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Items: 1 to 50 of 695

1.

Structure of the active GGEEF domain of a diguanylate cyclase from Vibrio cholerae.

Chouhan OP, Roske Y, Heinemann U, Biswas S.

Biochem Biophys Res Commun. 2020 Mar 5;523(2):287-292. doi: 10.1016/j.bbrc.2019.11.179. Epub 2019 Dec 18.

PMID:
31862141
2.

Structural Features of Tight-Junction Proteins.

Heinemann U, Schuetz A.

Int J Mol Sci. 2019 Nov 29;20(23). pii: E6020. doi: 10.3390/ijms20236020. Review.

3.

Common Mode of Remodeling AAA ATPases p97/CDC48 by Their Disassembling Cofactors ASPL/PUX1.

Banchenko S, Arumughan A, Petrović S, Schwefel D, Wanker EE, Roske Y, Heinemann U.

Structure. 2019 Dec 3;27(12):1830-1841.e3. doi: 10.1016/j.str.2019.10.001. Epub 2019 Oct 21.

PMID:
31648844
4.

Structure-Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases.

Małecki PH, Rüger N, Roatsch M, Krylova O, Link A, Jung M, Heinemann U, Weiss MS.

ChemMedChem. 2019 Nov 6;14(21):1828-1839. doi: 10.1002/cmdc.201900441. Epub 2019 Oct 10.

5.

Persistent increase in ventral hippocampal long-term potentiation by juvenile stress: A role for astrocytic glutamine synthetase.

Ivens S, Çalışkan G, Papageorgiou I, Cesetti T, Malich A, Kann O, Heinemann U, Stork O, Albrecht A.

Glia. 2019 Dec;67(12):2279-2293. doi: 10.1002/glia.23683. Epub 2019 Jul 17.

PMID:
31313857
6.

Time-resolved DNA release from an O-antigen-specific Salmonella bacteriophage with a contractile tail.

Broeker NK, Roske Y, Valleriani A, Stephan MS, Andres D, Koetz J, Heinemann U, Barbirz S.

J Biol Chem. 2019 Aug 2;294(31):11751-11761. doi: 10.1074/jbc.RA119.008133. Epub 2019 Jun 12.

PMID:
31189652
7.

Seizure-induced microvascular injury is associated with impaired neurovascular coupling and blood-brain barrier dysfunction.

Prager O, Kamintsky L, Hasam-Henderson LA, Schoknecht K, Wuntke V, Papageorgiou I, Swolinsky J, Muoio V, Bar-Klein G, Vazana U, Heinemann U, Friedman A, Kovács R.

Epilepsia. 2019 Feb;60(2):322-336. doi: 10.1111/epi.14631. Epub 2019 Jan 4.

8.

Seizure forecasting using single robust linear feature as correlation vector of seizure-like events in brain slices preparation in vitro.

Abbas MK, Raza ML, Zaidi SSH, Khan BM, Heinemann U.

Neurol Res. 2019 Feb;41(2):99-109. doi: 10.1080/01616412.2018.1532481. Epub 2018 Oct 17.

PMID:
30332347
9.

Solvent Networks Tune Thermodynamics of Oligosaccharide Complex Formation in an Extended Protein Binding Site.

Kunstmann S, Gohlke U, Broeker NK, Roske Y, Heinemann U, Santer M, Barbirz S.

J Am Chem Soc. 2018 Aug 22;140(33):10447-10455. doi: 10.1021/jacs.8b03719. Epub 2018 Aug 9.

PMID:
30044908
10.

Structural changes of TasA in biofilm formation of Bacillus subtilis.

Diehl A, Roske Y, Ball L, Chowdhury A, Hiller M, Molière N, Kramer R, Stöppler D, Worth CL, Schlegel B, Leidert M, Cremer N, Erdmann N, Lopez D, Stephanowitz H, Krause E, van Rossum BJ, Schmieder P, Heinemann U, Turgay K, Akbey Ü, Oschkinat H.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3237-3242. doi: 10.1073/pnas.1718102115. Epub 2018 Mar 12.

11.

Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus.

Papageorgiou IE, Valous NA, Lahrmann B, Janova H, Klaft ZJ, Koch A, Schneider UC, Vajkoczy P, Heppner FL, Grabe N, Halama N, Heinemann U, Kann O.

Glia. 2018 May;66(5):920-933. doi: 10.1002/glia.23292. Epub 2018 Jan 19.

PMID:
29350438
12.

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.

Ming Q, Roske Y, Schuetz A, Walentin K, Ibraimi I, Schmidt-Ott KM, Heinemann U.

Nucleic Acids Res. 2018 Feb 28;46(4):2082-2095. doi: 10.1093/nar/gkx1299.

13.

A novel form of RNA double helix based on G·U and C·A+ wobble base pairing.

Garg A, Heinemann U.

RNA. 2018 Feb;24(2):209-218. doi: 10.1261/rna.064048.117. Epub 2017 Nov 9.

14.

Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK1-WG4 report of the AES/ILAE Translational Task Force of the ILAE.

Raimondo JV, Heinemann U, de Curtis M, Goodkin HP, Dulla CG, Janigro D, Ikeda A, Lin CK, Jiruska P, Galanopoulou AS, Bernard C.

Epilepsia. 2017 Nov;58 Suppl 4:40-52. doi: 10.1111/epi.13901. Review.

15.

DNA versus RNA oxidation in Parkinson's disease: Which is more important?

Gmitterová K, Gawinecka J, Heinemann U, Valkovič P, Zerr I.

Neurosci Lett. 2018 Jan 1;662:22-28. doi: 10.1016/j.neulet.2017.09.048. Epub 2017 Sep 27.

PMID:
28963060
16.

Event-Associated Oxygen Consumption Rate Increases ca. Five-Fold When Interictal Activity Transforms into Seizure-Like Events In Vitro.

Schoknecht K, Berndt N, Rösner J, Heinemann U, Dreier JP, Kovács R, Friedman A, Liotta A.

Int J Mol Sci. 2017 Sep 7;18(9). pii: E1925. doi: 10.3390/ijms18091925.

17.

Contribution of Intrinsic Lactate to Maintenance of Seizure Activity in Neocortical Slices from Patients with Temporal Lobe Epilepsy and in Rat Entorhinal Cortex.

Angamo EA, ul Haq R, Rösner J, Gabriel S, Gerevich Z, Heinemann U, Kovács R.

Int J Mol Sci. 2017 Aug 23;18(9). pii: E1835. doi: 10.3390/ijms18091835.

18.

TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults.

Kim SY, Senatorov VV Jr, Morrissey CS, Lippmann K, Vazquez O, Milikovsky DZ, Gu F, Parada I, Prince DA, Becker AJ, Heinemann U, Friedman A, Kaufer D.

Sci Rep. 2017 Aug 9;7(1):7711. doi: 10.1038/s41598-017-07394-3.

19.

Combining EPR spectroscopy and X-ray crystallography to elucidate the structure and dynamics of conformationally constrained spin labels in T4 lysozyme single crystals.

Consentius P, Gohlke U, Loll B, Alings C, Heinemann U, Wahl MC, Risse T.

Phys Chem Chem Phys. 2017 Aug 9;19(31):20723-20734. doi: 10.1039/c7cp03144k.

PMID:
28740983
20.

Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization.

Schuetz A, Radusheva V, Krug SM, Heinemann U.

Ann N Y Acad Sci. 2017 Oct;1405(1):147-159. doi: 10.1111/nyas.13408. Epub 2017 Jun 29.

PMID:
28661558
21.

Neuropsychological Symptoms in Sporadic Creutzfeldt-Jakob Disease Patients in Germany.

Krasnianski A, Bohling GT, Heinemann U, Varges D, Meissner B, Schulz-Schaeffer WJ, Reif A, Zerr I.

J Alzheimers Dis. 2017;59(1):329-337. doi: 10.3233/JAD-161129.

PMID:
28598840
22.

Tricellulin is a target of the ubiquitin ligase Itch.

Jennek S, Mittag S, Reiche J, Westphal JK, Seelk S, Dörfel MJ, Pfirrmann T, Friedrich K, Schütz A, Heinemann U, Huber O.

Ann N Y Acad Sci. 2017 Jun;1397(1):157-168. doi: 10.1111/nyas.13349. Epub 2017 Apr 24.

PMID:
28436082
23.

Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells.

Carter DM, Specker E, Przygodda J, Neuenschwander M, von Kries JP, Heinemann U, Nazaré M, Gohlke U.

SLAS Discov. 2017 Aug;22(7):801-812. doi: 10.1177/2472555217699157. Epub 2017 Mar 27.

PMID:
28346812
24.

Internal Dynamics of the 3-Pyrroline-N-Oxide Ring in Spin-Labeled Proteins.

Consentius P, Loll B, Gohlke U, Alings C, Müller C, Müller R, Teutloff C, Heinemann U, Kaupp M, Wahl MC, Risse T.

J Phys Chem Lett. 2017 Mar 16;8(6):1113-1117. doi: 10.1021/acs.jpclett.6b02971. Epub 2017 Feb 23.

PMID:
28221042
25.

Neurobiological consequences of juvenile stress: A GABAergic perspective on risk and resilience.

Albrecht A, Müller I, Ardi Z, Çalışkan G, Gruber D, Ivens S, Segal M, Behr J, Heinemann U, Stork O, Richter-Levin G.

Neurosci Biobehav Rev. 2017 Mar;74(Pt A):21-43. doi: 10.1016/j.neubiorev.2017.01.005. Epub 2017 Jan 11. Review.

PMID:
28088535
26.

The hippocampus influences assimilation and accommodation of schemata that are not hippocampus-dependent.

Armelin A, Heinemann U, de Hoz L.

Hippocampus. 2017 Mar;27(3):315-331. doi: 10.1002/hipo.22687. Epub 2017 Jan 16.

PMID:
27935155
27.

Doxycycline in early CJD: a double-blinded randomised phase II and observational study.

Varges D, Manthey H, Heinemann U, Ponto C, Schmitz M, Schulz-Schaeffer WJ, Krasnianski A, Breithaupt M, Fincke F, Kramer K, Friede T, Zerr I.

J Neurol Neurosurg Psychiatry. 2017 Feb;88(2):119-125. doi: 10.1136/jnnp-2016-313541. Epub 2016 Nov 2.

28.

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.

Arumughan A, Roske Y, Barth C, Forero LL, Bravo-Rodriguez K, Redel A, Kostova S, McShane E, Opitz R, Faelber K, Rau K, Mielke T, Daumke O, Selbach M, Sanchez-Garcia E, Rocks O, Panáková D, Heinemann U, Wanker EE.

Nat Commun. 2016 Oct 20;7:13047. doi: 10.1038/ncomms13047.

29.

Pretreatment with β-adrenergic receptor agonists facilitates induction of LTP and sharp wave ripple complexes in rodent hippocampus.

Ul Haq R, Anderson M, Liotta A, Shafiq M, Sherkheli MA, Heinemann U.

Hippocampus. 2016 Dec;26(12):1486-1492. doi: 10.1002/hipo.22665. Epub 2016 Oct 18.

PMID:
27699900
30.

Tracking Transient Conformational States of T4 Lysozyme at Room Temperature Combining X-ray Crystallography and Site-Directed Spin Labeling.

Consentius P, Gohlke U, Loll B, Alings C, Müller R, Heinemann U, Kaupp M, Wahl M, Risse T.

J Am Chem Soc. 2016 Oct 5;138(39):12868-12875. Epub 2016 Sep 27.

PMID:
27673570
31.

A neuronal lactate uptake inhibitor slows recovery of extracellular ion concentration changes in the hippocampal CA3 region by affecting energy metabolism.

Angamo EA, Rösner J, Liotta A, Kovács R, Heinemann U.

J Neurophysiol. 2016 Nov 1;116(5):2420-2430. doi: 10.1152/jn.00327.2016. Epub 2016 Aug 24.

32.

WONOEP appraisal: Molecular and cellular biomarkers for epilepsy.

Walker LE, Janigro D, Heinemann U, Riikonen R, Bernard C, Patel M.

Epilepsia. 2016 Sep;57(9):1354-62. doi: 10.1111/epi.13460. Epub 2016 Jul 4. Review.

33.

Minimizing photodecomposition of flavin adenine dinucleotide fluorescence by the use of pulsed LEDs.

Rösner J, Liotta A, Angamo EA, Spies C, Heinemann U, Kovács R.

J Microsc. 2016 Nov;264(2):215-223. doi: 10.1111/jmi.12436. Epub 2016 Jul 1.

34.

Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group.

Dreier JP, Fabricius M, Ayata C, Sakowitz OW, Shuttleworth CW, Dohmen C, Graf R, Vajkoczy P, Helbok R, Suzuki M, Schiefecker AJ, Major S, Winkler MK, Kang EJ, Milakara D, Oliveira-Ferreira AI, Reiffurth C, Revankar GS, Sugimoto K, Dengler NF, Hecht N, Foreman B, Feyen B, Kondziella D, Friberg CK, Piilgaard H, Rosenthal ES, Westover MB, Maslarova A, Santos E, Hertle D, Sánchez-Porras R, Jewell SL, Balança B, Platz J, Hinzman JM, Lückl J, Schoknecht K, Schöll M, Drenckhahn C, Feuerstein D, Eriksen N, Horst V, Bretz JS, Jahnke P, Scheel M, Bohner G, Rostrup E, Pakkenberg B, Heinemann U, Claassen J, Carlson AP, Kowoll CM, Lublinsky S, Chassidim Y, Shelef I, Friedman A, Brinker G, Reiner M, Kirov SA, Andrew RD, Farkas E, Güresir E, Vatter H, Chung LS, Brennan KC, Lieutaud T, Marinesco S, Maas AI, Sahuquillo J, Dahlem MA, Richter F, Herreras O, Boutelle MG, Okonkwo DO, Bullock MR, Witte OW, Martus P, van den Maagdenberg AM, Ferrari MD, Dijkhuizen RM, Shutter LA, Andaluz N, Schulte AP, MacVicar B, Watanabe T, Woitzik J, Lauritzen M, Strong AJ, Hartings JA.

J Cereb Blood Flow Metab. 2017 May;37(5):1595-1625. doi: 10.1177/0271678X16654496. Epub 2016 Jan 1. Review.

35.

Epileptiform activity and spreading depolarization in the blood-brain barrier-disrupted peri-infarct hippocampus are associated with impaired GABAergic inhibition and synaptic plasticity.

Lippmann K, Kamintsky L, Kim SY, Lublinsky S, Prager O, Nichtweiss JF, Salar S, Kaufer D, Heinemann U, Friedman A.

J Cereb Blood Flow Metab. 2017 May;37(5):1803-1819. doi: 10.1177/0271678X16652631. Epub 2016 Jan 1.

36.

Functional interaction of CCAAT/enhancer-binding-protein-α basic region mutants with E2F transcription factors and DNA.

Kowenz-Leutz E, Schuetz A, Liu Q, Knoblich M, Heinemann U, Leutz A.

Biochim Biophys Acta. 2016 Jul;1859(7):841-7. doi: 10.1016/j.bbagrm.2016.04.008. Epub 2016 Apr 27.

PMID:
27131901
37.

AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA.

Götz F, Roske Y, Schulz MS, Autenrieth K, Bertinetti D, Faelber K, Zühlke K, Kreuchwig A, Kennedy EJ, Krause G, Daumke O, Herberg FW, Heinemann U, Klussmann E.

Biochem J. 2016 Jul 1;473(13):1881-94. doi: 10.1042/BCJ20160242. Epub 2016 Apr 21.

38.

Adenosine A1 receptor-mediated suppression of carbamazepine-resistant seizure-like events in human neocortical slices.

Klaft ZJ, Hollnagel JO, Salar S, Calişkan G, Schulz SB, Schneider UC, Horn P, Koch A, Holtkamp M, Gabriel S, Gerevich Z, Heinemann U.

Epilepsia. 2016 May;57(5):746-56. doi: 10.1111/epi.13360. Epub 2016 Apr 18.

39.

Bacteriophage Tailspikes and Bacterial O-Antigens as a Model System to Study Weak-Affinity Protein-Polysaccharide Interactions.

Kang Y, Gohlke U, Engström O, Hamark C, Scheidt T, Kunstmann S, Heinemann U, Widmalm G, Santer M, Barbirz S.

J Am Chem Soc. 2016 Jul 27;138(29):9109-18. doi: 10.1021/jacs.6b00240. Epub 2016 Apr 25.

PMID:
27045683
40.

Cerebrospinal fluid markers in the differentiation of molecular subtypes of sporadic Creutzfeldt-Jakob disease.

Gmitterová K, Heinemann U, Krasnianski A, Gawinecka J, Zerr I.

Eur J Neurol. 2016 Jun;23(6):1126-33. doi: 10.1111/ene.12991. Epub 2016 Mar 31.

PMID:
27029507
41.

Hierarchical spike clustering analysis for investigation of interneuron heterogeneity.

Boehlen A, Heinemann U, Henneberger C.

Neurosci Lett. 2016 Apr 21;619:86-91. doi: 10.1016/j.neulet.2016.03.024. Epub 2016 Mar 14.

PMID:
26987719
42.

Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin.

Salar S, Lapilover E, Müller J, Hollnagel JO, Lippmann K, Friedman A, Heinemann U.

Neurobiol Dis. 2016 Jul;91:155-65. doi: 10.1016/j.nbd.2016.03.008. Epub 2016 Mar 10.

PMID:
26972679
43.

Identification of Parvalbumin Interneurons as Cellular Substrate of Fear Memory Persistence.

Çaliskan G, Müller I, Semtner M, Winkelmann A, Raza AS, Hollnagel JO, Rösler A, Heinemann U, Stork O, Meier JC.

Cereb Cortex. 2016 May;26(5):2325-2340. doi: 10.1093/cercor/bhw001. Epub 2016 Feb 22.

44.

Shifts in excitatory/inhibitory balance by juvenile stress: A role for neuron-astrocyte interaction in the dentate gyrus.

Albrecht A, Ivens S, Papageorgiou IE, Çalışkan G, Saiepour N, Brück W, Richter-Levin G, Heinemann U, Stork O.

Glia. 2016 Jun;64(6):911-22. doi: 10.1002/glia.22970. Epub 2016 Feb 15.

PMID:
26875694
45.

Serotonin dependent masking of hippocampal sharp wave ripples.

ul Haq R, Anderson ML, Hollnagel JO, Worschech F, Sherkheli MA, Behrens CJ, Heinemann U.

Neuropharmacology. 2016 Feb;101:188-203. doi: 10.1016/j.neuropharm.2015.09.026. Epub 2015 Sep 26.

PMID:
26409781
46.

Differential participation of pyramidal cells in generation of spontaneous sharp wave-ripples in the mouse subiculum in vitro.

Maslarova A, Lippmann K, Salar S, Rösler A, Heinemann U.

Neurobiol Learn Mem. 2015 Nov;125:113-9. doi: 10.1016/j.nlm.2015.08.008. Epub 2015 Aug 28.

PMID:
26318491
47.

In vitro seizure like events and changes in ionic concentration.

Antonio LL, Anderson ML, Angamo EA, Gabriel S, Klaft ZJ, Liotta A, Salar S, Sandow N, Heinemann U.

J Neurosci Methods. 2016 Feb 15;260:33-44. doi: 10.1016/j.jneumeth.2015.08.014. Epub 2015 Aug 21. Review.

PMID:
26300181
48.

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.

Murakawa Y, Hinz M, Mothes J, Schuetz A, Uhl M, Wyler E, Yasuda T, Mastrobuoni G, Friedel CC, Dölken L, Kempa S, Schmidt-Supprian M, Blüthgen N, Backofen R, Heinemann U, Wolf J, Scheidereit C, Landthaler M.

Nat Commun. 2015 Jul 14;6:7367. doi: 10.1038/ncomms8367.

49.

Clinical findings and diagnosis in genetic prion diseases in Germany.

Krasnianski A, Heinemann U, Ponto C, Kortt J, Kallenberg K, Varges D, Schulz-Schaeffer WJ, Kretzschmar HA, Zerr I.

Eur J Epidemiol. 2016 Feb;31(2):187-96. doi: 10.1007/s10654-015-0049-y. Epub 2015 Jun 16.

PMID:
26076917
50.

The immunoproteasome β5i subunit is a key contributor to ictogenesis in a rat model of chronic epilepsy.

Mishto M, Raza ML, de Biase D, Ravizza T, Vasuri F, Martucci M, Keller C, Bellavista E, Buchholz TJ, Kloetzel PM, Pession A, Vezzani A, Heinemann U.

Brain Behav Immun. 2015 Oct;49:188-96. doi: 10.1016/j.bbi.2015.05.007. Epub 2015 Jun 1.

PMID:
26044087

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