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Items: 1 to 50 of 363

1.

Chemotherapy accelerates age-related development of tauopathy and results in loss of synaptic integrity and cognitive impairment.

Chiang ACA, Huo X, Kavelaars A, Heijnen CJ.

Brain Behav Immun. 2019 Jul;79:319-325. doi: 10.1016/j.bbi.2019.04.005. Epub 2019 Apr 3.

2.

Cisplatin educates CD8+ T cells to prevent and resolve chemotherapy-induced peripheral neuropathy in mice.

Laumet G, Edralin JD, Dantzer R, Heijnen CJ, Kavelaars A.

Pain. 2019 Jun;160(6):1459-1468. doi: 10.1097/j.pain.0000000000001512.

PMID:
30720585
3.

Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin.

Boukelmoune N, Chiu GS, Kavelaars A, Heijnen CJ.

Acta Neuropathol Commun. 2018 Dec 12;6(1):139. doi: 10.1186/s40478-018-0644-8.

4.

Cisplatin treatment induces attention deficits and impairs synaptic integrity in the prefrontal cortex in mice.

Huo X, Reyes TM, Heijnen CJ, Kavelaars A.

Sci Rep. 2018 Nov 27;8(1):17400. doi: 10.1038/s41598-018-35919-x.

5.

Nasal administration of mesenchymal stem cells restores cisplatin-induced cognitive impairment and brain damage in mice.

Chiu GS, Boukelmoune N, Chiang ACA, Peng B, Rao V, Kingsley C, Liu HL, Kavelaars A, Kesler SR, Heijnen CJ.

Oncotarget. 2018 Oct 30;9(85):35581-35597. doi: 10.18632/oncotarget.26272. eCollection 2018 Oct 30.

6.

Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment.

Ma J, Huo X, Jarpe MB, Kavelaars A, Heijnen CJ.

Acta Neuropathol Commun. 2018 Oct 1;6(1):103. doi: 10.1186/s40478-018-0604-3.

7.

Patient-reported fatigue prior to treatment is prognostic of survival in patients with acute myeloid leukemia.

Lacourt TE, Kavelaars A, Ohanian M, Shah ND, Shelburne SA, Futreal A, Kontoyiannis DP, Heijnen CJ.

Oncotarget. 2018 Jul 27;9(58):31244-31252. doi: 10.18632/oncotarget.25787. eCollection 2018 Jul 27.

8.

Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling.

Laumet G, Edralin JD, Chiang AC, Dantzer R, Heijnen CJ, Kavelaars A.

Neuropsychopharmacology. 2018 Dec;43(13):2597-2605. doi: 10.1038/s41386-018-0154-1. Epub 2018 Jul 16.

PMID:
30054585
9.

Inflammation and fatigue in early, untreated Parkinson's Disease.

Herlofson K, Heijnen CJ, Lange J, Alves G, Tysnes OB, Friedman JH, Fagundes CP.

Acta Neurol Scand. 2018 Nov;138(5):394-399. doi: 10.1111/ane.12977. Epub 2018 Jun 26.

PMID:
29947088
10.

An effort expenditure perspective on cancer-related fatigue.

Lacourt TE, Vichaya EG, Escalante C, Manzullo EF, Gunn B, Hess KR, Heijnen CJ, Dantzer R.

Psychoneuroendocrinology. 2018 Oct;96:109-117. doi: 10.1016/j.psyneuen.2018.06.009. Epub 2018 Jun 9.

PMID:
29929087
11.

Low GRK2 Underlies Hyperalgesic Priming by Glial Cell-Derived Neurotrophic Factor.

Wang HJ, Gu HX, Eijkelkamp N, Heijnen CJ, Kavelaars A.

Front Pharmacol. 2018 Jun 5;9:592. doi: 10.3389/fphar.2018.00592. eCollection 2018.

12.

Motivational changes that develop in a mouse model of inflammation-induced depression are independent of indoleamine 2,3 dioxygenase.

Vichaya EG, Laumet G, Christian DL, Grossberg AJ, Estrada DJ, Heijnen CJ, Kavelaars A, Dantzer R.

Neuropsychopharmacology. 2019 Jan;44(2):364-371. doi: 10.1038/s41386-018-0075-z. Epub 2018 Apr 27.

PMID:
29760410
13.

The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure.

Lacourt TE, Vichaya EG, Chiu GS, Dantzer R, Heijnen CJ.

Front Behav Neurosci. 2018 Apr 26;12:78. doi: 10.3389/fnbeh.2018.00078. eCollection 2018. Review.

14.

Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: Targeting the source.

Ma J, Kavelaars A, Dougherty PM, Heijnen CJ.

Cancer. 2018 Jun 1;124(11):2289-2298. doi: 10.1002/cncr.31248. Epub 2018 Feb 20. Review.

15.

Identification of FAM173B as a protein methyltransferase promoting chronic pain.

Willemen HLDM, Kavelaars A, Prado J, Maas M, Versteeg S, Nellissen LJJ, Tromp J, Gonzalez Cano R, Zhou W, Jakobsson ME, Małecki J, Posthuma G, Habib AM, Heijnen CJ, Falnes PØ, Eijkelkamp N.

PLoS Biol. 2018 Feb 14;16(2):e2003452. doi: 10.1371/journal.pbio.2003452. eCollection 2018 Feb.

16.

Neonatal corticosteroid therapy affects growth patterns in early infancy.

Tijsseling D, Ter Wolbeek M, Derks JB, de Vries WB, Heijnen CJ, van Bel F, Mulder EJH.

PLoS One. 2018 Feb 12;13(2):e0192162. doi: 10.1371/journal.pone.0192162. eCollection 2018.

17.

Associations of inflammation with symptom burden in patients with acute myeloid leukemia.

Lacourt TE, Kavelaars A, Galloway-Peña JR, Sahasrabhojane PV, Shah ND, Futreal A, Kontoyiannis DP, Shelburne SA, Heijnen CJ.

Psychoneuroendocrinology. 2018 Mar;89:203-208. doi: 10.1016/j.psyneuen.2018.01.018.

PMID:
29414033
18.

Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy.

Singhmar P, Huo X, Li Y, Dougherty PM, Mei F, Cheng X, Heijnen CJ, Kavelaars A.

Pain. 2018 May;159(5):884-893. doi: 10.1097/j.pain.0000000000001160.

19.

Intranasal Stem Cell Treatment as a Novel Therapy for Subarachnoid Hemorrhage.

Nijboer CH, Kooijman E, van Velthoven CT, van Tilborg E, Tiebosch IA, Eijkelkamp N, Dijkhuizen RM, Kesecioglu J, Heijnen CJ.

Stem Cells Dev. 2018 Mar 1;27(5):313-325. doi: 10.1089/scd.2017.0148. Epub 2018 Jan 8.

PMID:
29310519
20.

FOXP1 Promotes Embryonic Neural Stem Cell Differentiation by Repressing Jagged1 Expression.

Braccioli L, Vervoort SJ, Adolfs Y, Heijnen CJ, Basak O, Pasterkamp RJ, Nijboer CH, Coffer PJ.

Stem Cell Reports. 2017 Nov 14;9(5):1530-1545. doi: 10.1016/j.stemcr.2017.10.012.

21.

Attachment and telomere length: more evidence for psychobiological connections between close relationships, health, and aging.

Murdock KW, Zilioli S, Ziauddin K, Heijnen CJ, Fagundes CP.

J Behav Med. 2018 Jun;41(3):333-343. doi: 10.1007/s10865-017-9895-2. Epub 2017 Oct 24.

22.

Combined fetal inflammation and postnatal hypoxia causes myelin deficits and autism-like behavior in a rat model of diffuse white matter injury.

van Tilborg E, Achterberg EJM, van Kammen CM, van der Toorn A, Groenendaal F, Dijkhuizen RM, Heijnen CJ, Vanderschuren LJMJ, Benders MNJL, Nijboer CHA.

Glia. 2018 Jan;66(1):78-93. doi: 10.1002/glia.23216. Epub 2017 Sep 19.

23.

Longitudinal changes in glucocorticoid receptor exon 1F methylation and psychopathology after military deployment.

Schür RR, Boks MP, Rutten BPF, Daskalakis NP, de Nijs L, van Zuiden M, Kavelaars A, Heijnen CJ, Joëls M, Kahn RS, Geuze E, Vermetten E, Vinkers CH.

Transl Psychiatry. 2017 Jul 25;7(7):e1181. doi: 10.1038/tp.2017.150.

24.

Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain.

Laumet G, Zhou W, Dantzer R, Edralin JD, Huo X, Budac DP, O'Connor JC, Lee AW, Heijnen CJ, Kavelaars A.

Brain Behav Immun. 2017 Nov;66:94-102. doi: 10.1016/j.bbi.2017.07.008. Epub 2017 Jul 11.

25.

Mechanisms of Neurotoxic Symptoms as a Result of Breast Cancer and Its Treatment: Considerations on the Contribution of Stress, Inflammation, and Cellular Bioenergetics.

Lacourt TE, Heijnen CJ.

Curr Breast Cancer Rep. 2017;9(2):70-81. doi: 10.1007/s12609-017-0245-8. Epub 2017 Apr 22. Review.

26.

Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy.

Maj MA, Ma J, Krukowski KN, Kavelaars A, Heijnen CJ.

Front Mol Neurosci. 2017 Apr 18;10:108. doi: 10.3389/fnmol.2017.00108. eCollection 2017.

27.

HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy.

Krukowski K, Ma J, Golonzhka O, Laumet GO, Gutti T, van Duzer JH, Mazitschek R, Jarpe MB, Heijnen CJ, Kavelaars A.

Pain. 2017 Jun;158(6):1126-1137. doi: 10.1097/j.pain.0000000000000893.

28.

Pifithrin-μ Prevents Cisplatin-Induced Chemobrain by Preserving Neuronal Mitochondrial Function.

Chiu GS, Maj MA, Rizvi S, Dantzer R, Vichaya EG, Laumet G, Kavelaars A, Heijnen CJ.

Cancer Res. 2017 Feb 1;77(3):742-752. doi: 10.1158/0008-5472.CAN-16-1817. Epub 2016 Nov 22.

29.

Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.

Baameur F, Singhmar P, Zhou Y, Hancock JF, Cheng X, Heijnen CJ, Kavelaars A.

Sci Rep. 2016 Nov 3;6:36370. doi: 10.1038/srep36370.

30.

CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain.

Krukowski K, Eijkelkamp N, Laumet G, Hack CE, Li Y, Dougherty PM, Heijnen CJ, Kavelaars A.

J Neurosci. 2016 Oct 26;36(43):11074-11083.

31.

Mesenchymal stem cells attenuate MRI-identifiable injury, protect white matter, and improve long-term functional outcomes after neonatal focal stroke in rats.

van Velthoven CT, Dzietko M, Wendland MF, Derugin N, Faustino J, Heijnen CJ, Ferriero DM, Vexler ZS.

J Neurosci Res. 2017 May;95(5):1225-1236. doi: 10.1002/jnr.23954. Epub 2016 Oct 26.

32.

Delayed administration of neural stem cells after hypoxia-ischemia reduces sensorimotor deficits, cerebral lesion size, and neuroinflammation in neonatal mice.

Braccioli L, Heijnen CJ, Coffer PJ, Nijboer CH.

Pediatr Res. 2017 Jan;81(1-1):127-135. doi: 10.1038/pr.2016.172. Epub 2016 Sep 15.

PMID:
27632779
33.

IL4-10 Fusion Protein Is a Novel Drug to Treat Persistent Inflammatory Pain.

Eijkelkamp N, Steen-Louws C, Hartgring SA, Willemen HL, Prado J, Lafeber FP, Heijnen CJ, Hack CE, van Roon JA, Kavelaars A.

J Neurosci. 2016 Jul 13;36(28):7353-63. doi: 10.1523/JNEUROSCI.0092-16.2016.

34.

Executive functioning and diabetes: The role of anxious arousal and inflammation.

Murdock KW, LeRoy AS, Lacourt TE, Duke DC, Heijnen CJ, Fagundes CP.

Psychoneuroendocrinology. 2016 Sep;71:102-9. doi: 10.1016/j.psyneuen.2016.05.006. Epub 2016 May 18.

35.

Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice.

Zhou W, Kavelaars A, Heijnen CJ.

PLoS One. 2016 Mar 28;11(3):e0151890. doi: 10.1371/journal.pone.0151890. eCollection 2016.

36.

Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy.

Zhang H, Li Y, de Carvalho-Barbosa M, Kavelaars A, Heijnen CJ, Albrecht PJ, Dougherty PM.

J Pain. 2016 Jul;17(7):775-86. doi: 10.1016/j.jpain.2016.02.011. Epub 2016 Mar 12.

37.

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.

Singhmar P, Huo X, Eijkelkamp N, Berciano SR, Baameur F, Mei FC, Zhu Y, Cheng X, Hawke D, Mayor F Jr, Murga C, Heijnen CJ, Kavelaars A.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3036-41. doi: 10.1073/pnas.1516036113. Epub 2016 Feb 29.

38.

Impaired oligodendrocyte maturation in preterm infants: Potential therapeutic targets.

van Tilborg E, Heijnen CJ, Benders MJ, van Bel F, Fleiss B, Gressens P, Nijboer CH.

Prog Neurobiol. 2016 Jan;136:28-49. doi: 10.1016/j.pneurobio.2015.11.002. Epub 2015 Dec 2. Review.

PMID:
26655283
39.

Sickness behavior induced by cisplatin chemotherapy and radiotherapy in a murine head and neck cancer model is associated with altered mitochondrial gene expression.

Vichaya EG, Molkentine JM, Vermeer DW, Walker AK, Feng R, Holder G, Luu K, Mason RM, Saligan L, Heijnen CJ, Kavelaars A, Mason KA, Lee JH, Dantzer R.

Behav Brain Res. 2016 Jan 15;297:241-50. doi: 10.1016/j.bbr.2015.10.024. Epub 2015 Oct 22.

40.

Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ.

Krukowski K, Nijboer CH, Huo X, Kavelaars A, Heijnen CJ.

Pain. 2015 Nov;156(11):2184-92. doi: 10.1097/j.pain.0000000000000290.

41.

Assessment of long-term safety and efficacy of intranasal mesenchymal stem cell treatment for neonatal brain injury in the mouse.

Donega V, Nijboer CH, van Velthoven CT, Youssef SA, de Bruin A, van Bel F, Kavelaars A, Heijnen CJ.

Pediatr Res. 2015 Nov;78(5):520-6. doi: 10.1038/pr.2015.145. Epub 2015 Aug 13.

42.

Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2.

Vila-Bedmar R, Cruces-Sande M, Lucas E, Willemen HL, Heijnen CJ, Kavelaars A, Mayor F Jr, Murga C.

Sci Signal. 2015 Jul 21;8(386):ra73. doi: 10.1126/scisignal.aaa4374.

43.

Mechanisms of chemotherapy-induced behavioral toxicities.

Vichaya EG, Chiu GS, Krukowski K, Lacourt TE, Kavelaars A, Dantzer R, Heijnen CJ, Walker AK.

Front Neurosci. 2015 Apr 21;9:131. doi: 10.3389/fnins.2015.00131. eCollection 2015. Review.

44.

The neonatal brain is not protected by osteopontin peptide treatment after hypoxia-ischemia.

Bonestroo HJ, Nijboer CH, van Velthoven CT, van Bel F, Heijnen CJ.

Dev Neurosci. 2015;37(2):142-52. doi: 10.1159/000369093. Epub 2015 Mar 11.

PMID:
25765537
45.

Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice.

Zhou W, Dantzer R, Budac DP, Walker AK, Mao-Ying QL, Lee AW, Heijnen CJ, Kavelaars A.

Brain Behav Immun. 2015 May;46:147-53. doi: 10.1016/j.bbi.2015.01.013. Epub 2015 Jan 28.

46.

Development of cerebral gray and white matter injury and cerebral inflammation over time after inflammatory perinatal asphyxia.

Bonestroo HJ, Heijnen CJ, Groenendaal F, van Bel F, Nijboer CH.

Dev Neurosci. 2015;37(1):78-94. doi: 10.1159/000368770. Epub 2015 Jan 23.

47.

Neonatal glucocorticoid treatment: long-term effects on the hypothalamus-pituitary-adrenal axis, immune system, and problem behavior in 14-17 year old adolescents.

Ter Wolbeek M, Kavelaars A, de Vries WB, Tersteeg-Kamperman M, Veen S, Kornelisse RF, van Weissenbruch M, Baerts W, Liem KD, van Bel F, Heijnen CJ.

Brain Behav Immun. 2015 Mar;45:128-38. doi: 10.1016/j.bbi.2014.10.017. Epub 2014 Nov 8.

PMID:
25449580
48.

Intranasal administration of human MSC for ischemic brain injury in the mouse: in vitro and in vivo neuroregenerative functions.

Donega V, Nijboer CH, Braccioli L, Slaper-Cortenbach I, Kavelaars A, van Bel F, Heijnen CJ.

PLoS One. 2014 Nov 14;9(11):e112339. doi: 10.1371/journal.pone.0112339. eCollection 2014.

49.

Cytokine production as a putative biological mechanism underlying stress sensitization in high combat exposed soldiers.

Smid GE, van Zuiden M, Geuze E, Kavelaars A, Heijnen CJ, Vermetten E.

Psychoneuroendocrinology. 2015 Jan;51:534-46. doi: 10.1016/j.psyneuen.2014.07.010. Epub 2014 Jul 23.

PMID:
25106657
50.

The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model.

Mao-Ying QL, Kavelaars A, Krukowski K, Huo XJ, Zhou W, Price TJ, Cleeland C, Heijnen CJ.

PLoS One. 2014 Jun 23;9(6):e100701. doi: 10.1371/journal.pone.0100701. eCollection 2014.

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