Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 64

1.

Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling.

Spaan CN, Smit WL, van Lidth de Jeude JF, Meijer BJ, Muncan V, van den Brink GR, Heijmans J.

Cell Death Dis. 2019 Jun 21;10(7):490. doi: 10.1038/s41419-019-1729-4.

2.

Epithelial endoplasmic reticulum stress orchestrates a protective IgA response.

Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME, Glickman JN, Fuhler GM, Palm NW, de Zoete MR, van der Woude CJ, Yuan GC, Wucherpfennig KW, Targan SR, Rosenstiel P, Flavell RA, McCoy KD, Macpherson AJ, Kaser A, Blumberg RS.

Science. 2019 Mar 1;363(6430):993-998. doi: 10.1126/science.aat7186.

3.

Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+-Taurocholate Cotransporting Polypeptide.

Robin MJD, Appelman MD, Vos HR, van Es RM, Paton JC, Paton AW, Burgering B, Fickert P, Heijmans J, van de Graaf SFJ.

Hepatol Commun. 2018 Oct 23;2(12):1550-1566. doi: 10.1002/hep4.1262. eCollection 2018 Dec.

4.

Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation.

van Lidth de Jeude JF, Spaan CN, Meijer BJ, Smit WL, Soeratram TTD, Wielenga MCB, Westendorp BF, Lee AS, Meisner S, Vermeulen JLM, Wildenberg ME, van den Brink GR, Muncan V, Heijmans J.

Cancer Res. 2018 Nov 1;78(21):6098-6106. doi: 10.1158/0008-5472.CAN-17-3600. Epub 2018 Sep 19.

5.

Colorectal tumor prevention by the progestin medroxyprogesterone acetate is critically dependent on postmenopausal status.

Meijer BJ, Wielenga MCB, Hoyer PB, Amos-Landgraf JM, Hakvoort TBM, Muncan V, Heijmans J, van den Brink GR.

Oncotarget. 2018 Jul 17;9(55):30561-30567. doi: 10.18632/oncotarget.25703. eCollection 2018 Jul 17.

6.

Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response.

Westendorp BF, Büller NVJA, Karpus ON, van Dop WA, Koster J, Versteeg R, Koelink PJ, Snel CY, Meisner S, Roelofs JJTH, Uhmann A, Ver Loren van Themaat E, Heijmans J, Hahn H, Muncan V, Wildenberg ME, van den Brink GR.

Cell Mol Gastroenterol Hepatol. 2017 Sep 5;5(1):67-82.e1. doi: 10.1016/j.jcmgh.2017.08.004. eCollection 2018.

7.

Upper wide-angle viewing system for ITER.

Lasnier CJ, McLean AG, Gattuso A, O'Neill R, Smiley M, Vasquez J, Feder R, Smith M, Stratton B, Johnson D, Verlaan AL, Heijmans JA.

Rev Sci Instrum. 2016 Nov;87(11):11D426.

PMID:
27910636
8.

Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells.

van Lidth de Jeude JF, Meijer BJ, Wielenga MCB, Spaan CN, Baan B, Rosekrans SL, Meisner S, Shen YH, Lee AS, Paton JC, Paton AW, Muncan V, van den Brink GR, Heijmans J.

Oncogene. 2017 Jun 15;36(24):3397-3405. doi: 10.1038/onc.2016.326. Epub 2016 Nov 7.

PMID:
27819675
9.

Glucocorticoid-Induced Attenuation of the Inflammatory Response in Zebrafish.

Chatzopoulou A, Heijmans JP, Burgerhout E, Oskam N, Spaink HP, Meijer AH, Schaaf MJ.

Endocrinology. 2016 Jul;157(7):2772-84. doi: 10.1210/en.2015-2050. Epub 2016 May 24.

PMID:
27219276
10.

CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes.

Evers B, Jastrzebski K, Heijmans JP, Grernrum W, Beijersbergen RL, Bernards R.

Nat Biotechnol. 2016 Jun;34(6):631-3. doi: 10.1038/nbt.3536. Epub 2016 Apr 25.

PMID:
27111720
11.

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer.

Michaut M, Chin SF, Majewski I, Severson TM, Bismeijer T, de Koning L, Peeters JK, Schouten PC, Rueda OM, Bosma AJ, Tarrant F, Fan Y, He B, Xue Z, Mittempergher L, Kluin RJ, Heijmans J, Snel M, Pereira B, Schlicker A, Provenzano E, Ali HR, Gaber A, O'Hurley G, Lehn S, Muris JJ, Wesseling J, Kay E, Sammut SJ, Bardwell HA, Barbet AS, Bard F, Lecerf C, O'Connor DP, Vis DJ, Benes CH, McDermott U, Garnett MJ, Simon IM, Jirström K, Dubois T, Linn SC, Gallagher WM, Wessels LF, Caldas C, Bernards R.

Sci Rep. 2016 Jan 5;6:18517. doi: 10.1038/srep18517.

12.

ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy.

Wielenga MCB, Colak S, Heijmans J, van Lidth de Jeude JF, Rodermond HM, Paton JC, Paton AW, Vermeulen L, Medema JP, van den Brink GR.

Cell Rep. 2015 Oct 20;13(3):489-494. doi: 10.1016/j.celrep.2015.09.016. Epub 2015 Oct 8.

13.

Lack of guilt, guilt, and shame: a multi-informant study on the relations between self-conscious emotions and psychopathology in clinically referred children and adolescents.

Muris P, Meesters C, Heijmans J, van Hulten S, Kaanen L, Oerlemans B, Stikkelbroeck T, Tielemans T.

Eur Child Adolesc Psychiatry. 2016 Apr;25(4):383-96. doi: 10.1007/s00787-015-0749-6. Epub 2015 Jul 29.

14.

Hemodilution Combined With Hypercapnia Impairs Cerebral Autoregulation During Normothermic Cardiopulmonary Bypass.

Ševerdija EE, Vranken NP, Simons AP, Gommer ED, Heijmans JH, Maessen JG, Weerwind PW.

J Cardiothorac Vasc Anesth. 2015 Oct;29(5):1194-9. doi: 10.1053/j.jvca.2015.03.022. Epub 2015 Apr 2.

PMID:
26146135
15.

Survival of the fittest: retrospective cohort study of the longevity of Olympic medallists in the modern era.

Clarke PM, Walter SJ, Hayen A, Mallon WJ, Heijmans J, Studdert DM.

Br J Sports Med. 2015 Jul;49(13):898-902. doi: 10.1136/bjsports-2015-e8308rep.

PMID:
26084528
16.

A protocol for lentiviral transduction and downstream analysis of intestinal organoids.

Van Lidth de Jeude JF, Vermeulen JL, Montenegro-Miranda PS, Van den Brink GR, Heijmans J.

J Vis Exp. 2015 Apr 20;(98). doi: 10.3791/52531.

17.

Azathioprine does not reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis.

Wielenga MC, van Lidth de Jeude JF, Rosekrans SL, Levin AD, Schukking M, D'Haens GR, Heijmans J, Jansen M, Muncan V, van den Brink GR.

World J Gastroenterol. 2014 Nov 28;20(44):16683-9. doi: 10.3748/wjg.v20.i44.16683.

18.

Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones.

Amos-Landgraf JM, Heijmans J, Wielenga MC, Dunkin E, Krentz KJ, Clipson L, Ederveen AG, Groothuis PG, Mosselman S, Muncan V, Hommes DW, Shedlovsky A, Dove WF, van den Brink GR.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16514-9. doi: 10.1073/pnas.1323064111. Epub 2014 Nov 3.

19.

Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice.

Büller NV, Rosekrans SL, Metcalfe C, Heijmans J, van Dop WA, Fessler E, Jansen M, Ahn C, Vermeulen JL, Westendorp BF, Robanus-Maandag EC, Offerhaus GJ, Medema JP, D'Haens GR, Wildenberg ME, de Sauvage FJ, Muncan V, van den Brink GR.

Gastroenterology. 2015 Jan;148(1):170-180.e6. doi: 10.1053/j.gastro.2014.10.006. Epub 2014 Oct 13.

PMID:
25307863
20.

Hemolysis during cardiac surgery is associated with increased intravascular nitric oxide consumption and perioperative kidney and intestinal tissue damage.

Vermeulen Windsant IC, de Wit NC, Sertorio JT, van Bijnen AA, Ganushchak YM, Heijmans JH, Tanus-Santos JE, Jacobs MJ, Maessen JG, Buurman WA.

Front Physiol. 2014 Sep 8;5:340. doi: 10.3389/fphys.2014.00340. eCollection 2014.

21.

OsJAR1 is required for JA-regulated floret opening and anther dehiscence in rice.

Xiao Y, Chen Y, Charnikhova T, Mulder PP, Heijmans J, Hoogenboom A, Agalou A, Michel C, Morel JB, Dreni L, Kater MM, Bouwmeester H, Wang M, Zhu Z, Ouwerkerk PB.

Plant Mol Biol. 2014 Sep;86(1-2):19-33. doi: 10.1007/s11103-014-0212-y. Epub 2014 Jun 20.

PMID:
24947835
22.

ER stress induces epithelial differentiation in the mouse oesophagus.

Rosekrans SL, Heijmans J, Büller NV, Westerlund J, Lee AS, Muncan V, van den Brink GR.

Gut. 2015 Feb;64(2):195-202. doi: 10.1136/gutjnl-2013-306347. Epub 2014 Apr 30.

PMID:
24789843
23.

Correction: Intestinal Tumorigenesis Is Not Affected by Progesterone Signaling in Rodent Models.

Heijmans J, Muncan V, Jacobs RJ, de Jonge-Muller ESM, Graven L, Biemond I, Ederveen AG, Groothuis PG, Mosselman S, Hardwick JC, Hommes DW, van den Brink GR.

PLoS One. 2013 Jun 5;8(6). doi: 10.1371/annotation/b60d4ec5-4c6f-43ab-9f63-322e3cd59636. eCollection 2013.

24.

ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.

Heijmans J, van Lidth de Jeude JF, Koo BK, Rosekrans SL, Wielenga MC, van de Wetering M, Ferrante M, Lee AS, Onderwater JJ, Paton JC, Paton AW, Mommaas AM, Kodach LL, Hardwick JC, Hommes DW, Clevers H, Muncan V, van den Brink GR.

Cell Rep. 2013 Apr 25;3(4):1128-39. doi: 10.1016/j.celrep.2013.02.031. Epub 2013 Mar 28.

25.

Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer.

Heijmans J, Wielenga MC, Rosekrans SL, van Lidth de Jeude JF, Roelofs J, Groothuis P, Ederveen A, de Jonge-Muller ES, Biemond I, Hardwick JC, D'Haens G, Hommes DW, Muncan V, van den Brink GR.

Gut. 2014 Feb;63(2):310-6. doi: 10.1136/gutjnl-2012-304216. Epub 2013 Feb 13.

PMID:
23408349
26.

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.

Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Göktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, Lang R, Neumann J, Kirchner T, Taketo MM, van den Brink GR, Sansom OJ, Arkan MC, Greten FR.

Cell. 2013 Jan 17;152(1-2):25-38. doi: 10.1016/j.cell.2012.12.012. Epub 2012 Dec 27.

27.

Survival of the fittest: retrospective cohort study of the longevity of Olympic medallists in the modern era.

Clarke PM, Walter SJ, Hayen A, Mallon WJ, Heijmans J, Studdert DM.

BMJ. 2012 Dec 13;345:e8308. doi: 10.1136/bmj.e8308.

PMID:
23241272
28.

Rage mediated DAMP signaling in intestinal tumorigenesis.

Heijmans J, Büller NV, Muncan V, van den Brink GR.

Oncoimmunology. 2012 Oct 1;1(7):1165-1166.

29.

Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit.

Pelczar P, Zibat A, van Dop WA, Heijmans J, Bleckmann A, Gruber W, Nitzki F, Uhmann A, Guijarro MV, Hernando E, Dittmann K, Wienands J, Dressel R, Wojnowski L, Binder C, Taguchi T, Beissbarth T, Hogendoorn PC, Antonescu CR, Rubin BP, Schulz-Schaeffer W, Aberger F, van den Brink GR, Hahn H.

Gastroenterology. 2013 Jan;144(1):134-144.e6. doi: 10.1053/j.gastro.2012.09.061. Epub 2012 Oct 3.

30.

Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus.

van Dop WA, Rosekrans SL, Uhmann A, Jaks V, Offerhaus GJ, van den Bergh Weerman MA, Kasper M, Heijmans J, Hardwick JC, Verspaget HW, Hommes DW, Toftgård R, Hahn H, van den Brink GR.

Gut. 2013 Mar;62(3):348-57. doi: 10.1136/gutjnl-2011-301141. Epub 2012 Apr 13.

PMID:
22504664
31.

Rage signalling promotes intestinal tumourigenesis.

Heijmans J, Büller NV, Hoff E, Dihal AA, van der Poll T, van Zoelen MA, Bierhaus A, Biemond I, Hardwick JC, Hommes DW, Muncan V, van den Brink GR.

Oncogene. 2013 Feb 28;32(9):1202-6. doi: 10.1038/onc.2012.119. Epub 2012 Apr 2.

PMID:
22469986
32.

5-Aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer.

Baan B, Dihal AA, Hoff E, Bos CL, Voorneveld PW, Koelink PJ, Wildenberg ME, Muncan V, Heijmans J, Verspaget HW, Richel DJ, Hardwick JC, Hommes DW, Peppelenbosch MP, van den Brink GR.

Gut. 2012 Dec;61(12):1708-15. doi: 10.1136/gutjnl-2011-301626. Epub 2011 Dec 20.

PMID:
22187071
33.

Blimp1 regulates the transition of neonatal to adult intestinal epithelium.

Muncan V, Heijmans J, Krasinski SD, Büller NV, Wildenberg ME, Meisner S, Radonjic M, Stapleton KA, Lamers WH, Biemond I, van den Bergh Weerman MA, O'Carroll D, Hardwick JC, Hommes DW, van den Brink GR.

Nat Commun. 2011 Aug 30;2:452. doi: 10.1038/ncomms1463.

34.

Intestinal tumorigenesis is not affected by progesterone signaling in rodent models.

Heijmans J, Muncan V, Jacobs RJ, de Jonge-Muller ES, Graven L, Biemond I, Ederveen AG, Groothuis PG, Mosselman S, Hardwick JC, Hommes DW, van den Brink GR.

PLoS One. 2011;6(7):e22620. doi: 10.1371/journal.pone.0022620. Epub 2011 Jul 27. Erratum in: PLoS One. 2013 Jun 5;8(6):.

35.

Retrograde autologous priming reduces transfusion requirements in coronary artery bypass surgery.

Severdija EE, Heijmans JH, Theunissen M, Maessen JG, Roekaerts PH, Weerwind PW.

Perfusion. 2011 Jul;26(4):315-21. doi: 10.1177/0267659111408379. Epub 2011 May 18.

PMID:
21593085
36.

Predictors of cardiac responsiveness to fluid therapy after cardiac surgery.

Heijmans JH, Ganushak YM, Theunissen MS, Maessen JG, Roekaerts PJ.

Acta Anaesthesiol Belg. 2010;61(3):151-8.

PMID:
21268571
37.

Role of mast cells in colorectal cancer development, the jury is still out.

Heijmans J, Büller NV, Muncan V, van den Brink GR.

Biochim Biophys Acta. 2012 Jan;1822(1):9-13. doi: 10.1016/j.bbadis.2010.12.001. Epub 2010 Dec 9. Review.

38.

Characterization of expression in mice of a transgene containing 3.3 kb of the human lactase-phlorizin hydrolase (LPH) 5' flanking sequence.

Baffour-Awuah NY, Delemarre E, Fujiwara Y, Heijmans J, Boerwinkel D, Algra S, Fialkovich JJ, Islam S, Bosse T, Grand RJ, Krasinski SD, Montgomery RK.

Dig Dis Sci. 2011 Jan;56(1):59-69. doi: 10.1007/s10620-010-1480-2. Epub 2010 Nov 18.

39.

Morphogens and the parietal cell: shaping up acid secretion.

Heijmans J, van den Brink GR.

Gastroenterology. 2010 Dec;139(6):1830-3. doi: 10.1053/j.gastro.2010.10.035. Epub 2010 Oct 26. No abstract available.

PMID:
21029799
40.

Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine.

van Dop WA, Heijmans J, Büller NV, Snoek SA, Rosekrans SL, Wassenberg EA, van den Bergh Weerman MA, Lanske B, Clarke AR, Winton DJ, Wijgerde M, Offerhaus GJ, Hommes DW, Hardwick JC, de Jonge WJ, Biemond I, van den Brink GR.

Gastroenterology. 2010 Nov;139(5):1665-76, 1676.e1-10. doi: 10.1053/j.gastro.2010.07.045. Epub 2010 Aug 1.

PMID:
20682322
41.

The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer.

Kodach LL, Jacobs RJ, Heijmans J, van Noesel CJ, Langers AM, Verspaget HW, Hommes DW, Offerhaus GJ, van den Brink GR, Hardwick JC.

Carcinogenesis. 2010 Sep;31(9):1567-75. doi: 10.1093/carcin/bgq147. Epub 2010 Jul 14.

42.

Hemolysis is associated with acute kidney injury during major aortic surgery.

Vermeulen Windsant IC, Snoeijs MG, Hanssen SJ, Altintas S, Heijmans JH, Koeppel TA, Schurink GW, Buurman WA, Jacobs MJ.

Kidney Int. 2010 May;77(10):913-20. doi: 10.1038/ki.2010.24. Epub 2010 Feb 24.

43.

The EmBlocker: efficiency of a new ultrasonic embolic protection device adjunctive to heart valve surgery.

Sauren LD, la Meir M, Bolotin G, van der Veen FH, Heijmans JH, Mess WH, Maessen JG.

Ann Thorac Surg. 2009 Jul;88(1):253-7. doi: 10.1016/j.athoracsur.2009.01.058.

PMID:
19559235
44.

Depletion of the colonic epithelial precursor cell compartment upon conditional activation of the hedgehog pathway.

van Dop WA, Uhmann A, Wijgerde M, Sleddens-Linkels E, Heijmans J, Offerhaus GJ, van den Bergh Weerman MA, Boeckxstaens GE, Hommes DW, Hardwick JC, Hahn H, van den Brink GR.

Gastroenterology. 2009 Jun;136(7):2195-2203.e1-7. doi: 10.1053/j.gastro.2009.02.068. Epub 2009 Mar 6.

PMID:
19272384
45.

Visceral injury and systemic inflammation in patients undergoing extracorporeal circulation during aortic surgery.

Hanssen SJ, Derikx JP, Vermeulen Windsant IC, Heijmans JH, Koeppel TA, Schurink GW, Buurman WA, Jacobs MJ.

Ann Surg. 2008 Jul;248(1):117-25. doi: 10.1097/SLA.0b013e3181784cc5. Erratum in: Ann Surg. 2010 Jan;251(1):187.

PMID:
18580215
46.

Intracellular and extracellular expression of the major inducible 70kDa heat shock protein in experimental ischemia-reperfusion injury of the spinal cord.

Awad H, Suntres Z, Heijmans J, Smeak D, Bergdall-Costell V, Christofi FL, Magro C, Oglesbee M.

Exp Neurol. 2008 Aug;212(2):275-84. doi: 10.1016/j.expneurol.2008.03.024. Epub 2008 Apr 6.

PMID:
18511046
47.

Pulmonary function and inflammatory markers in patients undergoing coronary revascularisation with or without cardiopulmonary bypass.

Heijmans JH, Liem KS, Damoiseaux GM, Maessen JG, Roekaerts PM.

Anaesthesia. 2007 Dec;62(12):1233-40.

48.

Comparison of the modulatory effects of four different fast-track anesthetic techniques on the inflammatory response to cardiac surgery with cardiopulmonary bypass.

Heijmans J, Fransen E, Buurman W, Maessen J, Roekaerts P.

J Cardiothorac Vasc Anesth. 2007 Aug;21(4):512-8. Epub 2007 May 7.

PMID:
17678776
49.
50.

Short-stay intensive care after coronary artery bypass surgery: randomized clinical trial on safety and cost-effectiveness.

van Mastrigt GA, Heijmans J, Severens JL, Fransen EJ, Roekaerts P, Voss G, Maessen JG.

Crit Care Med. 2006 Jan;34(1):65-75.

PMID:
16374158

Supplemental Content

Loading ...
Support Center