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Items: 40

1.

hiPS Cell-Derived Neurons for High-Throughput Screening.

Traub S, Heilker R.

Methods Mol Biol. 2019;1994:243-263. doi: 10.1007/978-1-4939-9477-9_23.

PMID:
31124122
2.

Differentiation of hiPS Cells into Definitive Endoderm for High-Throughput Screening.

Bluhmki T, Traub S, Schruf E, Garnett J, Gantner F, Bischoff D, Heilker R.

Methods Mol Biol. 2019;1994:101-115. doi: 10.1007/978-1-4939-9477-9_9.

PMID:
31124108
3.

The power of combining phenotypic and target-focused drug discovery.

Heilker R, Lessel U, Bischoff D.

Drug Discov Today. 2019 Feb;24(2):526-532. doi: 10.1016/j.drudis.2018.10.009. Epub 2018 Oct 22. Review.

PMID:
30359770
4.

Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule.

Tautermann CS, Binder F, Büttner FH, Eickmeier C, Fiegen D, Gross U, Grundl MA, Heilker R, Hobson S, Hoerer S, Luippold A, Mack V, Montel F, Peters S, Bhattacharya S, Vaidehi N, Schnapp G, Thamm S, Zeeb M.

J Med Chem. 2019 Jan 10;62(1):306-316. doi: 10.1021/acs.jmedchem.8b00857. Epub 2018 Sep 12.

PMID:
30207464
5.

Pharmaceutical Characterization of Tropomyosin Receptor Kinase B-Agonistic Antibodies on Human Induced Pluripotent Stem (hiPS) Cell-Derived Neurons.

Traub S, Stahl H, Rosenbrock H, Simon E, Florin L, Hospach L, Hörer S, Heilker R.

J Pharmacol Exp Ther. 2017 Jun;361(3):355-365. doi: 10.1124/jpet.117.240184. Epub 2017 Mar 28.

PMID:
28351853
6.

Upscaling of hiPS Cell-Derived Neurons for High-Throughput Screening.

Traub S, Stahl H, Rosenbrock H, Simon E, Heilker R.

SLAS Discov. 2017 Mar;22(3):274-286. doi: 10.1177/1087057116678161. Epub 2016 Nov 16.

PMID:
28231034
7.

iPS cell derived neuronal cells for drug discovery.

Heilker R, Traub S, Reinhardt P, Schöler HR, Sterneckert J.

Trends Pharmacol Sci. 2014 Oct;35(10):510-9. doi: 10.1016/j.tips.2014.07.003. Epub 2014 Aug 3. Review.

PMID:
25096281
8.

Phenotypic analysis of chemokine-driven actin reorganization in primary human neutrophils.

Kredel S, Wolff M, Gierschik P, Heilker R.

Assay Drug Dev Technol. 2014 Mar;12(2):120-8. doi: 10.1089/adt.2013.553. Epub 2014 Feb 28.

PMID:
24579814
9.

Assay Related Target Similarity (ARTS) - chemogenomics approach for quantitative comparison of biological targets.

Bieler M, Heilker R, Köppen H, Schneider G.

J Chem Inf Model. 2011 Aug 22;51(8):1897-905. doi: 10.1021/ci200105t. Epub 2011 Jul 29.

PMID:
21761911
10.

High-content analysis of CCR2 antagonists on human primary monocytes.

Kredel S, Wolff M, Hobbie S, Bieler M, Gierschik P, Heilker R.

J Biomol Screen. 2011 Aug;16(7):683-93. doi: 10.1177/1087057111406884. Epub 2011 May 3.

PMID:
21540351
11.

In vivo inhibition of epidermal growth factor receptor autophosphorylation prevents receptor internalization.

Wolff M, Tetzlaff K, Nivens MC, Schneider FJ, Jung B, Hohlfeld J, Heilker R.

Exp Cell Res. 2011 Jan 1;317(1):42-50. doi: 10.1016/j.yexcr.2010.09.009. Epub 2010 Sep 18.

PMID:
20858487
12.

An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction.

East SP, Bamford S, Dietz MG, Eickmeier C, Flegg A, Ferger B, Gemkow MJ, Heilker R, Hengerer B, Kotey A, Loke P, Schänzle G, Schubert HD, Scott J, Whittaker M, Williams M, Zawadzki P, Gerlach K.

Bioorg Med Chem Lett. 2010 Aug 15;20(16):4901-5. doi: 10.1016/j.bmcl.2010.06.078. Epub 2010 Jun 25.

PMID:
20638279
13.

High content screening of CXCR2-dependent signalling pathways.

Wolff M, Kredel S, Haasen D, Wiedenmann J, Nienhaus GU, Kistler B, Oswald F, Heilker R.

Comb Chem High Throughput Screen. 2010 Jan;13(1):3-15.

PMID:
20214572
14.

Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease.

Woodruff PG, Wolff M, Hohlfeld JM, Krug N, Dransfield MT, Sutherland ER, Criner GJ, Kim V, Prasse A, Nivens MC, Tetzlaff K, Heilker R, Fahy JV.

Am J Respir Crit Care Med. 2010 Mar 1;181(5):438-45. doi: 10.1164/rccm.200909-1415OC. Epub 2009 Dec 10.

PMID:
20007923
15.

CXCR2 inverse agonism detected by arrestin redistribution.

Kredel S, Wolff M, Wiedenmann J, Moepps B, Nienhaus GU, Gierschik P, Kistler B, Heilker R.

J Biomol Screen. 2009 Oct;14(9):1076-91. doi: 10.1177/1087057109344616. Epub 2009 Sep 22.

PMID:
19773589
16.

mRuby, a bright monomeric red fluorescent protein for labeling of subcellular structures.

Kredel S, Oswald F, Nienhaus K, Deuschle K, Röcker C, Wolff M, Heilker R, Nienhaus GU, Wiedenmann J.

PLoS One. 2009;4(2):e4391. doi: 10.1371/journal.pone.0004391. Epub 2009 Feb 5.

17.

G-protein-coupled receptor-focused drug discovery using a target class platform approach.

Heilker R, Wolff M, Tautermann CS, Bieler M.

Drug Discov Today. 2009 Mar;14(5-6):231-40. doi: 10.1016/j.drudis.2008.11.011. Epub 2009 Jan 22. Review.

PMID:
19121411
18.

Activation and translocation of glucokinase in rat primary hepatocytes monitored by high content image analysis.

Wolff M, Kauschke SG, Schmidt S, Heilker R.

J Biomol Screen. 2008 Oct;13(9):837-46. doi: 10.1177/1087057108323910. Epub 2008 Sep 23.

PMID:
18812575
19.

Cell-based assays in practice: cell markers from autofluorescent proteins of the GFP-family.

Wolff M, Kredel S, Wiedenmann J, Nienhaus GU, Heilker R.

Comb Chem High Throughput Screen. 2008 Sep;11(8):602-9. Review.

PMID:
18795879
20.

Trans-cis isomerization is responsible for the red-shifted fluorescence in variants of the red fluorescent protein eqFP611.

Nienhaus K, Nar H, Heilker R, Wiedenmann J, Nienhaus GU.

J Am Chem Soc. 2008 Sep 24;130(38):12578-9. doi: 10.1021/ja8046443. Epub 2008 Aug 30.

PMID:
18761441
21.

Optimized and far-red-emitting variants of fluorescent protein eqFP611.

Kredel S, Nienhaus K, Oswald F, Wolff M, Ivanchenko S, Cymer F, Jeromin A, Michel FJ, Spindler KD, Heilker R, Nienhaus GU, Wiedenmann J.

Chem Biol. 2008 Mar;15(3):224-33. doi: 10.1016/j.chembiol.2008.02.008.

22.

Pharmacological profiling of chemokine receptor-directed compounds using high-content screening.

Haasen D, Merk S, Seither P, Martyres D, Hobbie S, Heilker R.

J Biomol Screen. 2008 Jan;13(1):40-53. doi: 10.1177/1087057107312128.

PMID:
18227225
23.

High content screening to monitor G protein-coupled receptor internalisation.

Heilker R.

Ernst Schering Found Symp Proc. 2006;(2):229-47. Review.

PMID:
17703585
24.

Novel fluorescent proteins for high-content screening.

Wolff M, Wiedenmann J, Nienhaus GU, Valler M, Heilker R.

Drug Discov Today. 2006 Dec;11(23-24):1054-60. Epub 2006 Sep 25. Review.

PMID:
17129823
25.

G protein-coupled receptor internalization assays in the high-content screening format.

Haasen D, Schnapp A, Valler MJ, Heilker R.

Methods Enzymol. 2006;414:121-39.

PMID:
17110190
26.

Automated high content screening for phosphoinositide 3 kinase inhibition using an AKT 1 redistribution assay.

Wolff M, Haasen D, Merk S, Kroner M, Maier U, Bordel S, Wiedenmann J, Nienhaus GU, Valler M, Heilker R.

Comb Chem High Throughput Screen. 2006 Jun;9(5):339-50.

PMID:
16787147
27.

Photoconvertible fluorescent protein EosFP: biophysical properties and cell biology applications.

Nienhaus GU, Nienhaus K, Hölzle A, Ivanchenko S, Renzi F, Oswald F, Wolff M, Schmitt F, Röcker C, Vallone B, Weidemann W, Heilker R, Nar H, Wiedenmann J.

Photochem Photobiol. 2006 Mar-Apr;82(2):351-8. Review.

PMID:
16613485
28.

Comparison of G-protein coupled receptor desensitization-related beta-arrestin redistribution using confocal and non-confocal imaging.

Haasen D, Wolff M, Valler MJ, Heilker R.

Comb Chem High Throughput Screen. 2006 Jan;9(1):37-47.

PMID:
16454685
29.

Confocal fluorescence microscopy for high-throughput screening of G-protein coupled receptors.

Heilker R, Zemanova L, Valler MJ, Nienhaus GU.

Curr Med Chem. 2005;12(22):2551-9. Review.

PMID:
16248815
30.

High-throughput screening of interactions between G protein-coupled receptors and ligands using confocal optics microscopy.

Zemanová L, Schenk A, Valler MJ, Nienhaus GU, Heilker R.

Methods Mol Biol. 2005;305:365-84.

PMID:
15940007
31.

Peptide protein binding assay using ImageFlashPlates or Imaging Beads.

Merk SE, Schubert HD, Moreth W, Valler MJ, Heilker R.

Comb Chem High Throughput Screen. 2004 Dec;7(8):763-70.

PMID:
15578938
32.

Endothelin receptor in virus-like particles: ligand binding observed by fluorescence fluctuation spectroscopy.

Zemanová L, Schenk A, Hunt N, Nienhaus GU, Heilker R.

Biochemistry. 2004 Jul 20;43(28):9021-8.

PMID:
15248759
33.

Time-resolved fluorescence measurements using microlens array and area imaging devices.

Merk S, Lietz A, Kroner M, Valler M, Heilker R.

Comb Chem High Throughput Screen. 2004 Feb;7(1):45-54.

PMID:
14965260
34.

Confocal optics microscopy for biochemical and cellular high-throughput screening.

Zemanová L, Schenk A, Valler MJ, Nienhaus GU, Heilker R.

Drug Discov Today. 2003 Dec 1;8(23):1085-93. Review. Erratum in: Drug Discov Today. 2004 Jan 1;9(1):26.

PMID:
14693468
35.
36.

Recognition of sorting signals by clathrin adaptors.

Heilker R, Spiess M, Crottet P.

Bioessays. 1999 Jul;21(7):558-67. Review.

PMID:
10472183
37.

The kinetics of association and phosphorylation of IkappaB isoforms by IkappaB kinase 2 correlate with their cellular regulation in human endothelial cells.

Heilker R, Freuler F, Vanek M, Pulfer R, Kobel T, Peter J, Zerwes HG, Hofstetter H, Eder J.

Biochemistry. 1999 May 11;38(19):6231-8.

PMID:
10320352
38.

All three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complex.

Heilker R, Freuler F, Pulfer R, Di Padova F, Eder J.

Eur J Biochem. 1999 Jan;259(1-2):253-61.

39.

In vitro binding of clathrin adaptors to sorting signals correlates with endocytosis and basolateral sorting.

Heilker R, Manning-Krieg U, Zuber JF, Spiess M.

EMBO J. 1996 Jun 3;15(11):2893-9.

40.

Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins.

Tashiro K, Tada H, Heilker R, Shirozu M, Nakano T, Honjo T.

Science. 1993 Jul 30;261(5121):600-3.

PMID:
8342023

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