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Items: 1 to 50 of 380

1.

An EGFR-Induced Drosophila Lung Tumor Model Identifies Alternative Combination Treatments.

Bossen J, Uliczka K, Steen L, Pfefferkorn R, Mai MM, Burkhardt L, Spohn M, Bruchhaus I, Fink C, Heine H, Roeder T.

Mol Cancer Ther. 2019 Sep;18(9):1659-1668. doi: 10.1158/1535-7163.MCT-19-0168. Epub 2019 Jun 19.

PMID:
31217165
2.

2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms.

Freund I, Buhl DK, Boutin S, Kotter A, Pichot F, Marchand V, Vierbuchen T, Heine H, Motorin Y, Helm M, Dalpke AH, Eigenbrod T.

RNA. 2019 Jul;25(7):869-880. doi: 10.1261/rna.070243.118. Epub 2019 Apr 24.

PMID:
31019095
3.

Lipophilic Allergens, Different Modes of Allergen-Lipid Interaction and Their Impact on Asthma and Allergy.

Jappe U, Schwager C, Schromm AB, González Roldán N, Stein K, Heine H, Duda KA.

Front Immunol. 2019 Feb 14;10:122. doi: 10.3389/fimmu.2019.00122. eCollection 2019. Review.

4.

RNA is taking its Toll: Impact of RNA-specific Toll-like receptors on health and disease.

Vierbuchen T, Stein K, Heine H.

Allergy. 2019 Feb;74(2):223-235. doi: 10.1111/all.13680. Epub 2018 Dec 17. Review.

PMID:
30475385
5.

Disaccharide-Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide-Induced Inflammation.

Borio A, Holgado A, Garate JA, Beyaert R, Heine H, Zamyatina A.

ChemMedChem. 2018 Nov 6;13(21):2317-2331. doi: 10.1002/cmdc.201800505. Epub 2018 Oct 23.

PMID:
30276970
6.

Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics.

Adanitsch F, Shi J, Shao F, Beyaert R, Heine H, Zamyatina A.

Chem Sci. 2018 Mar 15;9(16):3957-3963. doi: 10.1039/c7sc05323a. eCollection 2018 Apr 28.

7.

The Human-Associated Archaeon Methanosphaera stadtmanae Is Recognized through Its RNA and Induces TLR8-Dependent NLRP3 Inflammasome Activation.

Vierbuchen T, Bang C, Rosigkeit H, Schmitz RA, Heine H.

Front Immunol. 2017 Nov 13;8:1535. doi: 10.3389/fimmu.2017.01535. eCollection 2017.

8.

Immunogenic properties of the human gut-associated archaeon Methanomassiliicoccus luminyensis and its susceptibility to antimicrobial peptides.

Bang C, Vierbuchen T, Gutsmann T, Heine H, Schmitz RA.

PLoS One. 2017 Oct 5;12(10):e0185919. doi: 10.1371/journal.pone.0185919. eCollection 2017.

9.

Reply to Tantibhedhyangkul et al., 'Suspected Mycoplasma Contamination in the Study "Toll-Like Receptor 2 Recognizes Orientia tsutsugamushi and Increases Susceptibility to Murine Experimental Scrub Typhus"'.

Gharaibeh M, Hagedorn M, Lilla S, Hauptmann M, Heine H, Fleischer B, Keller C.

Infect Immun. 2017 Aug 18;85(9). pii: e00326-17. doi: 10.1128/IAI.00326-17. Print 2017 Sep. No abstract available.

10.

The Fluorocycline TP-271 Is Efficacious in Models of Aerosolized Bacillus anthracis Infection in BALB/c Mice and Cynomolgus Macaques.

Grossman TH, Anderson MS, Drabek L, Gooldy M, Heine HS, Henning LN, Lin W, Newman JV, Nevarez R, Siefkas-Patterson K, Radcliff AK, Sutcliffe JA.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01103-17. doi: 10.1128/AAC.01103-17. Print 2017 Oct.

11.

Evaluation of Combination Drug Therapy for Treatment of Antibiotic-Resistant Inhalation Anthrax in a Murine Model.

Heine HS, Shadomy SV, Boyer AE, Chuvala L, Riggins R, Kesterson A, Myrick J, Craig J, Candela MG, Barr JR, Hendricks K, Bower WA, Walke H, Drusano GL.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00788-17. doi: 10.1128/AAC.00788-17. Print 2017 Sep.

12.

In Vitro Antibiotic Susceptibilities of Francisella tularensis Determined by Broth Microdilution following CLSI Methods.

Heine HS, Miller L, Halasohoris S, Purcell BK.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00612-17. doi: 10.1128/AAC.00612-17. Print 2017 Sep.

13.

Influences of environmental bacteria and their metabolites on allergies, asthma, and host microbiota.

Jatzlauk G, Bartel S, Heine H, Schloter M, Krauss-Etschmann S.

Allergy. 2017 Dec;72(12):1859-1867. doi: 10.1111/all.13220. Epub 2017 Jun 28. Review.

PMID:
28600901
14.

The Fluorocycline TP-271 Is Efficacious in Models of Aerosolized Francisella tularensis SCHU S4 Infection in BALB/c Mice and Cynomolgus Macaques.

Grossman TH, Anderson MS, Christ D, Gooldy M, Henning LN, Heine HS, Kindt MV, Lin W, Siefkas-Patterson K, Radcliff AK, Tam VH, Sutcliffe JA.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00448-17. doi: 10.1128/AAC.00448-17. Print 2017 Aug.

15.

Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons.

Lindner K, Ströbele M, Schlick S, Webering S, Jenckel A, Kopf J, Danov O, Sewald K, Buj C, Creutzenberg O, Tillmann T, Pohlmann G, Ernst H, Ziemann C, Hüttmann G, Heine H, Bockhorn H, Hansen T, König P, Fehrenbach H.

Part Fibre Toxicol. 2017 Mar 21;14(1):8. doi: 10.1186/s12989-017-0189-1.

16.

Plasmodium falciparum Heat Shock Protein 70 Lacks Immune Modulatory Activity.

Pooe OJ, Köllisch G, Heine H, Shonhai A.

Protein Pept Lett. 2017;24(6):503-510. doi: 10.2174/0929866524666170214141909.

PMID:
28201964
17.

Toll-Like Receptor 2 Recognizes Orientia tsutsugamushi and Increases Susceptibility to Murine Experimental Scrub Typhus.

Gharaibeh M, Hagedorn M, Lilla S, Hauptmann M, Heine H, Fleischer B, Keller C.

Infect Immun. 2016 Nov 18;84(12):3379-3387. Print 2016 Dec.

18.

Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects.

Stein K, Brand S, Jenckel A, Sigmund A, Chen ZJ, Kirschning CJ, Kauth M, Heine H.

J Allergy Clin Immunol. 2017 Feb;139(2):667-678.e5. doi: 10.1016/j.jaci.2016.06.018. Epub 2016 Jul 15.

PMID:
27544739
19.

Allergy protection by cowshed bacteria - recent findings and future prospects.

Kauth M, Heine H.

Pediatr Allergy Immunol. 2016 Jun;27(4):340-7. doi: 10.1111/pai.12559. Review.

PMID:
26919229
20.

Dual-role FilmArray® diagnostics for high-impact viral diseases.

Dorsch M, Meehan B, Michalski WP, Heine HG, Foord AJ, Carlile G, Wang J, McCullough S, Zuelke K.

Aust Vet J. 2016 Mar;94(3):64-6. doi: 10.1111/avj.12412.

PMID:
26914951
21.

Natural History of Francisella tularensis in Aerosol-Challenged BALB/c Mice.

Heine HS, Chuvala L, Riggins R, Cirz R, Cass R, Louie A, Drusano GL.

Antimicrob Agents Chemother. 2016 Jan 11;60(3):1834-40. doi: 10.1128/AAC.02887-15.

22.

Interleukin-4 and interferon-γ orchestrate an epithelial polarization in the airways.

Zissler UM, Chaker AM, Effner R, Ulrich M, Guerth F, Piontek G, Dietz K, Regn M, Knapp B, Theis FJ, Heine H, Suttner K, Schmidt-Weber CB.

Mucosal Immunol. 2016 Jul;9(4):917-26. doi: 10.1038/mi.2015.110. Epub 2015 Nov 18.

PMID:
26577568
23.

Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides.

Martinez de Tejada G, Heinbockel L, Ferrer-Espada R, Heine H, Alexander C, Bárcena-Varela S, Goldmann T, Correa W, Wiesmüller KH, Gisch N, Sánchez-Gómez S, Fukuoka S, Schürholz T, Gutsmann T, Brandenburg K.

Sci Rep. 2015 Sep 22;5:14292. doi: 10.1038/srep14292.

24.

ORMDL deregulation increases stress responses and modulates repair pathways in Drosophila airways.

Kallsen K, Zehethofer N, Abdelsadik A, Lindner B, Kabesch M, Heine H, Roeder T.

J Allergy Clin Immunol. 2015 Oct;136(4):1105-8. doi: 10.1016/j.jaci.2015.04.009. Epub 2015 Jun 5. No abstract available. Erratum in: J Allergy Clin Immunol. 2017 Sep;140(3):894.

PMID:
25979522
25.

Detection of highly pathogenic zoonotic influenza virus H5N6 by reverse-transcriptase quantitative polymerase chain reaction.

Heine HG, Foord AJ, Wang J, Valdeter S, Walker S, Morrissy C, Wong FY, Meehan B.

Virol J. 2015 Feb 8;12:18. doi: 10.1186/s12985-015-0250-3.

26.

In vitro antibiotic susceptibilities of Yersinia pestis determined by broth microdilution following CLSI methods.

Heine HS, Hershfield J, Marchand C, Miller L, Halasohoris S, Purcell BK, Worsham PL.

Antimicrob Agents Chemother. 2015 Apr;59(4):1919-21. doi: 10.1128/AAC.04548-14. Epub 2015 Jan 12.

27.

Salmonella enterica serovar Typhimurium ΔmsbB triggers exacerbated inflammation in Nod2 deficient mice.

Claes AK, Steck N, Schultz D, Zähringer U, Lipinski S, Rosenstiel P, Geddes K, Philpott DJ, Heine H, Grassl GA.

PLoS One. 2014 Nov 25;9(11):e113645. doi: 10.1371/journal.pone.0113645. eCollection 2014.

28.

Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold.

Garate JA, Stöckl J, Fernández-Alonso Mdel C, Artner D, Haegman M, Oostenbrink C, Jiménez-Barbero J, Beyaert R, Heine H, Kosma P, Zamyatina A.

Innate Immun. 2015 Jul;21(5):490-503. doi: 10.1177/1753425914550426. Epub 2014 Nov 13.

29.

Total Synthesis of Five Lipoteichoic acids of Clostridium difficile.

Hogendorf WF, Gisch N, Schwudke D, Heine H, Bols M, Pedersen CM.

Chemistry. 2014 Oct 13;20(42):13511-6. doi: 10.1002/chem.201404336. Epub 2014 Aug 28.

PMID:
25168290
30.

Isolation of Enterococcus faecium NM113, Enterococcus faecium NM213 and Lactobacillus casei NM512 as novel probiotics with immunomodulatory properties.

Mansour NM, Heine H, Abdou SM, Shenana ME, Zakaria MK, El-Diwany A.

Microbiol Immunol. 2014 Oct;58(10):559-69. doi: 10.1111/1348-0421.12187.

31.

SNP genotyping of animal and human derived isolates of Mycobacterium avium subsp. paratuberculosis.

Wynne JW, Beller C, Boyd V, Francis B, Gwoźdź J, Carajias M, Heine HG, Wagner J, Kirkwood CD, Michalski WP.

Vet Microbiol. 2014 Aug 27;172(3-4):479-85. doi: 10.1016/j.vetmic.2014.05.024. Epub 2014 May 29.

PMID:
24970365
32.

The intestinal archaea Methanosphaera stadtmanae and Methanobrevibacter smithii activate human dendritic cells.

Bang C, Weidenbach K, Gutsmann T, Heine H, Schmitz RA.

PLoS One. 2014 Jun 10;9(6):e99411. doi: 10.1371/journal.pone.0099411. eCollection 2014.

33.

Flavivirus detection and differentiation by a microsphere array assay.

Foord AJ, Boyd V, White JR, Williams DT, Colling A, Heine HG.

J Virol Methods. 2014 Jul;203:65-72. doi: 10.1016/j.jviromet.2014.03.018. Epub 2014 Mar 30.

PMID:
24690622
34.

Evaluation of imipenem for prophylaxis and therapy of Yersinia pestis delivered by aerosol in a mouse model of pneumonic plague.

Heine HS, Louie A, Adamovicz JJ, Amemiya K, Fast RL, Miller L, Opal SM, Palardy J, Parejo NA, Sörgel F, Kinzig-Schippers M, Drusano GL.

Antimicrob Agents Chemother. 2014 Jun;58(6):3276-84. doi: 10.1128/AAC.02420-14. Epub 2014 Mar 31.

35.

Hendra virus vaccine, a one health approach to protecting horse, human, and environmental health.

Middleton D, Pallister J, Klein R, Feng YR, Haining J, Arkinstall R, Frazer L, Huang JA, Edwards N, Wareing M, Elhay M, Hashmi Z, Bingham J, Yamada M, Johnson D, White J, Foord A, Heine HG, Marsh GA, Broder CC, Wang LF.

Emerg Infect Dis. 2014 Mar;20(3):372-9. doi: 10.3201/eid2003.131159.

36.

Microsphere suspension array assays for detection and differentiation of Hendra and Nipah viruses.

Foord AJ, White JR, Colling A, Heine HG.

Biomed Res Int. 2013;2013:289295. doi: 10.1155/2013/289295. Epub 2013 Feb 6.

37.

Neonatal supplementation of processed supernatant from Lactobacillus rhamnosus GG improves allergic airway inflammation in mice later in life.

Harb H, van Tol EA, Heine H, Braaksma M, Gross G, Overkamp K, Hennen M, Alrifai M, Conrad ML, Renz H, Garn H.

Clin Exp Allergy. 2013 Mar;43(3):353-64. doi: 10.1111/cea.12047.

PMID:
23414544
38.

Natural history of Yersinia pestis pneumonia in aerosol-challenged BALB/c mice.

Heine HS, Chuvala L, Riggins R, Hurteau G, Cirz R, Cass R, Louie A, Drusano GL.

Antimicrob Agents Chemother. 2013 May;57(5):2010-5. doi: 10.1128/AAC.02504-12. Epub 2013 Feb 12.

39.

Farm-derived Gram-positive bacterium Staphylococcus sciuri W620 prevents asthma phenotype in HDM- and OVA-exposed mice.

Hagner S, Harb H, Zhao M, Stein K, Holst O, Ege MJ, Mayer M, Matthes J, Bauer J, von Mutius E, Renz H, Heine H, Pfefferle PI, Garn H.

Allergy. 2013 Mar;68(3):322-9. doi: 10.1111/all.12094. Epub 2013 Feb 1.

PMID:
23369007
40.

Promotion of Hendra virus replication by microRNA 146a.

Stewart CR, Marsh GA, Jenkins KA, Gantier MP, Tizard ML, Middleton D, Lowenthal JW, Haining J, Izzard L, Gough TJ, Deffrasnes C, Stambas J, Robinson R, Heine HG, Pallister JA, Foord AJ, Bean AG, Wang LF.

J Virol. 2013 Apr;87(7):3782-91. doi: 10.1128/JVI.01342-12. Epub 2013 Jan 23.

41.

Dermatophagoides pteronyssinus major allergen 1 activates the innate immune response of the fruit fly Drosophila melanogaster.

Warmbold C, Uliczka K, Rus F, Suck R, Petersen A, Silverman N, Ulmer AJ, Heine H, Roeder T.

J Immunol. 2013 Jan 1;190(1):366-71. doi: 10.4049/jimmunol.1201347. Epub 2012 Nov 30.

42.

Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells.

Kallsen K, Andresen E, Heine H.

PLoS One. 2012;7(11):e50000. doi: 10.1371/journal.pone.0050000. Epub 2012 Nov 20.

43.

The structure of the extracellular teichoic acids from the allergy-protective bacterium Lactococcus lactis G121.

Fischer K, Vinogradov E, Lindner B, Heine H, Holst O.

Biol Chem. 2012 Aug;393(8):749-55. doi: 10.1515/hsz-2012-0142.

PMID:
22944677
44.

Hendra virus detection using Loop-Mediated Isothermal Amplification.

Foord AJ, Middleton D, Heine HG.

J Virol Methods. 2012 Apr;181(1):93-6. doi: 10.1016/j.jviromet.2012.01.020. Epub 2012 Feb 2.

PMID:
22327143
45.

Experimental infection of horses with Hendra virus/Australia/horse/2008/Redlands.

Marsh GA, Haining J, Hancock TJ, Robinson R, Foord AJ, Barr JA, Riddell S, Heine HG, White JR, Crameri G, Field HE, Wang LF, Middleton D.

Emerg Infect Dis. 2011 Dec;17(12):2232-8. doi: 10.3201/eid1712.111162.

46.

Impact of spores on the comparative efficacies of five antibiotics for treatment of Bacillus anthracis in an in vitro hollow fiber pharmacodynamic model.

Louie A, VanScoy BD, Brown DL, Kulawy RW, Heine HS, Drusano GL.

Antimicrob Agents Chemother. 2012 Mar;56(3):1229-39. doi: 10.1128/AAC.01109-10. Epub 2011 Dec 12.

47.

LPS-induced cytokine production in human monocytes and macrophages.

Rossol M, Heine H, Meusch U, Quandt D, Klein C, Sweet MJ, Hauschildt S.

Crit Rev Immunol. 2011;31(5):379-446. Review.

PMID:
22142165
48.

Differential effects of linezolid and ciprofloxacin on toxin production by Bacillus anthracis in an in vitro pharmacodynamic system.

Louie A, Vanscoy BD, Heine HS 3rd, Liu W, Abshire T, Holman K, Kulawy R, Brown DL, Drusano GL.

Antimicrob Agents Chemother. 2012 Jan;56(1):513-7. doi: 10.1128/AAC.05724-11. Epub 2011 Nov 7.

49.

Immunization with an anti-idiotypic antibody against the broadly lipopolysaccharide-reactive antibody WN1 222-5 induces Escherichia coli R3-core-type specific antibodies in rabbits.

Brade L, Heine H, Raina S, Klein G, Di Padova F, Brade H, Müller-Loennies S.

Innate Immun. 2012 Apr;18(2):279-93. doi: 10.1177/1753425911401055. Epub 2011 Aug 15.

PMID:
21844130
50.

Increased expression of beta-defensin 1 (DEFB1) in chronic obstructive pulmonary disease.

Andresen E, Günther G, Bullwinkel J, Lange C, Heine H.

PLoS One. 2011;6(7):e21898. doi: 10.1371/journal.pone.0021898. Epub 2011 Jul 19.

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