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Items: 1 to 50 of 532

1.

Why Z-drugs are used even if doctors and nurses feel unable to judge their benefits and risks-a hospital survey.

Heinemann S, Brockmöller J, Hagmayer Y, Himmel W.

Eur J Clin Pharmacol. 2019 Nov 16. doi: 10.1007/s00228-019-02783-1. [Epub ahead of print]

PMID:
31732756
2.

Structural insights into heme binding to IL-36α proinflammatory cytokine.

Wißbrock A, Goradia NB, Kumar A, Paul George AA, Kühl T, Bellstedt P, Ramachandran R, Hoffmann P, Galler K, Popp J, Neugebauer U, Hampel K, Zimmermann B, Adam S, Wiendl M, Krönke G, Hamza I, Heinemann SH, Frey S, Hueber AJ, Ohlenschläger O, Imhof D.

Sci Rep. 2019 Nov 15;9(1):16893. doi: 10.1038/s41598-019-53231-0.

3.

Calcium Phosphate Bone Graft Substitutes with High Mechanical Load Capacity and High Degree of Interconnecting Porosity.

Hettich G, Schierjott RA, Epple M, Gbureck U, Heinemann S, Mozaffari-Jovein H, Grupp TM.

Materials (Basel). 2019 Oct 23;12(21). pii: E3471. doi: 10.3390/ma12213471.

4.

[Only artificial intelligence can heal us? : Artificial intelligence in medicine as deus ex machina, grands recits nouveaux or supertool?]

Heinemann S.

Urologe A. 2019 Sep;58(9):1007-1015. doi: 10.1007/s00120-019-1011-5. Review. German.

PMID:
31432239
5.

Labile heme impairs hepatic microcirculation and promotes hepatic injury.

Englert FA, Seidel RA, Galler K, Gouveia Z, Soares MP, Neugebauer U, Clemens MG, Sponholz C, Heinemann SH, Pohnert G, Bauer M, Weis S.

Arch Biochem Biophys. 2019 Sep 15;672:108075. doi: 10.1016/j.abb.2019.108075. Epub 2019 Aug 11.

6.

Membrane potential manipulation with visible flash lamp illumination of targeted microbeads.

Ojha NK, Jin J, Arifin JC, Rühl P, Heinemann SH.

Biochem Biophys Res Commun. 2019 Sep 17;517(2):297-302. doi: 10.1016/j.bbrc.2019.07.080. Epub 2019 Jul 25.

PMID:
31353087
7.

Linkage Evidence for a Two-Locus Inheritance of LQT-Associated Seizures in a Multigenerational LQT Family With a Novel KCNQ1 Loss-of-Function Mutation.

Prüss H, Gessner G, Heinemann SH, Rüschendorf F, Ruppert AK, Schulz H, Sander T, Rimpau W.

Front Neurol. 2019 Jun 25;10:648. doi: 10.3389/fneur.2019.00648. eCollection 2019.

8.

Effect of Conformational Diversity on the Bioactivity of µ-Conotoxin PIIIA Disulfide Isomers.

Paul George AA, Heimer P, Leipold E, Schmitz T, Kaufmann D, Tietze D, Heinemann SH, Imhof D.

Mar Drugs. 2019 Jul 2;17(7). pii: E390. doi: 10.3390/md17070390.

9.

Disruption of Membrane Integrity by the Bacterium-Derived Antifungal Jagaricin.

Fischer D, Gessner G, Fill TP, Barnett R, Tron K, Dornblut K, Kloss F, Stallforth P, Hube B, Heinemann SH, Hertweck C, Scherlach K, Brunke S.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00707-19. doi: 10.1128/AAC.00707-19. Print 2019 Sep.

PMID:
31235622
10.

Patient-reported factors associated with the desire to continue taking sleep-inducing drugs after hospital discharge: A survey of older adults.

Heinemann S, Neukirchen F, Nau R, Hummers E, Himmel W.

Pharmacoepidemiol Drug Saf. 2019 Jul;28(7):1014-1022. doi: 10.1002/pds.4806. Epub 2019 Jun 10.

11.

Large-conductance Ca2+- and voltage-gated K+ channels form and break interactions with membrane lipids during each gating cycle.

Tian Y, Heinemann SH, Hoshi T.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8591-8596. doi: 10.1073/pnas.1901381116. Epub 2019 Apr 9.

12.

ANK2 functionally interacts with KCNH2 aggravating long QT syndrome in a double mutation carrier.

Gessner G, Runge S, Koenen M, Heinemann SH, Koenen M, Haas J, Meder B, Thomas D, Katus HA, Schweizer PA.

Biochem Biophys Res Commun. 2019 May 14;512(4):845-851. doi: 10.1016/j.bbrc.2019.03.162. Epub 2019 Mar 28.

PMID:
30929919
13.

Organically modified hydroxyapatite (ormoHAP) nanospheres stimulate the differentiation of osteoblast and osteoclast precursors: a co-culture study.

Heinemann C, Heinemann S, Rößler S, Kruppke B, Wiesmann HP, Hanke T.

Biomed Mater. 2019 Apr 15;14(3):035015. doi: 10.1088/1748-605X/ab0fad.

PMID:
30870824
14.

Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors.

Peigneur S, Cheneval O, Maiti M, Leipold E, Heinemann SH, Lescrinier E, Herdewijn P, De Lima ME, Craik DJ, Schroeder CI, Tytgat J.

FASEB J. 2019 Mar;33(3):3693-3703. doi: 10.1096/fj.201801909R. Epub 2018 Dec 3.

PMID:
30509130
15.

Modulation of K+ channel N-type inactivation by sulfhydration through hydrogen sulfide and polysulfides.

Yang K, Coburger I, Langner JM, Peter N, Hoshi T, Schönherr R, Heinemann SH.

Pflugers Arch. 2019 Apr;471(4):557-571. doi: 10.1007/s00424-018-2233-x. Epub 2018 Nov 10.

PMID:
30415410
16.

[Non-pharmacological treatment of hospital patients with sleeping problems - the nurse perspective].

Kauffmann L, Heinemann S, Himmel W, Hußmann O, Schlott T, Weiß V.

Pflege. 2018;31(6):291-300. doi: 10.1024/1012-5302/a000639. Epub 2018 Oct 16. German.

17.

The European IPF registry (eurIPFreg): baseline characteristics and survival of patients with idiopathic pulmonary fibrosis.

Guenther A, Krauss E, Tello S, Wagner J, Paul B, Kuhn S, Maurer O, Heinemann S, Costabel U, Barbero MAN, Müller V, Bonniaud P, Vancheri C, Wells A, Vasakova M, Pesci A, Sofia M, Klepetko W, Seeger W, Drakopanagiotakis F, Crestani B.

Respir Res. 2018 Jul 28;19(1):141. doi: 10.1186/s12931-018-0845-5.

18.

Studies into Slo1 K+ channels and their ligand docosahexaenoic acid in murine sepsis to delineate off-target effects of immunonutrition.

Wissuwa B, Heinemann SH, Bauer M, Coldewey SM.

Life Sci. 2018 Jun 15;203:112-120. doi: 10.1016/j.lfs.2018.04.031. Epub 2018 Apr 21.

PMID:
29684444
19.

Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin.

Kringel D, Geisslinger G, Resch E, Oertel BG, Thrun MC, Heinemann S, Lötsch J.

Pain. 2018 Jul;159(7):1366-1381. doi: 10.1097/j.pain.0000000000001222.

20.

The benefits of co-location in primary care practices: the perspectives of general practitioners and patients in 34 countries.

Bonciani M, Schäfer W, Barsanti S, Heinemann S, Groenewegen PP.

BMC Health Serv Res. 2018 Feb 21;18(1):132. doi: 10.1186/s12913-018-2913-4.

21.

Effect of bone sialoprotein coated three-dimensional printed calcium phosphate scaffolds on primary human osteoblasts.

Klein A, Baranowski A, Ritz U, Götz H, Heinemann S, Mattyasovszky S, Rommens PM, Hofmann A.

J Biomed Mater Res B Appl Biomater. 2018 Oct;106(7):2565-2575. doi: 10.1002/jbm.b.34073. Epub 2018 Jan 9.

PMID:
29316208
22.

High prevalence of prescription of psychotropic drugs for older patients in a general hospital.

Arnold I, Straube K, Himmel W, Heinemann S, Weiss V, Heyden L, Hummers-Pradier E, Nau R.

BMC Pharmacol Toxicol. 2017 Dec 4;18(1):76. doi: 10.1186/s40360-017-0183-0.

23.

Searching for factors that may reduce the use of benzodiazepines in hospitals - a survey of hospital doctors and nurses
.

Heinemann S, Himmel W.

Int J Clin Pharmacol Ther. 2017 Dec;55(12):905-910. doi: 10.5414/CP203104.

PMID:
29092732
24.

CO-independent modification of K+ channels by tricarbonyldichlororuthenium(II) dimer (CORM-2).

Gessner G, Sahoo N, Swain SM, Hirth G, Schönherr R, Mede R, Westerhausen M, Brewitz HH, Heimer P, Imhof D, Hoshi T, Heinemann SH.

Eur J Pharmacol. 2017 Nov 15;815:33-41. doi: 10.1016/j.ejphar.2017.10.006. Epub 2017 Oct 5.

25.

Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B-induced local skin hypersensitization in healthy subjects: a machine-learned analysis.

Lötsch J, Geisslinger G, Heinemann S, Lerch F, Oertel BG, Ultsch A.

Pain. 2018 Jan;159(1):11-24. doi: 10.1097/j.pain.0000000000001008.

26.

Strontium(II) and mechanical loading additively augment bone formation in calcium phosphate scaffolds.

Reitmaier S, Kovtun A, Schuelke J, Kanter B, Lemm M, Hoess A, Heinemann S, Nies B, Ignatius A.

J Orthop Res. 2018 Jan;36(1):106-117. doi: 10.1002/jor.23623. Epub 2017 Jun 26.

27.

Drug Release as a function of bioactivity, incubation regime, liquid, and initial load: Release of bortezomib from calcium phosphate-containing silica/collagen xerogels.

Kruppke B, Hose D, Schnettler R, Seckinger A, Rößler S, Hanke T, Heinemann S.

J Biomed Mater Res B Appl Biomater. 2018 Apr;106(3):1165-1173. doi: 10.1002/jbm.b.33931. Epub 2017 May 29.

PMID:
28556562
28.

Impact of higher-order heme degradation products on hepatic function and hemodynamics.

Seidel RA, Claudel T, Schleser FA, Ojha NK, Westerhausen M, Nietzsche S, Sponholz C, Cuperus F, Coldewey SM, Heinemann SH, Pohnert G, Trauner M, Bauer M.

J Hepatol. 2017 Aug;67(2):272-281. doi: 10.1016/j.jhep.2017.03.037. Epub 2017 Apr 12.

29.

Non-photonic sensing of membrane-delimited reactive species with a Na+ channel protein containing selenocysteine.

Ojha NK, Leipold E, Schönherr R, Hoshi T, Heinemann SH.

Sci Rep. 2017 Apr 5;7:46003. doi: 10.1038/srep46003.

30.

Synthesis and solution stability of water-soluble κ2N,κO-bis(3,5-dimethylpyrazolyl)ethanol manganese(i) tricarbonyl bromide (CORM-ONN1).

Mede R, Traber J, Klein M, Görls H, Gessner G, Hoffmann P, Schmitt M, Popp J, Heinemann SH, Neugebauer U, Westerhausen M.

Dalton Trans. 2017 Jan 31;46(5):1684-1693. doi: 10.1039/c6dt03551e.

PMID:
28102423
31.

Subtype-specific block of voltage-gated K+ channels by μ-conopeptides.

Leipold E, Ullrich F, Thiele M, Tietze AA, Terlau H, Imhof D, Heinemann SH.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1135-1140. doi: 10.1016/j.bbrc.2016.11.170. Epub 2016 Dec 2.

PMID:
27916464
32.

Bioactivity of topologically confined gramicidin A dimers.

Jadhav KB, Stein C, Makarewicz O, Pradel G, Lichtenecker RJ, Sack H, Heinemann SH, Arndt HD.

Bioorg Med Chem. 2017 Jan 1;25(1):261-268. doi: 10.1016/j.bmc.2016.10.033. Epub 2016 Nov 9.

PMID:
27865644
33.

Atomic determinants of BK channel activation by polyunsaturated fatty acids.

Tian Y, Aursnes M, Hansen TV, Tungen JE, Galpin JD, Leisle L, Ahern CA, Xu R, Heinemann SH, Hoshi T.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13905-13910. Epub 2016 Nov 14.

34.

Molecular Insights into the Mechanism of Calmodulin Inhibition of the EAG1 Potassium Channel.

Marques-Carvalho MJ, Oppermann J, Muñoz E, Fernandes AS, Gabant G, Cadene M, Heinemann SH, Schönherr R, Morais-Cabral JH.

Structure. 2016 Oct 4;24(10):1742-1754. doi: 10.1016/j.str.2016.07.020. Epub 2016 Sep 8.

35.

Electric field-assisted formation of organically modified hydroxyapatite (ormoHAP) spheres in carboxymethylated gelatin gels.

Heinemann C, Heinemann S, Kruppke B, Worch H, Thomas J, Wiesmann HP, Hanke T.

Acta Biomater. 2016 Oct 15;44:135-43. doi: 10.1016/j.actbio.2016.08.024. Epub 2016 Aug 17.

PMID:
27544814
36.

Performance of bioactive PMMA-based bone cement under load-bearing conditions: an in vivo evaluation and FE simulation.

Fottner A, Nies B, Kitanovic D, Steinbrück A, Mayer-Wagner S, Schröder C, Heinemann S, Pohl U, Jansson V.

J Mater Sci Mater Med. 2016 Sep;27(9):138. doi: 10.1007/s10856-016-5754-x. Epub 2016 Aug 16.

PMID:
27530301
37.

Understanding and reducing the prescription of hypnotics and sedatives at the interface of hospital care and general practice: a protocol for a mixed-methods study.

Heinemann S, Weiß V, Straube K, Nau R, Grimmsmann T, Himmel W, Hummers-Pradier E.

BMJ Open. 2016 Aug 5;6(8):e011908. doi: 10.1136/bmjopen-2016-011908.

38.

Stress-Related Job Analysis for Medical Students on Surgical Wards in Germany.

Chiapponi C, Meyer CY, Heinemann S, Meyer F, Biberthaler P, Bruns CJ, Kanz KG.

J Surg Educ. 2017 Jan - Feb;74(1):145-153. doi: 10.1016/j.jsurg.2016.06.002. Epub 2016 Jul 26.

PMID:
27468974
39.

[The use of benzodiazepines and Z-drugs for patients with sleeping problems - A survey among hospital doctors and nurses].

Weiß V, Heinemann S, Himmel W, Nau R, Hummers-Pradier E.

Dtsch Med Wochenschr. 2016 Jul;141(13):e121-6. doi: 10.1055/s-0042-102618. Epub 2016 Jun 30. German.

PMID:
27359319
40.

Molecular interaction of δ-conopeptide EVIA with voltage-gated Na(+) channels.

Tietze D, Leipold E, Heimer P, Böhm M, Winschel W, Imhof D, Heinemann SH, Tietze AA.

Biochim Biophys Acta. 2016 Sep;1860(9):2053-63. doi: 10.1016/j.bbagen.2016.06.013. Epub 2016 Jun 15. No abstract available.

PMID:
27316322
41.

Modulation of BK Channels by Small Endogenous Molecules and Pharmaceutical Channel Openers.

Hoshi T, Heinemann SH.

Int Rev Neurobiol. 2016;128:193-237. doi: 10.1016/bs.irn.2016.03.020. Epub 2016 May 4. Review.

PMID:
27238265
42.

Trends towards stronger primary care in three western European countries; 2006-2012.

van Loenen T, van den Berg MJ, Heinemann S, Baker R, Faber MJ, Westert GP.

BMC Fam Pract. 2016 May 28;17:59. doi: 10.1186/s12875-016-0458-3.

43.

Stereospecific capillary electrophoresis assays using pentapeptide substrates for the study of Aspergillus nidulans methionine sulfoxide reductase A and mutant enzymes.

Zhu Q, El-Mergawy RG, Zhou Y, Chen C, Heinemann SH, Schönherr R, Robaa D, Sippl W, Scriba GK.

Electrophoresis. 2016 Jul;37(14):2083-90. doi: 10.1002/elps.201600181. Epub 2016 Jun 8.

PMID:
27145186
44.

Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations.

Han B, He K, Cai C, Tang Y, Yang L, Heinemann SH, Hoshi T, Hou S.

Sci Rep. 2016 Mar 23;6:23417. doi: 10.1038/srep23417.

45.

Synergistic stress exacerbation in hippocampal neurons: Evidence favoring the dual-hit hypothesis of neurodegeneration.

Heinemann SD, Posimo JM, Mason DM, Hutchison DF, Leak RK.

Hippocampus. 2016 Aug;26(8):980-94. doi: 10.1002/hipo.22580. Epub 2016 Mar 29.

46.

Effects of macroporous, strontium loaded xerogel-scaffolds on new bone formation in critical-size metaphyseal fracture defects in ovariectomized rats.

Ray S, Thormann U, Sommer U, Khassawna TE, Hundgeburth M, Henß A, Rohnke M, Lips KS, Heiss C, Heinemann S, Hanke T, Dürselen L, Schnettler R, Alt V.

Injury. 2016 Jan;47 Suppl 1:S52-61. doi: 10.1016/S0020-1383(16)30013-4.

PMID:
26768293
47.

CORM-EDE1: A Highly Water-Soluble and Nontoxic Manganese-Based photoCORM with a Biogenic Ligand Sphere.

Mede R, Klein M, Claus RA, Krieck S, Quickert S, Görls H, Neugebauer U, Schmitt M, Gessner G, Heinemann SH, Popp J, Bauer M, Westerhausen M.

Inorg Chem. 2016 Jan 4;55(1):104-13. doi: 10.1021/acs.inorgchem.5b01904. Epub 2015 Dec 16.

PMID:
26672620
48.

Cold-aggravated pain in humans caused by a hyperactive NaV1.9 channel mutant.

Leipold E, Hanson-Kahn A, Frick M, Gong P, Bernstein JA, Voigt M, Katona I, Oliver Goral R, Altmüller J, Nürnberg P, Weis J, Hübner CA, Heinemann SH, Kurth I.

Nat Commun. 2015 Dec 8;6:10049. doi: 10.1038/ncomms10049.

49.

Ca(2+)/calmodulin regulates Kvβ1.1-mediated inactivation of voltage-gated K(+) channels.

Swain SM, Sahoo N, Dennhardt S, Schönherr R, Heinemann SH.

Sci Rep. 2015 Oct 21;5:15509. doi: 10.1038/srep15509.

50.

Reactive species modify NaV1.8 channels and affect action potentials in murine dorsal root ganglion neurons.

Schink M, Leipold E, Schirmeyer J, Schönherr R, Hoshi T, Heinemann SH.

Pflugers Arch. 2016 Jan;468(1):99-110. doi: 10.1007/s00424-015-1735-z. Epub 2015 Sep 17.

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