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De novo purine biosynthesis is required for intracellular growth of Staphylococcus aureus and for the hypervirulence phenotype of a purR mutant.

Goncheva MI, Flannagan RS, Heinrichs DE.

Infect Immun. 2020 Feb 24. pii: IAI.00104-20. doi: 10.1128/IAI.00104-20. [Epub ahead of print]


Identification of Key Determinants of Staphylococcus aureus Vaginal Colonization.

Deng L, Schilcher K, Burcham LR, Kwiecinski JM, Johnson PM, Head SR, Heinrichs DE, Horswill AR, Doran KS.

mBio. 2019 Dec 24;10(6). pii: e02321-19. doi: 10.1128/mBio.02321-19.


Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA.

El-Halfawy OM, Czarny TL, Flannagan RS, Day J, Bozelli JC Jr, Kuiack RC, Salim A, Eckert P, Epand RM, McGavin MJ, Organ MG, Heinrichs DE, Brown ED.

Nat Chem Biol. 2020 Feb;16(2):143-149. doi: 10.1038/s41589-019-0401-8. Epub 2019 Nov 25.


Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host.

Perry WJ, Spraggins JM, Sheldon JR, Grunenwald CM, Heinrichs DE, Cassat JE, Skaar EP, Caprioli RM.

Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):21980-21982. doi: 10.1073/pnas.1913991116. Epub 2019 Oct 14.


The heme-sensitive regulator SbnI has a bifunctional role in staphyloferrin B production by Staphylococcus aureus.

Verstraete MM, Morales LD, Kobylarz MJ, Loutet SA, Laakso HA, Pinter TB, Stillman MJ, Heinrichs DE, Murphy MEP.

J Biol Chem. 2019 Jul 26;294(30):11622-11636. doi: 10.1074/jbc.RA119.007757. Epub 2019 Jun 13.


Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence.

Goncheva MI, Flannagan RS, Sterling BE, Laakso HA, Friedrich NC, Kaiser JC, Watson DW, Wilson CH, Sheldon JR, McGavin MJ, Kiser PK, Heinrichs DE.

Nat Commun. 2019 Feb 15;10(1):775. doi: 10.1038/s41467-019-08724-x.


A Fluorescence Based-Proliferation Assay for the Identification of Replicating Bacteria Within Host Cells.

Flannagan RS, Heinrichs DE.

Front Microbiol. 2018 Dec 12;9:3084. doi: 10.3389/fmicb.2018.03084. eCollection 2018.


DNA Binding and Sensor Specificity of FarR, a Novel TetR Family Regulator Required for Induction of the Fatty Acid Efflux Pump FarE in Staphylococcus aureus.

Alnaseri H, Kuiack RC, Ferguson KA, Schneider JET, Heinrichs DE, McGavin MJ.

J Bacteriol. 2019 Jan 11;201(3). pii: e00602-18. doi: 10.1128/JB.00602-18. Print 2019 Feb 1.


Branching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation.

Kaiser JC, Heinrichs DE.

mBio. 2018 Sep 4;9(5). pii: e01188-18. doi: 10.1128/mBio.01188-18. Review.


Correction: Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation.

Heilbronner S, Monk IR, Brozyna JR, Heinrichs DE, Skaar EP, Peschel A, Foster TJ.

PLoS Genet. 2018 Jul 27;14(7):e1007564. doi: 10.1371/journal.pgen.1007564. eCollection 2018 Jul.


Staphylococcus aureus Uses the GraXRS Regulatory System To Sense and Adapt to the Acidified Phagolysosome in Macrophages.

Flannagan RS, Kuiack RC, McGavin MJ, Heinrichs DE.

mBio. 2018 Jul 17;9(4). pii: e01143-18. doi: 10.1128/mBio.01143-18.


The surreptitious survival of the emerging pathogen Staphylococcus lugdunensis within macrophages as an immune evasion strategy.

Flannagan RS, Watson DW, Surewaard BGJ, Kubes P, Heinrichs DE.

Cell Microbiol. 2018 Nov;20(11):e12869. doi: 10.1111/cmi.12869. Epub 2018 Aug 7.


SbnI is a free serine kinase that generates O -phospho-l-serine for staphyloferrin B biosynthesis in Staphylococcus aureus.

Verstraete MM, Perez-Borrajero C, Brown KL, Heinrichs DE, Murphy MEP.

J Biol Chem. 2018 Apr 20;293(16):6147-6160. doi: 10.1074/jbc.RA118.001875. Epub 2018 Feb 26.


Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide.

Kaiser JC, King AN, Grigg JC, Sheldon JR, Edgell DR, Murphy MEP, Brinsmade SR, Heinrichs DE.

PLoS Genet. 2018 Jan 22;14(1):e1007159. doi: 10.1371/journal.pgen.1007159. eCollection 2018 Jan.


The role of two branched-chain amino acid transporters in Staphylococcus aureus growth, membrane fatty acid composition and virulence.

Kaiser JC, Sen S, Sinha A, Wilkinson BJ, Heinrichs DE.

Mol Microbiol. 2016 Dec;102(5):850-864. doi: 10.1111/mmi.13495. Epub 2016 Sep 27.


Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation.

Heilbronner S, Monk IR, Brozyna JR, Heinrichs DE, Skaar EP, Peschel A, Foster TJ.

PLoS Genet. 2016 Aug 30;12(8):e1006246. doi: 10.1371/journal.pgen.1006246. eCollection 2016 Aug. Erratum in: PLoS Genet. 2018 Jul 27;14(7):e1007564.


Iron Acquisition Strategies of Bacterial Pathogens.

Sheldon JR, Laakso HA, Heinrichs DE.

Microbiol Spectr. 2016 Apr;4(2). doi: 10.1128/microbiolspec.VMBF-0010-2015. Review.


Paradoxical acclimation responses in the thermal performance of insect immunity.

Ferguson LV, Heinrichs DE, Sinclair BJ.

Oecologia. 2016 May;181(1):77-85. doi: 10.1007/s00442-015-3529-6. Epub 2016 Feb 5.


Deciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis.

Kobylarz MJ, Grigg JC, Liu Y, Lee MS, Heinrichs DE, Murphy ME.

Biochemistry. 2016 Feb 16;55(6):927-39. doi: 10.1021/acs.biochem.5b01045. Epub 2016 Feb 3.


Antimicrobial Mechanisms of Macrophages and the Immune Evasion Strategies of Staphylococcus aureus.

Flannagan RS, Heit B, Heinrichs DE.

Pathogens. 2015 Nov 27;4(4):826-68. doi: 10.3390/pathogens4040826. Review.


A Heme-responsive Regulator Controls Synthesis of Staphyloferrin B in Staphylococcus aureus.

Laakso HA, Marolda CL, Pinter TB, Stillman MJ, Heinrichs DE.

J Biol Chem. 2016 Jan 1;291(1):29-40. doi: 10.1074/jbc.M115.696625. Epub 2015 Nov 3.


Intracellular replication of Staphylococcus aureus in mature phagolysosomes in macrophages precedes host cell death, and bacterial escape and dissemination.

Flannagan RS, Heit B, Heinrichs DE.

Cell Microbiol. 2016 Apr;18(4):514-35. doi: 10.1111/cmi.12527. Epub 2015 Oct 26.


Recent developments in understanding the iron acquisition strategies of gram positive pathogens.

Sheldon JR, Heinrichs DE.

FEMS Microbiol Rev. 2015 Jul;39(4):592-630. doi: 10.1093/femsre/fuv009. Epub 2015 Apr 9. Review.


Inducible Expression of a Resistance-Nodulation-Division-Type Efflux Pump in Staphylococcus aureus Provides Resistance to Linoleic and Arachidonic Acids.

Alnaseri H, Arsic B, Schneider JE, Kaiser JC, Scinocca ZC, Heinrichs DE, McGavin MJ.

J Bacteriol. 2015 Jun;197(11):1893-905. doi: 10.1128/JB.02607-14. Epub 2015 Mar 23.


Involvement of reductases IruO and NtrA in iron acquisition by Staphylococcus aureus.

Hannauer M, Arifin AJ, Heinrichs DE.

Mol Microbiol. 2015 Jun;96(6):1192-210. doi: 10.1111/mmi.13000. Epub 2015 Apr 11.


Involvement of major facilitator superfamily proteins SfaA and SbnD in staphyloferrin secretion in Staphylococcus aureus.

Hannauer M, Sheldon JR, Heinrichs DE.

FEBS Lett. 2015 Mar 12;589(6):730-7. doi: 10.1016/j.febslet.2015.02.002. Epub 2015 Feb 11.


Role of BrnQ1 and BrnQ2 in branched-chain amino acid transport and virulence in Staphylococcus aureus.

Kaiser JC, Omer S, Sheldon JR, Welch I, Heinrichs DE.

Infect Immun. 2015 Mar;83(3):1019-29. doi: 10.1128/IAI.02542-14. Epub 2014 Dec 29.


SbnG, a citrate synthase in Staphylococcus aureus: a new fold on an old enzyme.

Kobylarz MJ, Grigg JC, Sheldon JR, Heinrichs DE, Murphy ME.

J Biol Chem. 2014 Dec 5;289(49):33797-807. doi: 10.1074/jbc.M114.603175. Epub 2014 Oct 21.


Deferoxamine mesylate enhances virulence of community-associated methicillin resistant Staphylococcus aureus.

Arifin AJ, Hannauer M, Welch I, Heinrichs DE.

Microbes Infect. 2014 Nov;16(11):967-72. doi: 10.1016/j.micinf.2014.09.003. Epub 2014 Sep 22.


Role of lipase from community-associated methicillin-resistant Staphylococcus aureus strain USA300 in hydrolyzing triglycerides into growth-inhibitory free fatty acids.

Cadieux B, Vijayakumaran V, Bernards MA, McGavin MJ, Heinrichs DE.

J Bacteriol. 2014 Dec;196(23):4044-56. doi: 10.1128/JB.02044-14. Epub 2014 Sep 15.


Identification of a positively charged platform in Staphylococcus aureus HtsA that is essential for ferric staphyloferrin A transport.

Cooper JD, Hannauer M, Marolda CL, Briere LA, Heinrichs DE.

Biochemistry. 2014 Aug 12;53(31):5060-9. doi: 10.1021/bi500729h. Epub 2014 Jul 28.


Crystal and solution structure analysis of FhuD2 from Staphylococcus aureus in multiple unliganded conformations and bound to ferrioxamine-B.

Podkowa KJ, Briere LA, Heinrichs DE, Shilton BH.

Biochemistry. 2014 Apr 1;53(12):2017-31. doi: 10.1021/bi401349d. Epub 2014 Mar 19.


Growth promotion of the opportunistic human pathogen, Staphylococcus lugdunensis, by heme, hemoglobin, and coculture with Staphylococcus aureus.

Brozyna JR, Sheldon JR, Heinrichs DE.

Microbiologyopen. 2014 Apr;3(2):182-95. doi: 10.1002/mbo3.162. Epub 2014 Feb 7.


Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor.

Kobylarz MJ, Grigg JC, Takayama SJ, Rai DK, Heinrichs DE, Murphy ME.

Chem Biol. 2014 Mar 20;21(3):379-88. doi: 10.1016/j.chembiol.2013.12.011. Epub 2014 Jan 30.


Demonstration of the functional role of conserved Glu-Arg residues in the Staphylococcus aureus ferrichrome transporter.

Vinés ED, Speziali CD, Heinrichs DE.

Biometals. 2014 Feb;27(1):143-53. doi: 10.1007/s10534-013-9695-2. Epub 2013 Dec 22.


IsdB-dependent hemoglobin binding is required for acquisition of heme by Staphylococcus aureus.

Pishchany G, Sheldon JR, Dickson CF, Alam MT, Read TD, Gell DA, Heinrichs DE, Skaar EP.

J Infect Dis. 2014 Jun 1;209(11):1764-72. doi: 10.1093/infdis/jit817. Epub 2013 Dec 13.


Discovery of an iron-regulated citrate synthase in Staphylococcus aureus.

Cheung J, Murphy ME, Heinrichs DE.

Chem Biol. 2012 Dec 21;19(12):1568-78. doi: 10.1016/j.chembiol.2012.10.003.


Induction of the staphylococcal proteolytic cascade by antimicrobial fatty acids in community acquired methicillin resistant Staphylococcus aureus.

Arsic B, Zhu Y, Heinrichs DE, McGavin MJ.

PLoS One. 2012;7(9):e45952. doi: 10.1371/journal.pone.0045952. Epub 2012 Sep 24.


Multiprotein heme shuttle pathway in Staphylococcus aureus: iron-regulated surface determinant cog-wheel kinetics.

Tiedemann MT, Heinrichs DE, Stillman MJ.

J Am Chem Soc. 2012 Oct 10;134(40):16578-85. doi: 10.1021/ja305115y. Epub 2012 Oct 1.


The staphylococci and staphylococcal pathogenesis.

McGavin MJ, Heinrichs DE.

Front Cell Infect Microbiol. 2012 May 18;2:66. doi: 10.3389/fcimb.2012.00066. eCollection 2012. No abstract available.


The iron-regulated staphylococcal lipoproteins.

Sheldon JR, Heinrichs DE.

Front Cell Infect Microbiol. 2012 Apr 4;2:41. doi: 10.3389/fcimb.2012.00041. eCollection 2012. Review.


Mutation of L-2,3-diaminopropionic acid synthase genes blocks staphyloferrin B synthesis in Staphylococcus aureus.

Beasley FC, Cheung J, Heinrichs DE.

BMC Microbiol. 2011 Sep 9;11:199. doi: 10.1186/1471-2180-11-199.


A modulatory interleukin-10 response to staphylococcal peptidoglycan prevents Th1/Th17 adaptive immunity to Staphylococcus aureus.

Frodermann V, Chau TA, Sayedyahossein S, Toth JM, Heinrichs DE, Madrenas J.

J Infect Dis. 2011 Jul 15;204(2):253-62. doi: 10.1093/infdis/jir276.


Staphylococcal major autolysin (Atl) is involved in excretion of cytoplasmic proteins.

Pasztor L, Ziebandt AK, Nega M, Schlag M, Haase S, Franz-Wachtel M, Madlung J, Nordheim A, Heinrichs DE, Götz F.

J Biol Chem. 2010 Nov 19;285(47):36794-803. doi: 10.1074/jbc.M110.167312. Epub 2010 Sep 16.


Specificity of Staphyloferrin B recognition by the SirA receptor from Staphylococcus aureus.

Grigg JC, Cheung J, Heinrichs DE, Murphy ME.

J Biol Chem. 2010 Nov 5;285(45):34579-88. doi: 10.1074/jbc.M110.172924. Epub 2010 Sep 1.


Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence.

Wyatt MA, Wang W, Roux CM, Beasley FC, Heinrichs DE, Dunman PM, Magarvey NA.

Science. 2010 Jul 16;329(5989):294-6. doi: 10.1126/science.1188888. Epub 2010 Jun 3. Erratum in: Science. 2011 Sep 9;333(6048):1381.


The Staphylococcus aureus siderophore receptor HtsA undergoes localized conformational changes to enclose staphyloferrin A in an arginine-rich binding pocket.

Grigg JC, Cooper JD, Cheung J, Heinrichs DE, Murphy ME.

J Biol Chem. 2010 Apr 9;285(15):11162-71. doi: 10.1074/jbc.M109.097865. Epub 2010 Feb 10.

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