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N-Acetyltransferase 1 Knockout Elevates Acetyl Coenzyme A Levels and Reduces Anchorage-Independent Growth in Human Breast Cancer Cell Lines.

Stepp MW, Salazar-González RA, Hong KU, Doll MA, Hein DW.

J Oncol. 2019 Aug 20;2019:3860426. doi: 10.1155/2019/3860426. eCollection 2019.


Role of Human N-Acetyltransferase 2 Genetic Polymorphism on Aromatic Amine Carcinogen-Induced DNA Damage and Mutagenicity in a Chinese Hamster Ovary Cell Mutation Assay.

Baldauf KJ, Salazar-González RA, Doll MA, Pierce WM Jr, States JC, Hein DW.

Environ Mol Mutagen. 2019 Sep 6. doi: 10.1002/em.22331. [Epub ahead of print]


Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4'-methylenedianiline.

Salazar-González RA, Zhang X, Doll MA, Lykoudi A, Hein DW.

Arch Toxicol. 2019 Aug;93(8):2237-2246. doi: 10.1007/s00204-019-02516-4. Epub 2019 Jul 10.


Functional expression of human arylamine N-acetyltransferase NAT1*10 and NAT1*11 alleles: a mini review.

Hein DW, Fakis G, Boukouvala S.

Pharmacogenet Genomics. 2018 Oct;28(10):238-244. doi: 10.1097/FPC.0000000000000350. Review.


Expression and genotype-dependent catalytic activity of N-acetyltransferase 2 (NAT2) in human peripheral blood mononuclear cells and its modulation by Sirtuin 1.

Salazar-González RA, Turiján-Espinoza E, Hein DW, Milán-Segovia RC, Uresti-Rivera EE, Portales-Pérez DP.

Biochem Pharmacol. 2018 Oct;156:340-347. doi: 10.1016/j.bcp.2018.08.034. Epub 2018 Aug 25.


Knockout of human arylamine N-acetyltransferase 1 (NAT1) in MDA-MB-231 breast cancer cells leads to increased reserve capacity, maximum mitochondrial capacity, and glycolytic reserve capacity.

Carlisle SM, Trainor PJ, Doll MA, Stepp MW, Klinge CM, Hein DW.

Mol Carcinog. 2018 Nov;57(11):1458-1466. doi: 10.1002/mc.22869. Epub 2018 Jul 18.


Genetic and small molecule inhibition of arylamine N-acetyltransferase 1 reduces anchorage-independent growth in human breast cancer cell line MDA-MB-231.

Stepp MW, Doll MA, Carlisle SM, States JC, Hein DW.

Mol Carcinog. 2018 Apr;57(4):549-558. doi: 10.1002/mc.22779. Epub 2018 Feb 3.


Role of N-acetyltransferase 2 acetylation polymorphism in 4, 4'-methylene bis (2-chloroaniline) biotransformation.

Hein DW, Zhang X, Doll MA.

Toxicol Lett. 2018 Feb;283:100-105. doi: 10.1016/j.toxlet.2017.11.028. Epub 2017 Nov 24.


Arylamine N-acetyltransferase 1 in situ N-acetylation on CD3+ peripheral blood mononuclear cells correlate with NATb mRNA and NAT1 haplotype.

Salazar-González RA, Turiján-Espinoza E, Hein DW, Niño-Moreno PC, Romano-Moreno S, Milán-Segovia RC, Portales-Pérez DP.

Arch Toxicol. 2018 Feb;92(2):661-668. doi: 10.1007/s00204-017-2082-y. Epub 2017 Oct 17.


N-Acetyltransferase 2 Genotype-Dependent N-Acetylation of Hydralazine in Human Hepatocytes.

Allen CE, Doll MA, Hein DW.

Drug Metab Dispos. 2017 Dec;45(12):1276-1281. doi: 10.1124/dmd.117.078543. Epub 2017 Oct 10.


Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes.

Doll MA, Salazar-González RA, Bodduluri S, Hein DW.

Acta Pharm Sin B. 2017 Jul;7(4):517-522. doi: 10.1016/j.apsb.2017.05.003. Epub 2017 Jun 7.


Role of the N-acetylation polymorphism in solithromycin metabolism.

Hein DW, Doll MA.

Pharmacogenomics. 2017 Jun;18(8):765-772. doi: 10.2217/pgs-2017-0045. Epub 2017 Apr 24.


Genetic heterogeneity among slow acetylator N-acetyltransferase 2 phenotypes in cryopreserved human hepatocytes.

Doll MA, Hein DW.

Arch Toxicol. 2017 Jul;91(7):2655-2661. doi: 10.1007/s00204-017-1988-8. Epub 2017 May 17.


Daily Rhythm in Plasma N-acetyltryptamine.

Backlund PS, Urbanski HF, Doll MA, Hein DW, Bozinoski M, Mason CE, Coon SL, Klein DC.

J Biol Rhythms. 2017 Jun;32(3):195-211. doi: 10.1177/0748730417700458. Epub 2017 May 3.


Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism.

Stepp MW, Doll MA, Samuelson DJ, Sanders MA, States JC, Hein DW.

BMC Cancer. 2017 Mar 31;17(1):233. doi: 10.1186/s12885-017-3221-9.


Untargeted polar metabolomics of transformed MDA-MB-231 breast cancer cells expressing varying levels of human arylamine N-acetyltransferase 1.

Carlisle SM, Trainor PJ, Yin X, Doll MA, Stepp MW, States JC, Zhang X, Hein DW.

Metabolomics. 2016 Jul;12(7). pii: 111. Epub 2016 Jun 21.


Design and Success of a 21st Century Cancer Education Program at the University of Louisville.

Hein DW, Kidd CR.

J Cancer Educ. 2018 Apr;33(2):298-308. doi: 10.1007/s13187-016-1083-5.


Evaluation of Oxidative Stress Response Related Genetic Variants, Pro-oxidants, Antioxidants and Prostate Cancer.

Lavender N, Hein DW, Brock G, Kidd CR.

AIMS Med Sci. 2015;2(4):271-294. Epub 2015 Sep 10.


Folate-Dependent Hydrolysis of Acetyl-Coenzyme A by Recombinant Human and Rodent Arylamine N-Acetyltransferases.

Stepp MW, Mamaliga G, Doll MA, States JC, Hein DW.

Biochem Biophys Rep. 2015 Sep;3:45-50.


Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells.

Teng Y, Radde BN, Litchfield LM, Ivanova MM, Prough RA, Clark BJ, Doll MA, Hein DW, Klinge CM.

J Biol Chem. 2015 Jun 19;290(25):15799-811. doi: 10.1074/jbc.M115.641167. Epub 2015 May 11.


PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2.

McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE.

Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. Review. No abstract available.


Interaction of cigarette smoking and carcinogen-metabolizing polymorphisms in the risk of colorectal polyps.

Fu Z, Shrubsole MJ, Li G, Smalley WE, Hein DW, Cai Q, Ness RM, Zheng W.

Carcinogenesis. 2013 Apr;34(4):779-86. doi: 10.1093/carcin/bgs410. Epub 2013 Jan 8.


Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph consortium.

Gibson TM, Smedby KE, Skibola CF, Hein DW, Slager SL, de Sanjosé S, Vajdic CM, Zhang Y, Chiu BC, Wang SS, Hjalgrim H, Nieters A, Bracci PM, Kricker A, Zheng T, Kolar C, Cerhan JR, Darabi H, Becker N, Conde L, Holford TR, Weisenburger DD, De Roos AJ, Butterbach K, Riby J, Cozen W, Benavente Y, Palmers C, Holly EA, Sampson JN, Rothman N, Armstrong BK, Morton LM.

Cancer Causes Control. 2013 Jan;24(1):125-34. doi: 10.1007/s10552-012-0098-4. Epub 2012 Nov 18.


Using gene-environment interaction analyses to clarify the role of well-done meat and heterocyclic amine exposure in the etiology of colorectal polyps.

Fu Z, Shrubsole MJ, Li G, Smalley WE, Hein DW, Chen Z, Shyr Y, Cai Q, Ness RM, Zheng W.

Am J Clin Nutr. 2012 Nov;96(5):1119-28. doi: 10.3945/ajcn.112.040345. Epub 2012 Sep 26.


Interaction among apoptosis-associated sequence variants and joint effects on aggressive prostate cancer.

Lavender NA, Rogers EN, Yeyeodu S, Rudd J, Hu T, Zhang J, Brock GN, Kimbro KS, Moore JH, Hein DW, Kidd LC.

BMC Med Genomics. 2012 Apr 30;5:11. doi: 10.1186/1755-8794-5-11.


Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study.

Potts LF, Cambon AC, Ross OA, Rademakers R, Dickson DW, Uitti RJ, Wszolek ZK, Rai SN, Farrer MJ, Hein DW, Litvan I.

BMC Med Genet. 2012 Mar 17;13:16. doi: 10.1186/1471-2350-13-16.


Reduced 4-aminobiphenyl-induced liver tumorigenicity but not DNA damage in arylamine N-acetyltransferase null mice.

Sugamori KS, Brenneman D, Sanchez O, Doll MA, Hein DW, Pierce WM Jr, Grant DM.

Cancer Lett. 2012 May 28;318(2):206-13. doi: 10.1016/j.canlet.2011.12.022. Epub 2011 Dec 19.


Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct.

Millner LM, Doll MA, Stepp MW, States JC, Hein DW.

Carcinogenesis. 2012 Feb;33(2):348-55. doi: 10.1093/carcin/bgr273. Epub 2011 Nov 22. Erratum in: Carcinogenesis. 2012 Jul;33(7):1431.


Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes.

Hein DW, Doll MA.

Pharmacogenomics. 2012 Jan;13(1):31-41. doi: 10.2217/pgs.11.122. Epub 2011 Nov 17.


Phenotype of the most common "slow acetylator" arylamine N-acetyltransferase 1 genetic variant (NAT1*14B) is substrate-dependent.

Millner LM, Doll MA, Cai J, States JC, Hein DW.

Drug Metab Dispos. 2012 Jan;40(1):198-204. doi: 10.1124/dmd.111.041855. Epub 2011 Oct 18.


NATb/NAT1*4 promotes greater arylamine N-acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4-aminobiphenyl.

Millner LM, Doll MA, Cai J, States JC, Hein DW.

Mol Carcinog. 2012 Aug;51(8):636-46. doi: 10.1002/mc.20836. Epub 2011 Aug 11.


No association between variant N-acetyltransferase genes, cigarette smoking and Prostate Cancer susceptibility among men of African descent.

Kidd LC, Vancleave TT, Doll MA, Srivastava DS, Thacker B, Komolafe O, Pihur V, Brock GN, Hein DW.

Biomark Cancer. 2011 Feb 3;2011(3):1-13.


Hair dye use and risk of bladder cancer in the New England bladder cancer study.

Koutros S, Silverman DT, Baris D, Zahm SH, Morton LM, Colt JS, Hein DW, Moore LE, Johnson A, Schwenn M, Cherala S, Schned A, Doll MA, Rothman N, Karagas MR.

Int J Cancer. 2011 Dec 15;129(12):2894-904. doi: 10.1002/ijc.26245. Epub 2011 Aug 12.


Functional effects of genetic polymorphisms in the N-acetyltransferase 1 coding and 3' untranslated regions.

Zhu Y, States JC, Wang Y, Hein DW.

Birth Defects Res A Clin Mol Teratol. 2011 Feb;91(2):77-84. doi: 10.1002/bdra.20763. Epub 2011 Feb 2.


GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysis.

Moore LE, Baris DR, Figueroa JD, Garcia-Closas M, Karagas MR, Schwenn MR, Johnson AT, Lubin JH, Hein DW, Dagnall CL, Colt JS, Kida M, Jones MA, Schned AR, Cherala SS, Chanock SJ, Cantor KP, Silverman DT, Rothman N.

Carcinogenesis. 2011 Feb;32(2):182-9. doi: 10.1093/carcin/bgq223. Epub 2010 Oct 29.


Lack of association of the N-acetyltransferase NAT1*10 allele with prostate cancer incidence, grade, or stage among smokers in Finland.

Kidd LR, Hein DW, Woodson K, Taylor PR, Albanes D, Virtamo J, Tangrea JA.

Biochem Genet. 2011 Feb;49(1-2):73-82. doi: 10.1007/s10528-010-9386-4. Epub 2010 Oct 8.


A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background.

García-Closas M, Hein DW, Silverman D, Malats N, Yeager M, Jacobs K, Doll MA, Figueroa JD, Baris D, Schwenn M, Kogevinas M, Johnson A, Chatterjee N, Moore LE, Moeller T, Real FX, Chanock S, Rothman N.

Pharmacogenet Genomics. 2011 Apr;21(4):231-6. doi: 10.1097/FPC.0b013e32833e1b54.


Manganese superoxide dismutase expression as a function of genotype and lung cancer pathology.

Martin RC, Li Y, Liu Q, Barker DF, Doll MA, Hein DW.

Cancer Invest. 2010 Oct;28(8):813-9. doi: 10.3109/07357900903405918.


Codominant expression of N-acetylation and O-acetylation activities catalyzed by N-acetyltransferase 2 in human hepatocytes.

Doll MA, Zang Y, Moeller T, Hein DW.

J Pharmacol Exp Ther. 2010 Aug;334(2):540-4. doi: 10.1124/jpet.110.168567. Epub 2010 Apr 29.


An alternative cyclin-D1 splice site is not linked to inflammatory bowel disease-associated neoplasia.

Kanaan Z, Eichenberger MR, Young M, Colliver D, Crawford N, Cobbs GA, Hein DW, Galandiuk S.

Int J Biol Markers. 2010 Jan-Mar;25(1):27-31.


Variability in drug metabolizing enzyme activity in HIV-infected patients.

Jones AE, Brown KC, Werner RE, Gotzkowsky K, Gaedigk A, Blake M, Hein DW, van der Horst C, Kashuba AD.

Eur J Clin Pharmacol. 2010 May;66(5):475-85. doi: 10.1007/s00228-009-0777-6. Epub 2010 Jan 19.


Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx).

Metry KJ, Neale JR, Doll MA, Howarth AL, States JC, McGregor WG, Pierce WM Jr, Hein DW.

Mutat Res. 2010 Feb 3;684(1-2):66-73. doi: 10.1016/j.mrfmmm.2009.12.001. Epub 2009 Dec 11.


Relationship between N-acetyltransferase 2 single-nucleotide polymorphisms and phenotype.

Hein DW, Millner LM, Leggett CS, Doll MA.

Carcinogenesis. 2010 Feb;31(2):326-7; author reply 328-9. doi: 10.1093/carcin/bgp290. Epub 2009 Nov 23. No abstract available.


Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among men of African descent: a case-control study.

Lavender NA, Benford ML, VanCleave TT, Brock GN, Kittles RA, Moore JH, Hein DW, Kidd LC.

BMC Cancer. 2009 Nov 16;9:397. doi: 10.1186/1471-2407-9-397.


Genetic variation in N-acetyltransferases 1 and 2, cigarette smoking, and risk of non-Hodgkin lymphoma.

Kilfoy BA, Zheng T, Lan Q, Han X, Holford T, Hein DW, Qin Q, Leaderer B, Morton LM, Yeager M, Boyle P, Zhao P, Chanock S, Rothman N, Zhang Y.

Cancer Causes Control. 2010 Jan;21(1):127-33. doi: 10.1007/s10552-009-9442-8. Epub 2009 Oct 7.


N-acetyltransferase 2 genotype modification of active cigarette smoking on breast cancer risk among hispanic and non-hispanic white women.

Baumgartner KB, Schlierf TJ, Yang D, Doll MA, Hein DW.

Toxicol Sci. 2009 Nov;112(1):211-20. doi: 10.1093/toxsci/kfp199. Epub 2009 Aug 19.

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