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Items: 1 to 50 of 208

1.

Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy.

Dvela-Levitt M, Kost-Alimova M, Emani M, Kohnert E, Thompson R, Sidhom EH, Rivadeneira A, Sahakian N, Roignot J, Papagregoriou G, Montesinos MS, Clark AR, McKinney D, Gutierrez J, Roth M, Ronco L, Elonga E, Carter TA, Gnirke A, Melanson M, Hartland K, Wieder N, Hsu JC, Deltas C, Hughey R, Bleyer AJ, Kmoch S, Živná M, Barešova V, Kota S, Schlondorff J, Heiman M, Alper SL, Wagner F, Weins A, Golub TR, Lander ES, Greka A.

Cell. 2019 Jul 25;178(3):521-535.e23. doi: 10.1016/j.cell.2019.07.002.

PMID:
31348885
2.

Rice Flour and Bran Enriched with Blueberry Polyphenols Increases Storage Stability and Decreases Arsenic Content in Bran.

Boue SM, Daigle K, Beaulieu JC, Heiman M.

Foods. 2019 Jul 23;8(7). pii: E276. doi: 10.3390/foods8070276.

3.

Genome-Wide Genetic Screening in the Mammalian CNS.

Wertz MH, Heiman M.

In: Jaenisch R, Zhang F, Gage F, editors. Genome Editing in Neurosciences [Internet]. Cham (CH): Springer; 2017.
2017 Sep 15.

4.

"For Paul".

Bateup HS, Heiman M, Schaefer A.

Nat Neurosci. 2019 Aug;22(8):1203-1204. doi: 10.1038/s41593-019-0450-z. No abstract available.

PMID:
31263206
5.

A multicellular rosette-mediated collective dendrite extension.

Fan L, Kovacevic I, Heiman MG, Bao Z.

Elife. 2019 Feb 15;8. pii: e38065. doi: 10.7554/eLife.38065.

6.

Morphogenesis of neurons and glia within an epithelium.

Low IIC, Williams CR, Chong MK, McLachlan IG, Wierbowski BM, Kolotuev I, Heiman MG.

Development. 2019 Feb 20;146(4). pii: dev171124. doi: 10.1242/dev.171124.

PMID:
30683663
7.

Widespread Accumulation of Ribosome-Associated Isolated 3' UTRs in Neuronal Cell Populations of the Aging Brain.

Sudmant PH, Lee H, Dominguez D, Heiman M, Burge CB.

Cell Rep. 2018 Nov 27;25(9):2447-2456.e4. doi: 10.1016/j.celrep.2018.10.094.

8.

Ordered arrangement of dendrites within a C. elegans sensory nerve bundle.

Yip ZC, Heiman MG.

Elife. 2018 Aug 20;7. pii: e35825. doi: 10.7554/eLife.35825.

9.

A neuronal MAP kinase constrains growth of a Caenorhabditis elegans sensory dendrite throughout the life of the organism.

McLachlan IG, Beets I, de Bono M, Heiman MG.

PLoS Genet. 2018 Jun 7;14(6):e1007435. doi: 10.1371/journal.pgen.1007435. eCollection 2018 Jun.

10.

Normal aging induces A1-like astrocyte reactivity.

Clarke LE, Liddelow SA, Chakraborty C, Münch AE, Heiman M, Barres BA.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1896-E1905. doi: 10.1073/pnas.1800165115. Epub 2018 Feb 7.

11.

Animal models of obesity and diabetes mellitus.

Kleinert M, Clemmensen C, Hofmann SM, Moore MC, Renner S, Woods SC, Huypens P, Beckers J, de Angelis MH, Schürmann A, Bakhti M, Klingenspor M, Heiman M, Cherrington AD, Ristow M, Lickert H, Wolf E, Havel PJ, Müller TD, Tschöp MH.

Nat Rev Endocrinol. 2018 Mar;14(3):140-162. doi: 10.1038/nrendo.2017.161. Epub 2018 Jan 19. Review.

12.

Control of Huntington's Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2.

Hachigian LJ, Carmona V, Fenster RJ, Kulicke R, Heilbut A, Sittler A, Pereira de Almeida L, Mesirov JP, Gao F, Kolaczyk ED, Heiman M.

Cell Rep. 2017 Dec 5;21(10):2688-2695. doi: 10.1016/j.celrep.2017.11.018.

13.

A null mutation in SERPINE1 protects against biological aging in humans.

Khan SS, Shah SJ, Klyachko E, Baldridge AS, Eren M, Place AT, Aviv A, Puterman E, Lloyd-Jones DM, Heiman M, Miyata T, Gupta S, Shapiro AD, Vaughan DE.

Sci Adv. 2017 Nov 15;3(11):eaao1617. doi: 10.1126/sciadv.aao1617. eCollection 2017 Nov.

14.

Coordinated morphogenesis of neurons and glia.

Lamkin ER, Heiman MG.

Curr Opin Neurobiol. 2017 Dec;47:58-64. doi: 10.1016/j.conb.2017.09.011. Epub 2017 Oct 16. Review.

15.

Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements.

Pirhaji L, Milani P, Dalin S, Wassie BT, Dunn DE, Fenster RJ, Avila-Pacheco J, Greengard P, Clish CB, Heiman M, Lo DC, Fraenkel E.

Nat Commun. 2017 Sep 20;8(1):623. doi: 10.1038/s41467-017-00353-6.

16.

Resolving CNS mRNA Heterogeneity: Examining mRNA Alternative Polyadenylation at a Cell-Type-Specific Level.

Therrien M, Heiman M.

Neuron. 2017 Sep 13;95(6):1232-1233. doi: 10.1016/j.neuron.2017.08.045.

17.

Complete Plasminogen Activator Inhibitor 1 Deficiency.

Heiman M, Gupta S, Khan SS, Vaughan DE, Shapiro AD.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019.
2017 Aug 3.

18.

Ghrelin, Ghrelin O-Acyltransferase, and Carbohydrate Metabolism During Pregnancy in Calorie-Restricted Mice.

Trivedi A, Babic S, Heiman M, Gibson WT, Chanoine JP.

Horm Metab Res. 2017 Jan;49(1):64-72. doi: 10.1055/s-0042-116117. Epub 2016 Oct 4.

PMID:
27701682
19.

A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.

Nechipurenko IV, Olivier-Mason A, Kazatskaya A, Kennedy J, McLachlan IG, Heiman MG, Blacque OE, Sengupta P.

Dev Cell. 2016 Sep 12;38(5):493-506. doi: 10.1016/j.devcel.2016.07.013.

20.

Variable bleeding phenotype in an Amish pedigree with von Willebrand disease.

Gupta S, Heiman M, Duncan N, Hinckley J, Di Paola J, Shapiro AD.

Am J Hematol. 2016 Oct;91(10):E431-5. doi: 10.1002/ajh.24474. Epub 2016 Aug 22.

21.

Antidiabetic Potential of Purple and Red Rice (Oryza sativa L.) Bran Extracts.

Boue SM, Daigle KW, Chen MH, Cao H, Heiman ML.

J Agric Food Chem. 2016 Jul 6;64(26):5345-53. doi: 10.1021/acs.jafc.6b01909. Epub 2016 Jun 22.

PMID:
27285791
22.

Duplication of a Single Neuron in C. elegans Reveals a Pathway for Dendrite Tiling by Mutual Repulsion.

Yip ZC, Heiman MG.

Cell Rep. 2016 Jun 7;15(10):2109-2117. doi: 10.1016/j.celrep.2016.05.003. Epub 2016 May 26.

23.

Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake.

Li Z, Kelly L, Heiman M, Greengard P, Friedman JM.

Cell Metab. 2016 May 10;23(5):945. doi: 10.1016/j.cmet.2016.04.014. No abstract available.

24.

A healthy gastrointestinal microbiome is dependent on dietary diversity.

Heiman ML, Greenway FL.

Mol Metab. 2016 Mar 5;5(5):317-320. doi: 10.1016/j.molmet.2016.02.005. eCollection 2016 May. Review.

25.

Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake.

Li Z, Kelly L, Heiman M, Greengard P, Friedman JM.

Cell Metab. 2015 Dec 1;22(6):1059-67. doi: 10.1016/j.cmet.2015.10.012. Epub 2015 Nov 19.

26.

A novel gastrointestinal microbiome modulator from soy pods reduces absorption of dietary fat in mice.

Boué S, Fortgang I, Levy RJ Jr, Bhatnagar D, Burow M, Fahey G, Heiman ML.

Obesity (Silver Spring). 2016 Jan;24(1):87-95. doi: 10.1002/oby.21197. Epub 2015 Nov 20.

27.

Gastrointestinal microbiome modulator improves glucose tolerance in overweight and obese subjects: A randomized controlled pilot trial.

Rebello CJ, Burton J, Heiman M, Greenway FL.

J Diabetes Complications. 2015 Nov-Dec;29(8):1272-6. doi: 10.1016/j.jdiacomp.2015.08.023. Epub 2015 Sep 3.

28.

The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex.

Nie D, Chen Z, Ebrahimi-Fakhari D, Di Nardo A, Julich K, Robson VK, Cheng YC, Woolf CJ, Heiman M, Sahin M.

J Neurosci. 2015 Jul 29;35(30):10762-72. doi: 10.1523/JNEUROSCI.4796-14.2015.

29.

Computer-Assisted Transgenesis of Caenorhabditis elegans for Deep Phenotyping.

Gilleland CL, Falls AT, Noraky J, Heiman MG, Yanik MF.

Genetics. 2015 Sep;201(1):39-46. doi: 10.1534/genetics.115.179648. Epub 2015 Jul 10.

30.

Ghrelin.

Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH.

Mol Metab. 2015 Mar 21;4(6):437-60. doi: 10.1016/j.molmet.2015.03.005. eCollection 2015 Jun. Review.

31.

Addition of a Gastrointestinal Microbiome Modulator to Metformin Improves Metformin Tolerance and Fasting Glucose Levels.

Burton JH, Johnson M, Johnson J, Hsia DS, Greenway FL, Heiman ML.

J Diabetes Sci Technol. 2015 Jul;9(4):808-14. doi: 10.1177/1932296815577425. Epub 2015 Mar 23.

32.

FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis.

Kelley M, Yochem J, Krieg M, Calixto A, Heiman MG, Kuzmanov A, Meli V, Chalfie M, Goodman MB, Shaham S, Frand A, Fay DS.

Elife. 2015 Mar 23;4. doi: 10.7554/eLife.06565.

33.

Acylated ghrelin is not required for the surge in pituitary growth hormone observed in pregnant mice.

Trivedi A, Babic S, Heiman M, Gibson WT, Chanoine JP.

Peptides. 2015 Mar;65:29-33. doi: 10.1016/j.peptides.2015.01.005. Epub 2015 Jan 30.

PMID:
25645493
34.

Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function.

Uematsu K, Heiman M, Zelenina M, Padovan J, Chait BT, Aperia A, Nishi A, Greengard P.

J Neurochem. 2015 Mar;132(6):677-86. doi: 10.1111/jnc.13038. Epub 2015 Mar 4.

35.

The many glia of a tiny nematode: studying glial diversity using Caenorhabditis elegans.

Mizeracka K, Heiman MG.

Wiley Interdiscip Rev Dev Biol. 2015 Mar-Apr;4(2):151-60. doi: 10.1002/wdev.171. Epub 2015 Jan 21. Review.

PMID:
25611728
36.

Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington's disease.

Shema R, Kulicke R, Cowley GS, Stein R, Root DE, Heiman M.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):268-72. doi: 10.1073/pnas.1417231112. Epub 2014 Dec 22.

37.

Nitric oxide regulates synaptic transmission between spiny projection neurons.

Sagi Y, Heiman M, Peterson JD, Musatov S, Scarduzio M, Logan SM, Kaplitt MG, Surmeier DJ, Heintz N, Greengard P.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17636-41. doi: 10.1073/pnas.1420162111. Epub 2014 Nov 20. Erratum in: Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1811.

38.

Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia.

Fieblinger T, Graves SM, Sebel LE, Alcacer C, Plotkin JL, Gertler TS, Chan CS, Heiman M, Greengard P, Cenci MA, Surmeier DJ.

Nat Commun. 2014 Oct 31;5:5316. doi: 10.1038/ncomms6316.

39.

The level of circulating octanoate does not predict ghrelin O-acyl transferase (GOAT)-mediated acylation of ghrelin during fasting.

Nass R, Nikolayev A, Liu J, Pezzoli SS, Farhy LS, Patrie J, Gaylinn BD, Heiman M, Thorner MO.

J Clin Endocrinol Metab. 2015 Jan;100(1):E110-3. doi: 10.1210/jc.2014-1318.

40.

Cell type-specific mRNA purification by translating ribosome affinity purification (TRAP).

Heiman M, Kulicke R, Fenster RJ, Greengard P, Heintz N.

Nat Protoc. 2014;9(6):1282-91. doi: 10.1038/nprot.2014.085. Epub 2014 May 8.

41.

Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia.

Heiman M, Heilbut A, Francardo V, Kulicke R, Fenster RJ, Kolaczyk ED, Mesirov JP, Surmeier DJ, Cenci MA, Greengard P.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4578-83. doi: 10.1073/pnas.1401819111. Epub 2014 Mar 5.

42.

The obstetric, gynaecological and fertility implications of homozygous PAI-1 deficiency: single-centre experience.

Heiman M, Gupta S, Shapiro AD.

Haemophilia. 2014 May;20(3):407-12. doi: 10.1111/hae.12313. Epub 2013 Nov 22.

PMID:
24261743
43.

Quantitative trait locus linkage analysis in a large Amish pedigree identifies novel candidate loci for erythrocyte traits.

Hinckley JD, Abbott D, Burns TL, Heiman M, Shapiro AD, Wang K, Di Paola J.

Mol Genet Genomic Med. 2013 Sep 1;1(3):131-141.

44.

Shaping dendrites with machinery borrowed from epithelia.

McLachlan IG, Heiman MG.

Curr Opin Neurobiol. 2013 Dec;23(6):1005-10. doi: 10.1016/j.conb.2013.06.011. Epub 2013 Jul 18. Review.

PMID:
23871793
45.

Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons.

Jordi E, Heiman M, Marion-Poll L, Guermonprez P, Cheng SK, Nairn AC, Greengard P, Girault JA.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9511-6. doi: 10.1073/pnas.1307116110. Epub 2013 May 20.

46.
47.

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR.

Cell Metab. 2012 Aug 8;16(2):250-64. doi: 10.1016/j.cmet.2012.07.007.

48.

Strain-specific regulation of striatal phenotype in Drd2-eGFP BAC transgenic mice.

Chan CS, Peterson JD, Gertler TS, Glajch KE, Quintana RE, Cui Q, Sebel LE, Plotkin JL, Shen W, Heiman M, Heintz N, Greengard P, Surmeier DJ.

J Neurosci. 2012 Jul 4;32(27):9124-32. doi: 10.1523/JNEUROSCI.0229-12.2012.

49.

Glyceollins, soy isoflavone phytoalexins, improve oral glucose disposal by stimulating glucose uptake.

Boué SM, Isakova IA, Burow ME, Cao H, Bhatnagar D, Sarver JG, Shinde KV, Erhardt PW, Heiman ML.

J Agric Food Chem. 2012 Jun 27;60(25):6376-82. doi: 10.1021/jf301057d. Epub 2012 Jun 15.

PMID:
22655912
50.

Combination of a Beta adrenoceptor modulator and a norepinephrine-serotonin uptake inhibitor for the treatment of obesity.

Jesudason CD, Baker JE, Bryant RD, Fisher JW, O'Farrell LS, Gaich GA, He MM, Kahl SD, Kriauciunas AV, Heiman ML, Peters MA, Rito CJ, Satterwhite JH, Tinsley FC, Trankle WG, Shuker AJ.

ACS Med Chem Lett. 2011 May 23;2(8):583-6. doi: 10.1021/ml200071k. eCollection 2011 Aug 11.

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