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Comparing methods for clinical investigator site inspection selection: a comparison of site selection methods of investigators in clinical trials.

Hein N, Rantou E, Schuette P.

J Biopharm Stat. 2019 Aug 28:1-14. doi: 10.1080/10543406.2019.1657134. [Epub ahead of print]


First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study.

Khot A, Brajanovski N, Cameron DP, Hein N, Maclachlan KH, Sanij E, Lim J, Soong J, Link E, Blombery P, Thompson ER, Fellowes A, Sheppard KE, McArthur GA, Pearson RB, Hannan RD, Poortinga G, Harrison SJ.

Cancer Discov. 2019 Aug;9(8):1036-1049. doi: 10.1158/2159-8290.CD-18-1455. Epub 2019 May 15.


Integrating field-based heat tents and cyber-physical system technology to phenotype high night-time temperature impact on winter wheat.

Hein NT, Wagner D, Bheemanahalli R, Šebela D, Bustamante C, Chiluwal A, Neilsen ML, Jagadish SVK.

Plant Methods. 2019 Apr 24;15:41. doi: 10.1186/s13007-019-0424-x. eCollection 2019.


n-3 Docosapentaenoic Acid Intake and Relationship with Plasma Long-Chain n-3 Fatty Acid Concentrations in the United States: NHANES 2003-2014.

Richter CK, Bisselou KS, Nordgren TM, Smith L, Appiah AK, Hein N, Anderson-Berry A, Kris-Etherton P, Hanson C, Skulas-Ray AC.

Lipids. 2019 Apr;54(4):221-230. doi: 10.1002/lipd.12146.


Cholera prevention and control in Asian countries.

Ahmed MU, Baquilod M, Deola C, Tu ND, Anh DD, Grasso C, Gautam A, Hamzah WM, Heng S, Iamsirithaworn S, Kadim M, Kar SK, Le Thi Quynh M, Lopez AL, Lynch J, Memon I, Mengel M, Long VN, Pandey BD, Quadri F, Saadatian-Elahi M, Gupta SS, Sultan A, Sur D, Tan DQ, Ha HTT, Hein NT, Lan PT, Upreti SR, Endtz H, Ganguly NK, Legros D, Picot V, Nair GB.

BMC Proc. 2018 Dec 7;12(Suppl 13):62. doi: 10.1186/s12919-018-0158-1. eCollection 2018.


Cash transfers and HIV/HSV-2 prevalence: A replication of a cluster randomized trial in Malawi.

Smith LM, Hein NA, Bagenda D.

PLoS One. 2019 Jan 31;14(1):e0210405. doi: 10.1371/journal.pone.0210405. eCollection 2019.


Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation.

Diesch J, Bywater MJ, Sanij E, Cameron DP, Schierding W, Brajanovski N, Son J, Sornkom J, Hein N, Evers M, Pearson RB, McArthur GA, Ganley ARD, O'Sullivan JM, Hannan RD, Poortinga G.

Commun Biol. 2019 Jan 28;2:39. doi: 10.1038/s42003-019-0284-y. eCollection 2019.


Omega-3 Fatty Acid Intake by Age, Gender, and Pregnancy Status in the United States: National Health and Nutrition Examination Survey 2003⁻2014.

Thompson M, Hein N, Hanson C, Smith LM, Anderson-Berry A, Richter CK, Stessy Bisselou K, Kusi Appiah A, Kris-Etherton P, Skulas-Ray AC, Nordgren TM.

Nutrients. 2019 Jan 15;11(1). pii: E177. doi: 10.3390/nu11010177.


High-Content Imaging Approaches to Quantitate Stress-Induced Changes in Nucleolar Morphology.

He JS, Soo P, Evers M, Parsons KM, Hein N, Hannan KM, Hannan RD, George AJ.

Assay Drug Dev Technol. 2018 Aug/Sep;16(6):320-332. doi: 10.1089/adt.2018.861.


Frequency of Community-acquired Methicillin-resistant Staphylococcus aureus in Pediatric Population in a General Hospital in São Paulo, Brazil, Over 5 Years.

Penteado FD, Tubero TZ, Hein N, Gilio AE.

Pediatr Infect Dis J. 2019 May;38(5):e87-e89. doi: 10.1097/INF.0000000000002158.


New Roles for the Nucleolus in Health and Disease.

Núñez Villacís L, Wong MS, Ferguson LL, Hein N, George AJ, Hannan KM.

Bioessays. 2018 May;40(5):e1700233. doi: 10.1002/bies.201700233. Epub 2018 Mar 30. Review.


Synthesis and Reactivity of a Low-Coordinate Iron(II) Hydride Complex: Applications in Catalytic Hydrodefluorination.

Hein NM, Pick FS, Fryzuk MD.

Inorg Chem. 2017 Dec 4;56(23):14513-14523. doi: 10.1021/acs.inorgchem.7b02199. Epub 2017 Nov 16.


Neoadjuvant treatment of pancreatic adenocarcinoma: a systematic review and meta-analysis of 5520 patients.

Dhir M, Malhotra GK, Sohal DPS, Hein NA, Smith LM, O'Reilly EM, Bahary N, Are C.

World J Surg Oncol. 2017 Oct 10;15(1):183. doi: 10.1186/s12957-017-1240-2. Review.


Role of plasma cells in Waldenström macroglobulinaemia.

El-Ayoubi A, Wang JQ, Hein N, Talaulikar D.

Pathology. 2017 Jun;49(4):337-345. doi: 10.1016/j.pathol.2017.02.004. Epub 2017 May 6. Review.


Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options.

Diwakarla C, Hannan K, Hein N, Yip D.

World J Gastroenterol. 2017 Apr 7;23(13):2276-2285. doi: 10.3748/wjg.v23.i13.2276. Review.


Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.

Hein N, Cameron DP, Hannan KM, Nguyen NN, Fong CY, Sornkom J, Wall M, Pavy M, Cullinane C, Diesch J, Devlin JR, George AJ, Sanij E, Quin J, Poortinga G, Verbrugge I, Baker A, Drygin D, Harrison SJ, Rozario JD, Powell JA, Pitson SM, Zuber J, Johnstone RW, Dawson MA, Guthridge MA, Wei A, McArthur GA, Pearson RB, Hannan RD.

Blood. 2017 May 25;129(21):2882-2895. doi: 10.1182/blood-2016-05-718171. Epub 2017 Mar 10.


Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.

Quin J, Chan KT, Devlin JR, Cameron DP, Diesch J, Cullinane C, Ahern J, Khot A, Hein N, George AJ, Hannan KM, Poortinga G, Sheppard KE, Khanna KK, Johnstone RW, Drygin D, McArthur GA, Pearson RB, Sanij E, Hannan RD.

Oncotarget. 2016 Aug 2;7(31):49800-49818. doi: 10.18632/oncotarget.10452.


Low coordinate iron derivatives stabilized by a β-diketiminate mimic. Synthesis and coordination chemistry of enamidophosphinimine scaffolds to generate diiron dinitrogen complexes.

Hein NM, Suzuki T, Ogawa T, Fryzuk MD.

Dalton Trans. 2016 Oct 7;45(37):14697-708. doi: 10.1039/c6dt01673a. Epub 2016 Jun 8.


Acute Hemorrhagic Edema of Infancy: an unusual diagnosis for the general pediatrician.

Cunha DF, Darcie AL, Benevides GN, Ferronato AE, Hein N, Lo DS, Yoshioka CR, Hirose M, Cardoso DM, Gilio AE.

Autops Case Rep. 2015 Sep 30;5(3):37-41. doi: 10.4322/acr.2015.020. eCollection 2015 Jul-Sep.


Dengue fever as a cause of hemophagocytic lymphohistiocytosis.

Hein N, Bergara GH, Moura NB, Cardoso DM, Hirose M, Ferronato AE, Pastorino AC, Lo DS, Gilio AE.

Autops Case Rep. 2015 Sep 30;5(3):33-6. doi: 10.4322/acr.2015.016. eCollection 2015 Jul-Sep.


Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma.

Devlin JR, Hannan KM, Hein N, Cullinane C, Kusnadi E, Ng PY, George AJ, Shortt J, Bywater MJ, Poortinga G, Sanij E, Kang J, Drygin D, O'Brien S, Johnstone RW, McArthur GA, Hannan RD, Pearson RB.

Cancer Discov. 2016 Jan;6(1):59-70. doi: 10.1158/2159-8290.CD-14-0673. Epub 2015 Oct 21.


Evaluation of a supervised multi-modal physical exercise program for prostate cancer survivors in the rehabilitation phase: Rationale and study protocol of the ProCaLife study.

Schega L, Törpel A, Hein N, Napiontek A, Wenzel C, Becker T.

Contemp Clin Trials. 2015 Nov;45(Pt B):311-319. doi: 10.1016/j.cct.2015.09.020. Epub 2015 Sep 30.


Neuropathy target esterase impairments cause Oliver-McFarlane and Laurence-Moon syndromes.

Hufnagel RB, Arno G, Hein ND, Hersheson J, Prasad M, Anderson Y, Krueger LA, Gregory LC, Stoetzel C, Jaworek TJ, Hull S, Li A, Plagnol V, Willen CM, Morgan TM, Prows CA, Hegde RS, Riazuddin S, Grabowski GA, Richardson RJ, Dieterich K, Huang T, Revesz T, Martinez-Barbera JP, Sisk RA, Jefferies C, Houlden H, Dattani MT, Fink JK, Dollfus H, Moore AT, Ahmed ZM.

J Med Genet. 2015 Feb;52(2):85-94. doi: 10.1136/jmedgenet-2014-102856. Epub 2014 Dec 5.


A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes.

Sanij E, Diesch J, Lesmana A, Poortinga G, Hein N, Lidgerwood G, Cameron DP, Ellul J, Goodall GJ, Wong LH, Dhillon AS, Hamdane N, Rothblum LI, Pearson RB, Haviv I, Moss T, Hannan RD.

Genome Res. 2015 Feb;25(2):201-12. doi: 10.1101/gr.176115.114. Epub 2014 Dec 1.


Cleavage of an aryl carbon-nitrogen bond of a phosphazido iron(II) complex promoted by hydride metathesis.

Ogawa T, Suzuki T, Hein NM, Pick FS, Fryzuk MD.

Dalton Trans. 2015 Jan 7;44(1):54-7. doi: 10.1039/c4dt03136a.


Otomastoiditis caused by Sphingomonas paucimobilis: case report and literature review.

Benevides GN, Hein N, Lo DS, Ferronato AE, Ragazzi SLB, Yoshioka CRM, Hirose M, Cardoso DM, Regina Dos Santos S, Gilio AE.

Autops Case Rep. 2014 Sep 30;4(3):13-20. doi: 10.4322/acr.2014.024. eCollection 2014 Jul-Sep.


The Alu-rich genomic architecture of SPAST predisposes to diverse and functionally distinct disease-associated CNV alleles.

Boone PM, Yuan B, Campbell IM, Scull JC, Withers MA, Baggett BC, Beck CR, Shaw CJ, Stankiewicz P, Moretti P, Goodwin WE, Hein N, Fink JK, Seong MW, Seo SH, Park SS, Karbassi ID, Batish SD, Ordóñez-Ugalde A, Quintáns B, Sobrido MJ, Stemmler S, Lupski JR.

Am J Hum Genet. 2014 Aug 7;95(2):143-61. doi: 10.1016/j.ajhg.2014.06.014. Epub 2014 Jul 24.


Cat-scratch disease presenting as multiple hepatic lesions: case report and literature review.

Baptista MA, Lo DS, Hein N, Hirose M, Yoshioka CRM, Ragazzi SLB, Gilio AE, Ferronato AE.

Autops Case Rep. 2014 Jun 30;4(2):43-48. doi: 10.4322/acr.2014.016. eCollection 2014 Apr-Jun.


Further studies toward a mouse model for biochemical assessment of neuropathic potential of organophosphorus compounds.

Makhaeva GF, Rudakova EV, Hein ND, Serebryakova OG, Kovaleva NV, Boltneva NP, Fink JK, Richardson RJ.

J Appl Toxicol. 2014 Dec;34(12):1426-35. doi: 10.1002/jat.2977. Epub 2014 Jan 7.


The nucleolus: an emerging target for cancer therapy.

Hein N, Hannan KM, George AJ, Sanij E, Hannan RD.

Trends Mol Med. 2013 Nov;19(11):643-54. doi: 10.1016/j.molmed.2013.07.005. Epub 2013 Aug 15. Review.


Hereditary spastic paraplegia type 43 (SPG43) is caused by mutation in C19orf12.

Landouré G, Zhu PP, Lourenço CM, Johnson JO, Toro C, Bricceno KV, Rinaldi C, Meilleur KG, Sangaré M, Diallo O, Pierson TM, Ishiura H, Tsuji S, Hein N, Fink JK, Stoll M, Nicholson G, Gonzalez MA, Speziani F, Dürr A, Stevanin G, Biesecker LG; NIH Intramural Sequencing Center, Accardi J, Landis DM, Gahl WA, Traynor BJ, Marques W Jr, Züchner S, Blackstone C, Fischbeck KH, Burnett BG.

Hum Mutat. 2013 Oct;34(10):1357-60. doi: 10.1002/humu.22378. Epub 2013 Aug 12.


Neuropathy target esterase (NTE): overview and future.

Richardson RJ, Hein ND, Wijeyesakere SJ, Fink JK, Makhaeva GF.

Chem Biol Interact. 2013 Mar 25;203(1):238-44. doi: 10.1016/j.cbi.2012.10.024. Epub 2012 Dec 3. Review.


Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.

Bywater MJ, Poortinga G, Sanij E, Hein N, Peck A, Cullinane C, Wall M, Cluse L, Drygin D, Anderes K, Huser N, Proffitt C, Bliesath J, Haddach M, Schwaebe MK, Ryckman DM, Rice WG, Schmitt C, Lowe SW, Johnstone RW, Pearson RB, McArthur GA, Hannan RD.

Cancer Cell. 2012 Jul 10;22(1):51-65. doi: 10.1016/j.ccr.2012.05.019.


Coronavirus HKU1 in children, Brazil, 1995.

Goes LG, Durigon EL, Campos AA, Hein N, Passos SD, Jerez JA.

Emerg Infect Dis. 2011 Jun;17(6):1147-8. doi: 10.3201/eid/1706.101381. No abstract available.


Signaling to the ribosome in cancer--It is more than just mTORC1.

Hannan KM, Sanij E, Hein N, Hannan RD, Pearson RB.

IUBMB Life. 2011 Feb;63(2):79-85. doi: 10.1002/iub.428. Review.


Motor neuron disease due to neuropathy target esterase mutation: enzyme analysis of fibroblasts from human subjects yields insights into pathogenesis.

Hein ND, Rainier SR, Richardson RJ, Fink JK.

Toxicol Lett. 2010 Nov 10;199(1):1-5. doi: 10.1016/j.toxlet.2010.06.020. Epub 2010 Sep 17.


Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties.

Hein ND, Stuckey JA, Rainier SR, Fink JK, Richardson RJ.

Toxicol Lett. 2010 Jul 1;196(2):67-73. doi: 10.1016/j.toxlet.2010.03.1120. Epub 2010 Apr 9.


Kinetics and mechanism of inhibition of serine esterases by fluorinated aminophosphonates.

Makhaeva GF, Aksinenko AY, Sokolov VB, Baskin II, Palyulin VA, Zefirov NS, Hein ND, Kampf JW, Wijeyesakere SJ, Richardson RJ.

Chem Biol Interact. 2010 Sep 6;187(1-3):177-84. doi: 10.1016/j.cbi.2009.12.018. Epub 2009 Dec 23.


Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.

Hydbring P, Bahram F, Su Y, Tronnersjö S, Högstrand K, von der Lehr N, Sharifi HR, Lilischkis R, Hein N, Wu S, Vervoorts J, Henriksson M, Grandien A, Lüscher B, Larsson LG.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):58-63. doi: 10.1073/pnas.0900121106. Epub 2009 Dec 4.


Regulation of the MAD1 promoter by G-CSF.

Jiang K, Hein N, Eckert K, Lüscher-Firzlaff J, Lüscher B.

Nucleic Acids Res. 2008 Mar;36(5):1517-31. doi: 10.1093/nar/gkn002. Epub 2008 Jan 18.


[Enamel microabrasion and in-office bleaching for fluorosis: a case report].

Hein N, Wrbas KT.

Schweiz Monatsschr Zahnmed. 2007;117(9):947-56. French, German.


Two-year clinical evaluation of Cerec 3D ceramic inlays inserted by undergraduate dental students.

Wrbas KT, Hein N, Schirrmeister JF, Altenburger MJ, Hellwig E.

Quintessence Int. 2007 Jul-Aug;38(7):575-81.


Molecular epidemiology of human adenovirus isolated from children hospitalized with acute respiratory infection in São Paulo, Brazil.

Moura PO, Roberto AF, Hein N, Baldacci E, Vieira SE, Ejzenberg B, Perrini P, Stewien KE, Durigon EL, Mehnert DU, Hársi CM.

J Med Virol. 2007 Feb;79(2):174-81.


Identification of Burkholderia pseudomallei genes required for the intracellular life cycle and in vivo virulence.

Pilatz S, Breitbach K, Hein N, Fehlhaber B, Schulze J, Brenneke B, Eberl L, Steinmetz I.

Infect Immun. 2006 Jun;74(6):3576-86.


Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes.

Leibowitz MD, Ardecky RJ, Boehm MF, Broderick CL, Carfagna MA, Crombie DL, D'Arrigo J, Etgen GJ, Faul MM, Grese TA, Havel H, Hein NI, Heyman RA, Jolley D, Klausing K, Liu S, Mais DE, Mapes CM, Marschke KB, Michellys PY, Montrose-Rafizadeh C, Ogilvie KM, Pascual B, Rungta D, Tyhonas JS, Urcan MS, Wardlow M, Yumibe N, Reifel-Miller A.

Endocrinology. 2006 Feb;147(2):1044-53. Epub 2005 Nov 3.


Effect of two antimicrobial agents on early in situ biofilm formation.

Auschill TM, Hein N, Hellwig E, Follo M, Sculean A, Arweiler NB.

J Clin Periodontol. 2005 Feb;32(2):147-52.


Individual vitality pattern of in situ dental biofilms at different locations in the oral cavity.

Arweiler NB, Hellwig E, Sculean A, Hein N, Auschill TM.

Caries Res. 2004 Sep-Oct;38(5):442-7.


Impact of the intraoral location on the rate of biofilm growth.

Auschill TM, Hellwig E, Sculean A, Hein N, Arweiler NB.

Clin Oral Investig. 2004 Jun;8(2):97-101. Epub 2004 Feb 19.


[Viral infections in hospitalized children affected by acute lower respiratory tract disease]

Miyao CR, Gilio AE, Vieira S, Hein N, Pahl MM, Betta SL, Durigon EL, Stewien KE, Queiroz DA, Botoso VF, Gomes MC, Lopes CL, Ejzenberg B, Okay Y.

J Pediatr (Rio J). 1999 Sep-Oct;75(5):334-44. Portuguese.

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