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Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11]CURB.

Best LM, Williams B, Le Foll B, Mansouri E, Bazinet RP, Lin L, De Luca V, Lagzdins D, Rusjan P, Tyndale RF, Wilson AA, Hendershot CS, Heilig M, Houle S, Tong J, Kish SJ, Boileau I.

Neuropsychopharmacology. 2020 Jan 7. doi: 10.1038/s41386-020-0606-2. [Epub ahead of print]


Repetitive transcranial magnetic stimulation targeting the insular cortex for reduction of heavy drinking in treatment-seeking alcohol-dependent subjects: a randomized controlled trial.

Perini I, Kämpe R, Arlestig T, Karlsson H, Löfberg A, Pietrzak M, Zangen A, Heilig M.

Neuropsychopharmacology. 2019 Nov 11. doi: 10.1038/s41386-019-0565-7. [Epub ahead of print]


Fear conditioning and extinction in alcohol dependence: Evidence for abnormal amygdala reactivity.

Muench C, Charlet K, Balderston NL, Grillon C, Heilig M, Cortes CR, Momenan R, Lohoff FW.

Addict Biol. 2019 Nov 8:e12835. doi: 10.1111/adb.12835. [Epub ahead of print]


Reliability of the Addiction Severity Index self-report form (ASI-SR): a self-administered questionnaire based on the Addiction Severity Index composite score domains.

Ljungvall H, Persson A, Åsenlöf P, Heilig M, Ekselius L.

Nord J Psychiatry. 2020 Jan;74(1):9-15. doi: 10.1080/08039488.2019.1666300. Epub 2019 Nov 7.


Activation of PPARγ Attenuates the Expression of Physical and Affective Nicotine Withdrawal Symptoms through Mechanisms Involving Amygdala and Hippocampus Neurotransmission.

Domi E, Caputi FF, Romualdi P, Domi A, Scuppa G, Candeletti S, Atkins A, Heilig M, Demopulos G, Gaitanaris G, Ciccocioppo R, Ubaldi M.

J Neurosci. 2019 Dec 4;39(49):9864-9875. doi: 10.1523/JNEUROSCI.1922-19.2019. Epub 2019 Nov 4.


Developing neuroscience-based treatments for alcohol addiction: A matter of choice?

Heilig M, Augier E, Pfarr S, Sommer WH.

Transl Psychiatry. 2019 Oct 8;9(1):255. doi: 10.1038/s41398-019-0591-6. Review.


Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial.

Mayo LM, Asratian A, Lindé J, Morena M, Haataja R, Hammar V, Augier G, Hill MN, Heilig M.

Biol Psychiatry. 2019 Aug 13. pii: S0006-3223(19)31589-6. doi: 10.1016/j.biopsych.2019.07.034. [Epub ahead of print]


Brain-based Classification of Negative Social Bias in Adolescents With Nonsuicidal Self-injury: Findings From Simulated Online Social Interaction.

Perini I, Gustafsson PA, Hamilton JP, Kämpe R, Mayo LM, Heilig M, Zetterqvist M.

EClinicalMedicine. 2019 Jul 6;13:81-90. doi: 10.1016/j.eclinm.2019.06.016. eCollection 2019 Aug.


Alcohol use disorders.

Carvalho AF, Heilig M, Perez A, Probst C, Rehm J.

Lancet. 2019 Aug 31;394(10200):781-792. doi: 10.1016/S0140-6736(19)31775-1. Review.


ICD-11 for Alcohol Use Disorders: Not a Convincing Answer to the Challenges.

Rehm J, Heilig M, Gual A.

Alcohol Clin Exp Res. 2019 Nov;43(11):2296-2300. doi: 10.1111/acer.14182. Epub 2019 Sep 5. No abstract available.


Lessons learned from community-based tuberculosis case-finding in western Kenya.

Okelloh D, Achola M, Opole J, Ogwang C, Agaya J, Sifuna P, Mchembere W, Cowden J, Heilig M, Borgdorff MW, Yuen CM, Cain KP.

Public Health Action. 2019 Jun 21;9(2):53-57. doi: 10.5588/pha.18.0085.


Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways.

Johnstone AL, Andrade NS, Barbier E, Khomtchouk BB, Rienas CA, Lowe K, Van Booven DJ, Domi E, Esanov R, Vilca S, Tapocik JD, Rodriguez K, Maryanski D, Keogh MC, Meinhardt MW, Sommer WH, Heilig M, Zeier Z, Wahlestedt C.

Addict Biol. 2019 Aug 1:e12816. doi: 10.1111/adb.12816. [Epub ahead of print]


Escalated Alcohol Self-Administration and Sensitivity to Yohimbine-Induced Reinstatement in Alcohol Preferring Rats: Potential Role of Neurokinin-1 Receptors in the Amygdala.

Nelson BS, Fulenwider HD, Nennig SE, Smith BM, Sequeira MK, Chimberoff SH, Richie CT, Cheng K, Rice KC, Harvey BK, Heilig M, Schank JR.

Neuroscience. 2019 Aug 10;413:77-85. doi: 10.1016/j.neuroscience.2019.06.023. Epub 2019 Jun 23.


In the face of stress: Interpreting individual differences in stress-induced facial expressions.

Mayo LM, Heilig M.

Neurobiol Stress. 2019 Apr 20;10:100166. doi: 10.1016/j.ynstr.2019.100166. eCollection 2019 Feb. Review.


Variation in the μ-Opioid Receptor Gene (OPRM1) Does Not Moderate Social-Rejection Sensitivity in Humans.

Persson E, Asutay E, Heilig M, Löfberg A, Pedersen N, Västfjäll D, Tinghög G.

Psychol Sci. 2019 Jul;30(7):1050-1062. doi: 10.1177/0956797619849894. Epub 2019 Jun 10.


A Hippocampal Signature of Posttraumatic Stress Disorder Vulnerability.

Mayo LM, Heilig M.

Biol Psychiatry. 2018 Jul 15;84(2):78-79. doi: 10.1016/j.biopsych.2018.04.015. Epub 2018 Jun 29. No abstract available.


Striatal Dopamine Release in Response to Morphine: A [11C]Raclopride Positron Emission Tomography Study in Healthy Men.

Spagnolo PA, Kimes A, Schwandt ML, Shokri-Kojori E, Thada S, Phillips KA, Diazgranados N, Preston KL, Herscovitch P, Tomasi D, Ramchandani VA, Heilig M.

Biol Psychiatry. 2019 Sep 1;86(5):356-364. doi: 10.1016/j.biopsych.2019.03.965. Epub 2019 Mar 15.


Efficacy of repetitive transcranial magnetic stimulation using a figure-8-coil or an H1-Coil in treatment of major depressive disorder; A randomized clinical trial.

Filipčić I, Šimunović Filipčić I, Milovac Ž, Sučić S, Gajšak T, Ivezić E, Bašić S, Bajić Ž, Heilig M.

J Psychiatr Res. 2019 Jul;114:113-119. doi: 10.1016/j.jpsychires.2019.04.020. Epub 2019 Apr 26.


Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans.

Ree A, Morrison I, Olausson H, Sailer U, Heilig M, Mayo LM.

J Vis Exp. 2019 Mar 15;(145). doi: 10.3791/59228.


Distinction of self-produced touch and social touch at cortical and spinal cord levels.

Boehme R, Hauser S, Gerling GJ, Heilig M, Olausson H.

Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2290-2299. doi: 10.1073/pnas.1816278116. Epub 2019 Jan 22.


Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: a concurrent 11C-raclopride positron emission tomography and functional magnetic resonance imaging investigation.

Hamilton JP, Sacchet MD, Hjørnevik T, Chin FT, Shen B, Kämpe R, Park JH, Knutson BD, Williams LM, Borg N, Zaharchuk G, Camacho MC, Mackey S, Heilig M, Drevets WC, Glover GH, Gambhir SS, Gotlib IH.

Transl Psychiatry. 2018 Nov 30;8(1):264. doi: 10.1038/s41398-018-0316-2.


Lack of Target Engagement Following Low-Frequency Deep Transcranial Magnetic Stimulation of the Anterior Insula.

Spagnolo PA, Wang H, Srivanitchapoom P, Schwandt M, Heilig M, Hallett M.

Neuromodulation. 2019 Dec;22(8):877-883. doi: 10.1111/ner.12875. Epub 2018 Oct 29.


Science-Based Actions Can Help Address the Opioid Crisis.

Epstein DH, Heilig M, Shaham Y.

Trends Pharmacol Sci. 2018 Nov;39(11):911-916. doi: 10.1016/ Review.


Neural Correlates of Compulsive Alcohol Seeking in Heavy Drinkers.

Grodin EN, Sussman L, Sundby K, Brennan GM, Diazgranados N, Heilig M, Momenan R.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Dec;3(12):1022-1031. doi: 10.1016/j.bpsc.2018.06.009. Epub 2018 Jul 9.


Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice.

Mayo LM, Asratian A, Lindé J, Holm L, Nätt D, Augier G, Stensson N, Vecchiarelli HA, Balsevich G, Aukema RJ, Ghafouri B, Spagnolo PA, Lee FS, Hill MN, Heilig M.

Mol Psychiatry. 2018 Aug 17. doi: 10.1038/s41380-018-0215-1. [Epub ahead of print]


Assessment of pioglitazone and proinflammatory cytokines during buprenorphine taper in patients with opioid use disorder.

Schroeder JR, Phillips KA, Epstein DH, Jobes ML, Furnari MA, Kennedy AP, Heilig M, Preston KL.

Psychopharmacology (Berl). 2018 Oct;235(10):2957-2966. doi: 10.1007/s00213-018-4986-5. Epub 2018 Aug 6.


Putting a good face on touch: Facial expression reflects the affective valence of caress-like touch across modalities.

Mayo LM, Lindé J, Olausson H, Heilig M, Morrison I.

Biol Psychol. 2018 Sep;137:83-90. doi: 10.1016/j.biopsycho.2018.07.001. Epub 2018 Jul 9.


A molecular mechanism for choosing alcohol over an alternative reward.

Augier E, Barbier E, Dulman RS, Licheri V, Augier G, Domi E, Barchiesi R, Farris S, Nätt D, Mayfield RD, Adermark L, Heilig M.

Science. 2018 Jun 22;360(6395):1321-1326. doi: 10.1126/science.aao1157.


The neurokinin-1 receptor mediates escalated alcohol intake induced by multiple drinking models.

Sequeira MK, Nelson BS, Fulenwider HD, King CE, Nennig SE, Bohannon JB, Cheng K, Rice KC, Heilig M, Schank JR.

Neuropharmacology. 2018 Jul 15;137:194-201. doi: 10.1016/j.neuropharm.2018.05.005. Epub 2018 May 3.


The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study.

Lee MR, Tapocik JD, Ghareeb M, Schwandt ML, Dias AA, Le AN, Cobbina E, Farinelli LA, Bouhlal S, Farokhnia M, Heilig M, Akhlaghi F, Leggio L.

Mol Psychiatry. 2020 Feb;25(2):461-475. doi: 10.1038/s41380-018-0064-y. Epub 2018 May 4.


Do we have an opioid crisis in Scandinavia? Time to act?

Heilig M, Tägil M.

Acta Orthop. 2018 Aug;89(4):368. doi: 10.1080/17453674.2018.1465285. Epub 2018 May 1. No abstract available.


The salience of self, not social pain, is encoded by dorsal anterior cingulate and insula.

Perini I, Gustafsson PA, Hamilton JP, Kämpe R, Zetterqvist M, Heilig M.

Sci Rep. 2018 Apr 18;8(1):6165. doi: 10.1038/s41598-018-24658-8.


Genetic Association and Expression Analyses of the Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) Gene in Alcohol Use Disorder-Relevance for Pain Signaling and Alcohol Use.

Lee JS, Sorcher JL, Rosen AD, Damadzic R, Sun H, Schwandt M, Heilig M, Kelly J, Mauro KL, Luo A, Rosoff D, Muench C, Jung J, Kaminsky ZA, Lohoff FW.

Alcohol Clin Exp Res. 2018 Jun;42(6):1034-1043. doi: 10.1111/acer.13751. Epub 2018 May 9.


Study of homogeneous bubble nucleation in liquid carbon dioxide by a hybrid approach combining molecular dynamics simulation and density gradient theory.

Langenbach K, Heilig M, Horsch M, Hasse H.

J Chem Phys. 2018 Mar 28;148(12):124702. doi: 10.1063/1.5022231.


Preclinical evaluation of the kappa-opioid receptor antagonist CERC-501 as a candidate therapeutic for alcohol use disorders.

Domi E, Barbier E, Augier E, Augier G, Gehlert D, Barchiesi R, Thorsell A, Holm L, Heilig M.

Neuropsychopharmacology. 2018 Aug;43(9):1805-1812. doi: 10.1038/s41386-018-0015-y. Epub 2018 Feb 5.


Several behavioral traits relevant for alcoholism are controlled by ɣ2 subunit containing GABAA receptors on dopamine neurons in mice.

Stojakovic A, Walczak M, Cieślak PE, Trenk A, Sköld J, Zajdel J, Mirrasekhian E, Karlsson C, Thorsell A, Heilig M, Parkitna JR, Błasiak T, Engblom D.

Neuropsychopharmacology. 2018 Jun;43(7):1548-1556. doi: 10.1038/s41386-018-0022-z. Epub 2018 Feb 5.


Neural responses to cues paired with methamphetamine in healthy volunteers.

Van Hedger K, Keedy SK, Mayo LM, Heilig M, de Wit H.

Neuropsychopharmacology. 2018 Jul;43(8):1732-1737. doi: 10.1038/s41386-017-0005-5. Epub 2018 Jan 30.


Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model.

Zallar LJ, Tunstall BJ, Richie CT, Zhang YJ, You ZB, Gardner EL, Heilig M, Pickel J, Koob GF, Vendruscolo LF, Harvey BK, Leggio L.

Int J Obes (Lond). 2019 Feb;43(2):344-354. doi: 10.1038/s41366-018-0013-5. Epub 2018 Jan 30.


Insula Sensitivity to Unfairness in Alcohol Use Disorder.

Cortes CR, Grodin EN, Mann CL, Mathur K, Kerich M, Zhu X, Schwandt M, Diazgranados N, George DT, Momenan R, Heilig M.

Alcohol Alcohol. 2018 May 1;53(3):201-208. doi: 10.1093/alcalc/agx115.


[The National Board of Health and Welfare's target levels signal a lack of trust].

Bejerot S, Landén M, Heilig M, Anckarsäter H, Waern M.

Lakartidningen. 2017 Nov 3;114. pii: EWFR. Swedish. No abstract available.


A cannabinoid receptor antagonist attenuates ghrelin-induced activation of the mesolimbic dopamine system in mice.

Kalafateli AL, Vallöf D, Jörnulf JW, Heilig M, Jerlhag E.

Physiol Behav. 2018 Feb 1;184:211-219. doi: 10.1016/j.physbeh.2017.12.005. Epub 2017 Dec 6.


Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [11C] PHNO-PET pilot trial in healthy humans.

Malik S, Jacobs M, Cho SS, Boileau I, Blumberger D, Heilig M, Wilson A, Daskalakis ZJ, Strafella AP, Zangen A, Le Foll B.

Brain Imaging Behav. 2018 Oct;12(5):1306-1317. doi: 10.1007/s11682-017-9800-1.


Intermittent Access to Ethanol Induces Escalated Alcohol Consumption in Primates.

Lindell SG, Schwandt ML, Suomi SJ, Rice KC, Heilig M, Barr CS.

J Addict Behav Ther Rehabil. 2017 Apr;6(1). pii: 163. doi: 10.4172/2324-9005.1000163. Epub 2017 Apr 7.


Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques.

Baker M, Lindell SG, Driscoll CA, Zhou Z, Yuan Q, Schwandt ML, Miller-Crews I, Simpson EA, Paukner A, Ferrari PF, Sindhu RK, Razaqyar M, Sommer WH, Lopez JF, Thompson RC, Goldman D, Heilig M, Higley JD, Suomi SJ, Barr CS.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11769-11774. doi: 10.1073/pnas.1706206114. Epub 2017 Oct 16.


Substance P and the Neurokinin-1 Receptor: The New CRF.

Schank JR, Heilig M.

Int Rev Neurobiol. 2017;136:151-175. doi: 10.1016/bs.irn.2017.06.008. Epub 2017 Aug 18. Review.


mTORC and ProSAPiP1: How Alcohol Changes Synapses of Reward Circuitry.

Barbier E, Heilig M.

Neuron. 2017 Sep 27;96(1):6-8. doi: 10.1016/j.neuron.2017.09.016.


Selective Lesioning of Nuclear Factor-κB Activated Cells in the Nucleus Accumbens Shell Attenuates Alcohol Place Preference.

Nennig SE, Fulenwider HD, Chimberoff SH, Smith BM, Eskew JE, Sequeira MK, Karlsson C, Liang C, Chen JF, Heilig M, Schank JR.

Neuropsychopharmacology. 2018 Apr;43(5):1032-1040. doi: 10.1038/npp.2017.214. Epub 2017 Sep 13.


[Opioid prescription changes in Sweden 2000–2015].

Bäckryd E, Heilig M, Hoffmann M.

Lakartidningen. 2017 May 2;114. pii: EFUE. Swedish.


A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans.

Aoun EG, Jimenez VA, Vendruscolo LF, Walter NAR, Barbier E, Ferrulli A, Haass-Koffler CL, Darakjian P, Lee MR, Addolorato G, Heilig M, Hitzemann R, Koob GF, Grant KA, Leggio L.

Mol Psychiatry. 2018 Jun;23(6):1466-1473. doi: 10.1038/mp.2017.97. Epub 2017 May 2.


The GABAB Positive Allosteric Modulator ADX71441 Attenuates Alcohol Self-Administration and Relapse to Alcohol Seeking in Rats.

Augier E, Dulman RS, Damadzic R, Pilling A, Hamilton JP, Heilig M.

Neuropsychopharmacology. 2017 Aug;42(9):1789-1799. doi: 10.1038/npp.2017.53. Epub 2017 Mar 15.

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