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Items: 40

1.

Atg7-knockdown reduces chemerin secretion in murine adipocytes.

Heinitz S, Gebhardt C, Piaggi P, Krüger J, Heyne H, Weiner J, Heiker JT, Stumvoll M, Blüher M, Baier L, Rudich A, Kovacs P, Tönjes A.

J Clin Endocrinol Metab. 2019 Jun 21. pii: jc.2018-01980. doi: 10.1210/jc.2018-01980. [Epub ahead of print]

PMID:
31225870
2.

A new p.(Ile66Serfs*93) IGF2 variant is associated with pre- and postnatal growth retardation.

Rockstroh D, Pfäffle H, Le Duc D, Rößler F, Schlensog-Schuster F, Heiker JT, Kratzsch J, Kiess W, Lemke JR, Abou Jamra R, Pfäffle R.

Eur J Endocrinol. 2019 Jan 1;180(1):K1-K13. doi: 10.1530/EJE-18-0601.

PMID:
30400067
3.

Letter to the Editor regarding Mörkl et al.'s paper: Gut microbiota, dietary intakes and intestinal permeability reflected by serum zonulin in women.

Scheffler L, Kovacs P, Fasano A, Heiker JT.

Eur J Nutr. 2018 Dec;57(8):2999-3000. doi: 10.1007/s00394-018-1835-6. No abstract available.

PMID:
30291419
4.

Novel Mutations in the Asparagine Synthetase Gene (ASNS) Associated With Microcephaly.

Schleinitz D, Seidel A, Stassart R, Klammt J, Hirrlinger PG, Winkler U, Köhler S, Heiker JT, Schönauer R, Bialek J, Krohn K, Hoffmann K, Kovacs P, Hirrlinger J.

Front Genet. 2018 Jul 13;9:245. doi: 10.3389/fgene.2018.00245. eCollection 2018.

5.

Molecular Mechanisms of Vaspin Action - From Adipose Tissue to Skin and Bone, from Blood Vessels to the Brain.

Weiner J, Zieger K, Pippel J, Heiker JT.

Adv Exp Med Biol. 2018 Jul 27. doi: 10.1007/5584_2018_241. [Epub ahead of print]

PMID:
30051323
6.

Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin.

Ulbricht D, Tindall CA, Oertwig K, Hanke S, Sträter N, Heiker JT.

Biol Chem. 2018 Sep 25;399(9):1079-1084. doi: 10.1515/hsz-2018-0108.

PMID:
29494334
7.

Widely Used Commercial ELISA Does Not Detect Precursor of Haptoglobin2, but Recognizes Properdin as a Potential Second Member of the Zonulin Family.

Scheffler L, Crane A, Heyne H, Tönjes A, Schleinitz D, Ihling CH, Stumvoll M, Freire R, Fiorentino M, Fasano A, Kovacs P, Heiker JT.

Front Endocrinol (Lausanne). 2018 Feb 5;9:22. doi: 10.3389/fendo.2018.00022. eCollection 2018.

8.

Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo.

Zieger K, Weiner J, Kunath A, Gericke M, Krause K, Kern M, Stumvoll M, Klöting N, Blüher M, Heiker JT.

Cell Mol Life Sci. 2018 Feb;75(4):727-742. doi: 10.1007/s00018-017-2658-y. Epub 2017 Sep 20.

9.

Vaspin suppresses cytokine-induced inflammation in 3T3-L1 adipocytes via inhibition of NFκB pathway.

Zieger K, Weiner J, Krause K, Schwarz M, Kohn M, Stumvoll M, Blüher M, Heiker JT.

Mol Cell Endocrinol. 2018 Jan 15;460:181-188. doi: 10.1016/j.mce.2017.07.022. Epub 2017 Jul 26.

PMID:
28756250
10.

Glycosylation of human vaspin (SERPINA12) and its impact on serpin activity, heparin binding and thermal stability.

Oertwig K, Ulbricht D, Hanke S, Pippel J, Bellmann-Sickert K, Sträter N, Heiker JT.

Biochim Biophys Acta Proteins Proteom. 2017 Sep;1865(9):1188-1194. doi: 10.1016/j.bbapap.2017.06.020. Epub 2017 Jun 29.

PMID:
28668641
11.

Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation.

Weiner J, Rohde K, Krause K, Zieger K, Klöting N, Kralisch S, Kovacs P, Stumvoll M, Blüher M, Böttcher Y, Heiker JT.

Mol Metab. 2017 Mar 28;6(6):482-493. doi: 10.1016/j.molmet.2017.03.004. eCollection 2017 Jun.

12.

Depletion of Jmjd1c impairs adipogenesis in murine 3T3-L1 cells.

Buerger F, Müller S, Ney N, Weiner J, Heiker JT, Kallendrusch S, Kovacs P, Schleinitz D, Thiery J, Stadler SC, Burkhardt R.

Biochim Biophys Acta Mol Basis Dis. 2017 Jul;1863(7):1709-1717. doi: 10.1016/j.bbadis.2017.05.011. Epub 2017 May 10.

13.

Thyroid hormones and browning of adipose tissue.

Weiner J, Hankir M, Heiker JT, Fenske W, Krause K.

Mol Cell Endocrinol. 2017 Dec 15;458:156-159. doi: 10.1016/j.mce.2017.01.011. Epub 2017 Jan 12. Review.

PMID:
28089823
14.

Dissociation Between Brown Adipose Tissue 18F-FDG Uptake and Thermogenesis in Uncoupling Protein 1-Deficient Mice.

Hankir MK, Kranz M, Keipert S, Weiner J, Andreasen SG, Kern M, Patt M, Klöting N, Heiker JT, Brust P, Hesse S, Jastroch M, Fenske WK.

J Nucl Med. 2017 Jul;58(7):1100-1103. doi: 10.2967/jnumed.116.186460. Epub 2017 Jan 12.

15.

Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice.

Weiner J, Kranz M, Klöting N, Kunath A, Steinhoff K, Rijntjes E, Köhrle J, Zeisig V, Hankir M, Gebhardt C, Deuther-Conrad W, Heiker JT, Kralisch S, Stumvoll M, Blüher M, Sabri O, Hesse S, Brust P, Tönjes A, Krause K.

Sci Rep. 2016 Dec 12;6:38124. doi: 10.1038/srep38124.

16.

Basic Residues of β-Sheet A Contribute to Heparin Binding and Activation of Vaspin (Serpin A12).

Ulbricht D, Oertwig K, Arnsburg K, Saalbach A, Pippel J, Sträter N, Heiker JT.

J Biol Chem. 2017 Jan 20;292(3):994-1004. doi: 10.1074/jbc.M116.748020. Epub 2016 Dec 9.

17.

A novel thermoregulatory role for PDE10A in mouse and human adipocytes.

Hankir MK, Kranz M, Gnad T, Weiner J, Wagner S, Deuther-Conrad W, Bronisch F, Steinhoff K, Luthardt J, Klöting N, Hesse S, Seibyl JP, Sabri O, Heiker JT, Blüher M, Pfeifer A, Brust P, Fenske WK.

EMBO Mol Med. 2016 Jul 1;8(7):796-812. doi: 10.15252/emmm.201506085. Print 2016 Jul.

18.

Anti-Inflammatory Action of Keratinocyte-Derived Vaspin: Relevance for the Pathogenesis of Psoriasis.

Saalbach A, Tremel J, Herbert D, Schwede K, Wandel E, Schirmer C, Anderegg U, Beck-Sickinger AG, Heiker JT, Schultz S, Magin T, Simon JC.

Am J Pathol. 2016 Mar;186(3):639-51. doi: 10.1016/j.ajpath.2015.10.030. Epub 2016 Jan 11.

PMID:
26783881
19.

The Effects of Thyroid Hormones on Gene Expression of Acyl-Coenzyme A Thioesterases in Adipose Tissue and Liver of Mice.

Krause K, Weiner J, Hönes S, Klöting N, Rijntjes E, Heiker JT, Gebhardt C, Köhrle J, Führer D, Steinhoff K, Hesse S, Moeller LC, Tönjes A.

Eur Thyroid J. 2015 Sep;4(Suppl 1):59-66. doi: 10.1159/000437304. Epub 2015 Jul 2.

20.

Crystal structure of cleaved vaspin (serpinA12).

Pippel J, Kuettner EB, Ulbricht D, Daberger J, Schultz S, Heiker JT, Sträter N.

Biol Chem. 2016 Jan 1;397(2):111-23. doi: 10.1515/hsz-2015-0229.

PMID:
26529565
21.

Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue.

Mardinoglu A, Heiker JT, Gärtner D, Björnson E, Schön MR, Flehmig G, Klöting N, Krohn K, Fasshauer M, Stumvoll M, Nielsen J, Blüher M.

Sci Rep. 2015 Oct 5;5:14841. doi: 10.1038/srep14841.

22.

A unique serpin P1' glutamate and a conserved β-sheet C arginine are key residues for activity, protease recognition and stability of serpinA12 (vaspin).

Ulbricht D, Pippel J, Schultz S, Meier R, Sträter N, Heiker JT.

Biochem J. 2015 Sep 15;470(3):357-67. doi: 10.1042/BJ20150643. Epub 2015 Jul 21.

PMID:
26199422
23.

Liver-restricted Repin1 deficiency improves whole-body insulin sensitivity, alters lipid metabolism, and causes secondary changes in adipose tissue in mice.

Kern M, Kosacka J, Hesselbarth N, Brückner J, Heiker JT, Flehmig G, Klöting I, Kovacs P, Matz-Soja M, Gebhardt R, Krohn K, Sales S, Abshagen K, Shevchenko A, Stumvoll M, Blüher M, Klöting N.

Diabetes. 2014 Oct;63(10):3295-309. doi: 10.2337/db13-0933. Epub 2014 Apr 23.

24.

Identification of genetic loci associated with different responses to high-fat diet-induced obesity in C57BL/6N and C57BL/6J substrains.

Heiker JT, Kunath A, Kosacka J, Flehmig G, Knigge A, Kern M, Stumvoll M, Kovacs P, Blüher M, Klöting N.

Physiol Genomics. 2014 Jun 1;46(11):377-84. doi: 10.1152/physiolgenomics.00014.2014. Epub 2014 Apr 1.

PMID:
24692188
25.

Vaspin (serpinA12) in obesity, insulin resistance, and inflammation.

Heiker JT.

J Pept Sci. 2014 May;20(5):299-306. doi: 10.1002/psc.2621. Epub 2014 Mar 5. Review.

PMID:
24596079
26.

Analysis of a rare functional truncating mutation rs61757459 in vaspin (SERPINA12) on circulating vaspin levels.

Breitfeld J, Heiker JT, Böttcher Y, Schleinitz D, Tönjes A, Weidle K, Krause K, Kuettner EB, Scholz M, Kiess W, Sträter N, Beck-Sickinger AG, Stumvoll M, Körner A, Blüher M, Kovacs P.

J Mol Med (Berl). 2013 Nov;91(11):1285-92. doi: 10.1007/s00109-013-1062-9. Epub 2013 Jun 12.

PMID:
23756768
27.

The polygenetically inherited metabolic syndrome of male WOKW rats is associated with enhanced autophagy in adipose tissue.

Kosacka J, Koch K, Gericke M, Nowicki M, Heiker JT, Klöting I, Stumvoll M, Blüher M, Klöting N.

Diabetol Metab Syndr. 2013 May 13;5:23. doi: 10.1186/1758-5996-5-23. eCollection 2013.

28.

Nicotinamide nucleotide transhydrogenase mRNA expression is related to human obesity.

Heiker JT, Kern M, Kosacka J, Flehmig G, Stumvoll M, Shang E, Lohmann T, Dreßler M, Kovacs P, Blüher M, Klöting N.

Obesity (Silver Spring). 2013 Mar;21(3):529-34. doi: 10.1002/oby.20095.

29.

Proteolytic activation of prochemerin by kallikrein 7 breaks an ionic linkage and results in C-terminal rearrangement.

Schultz S, Saalbach A, Heiker JT, Meier R, Zellmann T, Simon JC, Beck-Sickinger AG.

Biochem J. 2013 Jun 1;452(2):271-80. doi: 10.1042/BJ20121880.

PMID:
23495698
30.

Replication initiator 1 in adipose tissue function and human obesity.

Heiker JT, Klöting N.

Vitam Horm. 2013;91:97-105. doi: 10.1016/B978-0-12-407766-9.00005-5. Review.

PMID:
23374714
31.

Vaspin inhibits kallikrein 7 by serpin mechanism.

Heiker JT, Klöting N, Kovacs P, Kuettner EB, Sträter N, Schultz S, Kern M, Stumvoll M, Blüher M, Beck-Sickinger AG.

Cell Mol Life Sci. 2013 Jul;70(14):2569-83. doi: 10.1007/s00018-013-1258-8. Epub 2013 Jan 31.

32.

Adiponectin promotes the migration of circulating angiogenic cells through p38-mediated induction of the CXCR4 receptor.

Adams V, Heiker JT, Höllriegel R, Beck EB, Woitek FJ, Erbs S, Blüher M, Stumvoll M, Beck-Sickinger AG, Schuler G, Linke A.

Int J Cardiol. 2013 Sep 1;167(5):2039-46. doi: 10.1016/j.ijcard.2012.05.056. Epub 2012 Jun 7.

PMID:
22682478
33.

C57BL/6JRj mice are protected against diet induced obesity (DIO).

Kern M, Knigge A, Heiker JT, Kosacka J, Stumvoll M, Kovacs P, Blüher M, Klöting N.

Biochem Biophys Res Commun. 2012 Jan 13;417(2):717-20. doi: 10.1016/j.bbrc.2011.12.008. Epub 2011 Dec 8.

PMID:
22177950
34.

Central vaspin administration acutely reduces food intake and has sustained blood glucose-lowering effects.

Klöting N, Kovacs P, Kern M, Heiker JT, Fasshauer M, Schön MR, Stumvoll M, Beck-Sickinger AG, Blüher M.

Diabetologia. 2011 Jul;54(7):1819-23. doi: 10.1007/s00125-011-2137-1. Epub 2011 Apr 5.

PMID:
21465327
35.

Asborin inhibits Aldo/Keto reductase 1A1.

Scholz M, Steinhagen M, Heiker JT, Beck-Sickinger AG, Hey-Hawkins E.

ChemMedChem. 2011 Jan 3;6(1):89-93. doi: 10.1002/cmdc.201000368.

PMID:
20967818
36.

Access to gram scale amounts of functional globular adiponectin from E. coli inclusion bodies by alkaline-shock solubilization.

Heiker JT, Klöting N, Blüher M, Beck-Sickinger AG.

Biochem Biophys Res Commun. 2010 Jul 16;398(1):32-7. doi: 10.1016/j.bbrc.2010.06.020. Epub 2010 Jun 10.

PMID:
20541528
37.

Molecular mechanisms of signal transduction via adiponectin and adiponectin receptors.

Heiker JT, Kosel D, Beck-Sickinger AG.

Biol Chem. 2010 Sep;391(9):1005-18. doi: 10.1515/BC.2010.104. Review.

PMID:
20536390
38.

Dimerization of adiponectin receptor 1 is inhibited by adiponectin.

Kosel D, Heiker JT, Juhl C, Wottawah CM, Blüher M, Mörl K, Beck-Sickinger AG.

J Cell Sci. 2010 Apr 15;123(Pt 8):1320-8. doi: 10.1242/jcs.057919. Epub 2010 Mar 23.

39.

Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signaling.

Heiker JT, Wottawah CM, Juhl C, Kosel D, Mörl K, Beck-Sickinger AG.

Cell Signal. 2009 Jun;21(6):936-42. doi: 10.1016/j.cellsig.2009.02.003. Epub 2009 Feb 20.

PMID:
19233263
40.

Localization of novel adiponectin receptor constructs.

Deckert CM, Heiker JT, Beck-Sickinger AG.

J Recept Signal Transduct Res. 2006;26(5-6):647-57.

PMID:
17118803

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