discriminant function method.

Chou KC, Tomasselli AG, Reardon IM, Heinrikson RL.

Proteins. 1996 Jan;24(1):51-72.

PMID:
8628733
31.

Purification and structural characterization of the CD11b/CD18 integrin alpha subunit I domain reveals a folded conformation in solution.

Fairbanks MB, Pollock JR, Prairie MD, Scahill TA, Baczynskyj L, Heinrikson RL, Stockman BJ.

FEBS Lett. 1995 Aug 7;369(2-3):197-201.

32.

The differential processing of homodimers of reverse transcriptases from human immunodeficiency viruses type 1 and 2 is a consequence of the distinct specificities of the viral proteases.

Fan N, Rank KB, Leone JW, Heinrikson RL, Bannow CA, Smith CW, Evans DB, Poppe SM, Tarpley WG, Rothrock DJ, et al.

J Biol Chem. 1995 Jun 2;270(22):13573-9.

33.

CXC chemokines connective tissue activating peptide-III and neutrophil activating peptide-2 are heparin/heparan sulfate-degrading enzymes.

Hoogewerf AJ, Leone JW, Reardon IM, Howe WJ, Asa D, Heinrikson RL, Ledbetter SR.

J Biol Chem. 1995 Feb 17;270(7):3268-77.

34.

Effect of point mutations on the kinetics and the inhibition of human immunodeficiency virus type 1 protease: relationship to drug resistance.

Lin Y, Lin X, Hong L, Foundling S, Heinrikson RL, Thaisrivongs S, Leelamanit W, Raterman D, Shah M, Dunn BM, et al.

Biochemistry. 1995 Jan 31;34(4):1143-52.

PMID:
7827064
35.

Mutants of HIV-1 protease with enhanced stability to autodegradation.

Tomasselli AG, Mildner AM, Rothrock DJ, Sarcich JL, Lull J, Leone J, Heinrikson RL.

Adv Exp Med Biol. 1995;362:387-98. No abstract available.

PMID:
8540348
36.

Specificity of retroviral proteases: an analysis of viral and nonviral protein substrates.

Tomasselli AG, Heinrikson RL.

Methods Enzymol. 1994;241:279-301. Review. No abstract available.

PMID:
7854182
37.

Human immunodeficiency virus type-1 reverse transcriptase and ribonuclease H as substrates of the viral protease.

Tomasselli AG, Sarcich JL, Barrett LJ, Reardon IM, Howe WJ, Evans DB, Sharma SK, Heinrikson RL.

Protein Sci. 1993 Dec;2(12):2167-76.

38.

An active FK506-binding domain of 17,000 daltons is isolated following limited proteolysis of chicken thymus hsp56.

Yem AW, Reardon IM, Leone JW, Heinrikson RL, Deibel MR Jr.

Biochemistry. 1993 Nov 30;32(47):12571-6.

PMID:
7504525
39.

The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors.

Mulichak AM, Hui JO, Tomasselli AG, Heinrikson RL, Curry KA, Tomich CS, Thaisrivongs S, Sawyer TK, Watenpaugh KD.

J Biol Chem. 1993 Jun 25;268(18):13103-9.

40.

Large scale purification and refolding of HIV-1 protease from Escherichia coli inclusion bodies.

Hui JO, Tomasselli AG, Reardon IM, Lull JM, Brunner DP, Tomich CS, Heinrikson RL.

J Protein Chem. 1993 Jun;12(3):323-7.

PMID:
8397790
41.

Inhibitors of the protease from human immunodeficiency virus: synthesis, enzyme inhibition, and antiviral activity of a series of compounds containing the dihydroxyethylene transition-state isostere.

Thaisrivongs S, Turner SR, Strohbach JW, TenBrink RE, Tarpley WG, McQuade TJ, Heinrikson RL, Tomasselli AG, Hui JO, Howe WJ.

J Med Chem. 1993 Apr 16;36(8):941-52.

PMID:
8478908
43.
44.

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

Roher AE, Lowenson JD, Clarke S, Wolkow C, Wang R, Cotter RJ, Reardon IM, Z├╝rcher-Neely HA, Heinrikson RL, Ball MJ, et al.

J Biol Chem. 1993 Feb 15;268(5):3072-83.

45.

Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase.

Wilborn TW, Comer KA, Dooley TP, Reardon IM, Heinrikson RL, Falany CN.

Mol Pharmacol. 1993 Jan;43(1):70-7.

PMID:
8423770
46.

Alzheimer's disease and control brain contain soluble derivatives of the amyloid protein precursor that end within the beta amyloid protein region.

Pasternack JM, Palmert MR, Usiak M, Wang R, Zurcher-Neely H, Gonzalez-De Whitt PA, Fairbanks MB, Cheung T, Blades D, Heinrikson RL, et al.

Biochemistry. 1992 Nov 10;31(44):10936-40.

PMID:
1420205
47.

Chloroplast and cytoplasmic enzymes: isolation and sequencing of cDNAs coding for two distinct pea chloroplast aldolases.

Razdan K, Heinrikson RL, Zurcher-Neely H, Morris PW, Anderson LE.

Arch Biochem Biophys. 1992 Oct;298(1):192-7.

PMID:
1524427
48.

Sequence analysis, in vitro translation, and expression of the cDNA for rat liver minoxidil sulfotransferase.

Hirshey SJ, Dooley TP, Reardon IM, Heinrikson RL, Falany CN.

Mol Pharmacol. 1992 Aug;42(2):257-64.

PMID:
1513323
49.

Crystal structure of a complex of HIV-1 protease with a dihydroxyethylene-containing inhibitor: comparisons with molecular modeling.

Thanki N, Rao JK, Foundling SI, Howe WJ, Moon JB, Hui JO, Tomasselli AG, Heinrikson RL, Thaisrivongs S, Wlodawer A.

Protein Sci. 1992 Aug;1(8):1061-72.

50.

Purification and characterization of heterodimeric human immunodeficiency virus type 1 (HIV-1) reverse transcriptase produced by in vitro processing of p66 with recombinant HIV-1 protease.

Chattopadhyay D, Evans DB, Deibel MR Jr, Vosters AF, Eckenrode FM, Einspahr HM, Hui JO, Tomasselli AG, Zurcher-Neely HA, Heinrikson RL, et al.

J Biol Chem. 1992 Jul 15;267(20):14227-32.

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