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Items: 1 to 50 of 114

1.

Expeller Barrel Dry Heat and Moist Heat Pressure Duration Induce Changes in Canola Meal Protein for Ruminant Utilisation.

Heim R, Krebs G.

Animals (Basel). 2018 Aug 21;8(9). pii: E147. doi: 10.3390/ani8090147.

2.

Correction: Comparative assessment of gene-specific variant distribution in prenatal and postnatal cohorts tested for Noonan syndrome and related conditions.

Leach NT, Wilson Mathews DR, Rosenblum LS, Zhou Z, Zhu H, Heim RA.

Genet Med. 2019 Jul;21(7):1670. doi: 10.1038/s41436-018-0128-z.

PMID:
30050098
3.

Comparative assessment of gene-specific variant distribution in prenatal and postnatal cohorts tested for Noonan syndrome and related conditions.

Leach NT, Wilson Mathews DR, Rosenblum LS, Zhou Z, Zhu H, Heim RA.

Genet Med. 2019 Feb;21(2):417-425. doi: 10.1038/s41436-018-0062-0. Epub 2018 Jun 15. Erratum in: Genet Med. 2018 Jul 26;:.

PMID:
29907801
4.

Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis.

Migliore M Dr, Pontis S Dr, Fuentes de Arriba AL, Realini N, Torrente E, Armirotti A, Romeo E, Di Martino S, Russo D, Pizzirani D, Summa M, Lanfranco M, Ottonello G, Busquet P, Jung KM, Garcia-Guzman M, Heim R, Scarpelli R, Piomelli D.

Angew Chem Int Ed Engl. 2016 Sep 5;55(37):11193-11197. doi: 10.1002/anie.201603746. Epub 2016 Jul 12.

5.

Photoimmunotherapy Inhibits Tumor Recurrence After Surgical Resection on a Pancreatic Cancer Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model.

Hiroshima Y, Maawy A, Zhang Y, Guzman MG, Heim R, Makings L, Luiken GA, Kobayashi H, Tanaka K, Endo I, Hoffman RM, Bouvet M.

Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1469-74. doi: 10.1245/s10434-015-4553-9. Epub 2015 Apr 17.

PMID:
25893411
6.

Simple preparation of plant epidermal tissue for laser microdissection and downstream quantitative proteome and carbohydrate analysis.

Falter C, Ellinger D, von Hülsen B, Heim R, Voigt CA.

Front Plant Sci. 2015 Mar 27;6:194. doi: 10.3389/fpls.2015.00194. eCollection 2015.

7.

Near infra-red photoimmunotherapy with anti-CEA-IR700 results in extensive tumor lysis and a significant decrease in tumor burden in orthotopic mouse models of pancreatic cancer.

Maawy AA, Hiroshima Y, Zhang Y, Heim R, Makings L, Garcia-Guzman M, Luiken GA, Kobayashi H, Hoffman RM, Bouvet M.

PLoS One. 2015 Mar 23;10(3):e0121989. doi: 10.1371/journal.pone.0121989. eCollection 2015.

8.

1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols: a new class of potent and selective aldosterone synthase inhibitors.

Grombein CM, Hu Q, Heim R, Rau S, Zimmer C, Hartmann RW.

Eur J Med Chem. 2015 Jan 7;89:597-605. doi: 10.1016/j.ejmech.2014.10.027. Epub 2014 Oct 12.

PMID:
25462268
9.

The Ashkenazi Jewish carrier screening panel: evolution, status quo, and disparities.

Hoffman JD, Park JJ, Schreiber-Agus N, Kornreich R, Tanner AK, Keiles S, Friedman KJ, Heim RA.

Prenat Diagn. 2014 Dec;34(12):1161-7. doi: 10.1002/pd.4446. Epub 2014 Jul 31. Review.

PMID:
24996053
10.

Strategies for the modulation of phase II metabolism in a series of PKCε inhibitors.

Clemens JJ, Coon T, Busch BB, Asgian JL, Hudson S, Termin A, Flores TB, Tran D, Chiang P, Sperry S, Gross R, Abt J, Heim R, Lechner S, Twin H, Studley J, Brenchley G, Collier PN, Pierard F, Miller A, Mak C, Dvornikovs V, Jimenez JM, Stamos D.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3398-402. doi: 10.1016/j.bmcl.2014.05.082. Epub 2014 Jun 5.

PMID:
24939756
11.

Cystic fibrosis carrier testing in an ethnically diverse US population.

Rohlfs EM, Zhou Z, Heim RA, Nagan N, Rosenblum LS, Flynn K, Scholl T, Akmaev VR, Sirko-Osadsa DA, Allitto BA, Sugarman EA.

Clin Chem. 2011 Jun;57(6):841-8. doi: 10.1373/clinchem.2010.159285. Epub 2011 Apr 7.

12.

Nitric oxide: a regulator of eukaryotic initiation factor 2 kinases.

Tong L, Heim RA, Wu S.

Free Radic Biol Med. 2011 Jun 15;50(12):1717-25. doi: 10.1016/j.freeradbiomed.2011.03.032. Epub 2011 Apr 2. Review.

13.
14.

Theoretical studies on the interaction of partial agonists with the 5-HT2A receptor.

Silva ME, Heim R, Strasser A, Elz S, Dove S.

J Comput Aided Mol Des. 2011 Jan;25(1):51-66. doi: 10.1007/s10822-010-9400-2. Epub 2010 Nov 19.

PMID:
21088982
15.

Selective aldosterone synthase inhibitors reduce aldosterone formation in vitro and in vivo.

Ries C, Lucas S, Heim R, Birk B, Hartmann RW.

J Steroid Biochem Mol Biol. 2009 Sep;116(3-5):121-6. doi: 10.1016/j.jsbmb.2009.04.013. Epub 2009 May 7.

PMID:
19427380
16.

Physical fitness, but not acute exercise modulates event-related potential indices for executive control in healthy adolescents.

Stroth S, Kubesch S, Dieterle K, Ruchsow M, Heim R, Kiefer M.

Brain Res. 2009 May 7;1269:114-24. doi: 10.1016/j.brainres.2009.02.073. Epub 2009 Mar 11.

PMID:
19285042
17.

In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.

Lucas S, Heim R, Ries C, Schewe KE, Birk B, Hartmann RW.

J Med Chem. 2008 Dec 25;51(24):8077-87. doi: 10.1021/jm800888q.

PMID:
19049427
18.

Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.

Lucas S, Heim R, Negri M, Antes I, Ries C, Schewe KE, Bisi A, Gobbi S, Hartmann RW.

J Med Chem. 2008 Oct 9;51(19):6138-49. doi: 10.1021/jm800683c. Epub 2008 Sep 3.

PMID:
18763754
19.

Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.

Heim R, Lucas S, Grombein CM, Ries C, Schewe KE, Negri M, Müller-Vieira U, Birk B, Hartmann RW.

J Med Chem. 2008 Aug 28;51(16):5064-74. doi: 10.1021/jm800377h. Epub 2008 Aug 1.

PMID:
18672861
20.

Simultaneous detection of multiple point mutations using allele-specific oligonucleotides.

Napolitano NM, Rohlfs EM, Heim RA.

Curr Protoc Hum Genet. 2004 Sep;Chapter 9:Unit9.4. doi: 10.1002/0471142905.hg0904s41.

PMID:
18428368
21.

A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal.

Müh U, Hare BJ, Duerkop BA, Schuster M, Hanzelka BL, Heim R, Olson ER, Greenberg EP.

Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16948-52. Epub 2006 Oct 30.

22.

Novel Pseudomonas aeruginosa quorum-sensing inhibitors identified in an ultra-high-throughput screen.

Müh U, Schuster M, Heim R, Singh A, Olson ER, Greenberg EP.

Antimicrob Agents Chemother. 2006 Nov;50(11):3674-9. Epub 2006 Sep 11.

23.

Expedient construction of the vibsanin E core without the use of protecting groups.

Heim R, Wiedemann S, Williams CM, Bernhardt PV.

Org Lett. 2005 Mar 31;7(7):1327-9.

PMID:
15787498
24.
25.

Unprecedented photochemical induced cascading rearrangement of the 3-azabicyclo[3.3.1]nonane skeleton.

Williams CM, Heim R, Brecknell DJ, Bernhardt PV.

Org Biomol Chem. 2004 Mar 21;2(6):806-7. Epub 2004 Feb 19.

PMID:
15007404
26.

High allelic heterogeneity between Afro-Brazilians and Euro-Brazilians impacts cystic fibrosis genetic testing.

Raskin S, Pereira L, Reis F, Rosario NA, Ludwig N, Valentim L, Phillips JA 3rd, Allito B, Heim RA, Sugarman EA, Probst CM, Faucz F, Culpi L.

Genet Test. 2003 Fall;7(3):213-8.

PMID:
14641997
27.

Green fluorescent protein forms for energy transfer.

Heim R.

Methods Enzymol. 1999;302:408-23. No abstract available.

PMID:
12876789
28.

The I148T CFTR allele occurs on multiple haplotypes: a complex allele is associated with cystic fibrosis.

Rohlfs EM, Zhou Z, Sugarman EA, Heim RA, Pace RG, Knowles MR, Silverman LM, Allitto BA.

Genet Med. 2002 Sep-Oct;4(5):319-23.

PMID:
12394343
29.

Binding of a Pleckstrin homology domain protein to phosphoinositide in membranes: a miniaturized FRET-based assay for drug screening.

Hamman BD, Pollok BA, Bennett T, Allen J, Heim R.

J Biomol Screen. 2002 Feb;7(1):45-55.

PMID:
11897055
30.

Improved detection of CFTR mutations in southern California Hispanic CF patients.

Wong LJ, Wang J, Zhang YH, Hsu E, Heim RA, Bowman CM, Woo MS.

Hum Mutat. 2002 Jan;19(1):79. No abstract available.

PMID:
11754107
31.

Correlating cell cycle with apoptosis in a cell line expressing a tandem green fluorescent protein substrate specific for group II caspases.

Donahue CJ, Santoro M, Hupe D, Jones JM, Pollok B, Heim R, Giegel D.

Cytometry. 2001 Nov 1;45(3):225-34.

PMID:
11746091
32.

Improved detection of CFTR mutations in Southern California Hispanic CF patients.

Wong LJ, Wang J, Zhang YH, Hsu E, Heim RA, Bowman CM, Woo MS.

Hum Mutat. 2001 Oct;18(4):296-307.

PMID:
11668613
33.
34.

Development and application of a GFP-FRET intracellular caspase assay for drug screening.

Jones J, Heim R, Hare E, Stack J, Pollok BA.

J Biomol Screen. 2000 Oct;5(5):307-18.

PMID:
11080689
35.
36.

Using GFP in FRET-based applications.

Pollok BA, Heim R.

Trends Cell Biol. 1999 Feb;9(2):57-60. Review.

PMID:
10087619
37.

Dynamic and quantitative Ca2+ measurements using improved cameleons.

Miyawaki A, Griesbeck O, Heim R, Tsien RY.

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2135-40.

38.

Understanding structure-function relationships in the Aequorea victoria green fluorescent protein.

Cubitt AB, Woollenweber LA, Heim R.

Methods Cell Biol. 1999;58:19-30. Review. No abstract available.

PMID:
9891372
39.

Bcl-2 and Bax interactions in mitochondria probed with green fluorescent protein and fluorescence resonance energy transfer.

Mahajan NP, Linder K, Berry G, Gordon GW, Heim R, Herman B.

Nat Biotechnol. 1998 Jun;16(6):547-52.

PMID:
9624685
40.

Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin.

Miyawaki A, Llopis J, Heim R, McCaffery JM, Adams JA, Ikura M, Tsien RY.

Nature. 1997 Aug 28;388(6645):882-7.

PMID:
9278050
41.

Crystal structure and photodynamic behavior of the blue emission variant Y66H/Y145F of green fluorescent protein.

Wachter RM, King BA, Heim R, Kallio K, Tsien RY, Boxer SG, Remington SJ.

Biochemistry. 1997 Aug 12;36(32):9759-65.

PMID:
9245407
42.

What works. Ambulatory medical record shares information throughout the health system.

Heim R.

Health Manag Technol. 1997 Jun;18(7):26. No abstract available.

PMID:
10169791
44.

Double labelling of subcellular structures with organelle-targeted GFP mutants in vivo.

Rizzuto R, Brini M, De Giorgi F, Rossi R, Heim R, Tsien RY, Pozzan T.

Curr Biol. 1996 Feb 1;6(2):183-8.

46.

Understanding, improving and using green fluorescent proteins.

Cubitt AB, Heim R, Adams SR, Boyd AE, Gross LA, Tsien RY.

Trends Biochem Sci. 1995 Nov;20(11):448-55. Review.

PMID:
8578587
47.

Distribution of 13 truncating mutations in the neurofibromatosis 1 gene.

Heim RA, Kam-Morgan LN, Binnie CG, Corns DD, Cayouette MC, Farber RA, Aylsworth AS, Silverman LM, Luce MC.

Hum Mol Genet. 1995 Jun;4(6):975-81.

PMID:
7655472
48.

Changes in hip migration after selective dorsal rhizotomy for spastic quadriplegia in cerebral palsy.

Heim RC, Park TS, Vogler GP, Kaufman BA, Noetzel MJ, Ortman MR.

J Neurosurg. 1995 Apr;82(4):567-71.

PMID:
7897515
49.

Improved green fluorescence.

Heim R, Cubitt AB, Tsien RY.

Nature. 1995 Feb 23;373(6516):663-4. No abstract available.

PMID:
7854443
50.

Localization of gliosis in the corpus striatum of mice following cortical lesions.

Khoja I, Herranz AS, Williams JR, Cannon-Spoor HE, Heim RC, Freed WJ, Poltorak M.

Restor Neurol Neurosci. 1995 Jan 1;9(2):113-9. doi: 10.3233/RNN-1995-9206.

PMID:
21551839

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