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Items: 1 to 50 of 59

1.

Towards Raman spectroscopy of urine as screening tool.

Žukovskaja O, Ryabchykov O, Straßburger M, Heinekamp T, Brakhage AA, Hennings CJ, Hübner CA, Wegmann M, Cialla-May D, Bocklitz TW, Weber K, Popp J.

J Biophotonics. 2020 Jan;13(1):e201900143. doi: 10.1002/jbio.201900143. Epub 2019 Nov 19.

PMID:
31682320
2.

High-Throughput Gene Replacement in Aspergillus fumigatus.

Zhao C, Fraczek MG, Dineen L, Lebedinec R, Macheleidt J, Heinekamp T, Delneri D, Bowyer P, Brakhage AA, Bromley M.

Curr Protoc Microbiol. 2019 Sep;54(1):e88. doi: 10.1002/cpmc.88.

PMID:
31518064
3.

Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus.

Manfiolli AO, Siqueira FS, Dos Reis TF, Van Dijck P, Schrevens S, Hoefgen S, Föge M, Straßburger M, de Assis LJ, Heinekamp T, Rocha MC, Janevska S, Brakhage AA, Malavazi I, Goldman GH, Valiante V.

mBio. 2019 Mar 26;10(2). pii: e00215-19. doi: 10.1128/mBio.00215-19.

4.

Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase.

König S, Pace S, Pein H, Heinekamp T, Kramer J, Romp E, Straßburger M, Troisi F, Proschak A, Dworschak J, Scherlach K, Rossi A, Sautebin L, Haeggström JZ, Hertweck C, Brakhage AA, Gerstmeier J, Proschak E, Werz O.

Cell Chem Biol. 2019 Apr 18;26(4):524-534.e5. doi: 10.1016/j.chembiol.2019.01.001. Epub 2019 Feb 7.

PMID:
30745237
5.

The Zn2Cys6-type transcription factor LeuB cross-links regulation of leucine biosynthesis and iron acquisition in Aspergillus fumigatus.

Long N, Orasch T, Zhang S, Gao L, Xu X, Hortschansky P, Ye J, Zhang F, Xu K, Gsaller F, Straßburger M, Binder U, Heinekamp T, Brakhage AA, Haas H, Lu L.

PLoS Genet. 2018 Oct 26;14(10):e1007762. doi: 10.1371/journal.pgen.1007762. eCollection 2018 Oct.

6.

Proteome Analysis Reveals the Conidial Surface Protein CcpA Essential for Virulence of the Pathogenic Fungus Aspergillus fumigatus.

Voltersen V, Blango MG, Herrmann S, Schmidt F, Heinekamp T, Strassburger M, Krüger T, Bacher P, Lother J, Weiss E, Hünniger K, Liu H, Hortschansky P, Scheffold A, Löffler J, Krappmann S, Nietzsche S, Kurzai O, Einsele H, Kniemeyer O, Filler SG, Reichard U, Brakhage AA.

mBio. 2018 Oct 2;9(5). pii: e01557-18. doi: 10.1128/mBio.01557-18.

7.

Reconstitution of Enzymatic Carbon-Sulfur Bond Formation Reveals Detoxification-Like Strategy in Fungal Toxin Biosynthesis.

Scharf DH, Dworschak JD, Chankhamjon P, Scherlach K, Heinekamp T, Brakhage AA, Hertweck C.

ACS Chem Biol. 2018 Sep 21;13(9):2508-2512. doi: 10.1021/acschembio.8b00413. Epub 2018 Aug 17.

PMID:
30075079
8.

Heavy Metal-Induced Expression of PcaA Provides Cadmium Tolerance to Aspergillus fumigatus and Supports Its Virulence in the Galleria mellonella Model.

Bakti F, Sasse C, Heinekamp T, Pócsi I, Braus GH.

Front Microbiol. 2018 Apr 13;9:744. doi: 10.3389/fmicb.2018.00744. eCollection 2018.

9.

Proteomics of Aspergillus fumigatus Conidia-containing Phagolysosomes Identifies Processes Governing Immune Evasion.

Schmidt H, Vlaic S, Krüger T, Schmidt F, Balkenhol J, Dandekar T, Guthke R, Kniemeyer O, Heinekamp T, Brakhage AA.

Mol Cell Proteomics. 2018 Jun;17(6):1084-1096. doi: 10.1074/mcp.RA117.000069. Epub 2018 Mar 5.

10.

A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity.

Johns A, Scharf DH, Gsaller F, Schmidt H, Heinekamp T, Straßburger M, Oliver JD, Birch M, Beckmann N, Dobb KS, Gilsenan J, Rash B, Bignell E, Brakhage AA, Bromley MJ.

mBio. 2017 Jul 18;8(4). pii: e01504-16. doi: 10.1128/mBio.01504-16.

11.

SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus.

Jöhnk B, Bayram Ö, Abelmann A, Heinekamp T, Mattern DJ, Brakhage AA, Jacobsen ID, Valerius O, Braus GH.

PLoS Pathog. 2016 Sep 20;12(9):e1005899. doi: 10.1371/journal.ppat.1005899. eCollection 2016 Sep.

12.

The Crystal Structure of Peroxiredoxin Asp f3 Provides Mechanistic Insight into Oxidative Stress Resistance and Virulence of Aspergillus fumigatus.

Hillmann F, Bagramyan K, Straßburger M, Heinekamp T, Hong TB, Bzymek KP, Williams JC, Brakhage AA, Kalkum M.

Sci Rep. 2016 Sep 14;6:33396. doi: 10.1038/srep33396.

13.

An Iterative O-Methyltransferase Catalyzes 1,11-Dimethylation of Aspergillus fumigatus Fumaric Acid Amides.

Kalb D, Heinekamp T, Schieferdecker S, Nett M, Brakhage AA, Hoffmeister D.

Chembiochem. 2016 Oct 4;17(19):1813-1817. doi: 10.1002/cbic.201600293. Epub 2016 Aug 18.

PMID:
27442960
14.

The Aspergillus fumigatus conidial melanin production is regulated by the bifunctional bHLH DevR and MADS-box RlmA transcription factors.

Valiante V, Baldin C, Hortschansky P, Jain R, Thywißen A, Straßburger M, Shelest E, Heinekamp T, Brakhage AA.

Mol Microbiol. 2016 Oct;102(2):321-335. doi: 10.1111/mmi.13462. Epub 2016 Jul 28.

15.

The hypoxia-induced dehydrogenase HorA is required for coenzyme Q10 biosynthesis, azole sensitivity and virulence of Aspergillus fumigatus.

Kroll K, Shekhova E, Mattern DJ, Thywissen A, Jacobsen ID, Strassburger M, Heinekamp T, Shelest E, Brakhage AA, Kniemeyer O.

Mol Microbiol. 2016 Jul;101(1):92-108. doi: 10.1111/mmi.13377. Epub 2016 May 3.

16.

Transcription Factor SomA Is Required for Adhesion, Development and Virulence of the Human Pathogen Aspergillus fumigatus.

Lin CJ, Sasse C, Gerke J, Valerius O, Irmer H, Frauendorf H, Heinekamp T, Straßburger M, Tran VT, Herzog B, Braus-Stromeyer SA, Braus GH.

PLoS Pathog. 2015 Nov 3;11(11):e1005205. doi: 10.1371/journal.ppat.1005205. eCollection 2015.

17.

Identification of Aspergillus fumigatus Surface Components That Mediate Interaction of Conidia and Hyphae With Human Platelets.

Rambach G, Blum G, Latgé JP, Fontaine T, Heinekamp T, Hagleitner M, Jeckström H, Weigel G, Würtinger P, Pfaller K, Krappmann S, Löffler J, Lass-Flörl C, Speth C.

J Infect Dis. 2015 Oct 1;212(7):1140-9. doi: 10.1093/infdis/jiv191. Epub 2015 Mar 25.

PMID:
25810442
18.

Activity and Safety of Inhaled Itraconazole Nanosuspension in a Model Pulmonary Aspergillus fumigatus Infection in Inoculated Young Quails.

Wlaź P, Knaga S, Kasperek K, Wlaź A, Poleszak E, Jeżewska-Witkowska G, Winiarczyk S, Wyska E, Heinekamp T, Rundfeldt C.

Mycopathologia. 2015 Aug;180(1-2):35-42. doi: 10.1007/s11046-015-9885-2. Epub 2015 Mar 20.

19.

Virulence determinants of the human pathogenic fungus Aspergillus fumigatus protect against soil amoeba predation.

Hillmann F, Novohradská S, Mattern DJ, Forberger T, Heinekamp T, Westermann M, Winckler T, Brakhage AA.

Environ Microbiol. 2015 Aug;17(8):2858-69. doi: 10.1111/1462-2920.12808. Epub 2015 Mar 27.

PMID:
25684622
20.

Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus.

Macheleidt J, Scherlach K, Neuwirth T, Schmidt-Heck W, Straßburger M, Spraker J, Baccile JA, Schroeder FC, Keller NP, Hertweck C, Heinekamp T, Brakhage AA.

Mol Microbiol. 2015 Apr;96(1):148-62. doi: 10.1111/mmi.12926. Epub 2015 Mar 11.

21.

Genetic engineering activates biosynthesis of aromatic fumaric acid amides in the human pathogen Aspergillus fumigatus.

Kalb D, Heinekamp T, Lackner G, Scharf DH, Dahse HM, Brakhage AA, Hoffmeister D.

Appl Environ Microbiol. 2015 Mar;81(5):1594-600. doi: 10.1128/AEM.03268-14. Epub 2014 Dec 19.

22.

Interference of Aspergillus fumigatus with the immune response.

Heinekamp T, Schmidt H, Lapp K, Pähtz V, Shopova I, Köster-Eiserfunke N, Krüger T, Kniemeyer O, Brakhage AA.

Semin Immunopathol. 2015 Mar;37(2):141-52. doi: 10.1007/s00281-014-0465-1. Epub 2014 Nov 18. Review.

23.

Characterization of the Aspergillus fumigatus detoxification systems for reactive nitrogen intermediates and their impact on virulence.

Lapp K, Vödisch M, Kroll K, Strassburger M, Kniemeyer O, Heinekamp T, Brakhage AA.

Front Microbiol. 2014 Sep 11;5:469. doi: 10.3389/fmicb.2014.00469. eCollection 2014.

24.

Opposed effects of enzymatic gliotoxin N- and S-methylations.

Scharf DH, Habel A, Heinekamp T, Brakhage AA, Hertweck C.

J Am Chem Soc. 2014 Aug 20;136(33):11674-9. doi: 10.1021/ja5033106. Epub 2014 Aug 7.

PMID:
25062268
25.

The novel globin protein fungoglobin is involved in low oxygen adaptation of Aspergillus fumigatus.

Hillmann F, Linde J, Beckmann N, Cyrulies M, Strassburger M, Heinekamp T, Haas H, Guthke R, Kniemeyer O, Brakhage AA.

Mol Microbiol. 2014 Aug;93(3):539-53. doi: 10.1111/mmi.12679. Epub 2014 Jul 7.

26.

Melanin dependent survival of Apergillus fumigatus conidia in lung epithelial cells.

Amin S, Thywissen A, Heinekamp T, Saluz HP, Brakhage AA.

Int J Med Microbiol. 2014 Jul;304(5-6):626-36. doi: 10.1016/j.ijmm.2014.04.009. Epub 2014 Apr 26.

PMID:
24836942
27.

Human and plant fungal pathogens: the role of secondary metabolites.

Scharf DH, Heinekamp T, Brakhage AA.

PLoS Pathog. 2014 Jan 30;10(1):e1003859. doi: 10.1371/journal.ppat.1003859. eCollection 2014 Jan. Review. No abstract available.

28.

Flavoenzyme-catalyzed formation of disulfide bonds in natural products.

Scharf DH, Groll M, Habel A, Heinekamp T, Hertweck C, Brakhage AA, Huber EM.

Angew Chem Int Ed Engl. 2014 Feb 17;53(8):2221-4. doi: 10.1002/anie.201309302. Epub 2014 Jan 20.

PMID:
24446392
29.

Epidithiodiketopiperazine biosynthesis: a four-enzyme cascade converts glutathione conjugates into transannular disulfide bridges.

Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Willing K, Brakhage AA, Hertweck C.

Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11092-5. doi: 10.1002/anie.201305059. Epub 2013 Aug 26.

PMID:
24039048
30.

Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence.

Heinekamp T, Thywißen A, Macheleidt J, Keller S, Valiante V, Brakhage AA.

Front Microbiol. 2013 Jan 18;3:440. doi: 10.3389/fmicb.2012.00440. eCollection 2012.

31.

Regio- and stereoselective oxidative phenol coupling in Aspergillus niger.

Gil Girol C, Fisch KM, Heinekamp T, Günther S, Hüttel W, Piel J, Brakhage AA, Müller M.

Angew Chem Int Ed Engl. 2012 Sep 24;51(39):9788-91. doi: 10.1002/anie.201203603. Epub 2012 Sep 3.

PMID:
22945023
32.

Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway.

Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Roth M, Brakhage AA, Hertweck C.

Angew Chem Int Ed Engl. 2012 Oct 1;51(40):10064-8. doi: 10.1002/anie.201205041. Epub 2012 Aug 31. No abstract available.

PMID:
22936680
33.

Systems biology of fungal infection.

Horn F, Heinekamp T, Kniemeyer O, Pollmächer J, Valiante V, Brakhage AA.

Front Microbiol. 2012 Apr 2;3:108. doi: 10.3389/fmicb.2012.00108. eCollection 2012.

34.

Biosynthesis and function of gliotoxin in Aspergillus fumigatus.

Scharf DH, Heinekamp T, Remme N, Hortschansky P, Brakhage AA, Hertweck C.

Appl Microbiol Biotechnol. 2012 Jan;93(2):467-72. doi: 10.1007/s00253-011-3689-1. Epub 2011 Nov 18. Review.

PMID:
22094977
35.

Pyomelanin formation in Aspergillus fumigatus requires HmgX and the transcriptional activator HmgR but is dispensable for virulence.

Keller S, Macheleidt J, Scherlach K, Schmaler-Ripcke J, Jacobsen ID, Heinekamp T, Brakhage AA.

PLoS One. 2011;6(10):e26604. doi: 10.1371/journal.pone.0026604. Epub 2011 Oct 27.

36.

The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus.

Jain R, Valiante V, Remme N, Docimo T, Heinekamp T, Hertweck C, Gershenzon J, Haas H, Brakhage AA.

Mol Microbiol. 2011 Oct;82(1):39-53. doi: 10.1111/j.1365-2958.2011.07778.x. Epub 2011 Aug 30.

37.

A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis.

Scharf DH, Remme N, Habel A, Chankhamjon P, Scherlach K, Heinekamp T, Hortschansky P, Brakhage AA, Hertweck C.

J Am Chem Soc. 2011 Aug 17;133(32):12322-5. doi: 10.1021/ja201311d. Epub 2011 Jul 22.

PMID:
21749092
38.

Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatus Interferes with the Host Endocytosis Pathway.

Thywißen A, Heinekamp T, Dahse HM, Schmaler-Ripcke J, Nietzsche S, Zipfel PF, Brakhage AA.

Front Microbiol. 2011 May 3;2:96. doi: 10.3389/fmicb.2011.00096. eCollection 2011.

39.

Secretome analysis of Aspergillus fumigatus reveals Asp-hemolysin as a major secreted protein.

Wartenberg D, Lapp K, Jacobsen ID, Dahse HM, Kniemeyer O, Heinekamp T, Brakhage AA.

Int J Med Microbiol. 2011 Nov;301(7):602-11. doi: 10.1016/j.ijmm.2011.04.016. Epub 2011 Jun 11.

PMID:
21658997
40.

HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus.

Schrettl M, Beckmann N, Varga J, Heinekamp T, Jacobsen ID, Jöchl C, Moussa TA, Wang S, Gsaller F, Blatzer M, Werner ER, Niermann WC, Brakhage AA, Haas H.

PLoS Pathog. 2010 Sep 30;6(9):e1001124. doi: 10.1371/journal.ppat.1001124.

41.

Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus.

Scharf DH, Remme N, Heinekamp T, Hortschansky P, Brakhage AA, Hertweck C.

J Am Chem Soc. 2010 Jul 28;132(29):10136-41. doi: 10.1021/ja103262m.

PMID:
20593880
42.

Heptahelical receptors GprC and GprD of Aspergillus fumigatus Are essential regulators of colony growth, hyphal morphogenesis, and virulence.

Gehrke A, Heinekamp T, Jacobsen ID, Brakhage AA.

Appl Environ Microbiol. 2010 Jun;76(12):3989-98. doi: 10.1128/AEM.00052-10. Epub 2010 Apr 23.

43.

Homo- and heterodimers of tobacco bZIP proteins counteract as positive or negative regulators of transcription during pollen development.

Iven T, Strathmann A, Böttner S, Zwafink T, Heinekamp T, Guivarc'h A, Roitsch T, Dröge-Laser W.

Plant J. 2010 Jul 1;63(1):155-66. doi: 10.1111/j.1365-313X.2010.04230.x. Epub 2010 Apr 16.

44.

The MpkA MAP kinase module regulates cell wall integrity signaling and pyomelanin formation in Aspergillus fumigatus.

Valiante V, Jain R, Heinekamp T, Brakhage AA.

Fungal Genet Biol. 2009 Dec;46(12):909-18. doi: 10.1016/j.fgb.2009.08.005. Epub 2009 Aug 26.

PMID:
19715768
45.

The 2008 update of the Aspergillus nidulans genome annotation: a community effort.

Wortman JR, Gilsenan JM, Joardar V, Deegan J, Clutterbuck J, Andersen MR, Archer D, Bencina M, Braus G, Coutinho P, von Döhren H, Doonan J, Driessen AJ, Durek P, Espeso E, Fekete E, Flipphi M, Estrada CG, Geysens S, Goldman G, de Groot PW, Hansen K, Harris SD, Heinekamp T, Helmstaedt K, Henrissat B, Hofmann G, Homan T, Horio T, Horiuchi H, James S, Jones M, Karaffa L, Karányi Z, Kato M, Keller N, Kelly DE, Kiel JA, Kim JM, van der Klei IJ, Klis FM, Kovalchuk A, Krasevec N, Kubicek CP, Liu B, Maccabe A, Meyer V, Mirabito P, Miskei M, Mos M, Mullins J, Nelson DR, Nielsen J, Oakley BR, Osmani SA, Pakula T, Paszewski A, Paulsen I, Pilsyk S, Pócsi I, Punt PJ, Ram AF, Ren Q, Robellet X, Robson G, Seiboth B, van Solingen P, Specht T, Sun J, Taheri-Talesh N, Takeshita N, Ussery D, vanKuyk PA, Visser H, van de Vondervoort PJ, de Vries RP, Walton J, Xiang X, Xiong Y, Zeng AP, Brandt BW, Cornell MJ, van den Hondel CA, Visser J, Oliver SG, Turner G.

Fungal Genet Biol. 2009 Mar;46 Suppl 1:S2-13. doi: 10.1016/j.fgb.2008.12.003. Epub 2008 Dec 25.

46.

Production of pyomelanin, a second type of melanin, via the tyrosine degradation pathway in Aspergillus fumigatus.

Schmaler-Ripcke J, Sugareva V, Gebhardt P, Winkler R, Kniemeyer O, Heinekamp T, Brakhage AA.

Appl Environ Microbiol. 2009 Jan;75(2):493-503. doi: 10.1128/AEM.02077-08. Epub 2008 Nov 21.

47.

Molecular characterization of the Aspergillus fumigatus NCS-1 homologue, NcsA.

Mota Júnior AO, Malavazi I, Soriani FM, Heinekamp T, Jacobsen I, Brakhage AA, Savoldi M, Goldman MH, da Silva Ferreira ME, Goldman GH.

Mol Genet Genomics. 2008 Dec;280(6):483-95. doi: 10.1007/s00438-008-0381-y. Epub 2008 Oct 2.

PMID:
18830711
48.

SreA-mediated iron regulation in Aspergillus fumigatus.

Schrettl M, Kim HS, Eisendle M, Kragl C, Nierman WC, Heinekamp T, Werner ER, Jacobsen I, Illmer P, Yi H, Brakhage AA, Haas H.

Mol Microbiol. 2008 Oct;70(1):27-43. doi: 10.1111/j.1365-2958.2008.06376.x. Epub 2008 Aug 21.

49.

Protein kinase A regulates growth, sporulation, and pigment formation in Aspergillus fumigatus.

Grosse C, Heinekamp T, Kniemeyer O, Gehrke A, Brakhage AA.

Appl Environ Microbiol. 2008 Aug;74(15):4923-33. doi: 10.1128/AEM.00470-08. Epub 2008 Jun 6.

50.

The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response.

Valiante V, Heinekamp T, Jain R, Härtl A, Brakhage AA.

Fungal Genet Biol. 2008 May;45(5):618-27. Epub 2007 Sep 25.

PMID:
17981060

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