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Items: 1 to 50 of 324


Distinction of self-produced touch and social touch at cortical and spinal cord levels.

Boehme R, Hauser S, Gerling GJ, Heilig M, Olausson H.

Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2290-2299. doi: 10.1073/pnas.1816278116. Epub 2019 Jan 22.


Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: a concurrent 11C-raclopride positron emission tomography and functional magnetic resonance imaging investigation.

Hamilton JP, Sacchet MD, Hjørnevik T, Chin FT, Shen B, Kämpe R, Park JH, Knutson BD, Williams LM, Borg N, Zaharchuk G, Camacho MC, Mackey S, Heilig M, Drevets WC, Glover GH, Gambhir SS, Gotlib IH.

Transl Psychiatry. 2018 Nov 30;8(1):264. doi: 10.1038/s41398-018-0316-2.


Lack of Target Engagement Following Low-Frequency Deep Transcranial Magnetic Stimulation of the Anterior Insula.

Spagnolo PA, Wang H, Srivanitchapoom P, Schwandt M, Heilig M, Hallett M.

Neuromodulation. 2018 Oct 29. doi: 10.1111/ner.12875. [Epub ahead of print]


Science-Based Actions Can Help Address the Opioid Crisis.

Epstein DH, Heilig M, Shaham Y.

Trends Pharmacol Sci. 2018 Nov;39(11):911-916. doi: 10.1016/ Review.


Neural Correlates of Compulsive Alcohol Seeking in Heavy Drinkers.

Grodin EN, Sussman L, Sundby K, Brennan GM, Diazgranados N, Heilig M, Momenan R.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Dec;3(12):1022-1031. doi: 10.1016/j.bpsc.2018.06.009. Epub 2018 Jul 9.


Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice.

Mayo LM, Asratian A, Lindé J, Holm L, Nätt D, Augier G, Stensson N, Vecchiarelli HA, Balsevich G, Aukema RJ, Ghafouri B, Spagnolo PA, Lee FS, Hill MN, Heilig M.

Mol Psychiatry. 2018 Aug 17. doi: 10.1038/s41380-018-0215-1. [Epub ahead of print]


Assessment of pioglitazone and proinflammatory cytokines during buprenorphine taper in patients with opioid use disorder.

Schroeder JR, Phillips KA, Epstein DH, Jobes ML, Furnari MA, Kennedy AP, Heilig M, Preston KL.

Psychopharmacology (Berl). 2018 Oct;235(10):2957-2966. doi: 10.1007/s00213-018-4986-5. Epub 2018 Aug 6.


Putting a good face on touch: Facial expression reflects the affective valence of caress-like touch across modalities.

Mayo LM, Lindé J, Olausson H, Heilig M, Morrison I.

Biol Psychol. 2018 Sep;137:83-90. doi: 10.1016/j.biopsycho.2018.07.001. Epub 2018 Jul 9.


A molecular mechanism for choosing alcohol over an alternative reward.

Augier E, Barbier E, Dulman RS, Licheri V, Augier G, Domi E, Barchiesi R, Farris S, Nätt D, Mayfield RD, Adermark L, Heilig M.

Science. 2018 Jun 22;360(6395):1321-1326. doi: 10.1126/science.aao1157.


The neurokinin-1 receptor mediates escalated alcohol intake induced by multiple drinking models.

Sequeira MK, Nelson BS, Fulenwider HD, King CE, Nennig SE, Bohannon JB, Cheng K, Rice KC, Heilig M, Schank JR.

Neuropharmacology. 2018 Jul 15;137:194-201. doi: 10.1016/j.neuropharm.2018.05.005. Epub 2018 May 3.


The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study.

Lee MR, Tapocik JD, Ghareeb M, Schwandt ML, Dias AA, Le AN, Cobbina E, Farinelli LA, Bouhlal S, Farokhnia M, Heilig M, Akhlaghi F, Leggio L.

Mol Psychiatry. 2018 May 4. doi: 10.1038/s41380-018-0064-y. [Epub ahead of print]


Do we have an opioid crisis in Scandinavia? Time to act?

Heilig M, Tägil M.

Acta Orthop. 2018 Aug;89(4):368. doi: 10.1080/17453674.2018.1465285. Epub 2018 May 1. No abstract available.


The salience of self, not social pain, is encoded by dorsal anterior cingulate and insula.

Perini I, Gustafsson PA, Hamilton JP, Kämpe R, Zetterqvist M, Heilig M.

Sci Rep. 2018 Apr 18;8(1):6165. doi: 10.1038/s41598-018-24658-8.


Genetic Association and Expression Analyses of the Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) Gene in Alcohol Use Disorder-Relevance for Pain Signaling and Alcohol Use.

Lee JS, Sorcher JL, Rosen AD, Damadzic R, Sun H, Schwandt M, Heilig M, Kelly J, Mauro KL, Luo A, Rosoff D, Muench C, Jung J, Kaminsky ZA, Lohoff FW.

Alcohol Clin Exp Res. 2018 Jun;42(6):1034-1043. doi: 10.1111/acer.13751. Epub 2018 May 9.


Study of homogeneous bubble nucleation in liquid carbon dioxide by a hybrid approach combining molecular dynamics simulation and density gradient theory.

Langenbach K, Heilig M, Horsch M, Hasse H.

J Chem Phys. 2018 Mar 28;148(12):124702. doi: 10.1063/1.5022231.


Preclinical evaluation of the kappa-opioid receptor antagonist CERC-501 as a candidate therapeutic for alcohol use disorders.

Domi E, Barbier E, Augier E, Augier G, Gehlert D, Barchiesi R, Thorsell A, Holm L, Heilig M.

Neuropsychopharmacology. 2018 Aug;43(9):1805-1812. doi: 10.1038/s41386-018-0015-y. Epub 2018 Feb 5.


Several behavioral traits relevant for alcoholism are controlled by ɣ2 subunit containing GABAA receptors on dopamine neurons in mice.

Stojakovic A, Walczak M, Cieślak PE, Trenk A, Sköld J, Zajdel J, Mirrasekhian E, Karlsson C, Thorsell A, Heilig M, Parkitna JR, Błasiak T, Engblom D.

Neuropsychopharmacology. 2018 Jun;43(7):1548-1556. doi: 10.1038/s41386-018-0022-z. Epub 2018 Feb 5.


Neural responses to cues paired with methamphetamine in healthy volunteers.

Van Hedger K, Keedy SK, Mayo LM, Heilig M, de Wit H.

Neuropsychopharmacology. 2018 Jul;43(8):1732-1737. doi: 10.1038/s41386-017-0005-5. Epub 2018 Jan 30.


Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model.

Zallar LJ, Tunstall BJ, Richie CT, Zhang YJ, You ZB, Gardner EL, Heilig M, Pickel J, Koob GF, Vendruscolo LF, Harvey BK, Leggio L.

Int J Obes (Lond). 2019 Feb;43(2):344-354. doi: 10.1038/s41366-018-0013-5. Epub 2018 Jan 30.


Insula Sensitivity to Unfairness in Alcohol Use Disorder.

Cortes CR, Grodin EN, Mann CL, Mathur K, Kerich M, Zhu X, Schwandt M, Diazgranados N, George DT, Momenan R, Heilig M.

Alcohol Alcohol. 2018 May 1;53(3):201-208. doi: 10.1093/alcalc/agx115.


[The National Board of Health and Welfare's target levels signal a lack of trust].

Bejerot S, Landén M, Heilig M, Anckarsäter H, Waern M.

Lakartidningen. 2017 Nov 3;114. pii: EWFR. Swedish. No abstract available.


A cannabinoid receptor antagonist attenuates ghrelin-induced activation of the mesolimbic dopamine system in mice.

Kalafateli AL, Vallöf D, Jörnulf JW, Heilig M, Jerlhag E.

Physiol Behav. 2018 Feb 1;184:211-219. doi: 10.1016/j.physbeh.2017.12.005. Epub 2017 Dec 6.


Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [11C] PHNO-PET pilot trial in healthy humans.

Malik S, Jacobs M, Cho SS, Boileau I, Blumberger D, Heilig M, Wilson A, Daskalakis ZJ, Strafella AP, Zangen A, Le Foll B.

Brain Imaging Behav. 2018 Oct;12(5):1306-1317. doi: 10.1007/s11682-017-9800-1.


Intermittent Access to Ethanol Induces Escalated Alcohol Consumption in Primates.

Lindell SG, Schwandt ML, Suomi SJ, Rice KC, Heilig M, Barr CS.

J Addict Behav Ther Rehabil. 2017 Apr;6(1). pii: 163. doi: 10.4172/2324-9005.1000163. Epub 2017 Apr 7.


Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques.

Baker M, Lindell SG, Driscoll CA, Zhou Z, Yuan Q, Schwandt ML, Miller-Crews I, Simpson EA, Paukner A, Ferrari PF, Sindhu RK, Razaqyar M, Sommer WH, Lopez JF, Thompson RC, Goldman D, Heilig M, Higley JD, Suomi SJ, Barr CS.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11769-11774. doi: 10.1073/pnas.1706206114. Epub 2017 Oct 16.


Substance P and the Neurokinin-1 Receptor: The New CRF.

Schank JR, Heilig M.

Int Rev Neurobiol. 2017;136:151-175. doi: 10.1016/bs.irn.2017.06.008. Epub 2017 Aug 18. Review.


mTORC and ProSAPiP1: How Alcohol Changes Synapses of Reward Circuitry.

Barbier E, Heilig M.

Neuron. 2017 Sep 27;96(1):6-8. doi: 10.1016/j.neuron.2017.09.016.


Selective Lesioning of Nuclear Factor-κB Activated Cells in the Nucleus Accumbens Shell Attenuates Alcohol Place Preference.

Nennig SE, Fulenwider HD, Chimberoff SH, Smith BM, Eskew JE, Sequeira MK, Karlsson C, Liang C, Chen JF, Heilig M, Schank JR.

Neuropsychopharmacology. 2018 Apr;43(5):1032-1040. doi: 10.1038/npp.2017.214. Epub 2017 Sep 13.


[Opioid prescription changes in Sweden 2000–2015].

Bäckryd E, Heilig M, Hoffmann M.

Lakartidningen. 2017 May 2;114. pii: EFUE. Swedish.


A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans.

Aoun EG, Jimenez VA, Vendruscolo LF, Walter NAR, Barbier E, Ferrulli A, Haass-Koffler CL, Darakjian P, Lee MR, Addolorato G, Heilig M, Hitzemann R, Koob GF, Grant KA, Leggio L.

Mol Psychiatry. 2018 Jun;23(6):1466-1473. doi: 10.1038/mp.2017.97. Epub 2017 May 2.


The GABAB Positive Allosteric Modulator ADX71441 Attenuates Alcohol Self-Administration and Relapse to Alcohol Seeking in Rats.

Augier E, Dulman RS, Damadzic R, Pilling A, Hamilton JP, Heilig M.

Neuropsychopharmacology. 2017 Aug;42(9):1789-1799. doi: 10.1038/npp.2017.53. Epub 2017 Mar 15.


Addiction research and theory: a commentary on the Surgeon General's Report on alcohol, drugs, and health.

Badiani A, Berridge KC, Heilig M, Nutt DJ, Robinson TE.

Addict Biol. 2018 Jan;23(1):3-5. doi: 10.1111/adb.12497. Epub 2017 Feb 21.


Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE): A Pilot Study in Alcohol-dependent Women.

Persson A, Back SE, Killeen TK, Brady KT, Schwandt ML, Heilig M, Magnusson Å.

J Addict Med. 2017 Mar/Apr;11(2):119-125. doi: 10.1097/ADM.0000000000000286.


Genetic Deletion of Neuronal PPARγ Enhances the Emotional Response to Acute Stress and Exacerbates Anxiety: An Effect Reversed by Rescue of Amygdala PPARγ Function.

Domi E, Uhrig S, Soverchia L, Spanagel R, Hansson AC, Barbier E, Heilig M, Ciccocioppo R, Ubaldi M.

J Neurosci. 2016 Dec 14;36(50):12611-12623. Epub 2016 Nov 3.


FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence.

Spagnolo PA, Ramchandani VA, Schwandt ML, Kwako LE, George DT, Mayo LM, Hillard CJ, Heilig M.

Alcohol Clin Exp Res. 2016 Nov;40(11):2426-2434. doi: 10.1111/acer.13210. Epub 2016 Sep 26.


Reprogramming of mPFC transcriptome and function in alcohol dependence.

Heilig M, Barbier E, Johnstone AL, Tapocik J, Meinhardt MW, Pfarr S, Wahlestedt C, Sommer WH.

Genes Brain Behav. 2017 Jan;16(1):86-100. doi: 10.1111/gbb.12344. Epub 2016 Nov 24. Review.


Erratum to: The melanin-concentrating hormone-1 receptor modulates alcohol-induced reward and DARPP-32 phosphorylation.

Karlsson C, Rehman F, Damadzic R, Atkins AL, Schank JR, Gehlert DR, Steensland P, Thorsell A, Heilig M.

Psychopharmacology (Berl). 2016 Oct;233(21-22):3825. No abstract available.


Effect of the CRF1-receptor antagonist pexacerfont on stress-induced eating and food craving.

Epstein DH, Kennedy AP, Furnari M, Heilig M, Shaham Y, Phillips KA, Preston KL.

Psychopharmacology (Berl). 2016 Dec;233(23-24):3921-3932. Epub 2016 Sep 5.


Melanin-Concentrating Hormone and Its MCH-1 Receptor: Relationship Between Effects on Alcohol and Caloric Intake.

Karlsson C, Aziz AM, Rehman F, Pitcairn C, Barchiesi R, Barbier E, Wendel Hansen M, Gehlert D, Steensland P, Heilig M, Thorsell A.

Alcohol Clin Exp Res. 2016 Oct;40(10):2199-2207. doi: 10.1111/acer.13181. Epub 2016 Aug 31.


Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2.

Barbier E, Johnstone AL, Khomtchouk BB, Tapocik JD, Pitcairn C, Rehman F, Augier E, Borich A, Schank JR, Rienas CA, Van Booven DJ, Sun H, Nätt D, Wahlestedt C, Heilig M.

Mol Psychiatry. 2017 Dec;22(12):1746-1758. doi: 10.1038/mp.2016.131. Epub 2016 Aug 30.


The nociceptin/orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models.

Aziz AM, Brothers S, Sartor G, Holm L, Heilig M, Wahlestedt C, Thorsell A.

Psychopharmacology (Berl). 2016 Oct;233(19-20):3553-63. doi: 10.1007/s00213-016-4385-8. Epub 2016 Aug 11.


OPRM1 genotype interacts with serotonin system dysfunction to predict alcohol-heightened aggression in primates.

Driscoll CA, Lindell SG, Schwandt ML, Suomi SJ, Higley JD, Heilig M, Barr CS.

Addict Biol. 2017 Nov;22(6):1655-1664. doi: 10.1111/adb.12428. Epub 2016 Aug 3.


A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology.

Bernardi RE, Zohsel K, Hirth N, Treutlein J, Heilig M, Laucht M, Spanagel R, Sommer WH.

Transl Psychiatry. 2016 Jul 26;6(7):e861. doi: 10.1038/tp.2016.132.


The mGluR2 Positive Allosteric Modulator, AZD8529, and Cue-Induced Relapse to Alcohol Seeking in Rats.

Augier E, Dulman RS, Rauffenbart C, Augier G, Cross AJ, Heilig M.

Neuropsychopharmacology. 2016 Nov;41(12):2932-2940. doi: 10.1038/npp.2016.107. Epub 2016 Jun 24.


Time to connect: bringing social context into addiction neuroscience.

Heilig M, Epstein DH, Nader MA, Shaham Y.

Nat Rev Neurosci. 2016 Sep;17(9):592-9. doi: 10.1038/nrn.2016.67. Epub 2016 Jun 9. Review.


Proinflammatory signaling regulates voluntary alcohol intake and stress-induced consumption after exposure to social defeat stress in mice.

Karlsson C, Schank JR, Rehman F, Stojakovic A, Björk K, Barbier E, Solomon M, Tapocik J, Engblom D, Thorsell A, Heilig M.

Addict Biol. 2017 Sep;22(5):1279-1288. doi: 10.1111/adb.12416. Epub 2016 Jun 7.


The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research.

Heilig M, Sommer WH, Spanagel R.

Curr Top Behav Neurosci. 2016;28:151-71. doi: 10.1007/7854_2015_5006. Review.


Characterization of comorbid PTSD in treatment-seeking alcohol dependent inpatients: Severity and personality trait differences.

Sells JR, Waters AJ, Schwandt ML, Kwako LE, Heilig M, George DT, Ramchandani VA.

Drug Alcohol Depend. 2016 Jun 1;163:242-6. doi: 10.1016/j.drugalcdep.2016.03.016. Epub 2016 Mar 26.


The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But not of Anti-Craving Effects.

Schwandt ML, Cortes CR, Kwako LE, George DT, Momenan R, Sinha R, Grigoriadis DE, Pich EM, Leggio L, Heilig M.

Neuropsychopharmacology. 2016 Nov;41(12):2818-2829. doi: 10.1038/npp.2016.61. Epub 2016 Apr 25.

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