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Items: 9

1.

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies.

Nalls MA, Blauwendraat C, Vallerga CL, Heilbron K, Bandres-Ciga S, Chang D, Tan M, Kia DA, Noyce AJ, Xue A, Bras J, Young E, von Coelln R, Simón-Sánchez J, Schulte C, Sharma M, Krohn L, Pihlstrøm L, Siitonen A, Iwaki H, Leonard H, Faghri F, Gibbs JR, Hernandez DG, Scholz SW, Botia JA, Martinez M, Corvol JC, Lesage S, Jankovic J, Shulman LM, Sutherland M, Tienari P, Majamaa K, Toft M, Andreassen OA, Bangale T, Brice A, Yang J, Gan-Or Z, Gasser T, Heutink P, Shulman JM, Wood NW, Hinds DA, Hardy JA, Morris HR, Gratten J, Visscher PM, Graham RR, Singleton AB; 23andMe Research Team; System Genomics of Parkinson's Disease Consortium; International Parkinson's Disease Genomics Consortium.

Lancet Neurol. 2019 Dec;18(12):1091-1102. doi: 10.1016/S1474-4422(19)30320-5.

PMID:
31701892
2.

The Parkinson's Disease Mendelian Randomization Research Portal.

Noyce AJ, Bandres-Ciga S, Kim J, Heilbron K, Kia D, Hemani G, Xue A, Lawlor DA, Smith GD, Duran R, Gan-Or Z, Blauwendraat C, Gibbs JR; 23andMe Research Team5, International Parkinson's Disease Genomics Consortium (IPDGC), Hinds DA, Yang J, Visscher P, Cuzick J, Morris H, Hardy J, Wood NW, Nalls MA, Singleton AB.

Mov Disord. 2019 Oct 28. doi: 10.1002/mds.27873. [Epub ahead of print]

PMID:
31659794
3.

Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.

Blauwendraat C, Heilbron K, Vallerga CL, Bandres-Ciga S, von Coelln R, Pihlstrøm L, Simón-Sánchez J, Schulte C, Sharma M, Krohn L, Siitonen A, Iwaki H, Leonard H, Noyce AJ, Tan M, Gibbs JR, Hernandez DG, Scholz SW, Jankovic J, Shulman LM, Lesage S, Corvol JC, Brice A, van Hilten JJ, Marinus J; 23andMe Research Team, Eerola-Rautio J, Tienari P, Majamaa K, Toft M, Grosset DG, Gasser T, Heutink P, Shulman JM, Wood N, Hardy J, Morris HR, Hinds DA, Gratten J, Visscher PM, Gan-Or Z, Nalls MA, Singleton AB; International Parkinson's Disease Genomics Consortium (IPDGC).

Mov Disord. 2019 Jun;34(6):866-875. doi: 10.1002/mds.27659. Epub 2019 Apr 7.

PMID:
30957308
4.

The Parkinson's phenome-traits associated with Parkinson's disease in a broadly phenotyped cohort.

Heilbron K, Noyce AJ, Fontanillas P, Alipanahi B, Nalls MA; 23andMe Research Team, Cannon P.

NPJ Parkinsons Dis. 2019 Mar 27;5:4. doi: 10.1038/s41531-019-0077-5. eCollection 2019.

5.

The genomic basis of adaptation to the fitness cost of rifampicin resistance in Pseudomonas aeruginosa.

Qi Q, Toll-Riera M, Heilbron K, Preston GM, MacLean RC.

Proc Biol Sci. 2016 Jan 13;283(1822). pii: 20152452. doi: 10.1098/rspb.2015.2452.

6.

Discriminating selection on lateral plate phenotype and its underlying gene, Ectodysplasin, in threespine stickleback.

Rennison DJ, Heilbron K, Barrett RD, Schluter D.

Am Nat. 2015 Jan;185(1):150-6. doi: 10.1086/679280. Epub 2014 Nov 19.

PMID:
25560560
7.

Fitness is strongly influenced by rare mutations of large effect in a microbial mutation accumulation experiment.

Heilbron K, Toll-Riera M, Kojadinovic M, MacLean RC.

Genetics. 2014 Jul;197(3):981-90. doi: 10.1534/genetics.114.163147. Epub 2014 May 8.

8.

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity.

Marchant DJ, Bellac CL, Moraes TJ, Wadsworth SJ, Dufour A, Butler GS, Bilawchuk LM, Hendry RG, Robertson AG, Cheung CT, Ng J, Ang L, Luo Z, Heilbron K, Norris MJ, Duan W, Bucyk T, Karpov A, Devel L, Georgiadis D, Hegele RG, Luo H, Granville DJ, Dive V, McManus BM, Overall CM.

Nat Med. 2014 May;20(5):493-502. doi: 10.1038/nm.3508. Epub 2014 Apr 28.

PMID:
24784232
9.

Positive epistasis between co-infecting plasmids promotes plasmid survival in bacterial populations.

San Millan A, Heilbron K, MacLean RC.

ISME J. 2014 Mar;8(3):601-12. doi: 10.1038/ismej.2013.182. Epub 2013 Oct 24.

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