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Items: 22

1.

Highly sensitive simultaneous quantification of estrogenic tamoxifen metabolites and steroid hormones by LC-MS/MS.

Johänning J, Heinkele G, Precht JC, Brauch H, Eichelbaum M, Schwab M, Schroth W, Mürdter TE.

Anal Bioanal Chem. 2015 Sep;407(24):7497-502. doi: 10.1007/s00216-015-8907-8. Epub 2015 Jul 25.

PMID:
26206706
2.

Quantitative bile acid profiling by liquid chromatography quadrupole time-of-flight mass spectrometry: monitoring hepatitis B therapy by a novel Na(+)-taurocholate cotransporting polypeptide inhibitor.

Haag M, Hofmann U, Mürdter TE, Heinkele G, Leuthold P, Blank A, Haefeli WE, Alexandrov A, Urban S, Schwab M.

Anal Bioanal Chem. 2015 Sep;407(22):6815-25. doi: 10.1007/s00216-015-8853-5. Epub 2015 Jul 5.

PMID:
26143062
3.

A new [2H]-labelled α-trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates.

Heinkele G, Geditz MC, Ganchev B, Kerb R, Hofmann U, Mürdter TE.

J Labelled Comp Radiopharm. 2014 Oct;57(12):699-703. doi: 10.1002/jlcr.3243. Epub 2014 Oct 22.

PMID:
25339577
4.

LC-MS/MS method for the simultaneous quantification of artesunate and its metabolites dihydroartemisinin and dihydroartemisinin glucuronide in human plasma.

Geditz MC, Heinkele G, Ahmed A, Kremsner PG, Kerb R, Schwab M, Hofmann U.

Anal Bioanal Chem. 2014 Jul;406(17):4299-308. doi: 10.1007/s00216-014-7820-x. Epub 2014 Apr 24.

PMID:
24760398
5.

Simultaneous quantification of mefloquine (+)- and (-)-enantiomers and the carboxy metabolite in dried blood spots by liquid chromatography/tandem mass spectrometry.

Geditz MC, Lindner W, Lämmerhofer M, Heinkele G, Kerb R, Ramharter M, Schwab M, Hofmann U.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 1;968:32-9. doi: 10.1016/j.jchromb.2013.11.035. Epub 2013 Nov 25.

PMID:
24315337
6.

Simultaneous quantitative analysis of letrozole, its carbinol metabolite, and carbinol glucuronide in human plasma by LC-MS/MS.

Precht JC, Ganchev B, Heinkele G, Brauch H, Schwab M, Mürdter TE.

Anal Bioanal Chem. 2012 Apr;403(1):301-8. doi: 10.1007/s00216-012-5813-1. Epub 2012 Feb 25.

PMID:
22367241
7.

Simultaneous quantification of eleven thiopurine nucleotides by liquid chromatography-tandem mass spectrometry.

Hofmann U, Heinkele G, Angelberger S, Schaeffeler E, Lichtenberger C, Jaeger S, Reinisch W, Schwab M.

Anal Chem. 2012 Feb 7;84(3):1294-301. doi: 10.1021/ac2031699. Epub 2012 Jan 25.

PMID:
22220820
8.

Quantification of clomiphene metabolite isomers in human plasma by rapid-resolution liquid chromatography-electrospray ionization-tandem mass spectrometry.

Ganchev B, Heinkele G, Kerb R, Schwab M, Mürdter TE.

Anal Bioanal Chem. 2011 Jul;400(10):3429-41. doi: 10.1007/s00216-011-5045-9. Epub 2011 May 1.

PMID:
21533795
9.

Activity levels of tamoxifen metabolites at the estrogen receptor and the impact of genetic polymorphisms of phase I and II enzymes on their concentration levels in plasma.

Mürdter TE, Schroth W, Bacchus-Gerybadze L, Winter S, Heinkele G, Simon W, Fasching PA, Fehm T; German Tamoxifen and AI Clinicians Group, Eichelbaum M, Schwab M, Brauch H.

Clin Pharmacol Ther. 2011 May;89(5):708-17. doi: 10.1038/clpt.2011.27. Epub 2011 Mar 30. Erratum in: Clin Pharmacol Ther. 2012 Jun;91(6):1087.

PMID:
21451508
10.

Fate of the antibiotic sulfamethoxazole and its two major human metabolites in a water sediment test.

Radke M, Lauwigi C, Heinkele G, Mürdter TE, Letzel M.

Environ Sci Technol. 2009 May 1;43(9):3135-41.

PMID:
19534125
11.

Increased absorption of digoxin from the human jejunum due to inhibition of intestinal transporter-mediated efflux.

Igel S, Drescher S, Mürdter T, Hofmann U, Heinkele G, Tegude H, Glaeser H, Brenner SS, Somogyi AA, Omari T, Schäfer C, Eichelbaum M, Fromm MF.

Clin Pharmacokinet. 2007;46(9):777-85.

PMID:
17713975
12.

The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3.

Seithel A, Eberl S, Singer K, Auge D, Heinkele G, Wolf NB, Dörje F, Fromm MF, König J.

Drug Metab Dispos. 2007 May;35(5):779-86. Epub 2007 Feb 12.

PMID:
17296622
14.

Effects of ursodeoxycholic acid on P-glycoprotein and cytochrome P450 3A4-dependent pharmacokinetics in humans.

Becquemont L, Glaeser H, Drescher S, Hitzl M, Simon N, Murdter TE, Heinkele G, Hofmann U, Schaefer C, Burk O, Verstuyft C, Eichelbaum M, Fromm MF.

Clin Pharmacol Ther. 2006 May;79(5):449-60. Epub 2006 Apr 11.

PMID:
16678547
15.

Impact of concentration and rate of intraluminal drug delivery on absorption and gut wall metabolism of verapamil in humans.

Glaeser H, Drescher S, Hofmann U, Heinkele G, Somogyi AA, Eichelbaum M, Fromm MF.

Clin Pharmacol Ther. 2004 Sep;76(3):230-8.

PMID:
15371984
16.

Potent mechanism-based inhibition of human CYP2B6 by clopidogrel and ticlopidine.

Richter T, Mürdter TE, Heinkele G, Pleiss J, Tatzel S, Schwab M, Eichelbaum M, Zanger UM.

J Pharmacol Exp Ther. 2004 Jan;308(1):189-97. Epub 2003 Oct 16.

PMID:
14563790
17.

Simple and sensitive method for the determination of celecoxib in human serum by high-performance liquid chromatography with fluorescence detection.

Schönberger F, Heinkele G, Mürdter TE, Brenner S, Klotz U, Hofmann U.

J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Mar 5;768(2):255-60.

PMID:
11888053
18.

Determination of celecoxib in human plasma and rat microdialysis samples by liquid chromatography tandem mass spectrometry.

Bräutigam L, Vetter G, Tegeder I, Heinkele G, Geisslinger G.

J Chromatogr B Biomed Sci Appl. 2001 Sep 25;761(2):203-12.

PMID:
11587350
19.

Determination of propafenone and its phase I and phase II metabolites in plasma and urine by high-performance liquid chromatography-electrospray ionization mass spectrometry.

Hofmann U, Pecia M, Heinkele G, Dilger K, Kroemer HK, Eichelbaum M.

J Chromatogr B Biomed Sci Appl. 2000 Oct 1;748(1):113-23.

PMID:
11092591
20.

In vitro assessment of various cytochromes P450 and glucuronosyltransferases using the antiarrhythmic propafenone as a probe drug.

Kroemer HK, Botsch S, Heinkele G, Schick M.

Methods Enzymol. 1996;272:99-105. No abstract available.

PMID:
8791766
21.

Influence of renal function on the steady-state pharmacokinetics of the antiarrhythmic propafenone and its phase I and phase II metabolites.

Fromm MF, Botsch S, Heinkele G, Evers J, Kroemer HK.

Eur J Clin Pharmacol. 1995;48(3-4):279-83.

PMID:
7589055
22.

Rapid determination of CYP2D6 phenotype during propafenone therapy by analysing urinary excretion of propafenone glucuronides.

Botsch S, Heinkele G, Meese CO, Eichelbaum M, Kroemer HK.

Eur J Clin Pharmacol. 1994;46(2):133-5.

PMID:
8039531

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