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Select item 317327561.

Why Z-drugs are used even if doctors and nurses feel unable to judge their benefits and risks-a hospital survey.

Heinemann S, Brockmöller J, Hagmayer Y, Himmel W.

Eur J Clin Pharmacol. 2019 Nov 16. doi: 10.1007/s00228-019-02783-1. [Epub ahead of print]

PMID:: 31732756

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Select item 317294402.

Structural insights into heme binding to IL-36α proinflammatory cytokine.

Wißbrock A, Goradia NB, Kumar A, Paul George AA, Kühl T, Bellstedt P, Ramachandran R, Hoffmann P, Galler K, Popp J, Neugebauer U, Hampel K, Zimmermann B, Adam S, Wiendl M, Krönke G, Hamza I, Heinemann SH, Frey S, Hueber AJ, Ohlenschläger O, Imhof D.

Sci Rep. 2019 Nov 15;9(1):16893. doi: 10.1038/s41598-019-53231-0.

PMID:: 31729440

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Select item 316527043.

Calcium Phosphate Bone Graft Substitutes with High Mechanical Load Capacity and High Degree of Interconnecting Porosity.

Hettich G, Schierjott RA, Epple M, Gbureck U, Heinemann S, Mozaffari-Jovein H, Grupp TM.

Materials (Basel). 2019 Oct 23;12(21). pii: E3471. doi: 10.3390/ma12213471.

PMID:: 31652704

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Select item 314322394.

[Only artificial intelligence can heal us? : Artificial intelligence in medicine as deus ex machina, grands recits nouveaux or supertool?]

Heinemann S.

Urologe A. 2019 Sep;58(9):1007-1015. doi: 10.1007/s00120-019-1011-5. Review. German.

PMID:: 31432239

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Select item 314122605.

Labile heme impairs hepatic microcirculation and promotes hepatic injury.

Englert FA, Seidel RA, Galler K, Gouveia Z, Soares MP, Neugebauer U, Clemens MG, Sponholz C, Heinemann SH, Pohnert G, Bauer M, Weis S.

Arch Biochem Biophys. 2019 Sep 15;672:108075. doi: 10.1016/j.abb.2019.108075. Epub 2019 Aug 11.

PMID:: 31412260

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Select item 313530876.

Membrane potential manipulation with visible flash lamp illumination of targeted microbeads.

Ojha NK, Jin J, Arifin JC, Rühl P, Heinemann SH.

Biochem Biophys Res Commun. 2019 Sep 17;517(2):297-302. doi: 10.1016/j.bbrc.2019.07.080. Epub 2019 Jul 25.

PMID:: 31353087

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Select item 312934977.

Linkage Evidence for a Two-Locus Inheritance of LQT-Associated Seizures in a Multigenerational LQT Family With a Novel KCNQ1 Loss-of-Function Mutation.

Prüss H, Gessner G, Heinemann SH, Rüschendorf F, Ruppert AK, Schulz H, Sander T, Rimpau W.

Front Neurol. 2019 Jun 25;10:648. doi: 10.3389/fneur.2019.00648. eCollection 2019.

PMID:: 31293497

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Select item 312696968.

Effect of Conformational Diversity on the Bioactivity of µ-Conotoxin PIIIA Disulfide Isomers.

Paul George AA, Heimer P, Leipold E, Schmitz T, Kaufmann D, Tietze D, Heinemann SH, Imhof D.

Mar Drugs. 2019 Jul 2;17(7). pii: E390. doi: 10.3390/md17070390.

PMID:: 31269696

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Select item 312356229.

Disruption of Membrane Integrity by the Bacterium-Derived Antifungal Jagaricin.

Fischer D, Gessner G, Fill TP, Barnett R, Tron K, Dornblut K, Kloss F, Stallforth P, Hube B, Heinemann SH, Hertweck C, Scherlach K, Brunke S.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00707-19. doi: 10.1128/AAC.00707-19. Print 2019 Sep.

PMID:: 31235622

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Select item 3117961310.

Patient-reported factors associated with the desire to continue taking sleep-inducing drugs after hospital discharge: A survey of older adults.

Heinemann S, Neukirchen F, Nau R, Hummers E, Himmel W.

Pharmacoepidemiol Drug Saf. 2019 Jul;28(7):1014-1022. doi: 10.1002/pds.4806. Epub 2019 Jun 10.

PMID:: 31179613

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Select item 3096750811.

Large-conductance Ca²⁺- and voltage-gated K⁺ channels form and break interactions with membrane lipids during each gating cycle.

Tian Y, Heinemann SH, Hoshi T.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8591-8596. doi: 10.1073/pnas.1901381116. Epub 2019 Apr 9.

PMID:: 30967508

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Select item 3092991912.

ANK2 functionally interacts with KCNH2 aggravating long QT syndrome in a double mutation carrier.

Gessner G, Runge S, Koenen M, Heinemann SH, Koenen M, Haas J, Meder B, Thomas D, Katus HA, Schweizer PA.

Biochem Biophys Res Commun. 2019 May 14;512(4):845-851. doi: 10.1016/j.bbrc.2019.03.162. Epub 2019 Mar 28.

PMID:: 30929919

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Select item 3087082413.

Organically modified hydroxyapatite (ormoHAP) nanospheres stimulate the differentiation of osteoblast and osteoclast precursors: a co-culture study.

Heinemann C, Heinemann S, Rößler S, Kruppke B, Wiesmann HP, Hanke T.

Biomed Mater. 2019 Apr 15;14(3):035015. doi: 10.1088/1748-605X/ab0fad.

PMID:: 30870824

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Select item 3050913014.

Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors.

Peigneur S, Cheneval O, Maiti M, Leipold E, Heinemann SH, Lescrinier E, Herdewijn P, De Lima ME, Craik DJ, Schroeder CI, Tytgat J.

FASEB J. 2019 Mar;33(3):3693-3703. doi: 10.1096/fj.201801909R. Epub 2018 Dec 3.

PMID:: 30509130

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Select item 3041541015.

Modulation of K⁺ channel N-type inactivation by sulfhydration through hydrogen sulfide and polysulfides.

Yang K, Coburger I, Langner JM, Peter N, Hoshi T, Schönherr R, Heinemann SH.

Pflugers Arch. 2019 Apr;471(4):557-571. doi: 10.1007/s00424-018-2233-x. Epub 2018 Nov 10.

PMID:: 30415410

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Select item 3032526416.

[Non-pharmacological treatment of hospital patients with sleeping problems - the nurse perspective].

Kauffmann L, Heinemann S, Himmel W, Hußmann O, Schlott T, Weiß V.

Pflege. 2018;31(6):291-300. doi: 10.1024/1012-5302/a000639. Epub 2018 Oct 16. German.

PMID:: 30325264

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Select item 3005561317.

The European IPF registry (eurIPFreg): baseline characteristics and survival of patients with idiopathic pulmonary fibrosis.

Guenther A, Krauss E, Tello S, Wagner J, Paul B, Kuhn S, Maurer O, Heinemann S, Costabel U, Barbero MAN, Müller V, Bonniaud P, Vancheri C, Wells A, Vasakova M, Pesci A, Sofia M, Klepetko W, Seeger W, Drakopanagiotakis F, Crestani B.

Respir Res. 2018 Jul 28;19(1):141. doi: 10.1186/s12931-018-0845-5.

PMID:: 30055613

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Select item 2968444418.

Studies into Slo1 K⁺ channels and their ligand docosahexaenoic acid in murine sepsis to delineate off-target effects of immunonutrition.

Wissuwa B, Heinemann SH, Bauer M, Coldewey SM.

Life Sci. 2018 Jun 15;203:112-120. doi: 10.1016/j.lfs.2018.04.031. Epub 2018 Apr 21.

PMID:: 29684444

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Select item 2959615719.

Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin.

Kringel D, Geisslinger G, Resch E, Oertel BG, Thrun MC, Heinemann S, Lötsch J.

Pain. 2018 Jul;159(7):1366-1381. doi: 10.1097/j.pain.0000000000001222.

PMID:: 29596157

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Select item 2946698020.

The benefits of co-location in primary care practices: the perspectives of general practitioners and patients in 34 countries.

Bonciani M, Schäfer W, Barsanti S, Heinemann S, Groenewegen PP.

BMC Health Serv Res. 2018 Feb 21;18(1):132. doi: 10.1186/s12913-018-2913-4.

PMID:: 29466980

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Select item 2931620821.

Effect of bone sialoprotein coated three-dimensional printed calcium phosphate scaffolds on primary human osteoblasts.

Klein A, Baranowski A, Ritz U, Götz H, Heinemann S, Mattyasovszky S, Rommens PM, Hofmann A.

J Biomed Mater Res B Appl Biomater. 2018 Oct;106(7):2565-2575. doi: 10.1002/jbm.b.34073. Epub 2018 Jan 9.

PMID:: 29316208

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Select item 2920281122.

High prevalence of prescription of psychotropic drugs for older patients in a general hospital.

Arnold I, Straube K, Himmel W, Heinemann S, Weiss V, Heyden L, Hummers-Pradier E, Nau R.

BMC Pharmacol Toxicol. 2017 Dec 4;18(1):76. doi: 10.1186/s40360-017-0183-0.

PMID:: 29202811

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Select item 2909273223.

Searching for factors that may reduce the use of benzodiazepines in hospitals - a survey of hospital doctors and nurses .

Heinemann S, Himmel W.

Int J Clin Pharmacol Ther. 2017 Dec;55(12):905-910. doi: 10.5414/CP203104.

PMID:: 29092732

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Select item 2898727124.

CO-independent modification of K⁺ channels by tricarbonyldichlororuthenium(II) dimer (CORM-2).

Gessner G, Sahoo N, Swain SM, Hirth G, Schönherr R, Mede R, Westerhausen M, Brewitz HH, Heimer P, Imhof D, Hoshi T, Heinemann SH.

Eur J Pharmacol. 2017 Nov 15;815:33-41. doi: 10.1016/j.ejphar.2017.10.006. Epub 2017 Oct 5.

PMID:: 28987271

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Select item 2870053725.

Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B-induced local skin hypersensitization in healthy subjects: a machine-learned analysis.

Lötsch J, Geisslinger G, Heinemann S, Lerch F, Oertel BG, Ultsch A.

Pain. 2018 Jan;159(1):11-24. doi: 10.1097/j.pain.0000000000001008.

PMID:: 28700537

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Select item 2857461426.

Strontium(II) and mechanical loading additively augment bone formation in calcium phosphate scaffolds.

Reitmaier S, Kovtun A, Schuelke J, Kanter B, Lemm M, Hoess A, Heinemann S, Nies B, Ignatius A.

J Orthop Res. 2018 Jan;36(1):106-117. doi: 10.1002/jor.23623. Epub 2017 Jun 26.

PMID:: 28574614

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Select item 2855656227.

Drug Release as a function of bioactivity, incubation regime, liquid, and initial load: Release of bortezomib from calcium phosphate-containing silica/collagen xerogels.

Kruppke B, Hose D, Schnettler R, Seckinger A, Rößler S, Hanke T, Heinemann S.

J Biomed Mater Res B Appl Biomater. 2018 Apr;106(3):1165-1173. doi: 10.1002/jbm.b.33931. Epub 2017 May 29.

PMID:: 28556562

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Select item 2841229628.

Impact of higher-order heme degradation products on hepatic function and hemodynamics.

Seidel RA, Claudel T, Schleser FA, Ojha NK, Westerhausen M, Nietzsche S, Sponholz C, Cuperus F, Coldewey SM, Heinemann SH, Pohnert G, Trauner M, Bauer M.

J Hepatol. 2017 Aug;67(2):272-281. doi: 10.1016/j.jhep.2017.03.037. Epub 2017 Apr 12.

PMID:: 28412296

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Select item 2837879929.

Non-photonic sensing of membrane-delimited reactive species with a Na⁺ channel protein containing selenocysteine.

Ojha NK, Leipold E, Schönherr R, Hoshi T, Heinemann SH.

Sci Rep. 2017 Apr 5;7:46003. doi: 10.1038/srep46003.

PMID:: 28378799

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Select item 2810242330.

Synthesis and solution stability of water-soluble κ²N,κO-bis(3,5-dimethylpyrazolyl)ethanol manganese(i) tricarbonyl bromide (CORM-ONN1).

Mede R, Traber J, Klein M, Görls H, Gessner G, Hoffmann P, Schmitt M, Popp J, Heinemann SH, Neugebauer U, Westerhausen M.

Dalton Trans. 2017 Jan 31;46(5):1684-1693. doi: 10.1039/c6dt03551e.

PMID:: 28102423

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Select item 2791646431.

Subtype-specific block of voltage-gated K⁺ channels by μ-conopeptides.

Leipold E, Ullrich F, Thiele M, Tietze AA, Terlau H, Imhof D, Heinemann SH.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1135-1140. doi: 10.1016/j.bbrc.2016.11.170. Epub 2016 Dec 2.

PMID:: 27916464

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Select item 2786564432.

Bioactivity of topologically confined gramicidin A dimers.

Jadhav KB, Stein C, Makarewicz O, Pradel G, Lichtenecker RJ, Sack H, Heinemann SH, Arndt HD.

Bioorg Med Chem. 2017 Jan 1;25(1):261-268. doi: 10.1016/j.bmc.2016.10.033. Epub 2016 Nov 9.

PMID:: 27865644

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Select item 2784961233.

Atomic determinants of BK channel activation by polyunsaturated fatty acids.

Tian Y, Aursnes M, Hansen TV, Tungen JE, Galpin JD, Leisle L, Ahern CA, Xu R, Heinemann SH, Hoshi T.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13905-13910. Epub 2016 Nov 14.

PMID:: 27849612

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Select item 2761866034.

Molecular Insights into the Mechanism of Calmodulin Inhibition of the EAG1 Potassium Channel.

Marques-Carvalho MJ, Oppermann J, Muñoz E, Fernandes AS, Gabant G, Cadene M, Heinemann SH, Schönherr R, Morais-Cabral JH.

Structure. 2016 Oct 4;24(10):1742-1754. doi: 10.1016/j.str.2016.07.020. Epub 2016 Sep 8.

PMID:: 27618660

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Select item 2754481435.

Electric field-assisted formation of organically modified hydroxyapatite (ormoHAP) spheres in carboxymethylated gelatin gels.

Heinemann C, Heinemann S, Kruppke B, Worch H, Thomas J, Wiesmann HP, Hanke T.

Acta Biomater. 2016 Oct 15;44:135-43. doi: 10.1016/j.actbio.2016.08.024. Epub 2016 Aug 17.

PMID:: 27544814

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Select item 2753030136.

Performance of bioactive PMMA-based bone cement under load-bearing conditions: an in vivo evaluation and FE simulation.

Fottner A, Nies B, Kitanovic D, Steinbrück A, Mayer-Wagner S, Schröder C, Heinemann S, Pohl U, Jansson V.

J Mater Sci Mater Med. 2016 Sep;27(9):138. doi: 10.1007/s10856-016-5754-x. Epub 2016 Aug 16.

PMID:: 27530301

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Select item 2749623837.

Understanding and reducing the prescription of hypnotics and sedatives at the interface of hospital care and general practice: a protocol for a mixed-methods study.

Heinemann S, Weiß V, Straube K, Nau R, Grimmsmann T, Himmel W, Hummers-Pradier E.

BMJ Open. 2016 Aug 5;6(8):e011908. doi: 10.1136/bmjopen-2016-011908.

PMID:: 27496238

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Select item 2746897438.

Chiapponi C, Meyer CY, Heinemann S, Meyer F, Biberthaler P, Bruns CJ, Kanz KG.

J Surg Educ. 2017 Jan - Feb;74(1):145-153. doi: 10.1016/j.jsurg.2016.06.002. Epub 2016 Jul 26.

PMID:: 27468974

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Select item 2735931939.

[The use of benzodiazepines and Z-drugs for patients with sleeping problems - A survey among hospital doctors and nurses].

Weiß V, Heinemann S, Himmel W, Nau R, Hummers-Pradier E.

Dtsch Med Wochenschr. 2016 Jul;141(13):e121-6. doi: 10.1055/s-0042-102618. Epub 2016 Jun 30. German.

PMID:: 27359319

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Select item 2731632240.

Molecular interaction of δ-conopeptide EVIA with voltage-gated Na(+) channels.

Tietze D, Leipold E, Heimer P, Böhm M, Winschel W, Imhof D, Heinemann SH, Tietze AA.

Biochim Biophys Acta. 2016 Sep;1860(9):2053-63. doi: 10.1016/j.bbagen.2016.06.013. Epub 2016 Jun 15. No abstract available.

PMID:: 27316322

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Select item 2723826541.

Modulation of BK Channels by Small Endogenous Molecules and Pharmaceutical Channel Openers.

Hoshi T, Heinemann SH.

Int Rev Neurobiol. 2016;128:193-237. doi: 10.1016/bs.irn.2016.03.020. Epub 2016 May 4. Review.

PMID:: 27238265

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Select item 2723349842.

Trends towards stronger primary care in three western European countries; 2006-2012.

van Loenen T, van den Berg MJ, Heinemann S, Baker R, Faber MJ, Westert GP.

BMC Fam Pract. 2016 May 28;17:59. doi: 10.1186/s12875-016-0458-3.

PMID:: 27233498

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Select item 2714518643.

Stereospecific capillary electrophoresis assays using pentapeptide substrates for the study of Aspergillus nidulans methionine sulfoxide reductase A and mutant enzymes.

Zhu Q, El-Mergawy RG, Zhou Y, Chen C, Heinemann SH, Schönherr R, Robaa D, Sippl W, Scriba GK.

Electrophoresis. 2016 Jul;37(14):2083-90. doi: 10.1002/elps.201600181. Epub 2016 Jun 8.

PMID:: 27145186

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Select item 2700532044.

Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations.

Han B, He K, Cai C, Tang Y, Yang L, Heinemann SH, Hoshi T, Hou S.

Sci Rep. 2016 Mar 23;6:23417. doi: 10.1038/srep23417.

PMID:: 27005320

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Select item 2693447845.

Synergistic stress exacerbation in hippocampal neurons: Evidence favoring the dual-hit hypothesis of neurodegeneration.

Heinemann SD, Posimo JM, Mason DM, Hutchison DF, Leak RK.

Hippocampus. 2016 Aug;26(8):980-94. doi: 10.1002/hipo.22580. Epub 2016 Mar 29.

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Select item 2676829346.

Effects of macroporous, strontium loaded xerogel-scaffolds on new bone formation in critical-size metaphyseal fracture defects in ovariectomized rats.

Ray S, Thormann U, Sommer U, Khassawna TE, Hundgeburth M, Henß A, Rohnke M, Lips KS, Heiss C, Heinemann S, Hanke T, Dürselen L, Schnettler R, Alt V.

Injury. 2016 Jan;47 Suppl 1:S52-61. doi: 10.1016/S0020-1383(16)30013-4.

PMID:: 26768293

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Select item 2667262047.

CORM-EDE1: A Highly Water-Soluble and Nontoxic Manganese-Based photoCORM with a Biogenic Ligand Sphere.

Mede R, Klein M, Claus RA, Krieck S, Quickert S, Görls H, Neugebauer U, Schmitt M, Gessner G, Heinemann SH, Popp J, Bauer M, Westerhausen M.

Inorg Chem. 2016 Jan 4;55(1):104-13. doi: 10.1021/acs.inorgchem.5b01904. Epub 2015 Dec 16.

PMID:: 26672620

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Select item 2664591548.

Cold-aggravated pain in humans caused by a hyperactive NaV1.9 channel mutant.

Leipold E, Hanson-Kahn A, Frick M, Gong P, Bernstein JA, Voigt M, Katona I, Oliver Goral R, Altmüller J, Nürnberg P, Weis J, Hübner CA, Heinemann SH, Kurth I.

Nat Commun. 2015 Dec 8;6:10049. doi: 10.1038/ncomms10049.