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Items: 1 to 50 of 200

1.

Incidence and long-term outcomes of surgically treated childhood hepatic malignancies in Finland.

Tiusanen T, Hukkinen M, Leskinen O, Soini T, Kanerva JA, Jahnukainen T, Mäkisalo H, Heikinheimo M, Pakarinen MP.

Acta Paediatr. 2020 Feb;109(2):404-414. doi: 10.1111/apa.14952. Epub 2019 Aug 25.

PMID:
31350767
2.

GnRH-agonist deslorelin implant alters the progesterone release pattern during early pregnancy in gilts.

Haen SM, Heinonen M, Kauffold J, Heikinheimo M, Hoving LL, Soede NM, Peltoniemi OAT.

Reprod Domest Anim. 2019 Mar;54(3):464-472. doi: 10.1111/rda.13376. Epub 2019 Jan 11.

PMID:
30431675
3.

Transcription factor GATA4 associates with mesenchymal-like gene expression in human hepatoblastoma cells.

Soini T, Eloranta K, Pihlajoki M, Kyrönlahti A, Akinrinade O, Andersson N, Lohi J, Pakarinen MP, Wilson DB, Heikinheimo M.

Tumour Biol. 2018 Jul;40(7):1010428318785498. doi: 10.1177/1010428318785498.

PMID:
30074440
4.

Other Primary Malignancies Among Women With Adult-Type Ovarian Granulosa Cell Tumors.

Bryk S, Pukkala E, Färkkilä A, Heikinheimo M, Unkila-Kallio L, Riska A.

Int J Gynecol Cancer. 2018 Oct;28(8):1529-1534. doi: 10.1097/IGC.0000000000001333.

PMID:
30036228
5.

Haematopoietic Stem Cell Transplantation in Children Shifts the Coagulation System towards a Pro-Coagulant State.

Långström S, Koskenvuo M, Huttunen P, Lassila R, Taskinen M, Ranta S, Heikinheimo M, Mäkipernaa A.

Thromb Haemost. 2018 Aug;118(8):1390-1396. doi: 10.1055/s-0038-1661394. Epub 2018 Jun 30.

PMID:
29960273
6.

Transcription factor GATA6: a novel marker and putative inducer of ductal metaplasia in biliary atresia.

Soini T, Pihlajoki M, Andersson N, Lohi J, Huppert KA, Rudnick DA, Huppert SS, Wilson DB, Pakarinen MP, Heikinheimo M.

Am J Physiol Gastrointest Liver Physiol. 2018 May 1;314(5):G547-G558. doi: 10.1152/ajpgi.00362.2017. Epub 2018 Feb 1.

7.

Prothrombotic state in young females with severe early-onset obesity.

Loid P, Långström S, Viljakainen H, Mäkipernaa A, Heikinheimo M, Mäkitie O.

Pediatr Res. 2018 Jan;83(1-1):2-4. doi: 10.1038/pr.2017.248. Epub 2017 Oct 25. No abstract available.

PMID:
29068434
8.

Probing GATA factor function in mouse Leydig cells via testicular injection of adenoviral vectors.

Penny GM, Cochran RB, Pihlajoki M, Kyrönlahti A, Schrade A, Häkkinen M, Toppari J, Heikinheimo M, Wilson DB.

Reproduction. 2017 Oct;154(4):455-467. doi: 10.1530/REP-17-0311. Epub 2017 Jul 14.

9.

Downregulation of transcription factor GATA4 sensitizes human hepatoblastoma cells to doxorubicin-induced apoptosis.

Soini T, Pihlajoki M, Kyrönlahti A, Andersson LC, Wilson DB, Heikinheimo M.

Tumour Biol. 2017 Mar;39(3):1010428317695016. doi: 10.1177/1010428317695016.

PMID:
28349834
10.

Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary.

Färkkilä A, Haltia UM, Tapper J, McConechy MK, Huntsman DG, Heikinheimo M.

Ann Med. 2017 Aug;49(5):435-447. doi: 10.1080/07853890.2017.1294760. Epub 2017 Mar 6. Review.

PMID:
28276867
11.

Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells.

Haltia UM, Andersson N, Yadav B, Färkkilä A, Kulesskiy E, Kankainen M, Tang J, Bützow R, Riska A, Leminen A, Heikinheimo M, Kallioniemi O, Unkila-Kallio L, Wennerberg K, Aittokallio T, Anttonen M.

Gynecol Oncol. 2017 Mar;144(3):621-630. doi: 10.1016/j.ygyno.2016.12.016. Epub 2017 Jan 16.

PMID:
28104295
12.

Roles of human epididymis protein 4, carbohydrate antigen 125, inhibin B and anti-Müllerian hormone in the differential diagnosis and follow-up of ovarian granulosa cell tumors.

Haltia UM, Hallamaa M, Tapper J, Hynninen J, Alfthan H, Kalra B, Ritvos O, Heikinheimo M, Unkila-Kallio L, Perheentupa A, Färkkilä A.

Gynecol Oncol. 2017 Jan;144(1):83-89. doi: 10.1016/j.ygyno.2016.11.018. Epub 2016 Nov 18.

PMID:
27871721
13.

Circulating levels of TNF-related apoptosis inducing-ligand are decreased in patients with large adult-type granulosa cell tumors-implications for therapeutic potential.

Färkkilä A, Zauli G, Haltia UM, Pihlajoki M, Unkila-Kallio L, Secchiero P, Heikinheimo M.

Tumour Biol. 2016 Sep;37(9):11909-11916. Epub 2016 Apr 11.

PMID:
27067438
14.

Characteristics and outcome of recurrence in molecularly defined adult-type ovarian granulosa cell tumors.

Bryk S, Färkkilä A, Bützow R, Leminen A, Tapper J, Heikinheimo M, Unkila-Kallio L, Riska A.

Gynecol Oncol. 2016 Dec;143(3):571-577. doi: 10.1016/j.ygyno.2016.10.002. Epub 2016 Oct 10.

PMID:
27729108
15.

GLI1+ progenitor cells in the adrenal capsule of the adult mouse give rise to heterotopic gonadal-like tissue.

Dörner J, Martinez Rodriguez V, Ziegler R, Röhrig T, Cochran RS, Götz RM, Levin MD, Pihlajoki M, Heikinheimo M, Wilson DB.

Mol Cell Endocrinol. 2017 Feb 5;441:164-175. doi: 10.1016/j.mce.2016.08.043. Epub 2016 Aug 29.

16.

Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype.

McConechy MK, Färkkilä A, Horlings HM, Talhouk A, Unkila-Kallio L, van Meurs HS, Yang W, Rozenberg N, Andersson N, Zaby K, Bryk S, Bützow R, Halfwerk JB, Hooijer GK, van de Vijver MJ, Buist MR, Kenter GG, Brucker SY, Krämer B, Staebler A, Bleeker MC, Heikinheimo M, Kommoss S, Blake Gilks C, Anttonen M, Huntsman DG.

J Natl Cancer Inst. 2016 Jun 13;108(11). pii: djw134. doi: 10.1093/jnci/djw134. Print 2016 Nov. Erratum in: J Natl Cancer Inst. 2017 Apr 1;109(4):.

17.

GATA4 Regulates Blood-Testis Barrier Function and Lactate Metabolism in Mouse Sertoli Cells.

Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Fischer S, Rodriguez VM, Otte K, Velagapudi V, Toppari J, Wilson DB, Heikinheimo M.

Endocrinology. 2016 Jun;157(6):2416-31. doi: 10.1210/en.2015-1927. Epub 2016 Mar 14.

18.

GATA factors in endocrine neoplasia.

Pihlajoki M, Färkkilä A, Soini T, Heikinheimo M, Wilson DB.

Mol Cell Endocrinol. 2016 Feb 5;421:2-17. doi: 10.1016/j.mce.2015.05.027. Epub 2015 May 28. Review.

19.

Testicular steroidogenic cells to the rescue.

Heikinheimo M, Pihlajoki M, Schrade A, Kyrönlahti A, Wilson DB.

Endocrinology. 2015 May;156(5):1616-9. doi: 10.1210/en.2015-1222. No abstract available.

PMID:
25886071
20.

The clinical utility of serum anti-Müllerian hormone in the follow-up of ovarian adult-type granulosa cell tumors--A comparative study with inhibin B.

Färkkilä A, Koskela S, Bryk S, Alfthan H, Bützow R, Leminen A, Puistola U, Tapanainen JS, Heikinheimo M, Anttonen M, Unkila-Kallio L.

Int J Cancer. 2015 Oct 1;137(7):1661-71. doi: 10.1002/ijc.29532. Epub 2015 Apr 11.

21.

Adrenocortical zonation, renewal, and remodeling.

Pihlajoki M, Dörner J, Cochran RS, Heikinheimo M, Wilson DB.

Front Endocrinol (Lausanne). 2015 Mar 5;6:27. doi: 10.3389/fendo.2015.00027. eCollection 2015. Review.

22.

GATA4 is a key regulator of steroidogenesis and glycolysis in mouse Leydig cells.

Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Häkkinen M, Fischer S, Alastalo TP, Velagapudi V, Toppari J, Wilson DB, Heikinheimo M.

Endocrinology. 2015 May;156(5):1860-72. doi: 10.1210/en.2014-1931. Epub 2015 Feb 10.

23.

[Solid tumors in children].

Lohi O, Jahnukainen K, Huttunen P, Taskinen M, Taskinen S, Pakarinen M, Koivusalo A, Rintala R, Kanerva J, Grönroos M, Heikinheimo M, Vettenranta K.

Duodecim. 2014;130(20):2050-9. Review. Finnish.

PMID:
25558602
24.

Toying with fate: Redirecting the differentiation of adrenocortical progenitor cells into gonadal-like tissue.

Röhrig T, Pihlajoki M, Ziegler R, Cochran RS, Schrade A, Schillebeeckx M, Mitra RD, Heikinheimo M, Wilson DB.

Mol Cell Endocrinol. 2015 Jun 15;408:165-77. doi: 10.1016/j.mce.2014.12.003. Epub 2014 Dec 8. Review.

25.

Clinical characteristics and survival of patients with an adult-type ovarian granulosa cell tumor: a 56-year single-center experience.

Bryk S, Färkkilä A, Bützow R, Leminen A, Heikinheimo M, Anttonen M, Riska A, Unkila-Kallio L.

Int J Gynecol Cancer. 2015 Jan;25(1):33-41. doi: 10.1097/IGC.0000000000000304.

PMID:
25347095
26.

Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret.

Schillebeeckx M, Pihlajoki M, Gretzinger E, Yang W, Thol F, Hiller T, Löbs AK, Röhrig T, Schrade A, Cochran R, Jay PY, Heikinheimo M, Mitra RD, Wilson DB.

Mol Cell Endocrinol. 2015 Jan 5;399:122-30. doi: 10.1016/j.mce.2014.09.029. Epub 2014 Oct 5.

27.

Germ cell tumors in children and adolescents in Finland: trends over 1969-2008.

Pauniaho SL, Salonen J, Helminen M, Heikinheimo O, Vettenranta K, Heikinheimo M.

Cancer Causes Control. 2014 Oct;25(10):1337-41. doi: 10.1007/s10552-014-0439-6. Epub 2014 Jul 25.

PMID:
25060481
28.

HER2 and GATA4 are new prognostic factors for early-stage ovarian granulosa cell tumor-a long-term follow-up study.

Färkkilä A, Andersson N, Bützow R, Leminen A, Heikinheimo M, Anttonen M, Unkila-Kallio L.

Cancer Med. 2014 Jun;3(3):526-36. doi: 10.1002/cam4.230. Epub 2014 Mar 29.

29.

Late gadolinium enhancement (LGE) progresses with right ventricle volume in children after repair of tetralogy of fallot.

Ylitalo P, Pitkänen OM, Lauerma K, Holmström M, Rahkonen O, Heikinheimo M, Sairanen H, Jokinen E.

Int J Cardiol Heart Vessel. 2014 Feb 12;3:15-20. doi: 10.1016/j.ijchv.2014.01.002. eCollection 2014 Jun.

30.

Sensitivity of human granulosa cell tumor cells to epidermal growth factor receptor inhibition.

Andersson N, Anttonen M, Färkkilä A, Pihlajoki M, Bützow R, Unkila-Kallio L, Heikinheimo M.

J Mol Endocrinol. 2014 Mar 12;52(2):223-34. doi: 10.1530/JME-13-0286. Print 2014 Apr.

PMID:
24463098
31.

FOXL2, GATA4, and SMAD3 co-operatively modulate gene expression, cell viability and apoptosis in ovarian granulosa cell tumor cells.

Anttonen M, Pihlajoki M, Andersson N, Georges A, L'hôte D, Vattulainen S, Färkkilä A, Unkila-Kallio L, Veitia RA, Heikinheimo M.

PLoS One. 2014 Jan 9;9(1):e85545. doi: 10.1371/journal.pone.0085545. eCollection 2014.

32.

Never underestimate the complexity of remodeling.

Pihlajoki M, Heikinheimo M, Wilson DB.

Endocrinology. 2013 Dec;154(12):4446-9. doi: 10.1210/en.2013-1982. No abstract available.

PMID:
24273232
33.

Expression of Wnt and TGF-β pathway components and key adrenal transcription factors in adrenocortical tumors: association to carcinoma aggressiveness.

Parviainen H, Schrade A, Kiiveri S, Prunskaite-Hyyryläinen R, Haglund C, Vainio S, Wilson DB, Arola J, Heikinheimo M.

Pathol Res Pract. 2013 Aug;209(8):503-9. doi: 10.1016/j.prp.2013.06.002. Epub 2013 Jun 21.

34.

[Graduate schools under change--case report on a Finnish national graduate school].

Helve O, Lauronen J, Remes AM, Heikinheimo M, Mäkitie A.

Duodecim. 2013;129(5):514-20. Finnish.

PMID:
23520895
35.

Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice.

Pihlajoki M, Gretzinger E, Cochran R, Kyrönlahti A, Schrade A, Hiller T, Sullivan L, Shoykhet M, Schoeller EL, Brooks MD, Heikinheimo M, Wilson DB.

Endocrinology. 2013 May;154(5):1754-67. doi: 10.1210/en.2012-1892. Epub 2013 Mar 7.

36.

High prevalence of sacrococcygeal teratoma in Finland - a nationwide population-based study.

Pauniaho SL, Heikinheimo O, Vettenranta K, Salonen J, Stefanovic V, Ritvanen A, Rintala R, Heikinheimo M.

Acta Paediatr. 2013 Jun;102(6):e251-6. doi: 10.1111/apa.12211. Epub 2013 Mar 25.

PMID:
23432104
37.

[Evaluation of training of pediatric specialists].

Helve O, Korppi M, Qvist E, Rajantie J, Heikinheimo M.

Duodecim. 2013;129(1):64-9. Finnish.

PMID:
23431884
38.

The incidences of malignant gonadal and extragonadal germ cell tumors in males and females: a population-based study covering over 40 years in Finland.

Pauniaho SL, Salonen J, Helminen M, Vettenranta K, Heikinheimo M, Heikinheimo O.

Cancer Causes Control. 2012 Dec;23(12):1921-7. doi: 10.1007/s10552-012-0069-9. Epub 2012 Sep 26.

PMID:
23011538
39.

Thrombin formation and effect of unfractionated heparin during pediatric cardiac catheterization.

Chen D, Långström S, Petäjä J, Heikinheimo M, Pihkala J.

Catheter Cardiovasc Interv. 2013 Jun 1;81(7):1174-9. doi: 10.1002/ccd.24621. Epub 2013 Feb 26.

PMID:
22915548
40.

Adult ovarian granulosa cell tumor transcriptomics: prevalence of FOXL2 target genes misregulation gives insights into the pathogenic mechanism of the p.Cys134Trp somatic mutation.

Benayoun BA, Anttonen M, L'Hôte D, Bailly-Bechet M, Andersson N, Heikinheimo M, Veitia RA.

Oncogene. 2013 May 30;32(22):2739-46. doi: 10.1038/onc.2012.298. Epub 2012 Jul 16.

PMID:
22797072
41.

Enhanced thrombin generation and depressed anticoagulant function in children with pneumonia.

Långström S, Peltola V, Petäjä J, Ruuskanen O, Heikinheimo M.

Acta Paediatr. 2012 Sep;101(9):919-23. doi: 10.1111/j.1651-2227.2012.02746.x. Epub 2012 Jun 25.

PMID:
22646857
42.

GATA4 is a critical regulator of gonadectomy-induced adrenocortical tumorigenesis in mice.

Krachulec J, Vetter M, Schrade A, Löbs AK, Bielinska M, Cochran R, Kyrönlahti A, Pihlajoki M, Parviainen H, Jay PY, Heikinheimo M, Wilson DB.

Endocrinology. 2012 Jun;153(6):2599-611. doi: 10.1210/en.2011-2135. Epub 2012 Mar 28.

43.

Serum vascular endothelial growth factor A (VEGF) is elevated in patients with ovarian granulosa cell tumor (GCT), and VEGF inhibition by bevacizumab induces apoptosis in GCT in vitro.

Färkkilä A, Pihlajoki M, Tauriala H, Bützow R, Leminen A, Unkila-Kallio L, Heikinheimo M, Anttonen M.

J Clin Endocrinol Metab. 2011 Dec;96(12):E1973-81. doi: 10.1210/jc.2011-1812. Epub 2011 Oct 12.

PMID:
21994955
44.

Anti-Müllerian hormone inhibits growth of AMH type II receptor-positive human ovarian granulosa cell tumor cells by activating apoptosis.

Anttonen M, Färkkilä A, Tauriala H, Kauppinen M, Maclaughlin DT, Unkila-Kallio L, Bützow R, Heikinheimo M.

Lab Invest. 2011 Nov;91(11):1605-14. doi: 10.1038/labinvest.2011.116. Epub 2011 Aug 1.

45.

Transcription factor GATA-4 is abundantly expressed in childhood but not in adult liver tumors.

Soini T, Haveri H, Elo JM, Kauppinen M, Kyrönlahti A, Salo MK, Lohi J, Andersson LC, Wilson DB, Heikinheimo M.

J Pediatr Gastroenterol Nutr. 2012 Jan;54(1):101-8. doi: 10.1097/MPG.0b013e31822d52cf.

PMID:
21788913
46.

[Are there enough medical scientists in Finland?].

Renkonen R, Björkroth J, Helve O, Louhimo J, Rautava P, Remes A, Seppälä T, Turunen JP, Virjo I, Visakorpi T, Heikinheimo M.

Duodecim. 2011;127(10):1003-9. Finnish.

PMID:
21695999
47.

GATA4 deficiency impairs ovarian function in adult mice.

Kyrönlahti A, Vetter M, Euler R, Bielinska M, Jay PY, Anttonen M, Heikinheimo M, Wilson DB.

Biol Reprod. 2011 May;84(5):1033-44. doi: 10.1095/biolreprod.110.086850. Epub 2011 Jan 19.

48.

GATA4 regulates Sertoli cell function and fertility in adult male mice.

Kyrönlahti A, Euler R, Bielinska M, Schoeller EL, Moley KH, Toppari J, Heikinheimo M, Wilson DB.

Mol Cell Endocrinol. 2011 Feb 10;333(1):85-95. doi: 10.1016/j.mce.2010.12.019. Epub 2010 Dec 21.

49.

Expression of Transcription Factor GATA-6 in Alveolar Epithelial Cells Is Linked to Neonatal Lung Disease.

Vähätalo R, Asikainen TM, Karikoski R, Kinnula VL, White CW, Andersson S, Heikinheimo M, Myllärniemi M.

Neonatology. 2011;99(3):231-40. doi: 10.1159/000317827. Epub 2010 Nov 12.

50.

Vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 are highly expressed in ovarian granulosa cell tumors.

Färkkilä A, Anttonen M, Pociuviene J, Leminen A, Butzow R, Heikinheimo M, Unkila-Kallio L.

Eur J Endocrinol. 2011 Jan;164(1):115-22. doi: 10.1530/EJE-10-0849. Epub 2010 Nov 1.

PMID:
21041381

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