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Non-linear protein binding of phenytoin in clinical practice - development and validation of a mechanistic prediction model.

Ter Heine R, Kane SP, Huitema ADR, Krasowski MD, van Maarseveen EM.

Br J Clin Pharmacol. 2019 Jul 3. doi: 10.1111/bcp.14053. [Epub ahead of print]


Confirmed Hypoallergenicity of a Novel Whey-Based Extensively Hydrolyzed Infant Formula Containing Two Human Milk Oligosaccharides.

Nowak-Wegrzyn A, Czerkies L, Reyes K, Collins B, Heine RG.

Nutrients. 2019 Jun 26;11(7). pii: E1447. doi: 10.3390/nu11071447.


Chorioamnionitis and Infectious Complications after Vaginal Delivery.

DeNoble AE, Heine RP, Dotters-Katz SK.

Am J Perinatol. 2019 Jun 25. doi: 10.1055/s-0039-1692718. [Epub ahead of print]


Resident Education in Complex Obstetric Procedures: Are We Adequately Preparing Tomorrow's Obstetricians?

Dotters-Katz SK, Gray B, Heine RP, Propst K.

Am J Perinatol. 2019 Jun 25. doi: 10.1055/s-0039-1692714. [Epub ahead of print]


Exenatide twice-daily does not affect renal function or albuminuria compared to titrated insulin glargine in patients with type 2 diabetes mellitus: A post-hoc analysis of a 52-week randomised trial.

Muskiet MHA, Bunck MC, Heine RJ, Cornér A, Yki-Järvinen H, Eliasson B, Joles JA, Diamant M, Tonneijck L, van Raalte DH.

Diabetes Res Clin Pract. 2019 Jul;153:14-22. doi: 10.1016/j.diabres.2019.05.001. Epub 2019 May 9.


Efficacy of Non-Beta-lactam Antibiotics for Prevention of Cesarean Delivery Surgical Site Infections.

Harris BS, Hopkins MK, Villers MS, Weber JM, Pieper C, Grotegut CA, Swamy GK, Hughes BL, Heine RP.

AJP Rep. 2019 Apr;9(2):e167-e171. doi: 10.1055/s-0039-1685503. Epub 2019 Apr 30.


Hypoallergenicity of a whey-based, extensively hydrolyzed infant formula prepared with nonporcine enzymes.

Nowak-Węgrzyn A, Czerkies L, Kuslys M, Nutten S, Simons PJ, Collins B, Heine RG.

Allergy. 2019 Mar 21. doi: 10.1111/all.13780. [Epub ahead of print] No abstract available.


Pharmacokinetically-guided dosing of pemetrexed in a patient with renal impairment and a patient requiring hemodialysis.

de Rouw N, Croes S, Posthuma R, Agterhuis DE, Schoenmaekers JJAO, Derijks HJ, Burger DM, Dingemans AM, Ter Heine R.

Lung Cancer. 2019 Apr;130:156-158. doi: 10.1016/j.lungcan.2019.01.018. Epub 2019 Feb 1.


The cost-effectiveness of ertapenem for the treatment of chorioamnionitis after cesarean delivery.

Lim SL, Havrilesky LJ, Heine RP, Dotters-Katz S.

J Matern Fetal Neonatal Med. 2019 Mar 28:1-6. doi: 10.1080/14767058.2019.1597042. [Epub ahead of print]


The effect of neutropenia on the clinical pharmacokinetics of vancomycin in adults.

Bury D, Ter Heine R, van de Garde EMW, Nijziel MR, Grouls RJ, Deenen MJ.

Eur J Clin Pharmacol. 2019 Jul;75(7):921-928. doi: 10.1007/s00228-019-02657-6. Epub 2019 Mar 15.


The Effect of Non-penicillin Antibiotic Regimens on Neonatal Outcomes in Preterm Premature Rupture of Membranes.

Siegel AM, Heine RP, Dotters-Katz SK.

AJP Rep. 2019 Jan;9(1):e67-e71. doi: 10.1055/s-0039-1683378. Epub 2019 Mar 7.


Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study.

Edwards JM, Watson N, Focht C, Wynn C, Todd CA, Walter EB, Heine RP, Swamy GK.

Infect Dis Obstet Gynecol. 2019 Feb 3;2019:5430493. doi: 10.1155/2019/5430493. eCollection 2019.


Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab.

Wijnsma KL, Ter Heine R, Moes DJAR, Langemeijer S, Schols SEM, Volokhina EB, van den Heuvel LP, Wetzels JFM, van de Kar NCAJ, Brüggemann RJ.

Clin Pharmacokinet. 2019 Jul;58(7):859-874. doi: 10.1007/s40262-019-00742-8. Review.


Neurodevelopmental and behavioral consequences of perinatal exposure to the HIV drug efavirenz in a rodent model.

van de Wijer L, Garcia LP, Hanswijk SI, Rando J, Middelman A, Ter Heine R, Mast Q, Martens GJM, van der Ven AJAM, Kolk SM, Schellekens AFA, Homberg JR.

Transl Psychiatry. 2019 Feb 11;9(1):84. doi: 10.1038/s41398-019-0420-y.


Are prediction models for vaginal birth after cesarean accurate?

Harris BS, Heine RP, Park J, Faurot KR, Hopkins MK, Rivara AJ, Kemeny HR, Grotegut CA, Jelovsek JE.

Am J Obstet Gynecol. 2019 May;220(5):492.e1-492.e7. doi: 10.1016/j.ajog.2019.01.232. Epub 2019 Feb 1.


Evaluating darunavir/ritonavir dosing regimens for HIV-positive pregnant women using semi-mechanistic pharmacokinetic modelling.

Schalkwijk S, Ter Heine R, Colbers A, Capparelli E, Best BM, Cressey TR, Greupink R, Russel FGM, Moltó J, Mirochnick M, Karlsson MO, Burger DM.

J Antimicrob Chemother. 2019 Jan 30. doi: 10.1093/jac/dky567. [Epub ahead of print]


Personalized Tuberculosis Treatment Through Model-Informed Dosing of Rifampicin.

van Beek SW, Ter Heine R, Keizer RJ, Magis-Escurra C, Aarnoutse RE, Svensson EM.

Clin Pharmacokinet. 2019 Jun;58(6):815-826. doi: 10.1007/s40262-018-00732-2.


Pharmacokinetics and probability of target attainment for micafungin in normal-weight and morbidly obese adults.

Wasmann RE, Smit C, Ter Heine R, Koele SE, van Dongen EPH, Wiezer RMJ, Burger DM, Knibbe CAJ, Brüggemann RJM.

J Antimicrob Chemother. 2019 Apr 1;74(4):978-985. doi: 10.1093/jac/dky554.


Extensively hydrolysed infant formulas: Need for aligned definition of peptide size characteristics and standardisation of analytical methods.

Nutten S, Kuslys M, Maynard F, Affolter M, Heine RG, Levin ME, Blackhurst DM, Kirstein F, Kok D, Van der Watt GF, Marais AD.

S Afr Med J. 2018 Oct 26;108(11):887-888. doi: 10.7196/SAMJ.2018.v108i11.13616.


Bone-Targeting Radiopharmaceuticals as Monotherapy or Combined With Chemotherapy in Patients With Castration-Resistant Prostate Cancer Metastatic to Bone.

Bouman-Wammes EW, de Klerk JMH, Bloemendal HJ, Van Dodewaard-de Jong JM, Lange R, Ter Heine R, Verheul HMW, Van den Eertwegh AJM.

Clin Genitourin Cancer. 2019 Apr;17(2):e281-e292. doi: 10.1016/j.clgc.2018.11.014. Epub 2018 Nov 17. Review.


Population pharmacokinetic modelling of total and unbound flucloxacillin in non-critically ill patients to devise a rational continuous dosing regimen.

Wilkes S, van Berlo I, Ten Oever J, Jansman F, Ter Heine R.

Int J Antimicrob Agents. 2019 Mar;53(3):310-317. doi: 10.1016/j.ijantimicag.2018.11.018. Epub 2018 Nov 23.


Placenta Accreta Spectrum.

Society of Gynecologic Oncology; American College of Obstetricians and Gynecologists and the Society for Maternal–Fetal Medicine, Cahill AG, Beigi R, Heine RP, Silver RM, Wax JR.

Am J Obstet Gynecol. 2018 Dec;219(6):B2-B16. doi: 10.1016/j.ajog.2018.09.042.


The potential impact of hematocrit correction on evaluation of tacrolimus target exposure in pediatric kidney transplant patients.

Schijvens AM, van Hesteren FHS, Cornelissen EAM, Bootsma-Robroeks CMHHT, Brüggemann RJM, Burger DM, de Wildt SN, Schreuder MF, Ter Heine R.

Pediatr Nephrol. 2019 Mar;34(3):507-515. doi: 10.1007/s00467-018-4117-x. Epub 2018 Oct 30.


Model-Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities.

Keizer RJ, Ter Heine R, Frymoyer A, Lesko LJ, Mangat R, Goswami S.

CPT Pharmacometrics Syst Pharmacol. 2018 Dec;7(12):785-787. doi: 10.1002/psp4.12353. Epub 2018 Oct 16.


Hyperthermic intraperitoneal chemotherapy with oxaliplatin for peritoneal carcinomatosis: a clinical pharmacological perspective on a surgical procedure.

de Jong LAW, Elekonawo FMK, de Reuver PR, Bremers AJA, de Wilt JHW, Jansman FGA, Ter Heine R, van Erp NP.

Br J Clin Pharmacol. 2019 Jan;85(1):47-58. doi: 10.1111/bcp.13773. Epub 2018 Oct 25. Review.


Reactogenicity and immunogenicity of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant and nonpregnant women.

Fortner KB, Swamy GK, Broder KR, Jimenez-Truque N, Zhu Y, Moro PL, Liang J, Walter EB, Heine RP, Moody MA, Yoder S, Edwards KM.

Vaccine. 2018 Oct 8;36(42):6354-6360. doi: 10.1016/j.vaccine.2018.07.012. Epub 2018 Sep 13.


Antibiotics for the Prevention and Treatment of Postsurgical Obstetric Infections.

DeNoble AE, Kuller JA, Heine RP, Dotters-Katz S.

Obstet Gynecol Surv. 2018 Aug;73(8):475-485. doi: 10.1097/OGX.0000000000000590. No abstract available.


Pharmacokinetics of extended dose intervals of micafungin in haematology patients: optimizing antifungal prophylaxis.

Muilwijk EW, Maertens JA, van der Velden WJFM, Ter Heine R, Colbers A, Burger DM, Andes D, Theunissen K, Blijlevens NMA, Brüggemann RJM.

J Antimicrob Chemother. 2018 Nov 1;73(11):3095-3101. doi: 10.1093/jac/dky324.


Simulation-based suggestions to improve ibuprofen dosing for patent ductus arteriosus in preterm newborns.

Flint RB, Ter Heine R, Spaans E, Burger DM, de Klerk JCA, Allegaert K, Knibbe CAJ, Simons SHP.

Eur J Clin Pharmacol. 2018 Dec;74(12):1585-1591. doi: 10.1007/s00228-018-2529-y. Epub 2018 Jul 28.


Pharmacokinetics of HIV-Integrase Inhibitors During Pregnancy: Mechanisms, Clinical Implications and Knowledge Gaps.

van der Galiën R, Ter Heine R, Greupink R, Schalkwijk SJ, van Herwaarden AE, Colbers A, Burger DM.

Clin Pharmacokinet. 2019 Mar;58(3):309-323. doi: 10.1007/s40262-018-0684-z. Review.


Reduced Glucose Variability With Glucose-Dependent Versus Glucose-Independent Therapies Despite Similar Glucose Control and Hypoglycemia Rates in a Randomized, Controlled Study of Older Patients With Type 2 Diabetes Mellitus.

Pratley RE, Rosenstock J, Heller SR, Sinclair A, Heine RJ, Kiljański J, Brusko CS, Duan R, Festa A.

J Diabetes Sci Technol. 2018 Nov;12(6):1184-1191. doi: 10.1177/1932296818776993. Epub 2018 Jun 12.


Caspofungin dosage adjustments are not required for patients with Child-Pugh B or C cirrhosis.

Gustot T, Ter Heine R, Brauns E, Cotton F, Jacobs F, Brüggemann RJ.

J Antimicrob Chemother. 2018 Sep 1;73(9):2493-2496. doi: 10.1093/jac/dky189.


Protocol for the validation of sensitivity and specificity of the Cow's Milk-related Symptom Score (CoMiSS) against open food challenge in a single-blinded, prospective, multicentre trial in infants.

Vandenplas Y, Mukherjee R, Dupont C, Eigenmann P, Høst A, Kuitunen M, Ribes-Koninkx C, Shah N, Szajewska H, von Berg A, Heine RG, Zhao ZY; on behalf the Chinese CoMiSS Investigator Team.

BMJ Open. 2018 May 17;8(5):e019968. doi: 10.1136/bmjopen-2017-019968.


Pharmacokinetics of Anidulafungin in Obese and Normal-Weight Adults.

Wasmann RE, Ter Heine R, van Dongen EP, Burger DM, Lempers VJ, Knibbe CA, Brüggemann RJ.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00063-18. doi: 10.1128/AAC.00063-18. Print 2018 Jul.


Food Allergy Prevention and Treatment by Targeted Nutrition.

Heine RG.

Ann Nutr Metab. 2018;72 Suppl 3:33-45. doi: 10.1159/000487380. Epub 2018 Apr 9.


Pediatric Collagenous Gastritis and Colitis: A Case Series and Review of the Literature.

Matta J, Alex G, Cameron DJS, Chow CW, Hardikar W, Heine RG.

J Pediatr Gastroenterol Nutr. 2018 Sep;67(3):328-334. doi: 10.1097/MPG.0000000000001975.


A pharmacological rationale for improved everolimus dosing in oncology and transplant patients.

Ter Heine R, van Erp NP, Guchelaar HJ, de Fijter JW, Reinders MEJ, van Herpen CM, Burger DM, Moes DJAR.

Br J Clin Pharmacol. 2018 Jul;84(7):1575-1586. doi: 10.1111/bcp.13591. Epub 2018 May 6.


Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome.

Schijvens AM, Ter Heine R, de Wildt SN, Schreuder MF.

Pediatr Nephrol. 2019 Mar;34(3):389-403. doi: 10.1007/s00467-018-3929-z. Epub 2018 Mar 16.


A Mechanism-Based Population Pharmacokinetic Analysis Assessing the Feasibility of Efavirenz Dose Reduction to 400 mg in Pregnant Women.

Schalkwijk S, Ter Heine R, Colbers AC, Huitema ADR, Denti P, Dooley KE, Capparelli E, Best BM, Cressey TR, Greupink R, Russel FGM, Mirochnick M, Burger DM.

Clin Pharmacokinet. 2018 Nov;57(11):1421-1433. doi: 10.1007/s40262-018-0642-9.


Correction to: Better recognition, diagnosis and management of non-IgE-mediated cow's milk allergy in infancy: iMAP-an international interpretation of the MAP (Milk Allergy in Primary Care) guideline.

Venter C, Brown T, Meyer R, Walsh J, Shah N, Nowak-Węgrzyn A, Chen TX, Fleischer DM, Heine RG, Levin M, Vieira MC, Fox AT.

Clin Transl Allergy. 2018 Jan 25;8:4. doi: 10.1186/s13601-017-0189-0. eCollection 2018.


A clinically relevant decrease in abiraterone exposure associated with carbamazepine use in a patient with castration-resistant metastatic prostate cancer.

Benoist GE, van der Doelen MJ, Ter Heine R, van Erp NP, Mehra N.

Br J Clin Pharmacol. 2018 May;84(5):1064-1067. doi: 10.1111/bcp.13532. Epub 2018 Feb 21.


Lactose intolerance and gastrointestinal cow's milk allergy in infants and children - common misconceptions revisited.

Heine RG, AlRefaee F, Bachina P, De Leon JC, Geng L, Gong S, Madrazo JA, Ngamphaiboon J, Ong C, Rogacion JM.

World Allergy Organ J. 2017 Dec 12;10(1):41. doi: 10.1186/s40413-017-0173-0. eCollection 2017. Review.


Cost of illness of metastatic prostate cancer: a perspective of costs for new treatment options in The Netherlands.

Ter Heine R, Frederix GW, Geenen JW, Hövels AM, van Vulpen M, Kooistra A, De Klerk JM, Bloemendal HJ.

J Comp Eff Res. 2017 Oct;6(7):575-581. doi: 10.2217/cer-2017-0026. Epub 2017 Sep 13.


REducing STEroids in Relapsing Nephrotic syndrome: the RESTERN study- protocol of a national, double-blind, randomised, placebo-controlled, non-inferiority intervention study.

Schijvens AM, Dorresteijn EM, Roeleveld N, Ter Heine R, van Wijk JAE, Bouts AHM, Keijzer-Veen MG, van de Kar NCAJ, van den Heuvel LPWJ, Schreuder MF.

BMJ Open. 2017 Sep 27;7(9):e018148. doi: 10.1136/bmjopen-2017-018148.


Better recognition, diagnosis and management of non-IgE-mediated cow's milk allergy in infancy: iMAP-an international interpretation of the MAP (Milk Allergy in Primary Care) guideline.

Venter C, Brown T, Meyer R, Walsh J, Shah N, Nowak-Węgrzyn A, Chen TX, Fleischer DM, Heine RG, Levin M, Vieira MC, Fox AT.

Clin Transl Allergy. 2017 Aug 23;7:26. doi: 10.1186/s13601-017-0162-y. eCollection 2017. Review. Erratum in: Clin Transl Allergy. 2018 Jan 25;8:4.


Perioperative Antibiotic Choice in Labored versus Unlabored Cesareans and Risk of Postcesarean Infectious Morbidity.

Hopkins MK, Dotters-Katz S, Boggess K, Heine RP, Smid M.

Am J Perinatol. 2018 Jan;35(2):127-133. doi: 10.1055/s-0037-1606187. Epub 2017 Aug 24.


Closed-Incision Negative-Pressure Therapy in Obese Patients Undergoing Cesarean Delivery: A Randomized Controlled Trial.

Gunatilake RP, Swamy GK, Brancazio LR, Smrtka MP, Thompson JL, Gilner JB, Gray BA, Heine RP.

AJP Rep. 2017 Jul;7(3):e151-e157. doi: 10.1055/s-0037-1603956. Epub 2017 Jul 14.


Risk Factors for Postpartum Septic Pelvic Thrombophlebitis: A Multicenter Cohort.

Dotters-Katz SK, Smid MC, Grace MR, Thompson JL, Heine RP, Manuck T.

Am J Perinatol. 2017 Sep;34(11):1148-1151. doi: 10.1055/s-0037-1604245. Epub 2017 Jul 13. No abstract available.


Glycaemic outcomes of an Individualized treatMent aPproach for oldER vulnerable patIents: A randomized, controlled stUdy in type 2 diabetes Mellitus (IMPERIUM).

Heller SR, Pratley RE, Sinclair A, Festa A, Kiljański J, Brusko CS, Duan R, Heine RJ.

Diabetes Obes Metab. 2018 Jan;20(1):148-156. doi: 10.1111/dom.13051. Epub 2017 Aug 8.


Exploiting Pharmacokinetic Models of Tamoxifen and Endoxifen to Identify Factors Causing Subtherapeutic Concentrations in Breast Cancer Patients.

Klopp-Schulze L, Joerger M, Wicha SG, Ter Heine R, Csajka C, Parra-Guillen ZP, Kloft C.

Clin Pharmacokinet. 2018 Feb;57(2):229-242. doi: 10.1007/s40262-017-0555-z.


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