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Newly Identified Peptide, Peptide Lv, Promotes Pathological Angiogenesis.

Shi L, Zhao M, Abbey CA, Tsai SH, Xie W, Pham D, Chapman S, Bayless KJ, Hein TW, Rosa RH Jr, Ko ML, Kuo L, Ko GY.

J Am Heart Assoc. 2019 Nov 19;8(22):e013673. doi: 10.1161/JAHA.119.013673. Epub 2019 Nov 8.


Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis.

Kyritsi K, Chen L, O'Brien A, Francis H, Hein TW, Venter J, Wu N, Ceci L, Zhou T, Zawieja D, Gashev AA, Meng F, Invernizzi P, Fabris L, Wu C, Skill NJ, Saxena R, Liangpunsakul S, Alpini G, Glaser SS.

Hepatology. 2019 Jul 25. doi: 10.1002/hep.30880. [Epub ahead of print]


Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips.

Mathur T, Singh KA, R Pandian NK, Tsai SH, Hein TW, Gaharwar AK, Flanagan JM, Jain A.

Lab Chip. 2019 Jul 23;19(15):2500-2511. doi: 10.1039/c9lc00469f.


Hyperglycemia Enhances Constriction of Retinal Venules via Activation of the Reverse-Mode Sodium-Calcium Exchanger.

Chen YL, Xu W, Rosa RH Jr, Kuo L, Hein TW.

Diabetes. 2019 Aug;68(8):1624-1634. doi: 10.2337/db19-0069. Epub 2019 May 14.


Requisite roles of LOX-1, JNK, and arginase in diabetes-induced endothelial vasodilator dysfunction of porcine coronary arterioles.

Hein TW, Xu X, Ren Y, Xu W, Tsai SH, Thengchaisri N, Kuo L.

J Mol Cell Cardiol. 2019 Jun;131:82-90. doi: 10.1016/j.yjmcc.2019.04.015. Epub 2019 Apr 20.


Morphological and pharmacological characterization of the porcine popliteal artery: A novel model for study of lower limb arterial disease.

Frederick NE, Mitchell R, Hein TW, Bagher P.

Microcirculation. 2019 Aug;26(6):e12527. doi: 10.1111/micc.12527. Epub 2019 May 7.


Data on SD-OCT image acquisition, ultrastructural features, and horizontal tissue shrinkage in the porcine retina.

Xie W, Zhao M, Tsai SH, Burkes WL, Potts LB, Xu W, Payne HR, Hein TW, Kuo L, Rosa RH Jr.

Data Brief. 2018 Oct 27;21:1019-1025. doi: 10.1016/j.dib.2018.10.123. eCollection 2018 Dec.


Constriction of Retinal Venules to Endothelin-1: Obligatory Roles of ETA Receptors, Extracellular Calcium Entry, and Rho Kinase.

Chen YL, Ren Y, Xu W, Rosa RH Jr, Kuo L, Hein TW.

Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):5167-5175. doi: 10.1167/iovs.18-25369.


Correlation of spectral domain optical coherence tomography with histology and electron microscopy in the porcine retina.

Xie W, Zhao M, Tsai SH, Burkes WL, Potts LB, Xu W, Payne HR, Hein TW, Kuo L, Rosa RH Jr.

Exp Eye Res. 2018 Dec;177:181-190. doi: 10.1016/j.exer.2018.08.003. Epub 2018 Aug 16.


Intravitreal Stanniocalcin-1 Enhances New Blood Vessel Growth in a Rat Model of Laser-Induced Choroidal Neovascularization.

Zhao M, Xie W, Tsai SH, Hein TW, Rocke BA, Kuo L, Rosa RH Jr.

Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):1125-1133. doi: 10.1167/iovs.17-23083.


Alterations of Ocular Hemodynamics Impair Ophthalmic Vascular and Neuroretinal Function.

Tsai SH, Xie W, Zhao M, Rosa RH Jr, Hein TW, Kuo L.

Am J Pathol. 2018 Mar;188(3):818-827. doi: 10.1016/j.ajpath.2017.11.015. Epub 2018 Jan 5.


Enhanced endothelin-1/Rho-kinase signalling and coronary microvascular dysfunction in hypertensive myocardial hypertrophy.

Tsai SH, Lu G, Xu X, Ren Y, Hein TW, Kuo L.

Cardiovasc Res. 2017 Sep 1;113(11):1329-1337. doi: 10.1093/cvr/cvx103.


Histamine-Induced Dilation of Isolated Porcine Retinal Arterioles: Role of Endothelium-Derived Hyperpolarizing Factor.

Otani S, Nagaoka T, Omae T, Tanano I, Kamiya T, Ono S, Hein TW, Kuo L, Yoshida A.

Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4791-8. doi: 10.1167/iovs.15-19038.


Acute and Chronic Hyperglycemia Elicit JIP1/JNK-Mediated Endothelial Vasodilator Dysfunction of Retinal Arterioles.

Hein TW, Xu W, Xu X, Kuo L.

Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4333-40. doi: 10.1167/iovs.16-19990.


VEGF Receptor-2-Linked PI3K/Calpain/SIRT1 Activation Mediates Retinal Arteriolar Dilations to VEGF and Shear Stress.

Hein TW, Rosa RH Jr, Ren Y, Xu W, Kuo L.

Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5381-9. doi: 10.1167/iovs15-16950.


Endothelin-1 impairs coronary arteriolar dilation: Role of p38 kinase-mediated superoxide production from NADPH oxidase.

Thengchaisri N, Hein TW, Ren Y, Kuo L.

J Mol Cell Cardiol. 2015 Sep;86:75-84. doi: 10.1016/j.yjmcc.2015.07.014. Epub 2015 Jul 23.


Recombinant interleukin-1β dilates steelhead trout coronary microvessels: effect of temperature and role of the endothelium, nitric oxide and prostaglandins.

Costa IA, Hein TW, Secombes CJ, Gamperl AK.

J Exp Biol. 2015 Jul;218(Pt 14):2269-78. doi: 10.1242/jeb.119255. Epub 2015 May 29.


Cold-acclimation leads to differential regulation of the steelhead trout (Oncorhynchus mykiss) coronary microcirculation.

Costa IA, Hein TW, Gamperl AK.

Am J Physiol Regul Integr Comp Physiol. 2015 May 1;308(9):R743-54. doi: 10.1152/ajpregu.00353.2014. Epub 2015 Feb 25.


Role of endothelium in vasomotor responses to endothelin system and protein kinase C activation in porcine retinal arterioles.

Potts LB, Bradley PD, Xu W, Kuo L, Hein TW.

Invest Ophthalmol Vis Sci. 2013 Nov 15;54(12):7587-94. doi: 10.1167/iovs13-13178.


Selective activation of lectin-like oxidized low-density lipoprotein receptor-1 mediates C-reactive protein-evoked endothelial vasodilator dysfunction in coronary arterioles.

Hein TW, Qamirani E, Ren Y, Xu X, Thengchaisri N, Kuo L.

Circ Res. 2014 Jan 3;114(1):92-100. doi: 10.1161/CIRCRESAHA.114.301763. Epub 2013 Oct 18.


Vasomotor regulation of coronary microcirculation by oxidative stress: role of arginase.

Kuo L, Hein TW.

Front Immunol. 2013 Aug 19;4:237. doi: 10.3389/fimmu.2013.00237. eCollection 2013.


Effects of histidine-rich glycoprotein on cerebral blood vessels.

Steelman SM, Hein TW, Gorman A, Bix GJ.

J Cereb Blood Flow Metab. 2013 Sep;33(9):1373-5. doi: 10.1038/jcbfm.2013.106. Epub 2013 Jun 26.


Regulation of Coronary Vasomotor Function by Reactive Oxygen Species.

Kuo L, Thengchaisri N, Hein TW.

Mol Med Ther. 2012 Aug 8;1(1). pii: 1000101.


Cellular signalling pathways mediating dilation of porcine pial arterioles to adenosine A₂A receptor activation.

Hein TW, Xu W, Ren Y, Kuo L.

Cardiovasc Res. 2013 Jul 1;99(1):156-63. doi: 10.1093/cvr/cvt072. Epub 2013 Mar 27.


Differential progressive remodeling of coronary and cerebral arteries and arterioles in an aortic coarctation model of hypertension.

Hayenga HN, Hu JJ, Meyer CA, Wilson E, Hein TW, Kuo L, Humphrey JD.

Front Physiol. 2012 Nov 12;3:420. doi: 10.3389/fphys.2012.00420. eCollection 2012.


Temporal development of retinal arteriolar endothelial dysfunction in porcine type 1 diabetes.

Hein TW, Potts LB, Xu W, Yuen JZ, Kuo L.

Invest Ophthalmol Vis Sci. 2012 Dec 3;53(13):7943-9. doi: 10.1167/iovs.12-11005.


Retinal arteriolar responses to acute severe elevation in systemic blood pressure in cats: role of endothelium-derived factors.

Nakabayashi S, Nagaoka T, Tani T, Sogawa K, Hein TW, Kuo L, Yoshida A.

Exp Eye Res. 2012 Oct;103:63-70. doi: 10.1016/j.exer.2012.08.007. Epub 2012 Aug 24.


Constriction of retinal arterioles to endothelin-1: requisite role of rho kinase independent of protein kinase C and L-type calcium channels.

Potts LB, Ren Y, Lu G, Kuo E, Ngo E, Kuo L, Hein TW.

Invest Ophthalmol Vis Sci. 2012 May 17;53(6):2904-12. doi: 10.1167/iovs.12-9542.


Acute retinal ischemia inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles via enhanced superoxide production.

Hein TW, Ren Y, Potts LB, Yuan Z, Kuo E, Rosa RH Jr, Kuo L.

Invest Ophthalmol Vis Sci. 2012 Jan 3;53(1):30-6. doi: 10.1167/iovs.11-8753.


High glucose impairs EDHF-mediated dilation of coronary arterioles via reduced cytochrome P450 activity.

Tsai SH, Hein TW, Kuo L, Yang VC.

Microvasc Res. 2011 Nov;82(3):356-63. doi: 10.1016/j.mvr.2011.09.008. Epub 2011 Oct 1.


Vascular reactivity to calcitonin gene-related peptide is enhanced in subtotal nephrectomy-salt induced hypertension.

Supowit SC, Katki KA, Hein TW, Gupta P, Kuo L, Dickerson IM, Dipette DJ.

Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H683-8. doi: 10.1152/ajpheart.00598.2009. Epub 2011 Jun 10.


Oxidized low-density lipoprotein inhibits nitric oxide-mediated coronary arteriolar dilation by up-regulating endothelial arginase I.

Wang W, Hein TW, Zhang C, Zawieja DC, Liao JC, Kuo L.

Microcirculation. 2011 Jan;18(1):36-45. doi: 10.1111/j.1549-8719.2010.00066.x.


Divergent roles of nitric oxide and rho kinase in vasomotor regulation of human retinal arterioles.

Hein TW, Rosa RH Jr, Yuan Z, Roberts E, Kuo L.

Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1583-90. doi: 10.1167/iovs.09-4391. Epub 2009 Oct 22.


C-reactive protein impairs coronary arteriolar dilation to prostacyclin synthase activation: role of peroxynitrite.

Hein TW, Qamirani E, Ren Y, Kuo L.

J Mol Cell Cardiol. 2009 Aug;47(2):196-202. doi: 10.1016/j.yjmcc.2009.04.015. Epub 2009 May 3.


Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo.

Hein TW, Singh U, Vasquez-Vivar J, Devaraj S, Kuo L, Jialal I.

Atherosclerosis. 2009 Sep;206(1):61-8. doi: 10.1016/j.atherosclerosis.2009.02.002. Epub 2009 Feb 12.


Chronic hypoxia attenuates VEGF signaling and angiogenic responses by downregulation of KDR in human endothelial cells.

Olszewska-Pazdrak B, Hein TW, Olszewska P, Carney DH.

Am J Physiol Cell Physiol. 2009 May;296(5):C1162-70. doi: 10.1152/ajpcell.00533.2008. Epub 2009 Feb 25.


Functional and molecular characterization of the endothelin system in retinal arterioles.

Hein TW, Ren Y, Yuan Z, Xu W, Somvanshi S, Nagaoka T, Yoshida A, Kuo L.

Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3329-36. doi: 10.1167/iovs.08-3129. Epub 2009 Jan 17.


TP508 (Chrysalin) reverses endothelial dysfunction and increases perfusion and myocardial function in hearts with chronic ischemia.

Fossum TW, Olszewska-Pazdrak B, Mertens MM, Makarski LA, Miller MW, Hein TW, Kuo L, Clubb F, Fuller GM, Carney DH.

J Cardiovasc Pharmacol Ther. 2008 Sep;13(3):214-25. doi: 10.1177/1074248408321468.


C-reactive protein inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles via enhanced superoxide production.

Nagaoka T, Kuo L, Ren Y, Yoshida A, Hein TW.

Invest Ophthalmol Vis Sci. 2008 May;49(5):2053-60. doi: 10.1167/iovs.07-1387.


Sildenafil (Viagra) evokes retinal arteriolar dilation: dual pathways via NOS activation and phosphodiesterase inhibition.

Yuan Z, Hein TW, Rosa RH Jr, Kuo L.

Invest Ophthalmol Vis Sci. 2008 Feb;49(2):720-5. doi: 10.1167/iovs.07-1208.


Simvastatin elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and mevalonate-rho kinase pathways.

Nagaoka T, Hein TW, Yoshida A, Kuo L.

Invest Ophthalmol Vis Sci. 2007 Feb;48(2):825-32.


Upregulation of arginase by H2O2 impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles.

Thengchaisri N, Hein TW, Wang W, Xu X, Li Z, Fossum TW, Kuo L.

Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2035-42. Epub 2006 Jun 22.


Effect of systemic administration of simvastatin on retinal circulation.

Nagaoka T, Takahashi A, Sato E, Izumi N, Hein TW, Kuo L, Yoshida A.

Arch Ophthalmol. 2006 May;124(5):665-70.


Brimonidine evokes heterogeneous vasomotor response of retinal arterioles: diminished nitric oxide-mediated vasodilation when size goes small.

Rosa RH Jr, Hein TW, Yuan Z, Xu W, Pechal MI, Geraets RL, Newman JM, Kuo L.

Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H231-8. Epub 2006 Feb 17.


Activation of JNK and xanthine oxidase by TNF-alpha impairs nitric oxide-mediated dilation of coronary arterioles.

Zhang C, Hein TW, Wang W, Ren Y, Shipley RD, Kuo L.

J Mol Cell Cardiol. 2006 Feb;40(2):247-57. Epub 2006 Jan 18.


Sodium azide dilates coronary arterioles via activation of inward rectifier K+ channels and Na+-K+-ATPase.

Qamirani E, Razavi HM, Wu X, Davis MJ, Kuo L, Hein TW.

Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1617-23. Epub 2005 Dec 3.


Requisite roles of A2A receptors, nitric oxide, and KATP channels in retinal arteriolar dilation in response to adenosine.

Hein TW, Yuan Z, Rosa RH Jr, Kuo L.

Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2113-9.


C-reactive protein inhibits endothelium-dependent NO-mediated dilation in coronary arterioles by activating p38 kinase and NAD(P)H oxidase.

Qamirani E, Ren Y, Kuo L, Hein TW.

Arterioscler Thromb Vasc Biol. 2005 May;25(5):995-1001. Epub 2005 Feb 17.


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