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Hepatic acute phase proteins--regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling.

Bode JG, Albrecht U, Häussinger D, Heinrich PC, Schaper F.

Eur J Cell Biol. 2012 Jun-Jul;91(6-7):496-505. doi: 10.1016/j.ejcb.2011.09.008. Epub 2011 Nov 16. Review.


Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation.

Radtke S, Wüller S, Yang XP, Lippok BE, Mütze B, Mais C, de Leur HS, Bode JG, Gaestel M, Heinrich PC, Behrmann I, Schaper F, Hermanns HM.

J Cell Sci. 2010 Mar 15;123(Pt 6):947-59. doi: 10.1242/jcs.065326.


Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1).

Wiesinger MY, Haan S, Wüller S, Kauffmann ME, Recker T, Küster A, Heinrich PC, Müller-Newen G.

Chem Biol. 2009 Jul 31;16(7):783-94. doi: 10.1016/j.chembiol.2009.06.010.


Interleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes.

Bender H, Wiesinger MY, Nordhoff C, Schoenherr C, Haan C, Ludwig S, Weiskirchen R, Kato N, Heinrich PC, Haan S.

Hepatology. 2009 Aug;50(2):585-91. doi: 10.1002/hep.22988.


Induction of CCL13 expression in synovial fibroblasts highlights a significant role of oncostatin M in rheumatoid arthritis.

Hintzen C, Quaiser S, Pap T, Heinrich PC, Hermanns HM.

Arthritis Rheum. 2009 Jul;60(7):1932-43. doi: 10.1002/art.24602.


An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses.

Haan C, Kroy DC, Wüller S, Sommer U, Nöcker T, Rolvering C, Behrmann I, Heinrich PC, Haan S.

J Immunol. 2009 Mar 1;182(5):2969-77. doi: 10.4049/jimmunol.0800572.


Oncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression.

Hintzen C, Haan C, Tuckermann JP, Heinrich PC, Hermanns HM.

J Immunol. 2008 Nov 15;181(10):7341-9.


IL-31 receptor alpha expression in epidermal keratinocytes is modulated by cell differentiation and interferon gamma.

Heise R, Neis MM, Marquardt Y, Joussen S, Heinrich PC, Merk HF, Hermanns HM, Baron JM.

J Invest Dermatol. 2009 Jan;129(1):240-3. doi: 10.1038/jid.2008.183. Epub 2008 Jun 26. No abstract available.


SHPS-1/SIRP1alpha contributes to interleukin-6 signalling.

Sobota RM, Müller PJ, Khouri C, Ullrich A, Poli V, Noguchi T, Heinrich PC, Schaper F.

Cell Signal. 2008 Jul;20(7):1385-91. doi: 10.1016/j.cellsig.2008.03.005. Epub 2008 Mar 21.


Box 2 region of the oncostatin M receptor determines specificity for recruitment of Janus kinases and STAT5 activation.

Hintzen C, Evers C, Lippok BE, Volkmer R, Heinrich PC, Radtke S, Hermanns HM.

J Biol Chem. 2008 Jul 11;283(28):19465-77. doi: 10.1074/jbc.M710157200. Epub 2008 Apr 22.


Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation.

Sobota RM, Müller PJ, Heinrich PC, Schaper F.

Biochem J. 2008 May 15;412(1):65-72. doi: 10.1042/BJ20071572.


Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation.

Haan S, Margue C, Engrand A, Rolvering C, Schmitz-Van de Leur H, Heinrich PC, Behrmann I, Haan C.

J Immunol. 2008 Jan 15;180(2):998-1007.


Novel inhibitors for murine and human leukemia inhibitory factor based on fused soluble receptors.

Metz S, Naeth G, Heinrich PC, Müller-Newen G.

J Biol Chem. 2008 Mar 7;283(10):5985-95. doi: 10.1074/jbc.M706610200. Epub 2008 Jan 3.


Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases.

Kreis S, Munz GA, Haan S, Heinrich PC, Behrmann I.

Mol Cancer Res. 2007 Dec;5(12):1331-41. doi: 10.1158/1541-7786.MCR-07-0317.


Nucleocytoplasmic shuttling of persistently activated STAT3.

Herrmann A, Vogt M, Mönnigmann M, Clahsen T, Sommer U, Haan S, Poli V, Heinrich PC, Müller-Newen G.

J Cell Sci. 2007 Sep 15;120(Pt 18):3249-61. Epub 2007 Aug 28.


Activation of NF-kappaB by IL-1beta blocks IL-6-induced sustained STAT3 activation and STAT3-dependent gene expression of the human gamma-fibrinogen gene.

Albrecht U, Yang X, Asselta R, Keitel V, Tenchini ML, Ludwig S, Heinrich PC, Häussinger D, Schaper F, Bode JG.

Cell Signal. 2007 Sep;19(9):1866-78. Epub 2007 May 1.


Constitutive suppressor of cytokine signaling 3 expression confers a growth advantage to a human melanoma cell line.

Komyod W, Böhm M, Metze D, Heinrich PC, Behrmann I.

Mol Cancer Res. 2007 Mar;5(3):271-81.


Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade.

Ehlting C, Lai WS, Schaper F, Brenndörfer ED, Matthes RJ, Heinrich PC, Ludwig S, Blackshear PJ, Gaestel M, Häussinger D, Bode JG.

J Immunol. 2007 Mar 1;178(5):2813-26.


Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins.

Metz S, Wiesinger M, Vogt M, Lauks H, Schmalzing G, Heinrich PC, Müller-Newen G.

J Biol Chem. 2007 Jan 12;282(2):1238-48. Epub 2006 Nov 3.


Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis.

Neis MM, Peters B, Dreuw A, Wenzel J, Bieber T, Mauch C, Krieg T, Stanzel S, Heinrich PC, Merk HF, Bosio A, Baron JM, Hermanns HM.

J Allergy Clin Immunol. 2006 Oct;118(4):930-7. Epub 2006 Sep 1.


Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism.

Stross C, Radtke S, Clahsen T, Gerlach C, Volkmer-Engert R, Schaper F, Heinrich PC, Hermanns HM.

J Biol Chem. 2006 Mar 31;281(13):8458-68. Epub 2006 Feb 2.


Functional expression of the interleukin-11 receptor alpha-chain in normal colonic epithelium and colon cancer.

Deutscher N, Bataille F, Hausmann M, Kiessling S, Muller-Newen G, Leeb SN, Herfarth H, Heinrich PC, Schölmerich J, Rogler G.

Int J Colorectal Dis. 2006 Sep;21(6):573-81. Epub 2005 Nov 15.


Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells.

Giese B, Roderburg C, Sommerauer M, Wortmann SB, Metz S, Heinrich PC, Müller-Newen G.

J Cell Sci. 2005 Nov 1;118(Pt 21):5129-40.


Signaling through a mutant IFN-gamma receptor.

Costa-Pereira AP, Hermanns HM, Is'harc H, Williams TM, Watling D, Arulampalam V, Newman SJ, Heinrich PC, Kerr IM.

J Immunol. 2005 Nov 1;175(9):5958-65.


STAT5 contributes to interferon resistance of melanoma cells.

Wellbrock C, Weisser C, Hassel JC, Fischer P, Becker J, Vetter CS, Behrmann I, Kortylewski M, Heinrich PC, Schartl M.

Curr Biol. 2005 Sep 20;15(18):1629-39.


Interleukin-6 plays a crucial role in the hepatic expression of SOCS3 during acute inflammatory processes in vivo.

Yang XP, Schaper F, Teubner A, Lammert F, Heinrich PC, Matern S, Siewert E.

J Hepatol. 2005 Oct;43(4):704-10.


Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases.

Sommer U, Schmid C, Sobota RM, Lehmann U, Stevenson NJ, Johnston JA, Schaper F, Heinrich PC, Haan S.

J Biol Chem. 2005 Sep 9;280(36):31478-88. Epub 2005 Jul 6.


Oncostatin M-induced activation of stress-activated MAP kinases depends on tyrosine 861 in the OSM receptor and requires Jak1 but not Src kinases.

Böing I, Stross C, Radtke S, Lippok BE, Heinrich PC, Hermanns HM.

Cell Signal. 2006 Jan;18(1):50-61. Epub 2005 Jun 1.


Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation.

Haan S, Keller JF, Behrmann I, Heinrich PC, Haan C.

Cell Signal. 2005 Dec;17(12):1542-50.


Bow to your partner for signaling.

Hermanns HM, Müller-Newen G, Heinrich PC, Haan S.

Nat Struct Mol Biol. 2005 Jun;12(6):476-8. No abstract available.


Determinants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130.

Lehmann U, Sommer U, Smyczek T, Hörtner M, Frisch W, Volkmer-Engert R, Heinrich PC, Schaper F, Haan S.

Cell Signal. 2006 Jan;18(1):40-9. Epub 2005 May 31.


The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression.

Radtke S, Haan S, Jörissen A, Hermanns HM, Diefenbach S, Smyczek T, Schmitz-Vandeleur H, Heinrich PC, Behrmann I, Haan C.

J Biol Chem. 2005 Jul 8;280(27):25760-8. Epub 2005 May 12.


Are STATS arginine-methylated?

Komyod W, Bauer UM, Heinrich PC, Haan S, Behrmann I.

J Biol Chem. 2005 Jun 10;280(23):21700-5. Epub 2005 Apr 12.


The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling.

Clahsen T, Lehmann U, Stross C, Hermanns HM, Volkmer-Engert R, Schneider-Mergener J, Heinrich PC, Schaper F.

Cell Signal. 2005 May;17(5):559-69.


Multidisciplinary care in cancer: the fellowship of the ring.

Boyle FM, Robinson E, Dunn SM, Heinrich PC.

J Clin Oncol. 2005 Feb 1;23(4):916-20. No abstract available.


Interleukin-6-type cytokines upregulate expression of multidrug resistance-associated proteins in NHEK and dermal fibroblasts.

Dreuw A, Hermanns HM, Heise R, Joussen S, Rodríguez F, Marquardt Y, Jugert F, Merk HF, Heinrich PC, Baron JM.

J Invest Dermatol. 2005 Jan;124(1):28-37.


Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy.

Selander KS, Li L, Watson L, Merrell M, Dahmen H, Heinrich PC, Müller-Newen G, Harris KW.

Cancer Res. 2004 Oct 1;64(19):6924-33.


Interleukin-11 expression: its significance in eutopic and ectopic human implantation.

von Rango U, Alfer J, Kertschanska S, Kemp B, Müller-Newen G, Heinrich PC, Beier HM, Classen-Linke I.

Mol Hum Reprod. 2004 Nov;10(11):783-92. Epub 2004 Oct 1.


Interleukin-6 is a direct mediator of T cell migration.

Weissenbach M, Clahsen T, Weber C, Spitzer D, Wirth D, Vestweber D, Heinrich PC, Schaper F.

Eur J Immunol. 2004 Oct;34(10):2895-906.


Interleukin-6 regulates hepatic transporters during acute-phase response.

Siewert E, Dietrich CG, Lammert F, Heinrich PC, Matern S, Gartung C, Geier A.

Biochem Biophys Res Commun. 2004 Sep 10;322(1):232-8.


Dual function of interleukin-1beta for the regulation of interleukin-6-induced suppressor of cytokine signaling 3 expression.

Yang XP, Albrecht U, Zakowski V, Sobota RM, Häussinger D, Heinrich PC, Ludwig S, Bode JG, Schaper F.

J Biol Chem. 2004 Oct 22;279(43):45279-89. Epub 2004 Aug 11.


Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK.

Zhao L, Hart S, Cheng J, Melenhorst JJ, Bierie B, Ernst M, Stewart C, Schaper F, Heinrich PC, Ullrich A, Robinson GW, Hennighausen L.

J Biol Chem. 2004 Oct 15;279(42):44093-100. Epub 2004 Jul 30.


Characterization of the signaling capacities of the novel gp130-like cytokine receptor.

Dreuw A, Radtke S, Pflanz S, Lippok BE, Heinrich PC, Hermanns HM.

J Biol Chem. 2004 Aug 20;279(34):36112-20. Epub 2004 Jun 11.


The cytokine receptor gp130 and its soluble form are under hormonal control in human endometrium and decidua.

Classen-Linke I, Müller-Newen G, Heinrich PC, Beier HM, von Rango U.

Mol Hum Reprod. 2004 Jul;10(7):495-504. Epub 2004 May 7.


Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase.

Behrmann I, Smyczek T, Heinrich PC, Schmitz-Van de Leur H, Komyod W, Giese B, Müller-Newen G, Haan S, Haan C.

J Biol Chem. 2004 Aug 20;279(34):35486-93. Epub 2004 May 3.


Phage-displayed recombinant single-chain antibody fragments with high affinity for cholesteryl ester transfer protein (CETP): cDNA cloning, characterization and CETP quantification.

Ritsch A, Ebenbichler C, Naschberger E, Schgoer W, Stanzl U, Dietrich H, Heinrich PC, Saito K, Patsch JR.

Clin Chem Lab Med. 2004 Mar;42(3):247-55.


Polarity and lipid raft association of the components of the ciliary neurotrophic factor receptor complex in Madin-Darby canine kidney cells.

Buk DM, Waibel M, Braig C, Martens AS, Heinrich PC, Graeve L.

J Cell Sci. 2004 Apr 15;117(Pt 10):2063-75. Epub 2004 Mar 30.


Interferon-gamma-mediated growth regulation of melanoma cells: involvement of STAT1-dependent and STAT1-independent signals.

Kortylewski M, Komyod W, Kauffmann ME, Bosserhoff A, Heinrich PC, Behrmann I.

J Invest Dermatol. 2004 Feb;122(2):414-22.

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