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Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes.

Kanter JE, Shao B, Kramer F, Barnhart S, Shimizu-Albergine M, Vaisar T, Graham MJ, Crooke RM, Manuel CR, Haeusler RA, Mar D, Bomsztyk K, Hokanson JE, Kinney GL, Snell-Bergeon JK, Heinecke JW, Bornfeldt KE.

J Clin Invest. 2019 Jul 11;130. pii: 127308. doi: 10.1172/JCI127308.


Albuminuria, the High-Density Lipoprotein Proteome, and Coronary Artery Calcification in Type 1 Diabetes Mellitus.

Shao B, Zelnick LR, Wimberger J, Himmelfarb J, Brunzell J, Davidson WS, Snell-Bergeon JK, Bornfeldt KE, de Boer IH, Heinecke JW.

Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1483-1491. doi: 10.1161/ATVBAHA.119.312556. Epub 2019 May 16.


Apolipoprotein A1 Forms 5/5 and 5/4 Antiparallel Dimers in Human High-density Lipoprotein.

He Y, Song HD, Anantharamaiah GM, Palgunachari MN, Bornfeldt KE, Segrest JP, Heinecke JW.

Mol Cell Proteomics. 2019 May;18(5):854-864. doi: 10.1074/mcp.RA118.000878. Epub 2019 Jan 18.


Genetic control of the mouse HDL proteome defines HDL traits, function, and heterogeneity.

Pamir N, Pan C, Plubell DL, Hutchins PM, Tang C, Wimberger J, Irwin A, Vallim TQA, Heinecke JW, Lusis AJ.

J Lipid Res. 2019 Mar;60(3):594-608. doi: 10.1194/jlr.M090555. Epub 2019 Jan 8.


Cholesterol Mass Efflux Capacity, Incident Cardiovascular Disease, and Progression of Carotid Plaque.

Shea S, Stein JH, Jorgensen NW, McClelland RL, Tascau L, Shrager S, Heinecke JW, Yvan-Charvet L, Tall AR.

Arterioscler Thromb Vasc Biol. 2019 Jan;39(1):89-96. doi: 10.1161/ATVBAHA.118.311366.


GM-CSF driven myeloid cells in adipose tissue link weight gain and insulin resistance via formation of 2-aminoadipate.

Plubell DL, Fenton AM, Wilmarth PA, Bergstrom P, Zhao Y, Minnier J, Heinecke JW, Yang X, Pamir N.

Sci Rep. 2018 Jul 31;8(1):11485. doi: 10.1038/s41598-018-29250-8.


Sex steroids mediate discrete effects on HDL cholesterol efflux capacity and particle concentration in healthy men.

Rubinow KB, Vaisar T, Chao JH, Heinecke JW, Page ST.

J Clin Lipidol. 2018 Jul - Aug;12(4):1072-1082. doi: 10.1016/j.jacl.2018.04.013. Epub 2018 Apr 30.


Tertiary structure of apolipoprotein A-I in nascent high-density lipoproteins.

Pourmousa M, Song HD, He Y, Heinecke JW, Segrest JP, Pastor RW.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):5163-5168. doi: 10.1073/pnas.1721181115. Epub 2018 Apr 30.


A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state.

Melchior JT, Walker RG, Cooke AL, Morris J, Castleberry M, Thompson TB, Jones MK, Song HD, Rye KA, Oda MN, Sorci-Thomas MG, Thomas MJ, Heinecke JW, Mei X, Atkinson D, Segrest JP, Lund-Katz S, Phillips MC, Davidson WS.

Nat Struct Mol Biol. 2017 Dec;24(12):1093-1099. doi: 10.1038/nsmb.3501. Epub 2017 Nov 13.


Quantifying HDL proteins by mass spectrometry: how many proteins are there and what are their functions?

Shao B, Heinecke JW.

Expert Rev Proteomics. 2018 Jan;15(1):31-40. doi: 10.1080/14789450.2018.1402680. Epub 2017 Nov 13.


Time to ditch HDL-C as a measure of HDL function?

Ronsein GE, Heinecke JW.

Curr Opin Lipidol. 2017 Oct;28(5):414-418. doi: 10.1097/MOL.0000000000000446. Review.


Plasminogen promotes cholesterol efflux by the ABCA1 pathway.

Pamir N, Hutchins PM, Ronsein GE, Wei H, Tang C, Das R, Vaisar T, Plow E, Schuster V, Koschinsky ML, Reardon CA, Weinberg R, Dichek DA, Marcovina S, Getz GS, Heinecke JW.

JCI Insight. 2017 Aug 3;2(15). pii: 92176. doi: 10.1172/jci.insight.92176. eCollection 2017 Aug 3.


A Long Road Ahead for Discovering New HDL Metrics That Reflect Cardiovascular Disease Risk.

Heinecke JW, Bornfeldt KE.

J Am Coll Cardiol. 2017 Jul 11;70(2):179-181. doi: 10.1016/j.jacc.2017.05.038. No abstract available.


Cholesterol Efflux Capacity and Subclasses of HDL Particles in Healthy Women Transitioning Through Menopause.

El Khoudary SR, Hutchins PM, Matthews KA, Brooks MM, Orchard TJ, Ronsein GE, Heinecke JW.

J Clin Endocrinol Metab. 2016 Sep;101(9):3419-28. doi: 10.1210/jc.2016-2144. Epub 2016 Jul 11.


Patients With Coronary Endothelial Dysfunction Have Impaired Cholesterol Efflux Capacity and Reduced HDL Particle Concentration.

Monette JS, Hutchins PM, Ronsein GE, Wimberger J, Irwin AD, Tang C, Sara JD, Shao B, Vaisar T, Lerman A, Heinecke JW.

Circ Res. 2016 Jun 24;119(1):83-90. doi: 10.1161/CIRCRESAHA.116.308357. Epub 2016 Apr 25.


Niacin Therapy Increases High-Density Lipoprotein Particles and Total Cholesterol Efflux Capacity But Not ABCA1-Specific Cholesterol Efflux in Statin-Treated Subjects.

Ronsein GE, Hutchins PM, Isquith D, Vaisar T, Zhao XQ, Heinecke JW.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):404-11. doi: 10.1161/ATVBAHA.115.306268. Epub 2015 Dec 17.


Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway.

Pamir N, Hutchins P, Ronsein G, Vaisar T, Reardon CA, Getz GS, Lusis AJ, Heinecke JW.

J Lipid Res. 2016 Feb;57(2):246-57. doi: 10.1194/jlr.M063701. Epub 2015 Dec 15.


Targeted Proteomics Identifies Paraoxonase/Arylesterase 1 (PON1) and Apolipoprotein Cs as Potential Risk Factors for Hypoalphalipoproteinemia in Diabetic Subjects Treated with Fenofibrate and Rosiglitazone.

Ronsein GE, Reyes-Soffer G, He Y, Oda M, Ginsberg H, Heinecke JW.

Mol Cell Proteomics. 2016 Mar;15(3):1083-93. doi: 10.1074/mcp.M115.054528. Epub 2015 Dec 14.


Hematopoietic ABCA1 deletion promotes monocytosis and worsens diet-induced insulin resistance in mice.

Tang C, Liu Y, Yang W, Storey C, McMillen TS, Houston BA, Heinecke JW, LeBoeuf RC.

J Lipid Res. 2016 Jan;57(1):100-8. doi: 10.1194/jlr.M064303. Epub 2015 Nov 3.


Dysfunctional HDL and atherosclerotic cardiovascular disease.

Rosenson RS, Brewer HB Jr, Ansell BJ, Barter P, Chapman MJ, Heinecke JW, Kontush A, Tall AR, Webb NR.

Nat Rev Cardiol. 2016 Jan;13(1):48-60. doi: 10.1038/nrcardio.2015.124. Epub 2015 Sep 1. Review.


Cholesterol efflux capacity, macrophage reverse cholesterol transport and cardioprotective HDL.

Hutchins PM, Heinecke JW.

Curr Opin Lipidol. 2015 Oct;26(5):388-93. doi: 10.1097/MOL.0000000000000209. Review.


A Cluster of Proteins Implicated in Kidney Disease Is Increased in High-Density Lipoprotein Isolated from Hemodialysis Subjects.

Shao B, de Boer I, Tang C, Mayer PS, Zelnick L, Afkarian M, Heinecke JW, Himmelfarb J.

J Proteome Res. 2015 Jul 2;14(7):2792-806. doi: 10.1021/acs.jproteome.5b00060. Epub 2015 Jun 15.


Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity.

Vaisar T, Tang C, Babenko I, Hutchins P, Wimberger J, Suffredini AF, Heinecke JW.

J Lipid Res. 2015 Aug;56(8):1519-30. doi: 10.1194/jlr.M059089. Epub 2015 May 20.


Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion.

Pamir N, Liu NC, Irwin A, Becker L, Peng Y, Ronsein GE, Bornfeldt KE, Duffield JS, Heinecke JW.

J Biol Chem. 2015 Jun 5;290(23):14656-67. doi: 10.1074/jbc.M115.645820. Epub 2015 Apr 30.


Small HDL promotes cholesterol efflux by the ABCA1 pathway in macrophages: implications for therapies targeted to HDL.

Heinecke JW.

Circ Res. 2015 Mar 27;116(7):1101-3. doi: 10.1161/CIRCRESAHA.115.306052. No abstract available.


Parallel reaction monitoring (PRM) and selected reaction monitoring (SRM) exhibit comparable linearity, dynamic range and precision for targeted quantitative HDL proteomics.

Ronsein GE, Pamir N, von Haller PD, Kim DS, Oda MN, Jarvik GP, Vaisar T, Heinecke JW.

J Proteomics. 2015 Jan 15;113:388-99. doi: 10.1016/j.jprot.2014.10.017. Epub 2014 Oct 31.


An experimentally robust model of monomeric apolipoprotein A-I created from a chimera of two X-ray structures and molecular dynamics simulations.

Segrest JP, Jones MK, Shao B, Heinecke JW.

Biochemistry. 2014 Dec 9;53(48):7625-40. doi: 10.1021/bi501111j. Epub 2014 Nov 25.


Myeloperoxidase: a therapeutic target for preventing insulin resistance and the metabolic sequelae of obesity?

Heinecke JW, Goldberg IJ.

Diabetes. 2014 Dec;63(12):4001-3. doi: 10.2337/db14-1273. No abstract available.


Quantification of HDL particle concentration by calibrated ion mobility analysis.

Hutchins PM, Ronsein GE, Monette JS, Pamir N, Wimberger J, He Y, Anantharamaiah GM, Kim DS, Ranchalis JE, Jarvik GP, Vaisar T, Heinecke JW.

Clin Chem. 2014 Nov;60(11):1393-401. doi: 10.1373/clinchem.2014.228114. Epub 2014 Sep 15.


Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase.

Lee JT, Pamir N, Liu NC, Kirk EA, Averill MM, Becker L, Larson I, Hagman DK, Foster-Schubert KE, van Yserloo B, Bornfeldt KE, LeBoeuf RC, Kratz M, Heinecke JW.

Endocrinology. 2014 Sep;155(9):3409-20. doi: 10.1210/en.2014-1037. Epub 2014 Jun 10.


Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus.

Smith CK, Vivekanandan-Giri A, Tang C, Knight JS, Mathew A, Padilla RL, Gillespie BW, Carmona-Rivera C, Liu X, Subramanian V, Hasni S, Thompson PR, Heinecke JW, Saran R, Pennathur S, Kaplan MJ.

Arthritis Rheumatol. 2014 Sep;66(9):2532-2544. doi: 10.1002/art.38703.


Humans with atherosclerosis have impaired ABCA1 cholesterol efflux and enhanced high-density lipoprotein oxidation by myeloperoxidase.

Shao B, Tang C, Sinha A, Mayer PS, Davenport GD, Brot N, Oda MN, Zhao XQ, Heinecke JW.

Circ Res. 2014 May 23;114(11):1733-42. doi: 10.1161/CIRCRESAHA.114.303454. Epub 2014 Mar 19.


High-density lipoproteins: a consensus statement from the National Lipid Association.

Toth PP, Barter PJ, Rosenson RS, Boden WE, Chapman MJ, Cuchel M, D'Agostino RB Sr, Davidson MH, Davidson WS, Heinecke JW, Karas RH, Kontush A, Krauss RM, Miller M, Rader DJ.

J Clin Lipidol. 2013 Sep-Oct;7(5):484-525. doi: 10.1016/j.jacl.2013.08.001. Epub 2013 Aug 11. Review.


Translation of high-density lipoprotein function into clinical practice: current prospects and future challenges.

Rosenson RS, Brewer HB Jr, Ansell B, Barter P, Chapman MJ, Heinecke JW, Kontush A, Tall AR, Webb NR.

Circulation. 2013 Sep 10;128(11):1256-67. doi: 10.1161/CIRCULATIONAHA.113.000962. Review. No abstract available.


Conservation of apolipoprotein A-I's central domain structural elements upon lipid association on different high-density lipoprotein subclasses.

Oda MN, Budamagunta MS, Geier EG, Chandradas SH, Shao B, Heinecke JW, Voss JC, Cavigiolio G.

Biochemistry. 2013 Oct 1;52(39):6766-78. doi: 10.1021/bi4007012. Epub 2013 Sep 17.


Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions.

Kawakami T, Lichtnekert J, Thompson LJ, Karna P, Bouabe H, Hohl TM, Heinecke JW, Ziegler SF, Nelson PJ, Duffield JS.

J Immunol. 2013 Sep 15;191(6):3358-72. doi: 10.4049/jimmunol.1300342. Epub 2013 Aug 16.


TLR-2/TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney injury.

Campanholle G, Mittelsteadt K, Nakagawa S, Kobayashi A, Lin SL, Gharib SA, Heinecke JW, Hamerman JA, Altemeier WA, Duffield JS.

PLoS One. 2013 Jul 3;8(7):e68640. doi: 10.1371/journal.pone.0068640. Print 2013.


HDL's protein cargo: friend or foe in cardioprotection?

Heinecke JW.

Circulation. 2013 Feb 26;127(8):868-9. doi: 10.1161/CIRCULATIONAHA.112.000889. No abstract available.


High density lipoprotein is targeted for oxidation by myeloperoxidase in rheumatoid arthritis.

Vivekanandan-Giri A, Slocum JL, Byun J, Tang C, Sands RL, Gillespie BW, Heinecke JW, Saran R, Kaplan MJ, Pennathur S.

Ann Rheum Dis. 2013 Oct;72(10):1725-31. doi: 10.1136/annrheumdis-2012-202033. Epub 2013 Jan 12.


Cholesterol accumulation regulates expression of macrophage proteins implicated in proteolysis and complement activation.

Suzuki M, Becker L, Pritchard DK, Gharib SA, Wijsman EM, Bammler TK, Beyer RP, Vaisar T, Oram JF, Heinecke JW.

Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2910-8. doi: 10.1161/ATVBAHA.112.300383. Epub 2012 Oct 4.


The not-so-simple HDL story: A new era for quantifying HDL and cardiovascular risk?

Heinecke JW.

Nat Med. 2012 Sep;18(9):1346-7. doi: 10.1038/nm.2930. No abstract available.


Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity.

Rubinow KB, Vaisar T, Tang C, Matsumoto AM, Heinecke JW, Page ST.

J Lipid Res. 2012 Jul;53(7):1376-83. doi: 10.1194/jlr.P026005. Epub 2012 Apr 13.


Unique proteomic signatures distinguish macrophages and dendritic cells.

Becker L, Liu NC, Averill MM, Yuan W, Pamir N, Peng Y, Irwin AD, Fu X, Bornfeldt KE, Heinecke JW.

PLoS One. 2012;7(3):e33297. doi: 10.1371/journal.pone.0033297. Epub 2012 Mar 12.


Impact of mifepristone, a glucocorticoid/progesterone antagonist, on HDL cholesterol, HDL particle concentration, and HDL function.

Page ST, Krauss RM, Gross C, Ishida B, Heinecke JW, Tang C, Amory JK, Schaefer PM, Cox CJ, Kane J, Purnell JQ, Weinstein RL, Vaisar T.

J Clin Endocrinol Metab. 2012 May;97(5):1598-605. doi: 10.1210/jc.2011-2813. Epub 2012 Mar 7.


Advances in high density lipoprotein formation and metabolism: a tribute to John F. Oram (1945-2010).

Francis GA, Heinecke JW.

Biochim Biophys Acta. 2012 Mar;1821(3):343-4. doi: 10.1016/j.bbalip.2012.02.006. No abstract available.


Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1.

Kanter JE, Kramer F, Barnhart S, Averill MM, Vivekanandan-Giri A, Vickery T, Li LO, Becker L, Yuan W, Chait A, Braun KR, Potter-Perigo S, Sanda S, Wight TN, Pennathur S, Serhan CN, Heinecke JW, Coleman RA, Bornfeldt KE.

Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):E715-24. doi: 10.1073/pnas.1111600109. Epub 2012 Jan 17.


Acute sex steroid withdrawal increases cholesterol efflux capacity and HDL-associated clusterin in men.

Rubinow KB, Tang C, Hoofnagle AN, Snyder CN, Amory JK, Heinecke JW, Page ST.

Steroids. 2012 Apr;77(5):454-60. doi: 10.1016/j.steroids.2012.01.002. Epub 2012 Jan 15.


Myeloperoxidase targets apolipoprotein A-I, the major high density lipoprotein protein, for site-specific oxidation in human atherosclerotic lesions.

Shao B, Pennathur S, Heinecke JW.

J Biol Chem. 2012 Feb 24;287(9):6375-86. doi: 10.1074/jbc.M111.337345. Epub 2012 Jan 4.


Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL.

Elsøe S, Ahnström J, Christoffersen C, Hoofnagle AN, Plomgaard P, Heinecke JW, Binder CJ, Björkbacka H, Dahlbäck B, Nielsen LB.

Atherosclerosis. 2012 Mar;221(1):91-7. doi: 10.1016/j.atherosclerosis.2011.11.031. Epub 2011 Nov 27.


Metalloproteinase-mediated Shedding of Integrin β2 promotes macrophage efflux from inflammatory sites.

Gomez IG, Tang J, Wilson CL, Yan W, Heinecke JW, Harlan JM, Raines EW.

J Biol Chem. 2012 Feb 10;287(7):4581-9. doi: 10.1074/jbc.M111.321182. Epub 2011 Dec 14.

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