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Electron Tomography and Correlative Approaches in Platelet Studies.

Engberts KB, Seinen C, Geerts WJC, Heijnen HFG.

Methods Mol Biol. 2018;1812:55-79. doi: 10.1007/978-1-4939-8585-2_4.


Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy.

Baaten CCFMJ, Moenen FCJI, Henskens YMC, Swieringa F, Wetzels RJH, van Oerle R, Heijnen HFG, Ten Cate H, Holloway GP, Beckers EAM, Heemskerk JWM, van der Meijden PEJ.

Haematologica. 2018 Sep;103(9):1557-1567. doi: 10.3324/haematol.2017.185165. Epub 2018 Jun 7.


Live-cell Imaging of Platelet Degranulation and Secretion Under Flow.

Barendrecht AD, Verhoef JJF, Pignatelli S, Pasterkamp G, Heijnen HFG, Maas C.

J Vis Exp. 2017 Jul 10;(125). doi: 10.3791/55658.


Kinetics, subcellular localization, and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP).

Hugo M, Martínez A, Trujillo M, Estrada D, Mastrogiovanni M, Linares E, Augusto O, Issoglio F, Zeida A, Estrín DA, Heijnen HF, Piacenza L, Radi R.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1326-E1335. doi: 10.1073/pnas.1618611114. Epub 2017 Feb 8.


Polyphosphate nanoparticles on the platelet surface trigger contact system activation.

Verhoef JJ, Barendrecht AD, Nickel KF, Dijkxhoorn K, Kenne E, Labberton L, McCarty OJ, Schiffelers R, Heijnen HF, Hendrickx AP, Schellekens H, Fens MH, de Maat S, Renné T, Maas C.

Blood. 2017 Mar 23;129(12):1707-1717. doi: 10.1182/blood-2016-08-734988. Epub 2017 Jan 3.


Distinct surveillance pathway for immunopathology during acute infection via autophagy and SR-BI.

Pfeiler S, Khandagale AB, Magenau A, Nichols M, Heijnen HF, Rinninger F, Ziegler T, Seveau S, Schubert S, Zahler S, Verschoor A, Latz E, Massberg S, Gaus K, Engelmann B.

Sci Rep. 2016 Oct 3;6:34440. doi: 10.1038/srep34440.


PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time.

Kooijmans SAA, Fliervoet LAL, van der Meel R, Fens MHAM, Heijnen HFG, van Bergen En Henegouwen PMP, Vader P, Schiffelers RM.

J Control Release. 2016 Feb 28;224:77-85. doi: 10.1016/j.jconrel.2016.01.009. Epub 2016 Jan 7.


Ribosomal protein mutations induce autophagy through S6 kinase inhibition of the insulin pathway.

Heijnen HF, van Wijk R, Pereboom TC, Goos YJ, Seinen CW, van Oirschot BA, van Dooren R, Gastou M, Giles RH, van Solinge W, Kuijpers TW, Gazda HT, Bierings MB, Da Costa L, MacInnes AW.

PLoS Genet. 2014 May 29;10(5):e1004371. doi: 10.1371/journal.pgen.1004371. eCollection 2014.


FLow-induced PRotrusions (FLIPRs): a platelet-derived platform for the retrieval of microparticles by monocytes and neutrophils.

Tersteeg C, Heijnen HF, Eckly A, Pasterkamp G, Urbanus RT, Maas C, Hoefer IE, Nieuwland R, Farndale RW, Gachet C, de Groot PG, Roest M.

Circ Res. 2014 Feb 28;114(5):780-91. doi: 10.1161/CIRCRESAHA.114.302361. Epub 2014 Jan 9.


Lysosome-related organelles: unusual compartments become mainstream.

Marks MS, Heijnen HF, Raposo G.

Curr Opin Cell Biol. 2013 Aug;25(4):495-505. doi: 10.1016/ Epub 2013 May 29. Review.


Endosome-mediated autophagy: an unconventional MIIC-driven autophagic pathway operational in dendritic cells.

Kondylis V, van Nispen Tot Pannerden HE, van Dijk S, Ten Broeke T, Wubbolts R, Geerts WJ, Seinen C, Mutis T, Heijnen HF.

Autophagy. 2013 Jun 1;9(6):861-80. doi: 10.4161/auto.24111. Epub 2013 Mar 12.


SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models.

Meng R, Wang Y, Yao Y, Zhang Z, Harper DC, Heijnen HF, Sitaram A, Li W, Raposo G, Weiss MJ, Poncz M, Marks MS.

Blood. 2012 Jul 12;120(2):404-14. doi: 10.1182/blood-2011-11-389551. Epub 2012 May 18.


Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction.

Wang Y, Meng R, Hayes V, Fuentes R, Yu X, Abrams CS, Heijnen HF, Blobel GA, Marks MS, Poncz M.

Blood. 2011 Dec 1;118(23):6183-91. doi: 10.1182/blood-2011-06-363580. Epub 2011 Oct 11.


The acute effect of increased laser energy during the excimer laser-assisted non-occlusive anastomosis procedure on the vessel wall of the recipient artery: a histopathological study.

Biesbroek M, van Doormaal TP, van der Zwan A, Tulleken CA, Regli L, Heijnen HF, Vink A.

Lasers Surg Med. 2011 Aug;43(6):522-7. doi: 10.1002/lsm.21075.


Spatial organization of the transforming MHC class II compartment.

van Nispen tot Pannerden HE, Geerts WJ, Kleijmeer MJ, Heijnen HF.

Biol Cell. 2010 Nov;102(11):581-91. doi: 10.1042/BC20100046.


The α-granule proteome: novel proteins in normal and ghost granules in gray platelet syndrome.

Maynard DM, Heijnen HF, Gahl WA, Gunay-Aygun M.

J Thromb Haemost. 2010 Aug;8(8):1786-96. doi: 10.1111/j.1538-7836.2010.03932.x. Epub 2010 May 27.


The platelet interior revisited: electron tomography reveals tubular alpha-granule subtypes.

van Nispen tot Pannerden H, de Haas F, Geerts W, Posthuma G, van Dijk S, Heijnen HF.

Blood. 2010 Aug 19;116(7):1147-56. doi: 10.1182/blood-2010-02-268680. Epub 2010 May 3.


Platelet protein disulfide isomerase is localized in the dense tubular system and does not become surface expressed after activation.

van Nispen Tot Pannerden HE, van Dijk SM, Du V, Heijnen HF.

Blood. 2009 Nov 19;114(21):4738-40. doi: 10.1182/blood-2009-03-210450. Epub 2009 Oct 5.


Fibrinogen beta-chain tyrosine nitration is a prothrombotic risk factor.

Parastatidis I, Thomson L, Burke A, Chernysh I, Nagaswami C, Visser J, Stamer S, Liebler DC, Koliakos G, Heijnen HF, Fitzgerald GA, Weisel JW, Ischiropoulos H.

J Biol Chem. 2008 Dec 5;283(49):33846-53. doi: 10.1074/jbc.M805522200. Epub 2008 Sep 25.


Role of membrane cholesterol in platelet calcium signalling in response to VWF and collagen under stasis and flow.

van Lier M, Verhoef S, Cauwenberghs S, Heemskerk JW, Akkerman JW, Heijnen HF.

Thromb Haemost. 2008 Jun;99(6):1068-78. doi: 10.1160/TH07-08-0528.


Proteomic analysis of platelet alpha-granules using mass spectrometry.

Maynard DM, Heijnen HF, Horne MK, White JG, Gahl WA.

J Thromb Haemost. 2007 Sep;5(9):1945-55.


Increased protein nitration burden in the atherosclerotic lesions and plasma of apolipoprotein A-I deficient mice.

Parastatidis I, Thomson L, Fries DM, Moore RE, Tohyama J, Fu X, Hazen SL, Heijnen HF, Dennehy MK, Liebler DC, Rader DJ, Ischiropoulos H.

Circ Res. 2007 Aug 17;101(4):368-76. Epub 2007 Jul 5.


Lipid rafts facilitate the interaction of PECAM-1 with the glycoprotein VI-FcR gamma-chain complex in human platelets.

Lee FA, van Lier M, Relou IA, Foley L, Akkerman JW, Heijnen HF, Farndale RW.

J Biol Chem. 2006 Dec 22;281(51):39330-8. Epub 2006 Oct 26.


Subcellular localization of tyrosine-nitrated proteins is dictated by reactive oxygen species generating enzymes and by proximity to nitric oxide synthase.

Heijnen HF, van Donselaar E, Slot JW, Fries DM, Blachard-Fillion B, Hodara R, Lightfoot R, Polydoro M, Spielberg D, Thomson L, Regan EA, Crapo J, Ischiropoulos H.

Free Radic Biol Med. 2006 Jun 1;40(11):1903-13. Epub 2005 Nov 15.


Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells.

Greco TM, Hodara R, Parastatidis I, Heijnen HF, Dennehy MK, Liebler DC, Ischiropoulos H.

Proc Natl Acad Sci U S A. 2006 May 9;103(19):7420-5. Epub 2006 Apr 28.


Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress.

Reininger AJ, Heijnen HF, Schumann H, Specht HM, Schramm W, Ruggeri ZM.

Blood. 2006 May 1;107(9):3537-45. Epub 2006 Jan 31.


Adhesive surface determines raft composition in platelets adhered under flow.

van Lier M, Lee F, Farndale RW, Gorter G, Verhoef S, Ohno-Iwashita Y, Akkerman JW, Heijnen HF.

J Thromb Haemost. 2005 Nov;3(11):2514-25.


Impaired flow-induced dilation in mesenteric resistance arteries from receptor protein tyrosine phosphatase-mu-deficient mice.

Koop EA, Gebbink MF, Sweeney TE, Mathy MJ, Heijnen HF, Spaan JA, Voest EE, VanBavel E, Peters SL.

Am J Physiol Heart Circ Physiol. 2005 Mar;288(3):H1218-23.


Colocalization of eNOS and the catalytic subunit of PKA in endothelial cell junctions: a clue for regulated NO production.

Heijnen HF, Waaijenborg S, Crapo JD, Bowler RP, Akkerman JW, Slot JW.

J Histochem Cytochem. 2004 Oct;52(10):1277-85.


Recombinant factor VIIa restores aggregation of alphaIIbbeta3-deficient platelets via tissue factor-independent fibrin generation.

Lisman T, Adelmeijer J, Heijnen HF, de Groot PG.

Blood. 2004 Mar 1;103(5):1720-7. Epub 2003 Oct 30.


Concentration of rafts in platelet filopodia correlates with recruitment of c-Src and CD63 to these domains.

Heijnen HF, Van Lier M, Waaijenborg S, Ohno-Iwashita Y, Waheed AA, Inomata M, Gorter G, Möbius W, Akkerman JW, Slot JW.

J Thromb Haemost. 2003 Jun;1(6):1161-73.


Recycling compartments and the internal vesicles of multivesicular bodies harbor most of the cholesterol found in the endocytic pathway.

Möbius W, van Donselaar E, Ohno-Iwashita Y, Shimada Y, Heijnen HF, Slot JW, Geuze HJ.

Traffic. 2003 Apr;4(4):222-31.


Expression of inducible nitric-oxide synthase and intracellular protein tyrosine nitration in vascular smooth muscle cells: role of reactive oxygen species.

Fries DM, Paxinou E, Themistocleous M, Swanberg E, Griendling KK, Salvemini D, Slot JW, Heijnen HF, Hazen SL, Ischiropoulos H.

J Biol Chem. 2003 Jun 20;278(25):22901-7. Epub 2003 Apr 10.


Immunoelectron microscopic localization of cholesterol using biotinylated and non-cytolytic perfringolysin O.

Möbius W, Ohno-Iwashita Y, van Donselaar EG, Oorschot VM, Shimada Y, Fujimoto T, Heijnen HF, Geuze HJ, Slot JW.

J Histochem Cytochem. 2002 Jan;50(1):43-55.


Selective binding of perfringolysin O derivative to cholesterol-rich membrane microdomains (rafts).

Waheed AA, Shimada Y, Heijnen HF, Nakamura M, Inomata M, Hayashi M, Iwashita S, Slot JW, Ohno-Iwashita Y.

Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):4926-31. Epub 2001 Apr 17.


Exosome: from internal vesicle of the multivesicular body to intercellular signaling device.

Denzer K, Kleijmeer MJ, Heijnen HF, Stoorvogel W, Geuze HJ.

J Cell Sci. 2000 Oct;113 Pt 19:3365-74. Review.


Fibrinogen-coated albumin microcapsules reduce bleeding in severely thrombocytopenic rabbits.

Levi M, Friederich PW, Middleton S, de Groot PG, Wu YP, Harris R, Biemond BJ, Heijnen HF, Levin J, ten Cate JW.

Nat Med. 1999 Jan;5(1):107-11.


A fifty percent reduction of platelet surface glycoprotein Ib does not affect platelet adhesion under flow conditions.

van Zanten GH, Heijnen HF, Wu Y, Schut-Hese KM, Slootweg PJ, de Groot PG, Sixma JJ, Nieuwland R.

Blood. 1998 Apr 1;91(7):2353-9.


Multivesicular bodies are an intermediate stage in the formation of platelet alpha-granules.

Heijnen HF, Debili N, Vainchencker W, Breton-Gorius J, Geuze HJ, Sixma JJ.

Blood. 1998 Apr 1;91(7):2313-25.


Platelet adhesion to fibronectin in flow: the importance of von Willebrand factor and glycoprotein Ib.

Beumer S, Heijnen HF, IJsseldijk MJ, Orlando E, de Groot PG, Sixma JJ.

Blood. 1995 Nov 1;86(9):3452-60.


Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin).

Saelman EU, Nieuwenhuis HK, Hese KM, de Groot PG, Heijnen HF, Sage EH, Williams S, McKeown L, Gralnick HR, Sixma JJ.

Blood. 1994 Mar 1;83(5):1244-50.


Increased platelet deposition on atherosclerotic coronary arteries.

van Zanten GH, de Graaf S, Slootweg PJ, Heijnen HF, Connolly TM, de Groot PG, Sixma JJ.

J Clin Invest. 1994 Feb;93(2):615-32.


Structure-function studies on human C4b-binding protein using monoclonal antibodies.

Hessing M, Kanters D, Heijnen HF, Hackeng TM, Sixma JJ, Bouma BN.

Eur J Immunol. 1991 Sep;21(9):2077-85.


Biochemical and immunohistochemical characteristics of CD62 and CD63 monoclonal antibodies. Expression of GMP-140 and LIMP-CD63 (CD63 antigen) in human lymphoid tissues.

Metzelaar MJ, Schuurman HJ, Heijnen HF, Sixma JJ, Nieuwenhuis HK.

Virchows Arch B Cell Pathol Incl Mol Pathol. 1991;61(4):269-77.


Characterization of human factor VIII and interaction with von Willebrand factor. An electron microscopic study.

Heijnen HF, Koedam JA, Sandberg H, Beeser-Visser NH, Slot JW, Sixma JJ.

Eur J Biochem. 1990 Dec 12;194(2):491-8.


Platelet adhesion to vascular cells. The role of exogenous von Willebrand factor in platelet adhesion.

Nievelstein PF, de Groot PG, D'Alessio P, Heijnen HF, Orlando E, Sixma JJ.

Arteriosclerosis. 1990 May-Jun;10(3):462-9.


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