Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 76

1.

MiR-31-5p: a shared regulator of chronic mucus hypersecretion in asthma and chronic obstructive pulmonary disease.

Tasena H, Boudewijn IM, Faiz A, Timens W, Hylkema MN, Berg M, Ten Hacken NHT, Brandsma CA, Heijink IH, van den Berge M.

Allergy. 2019 Sep 23. doi: 10.1111/all.14060. [Epub ahead of print] No abstract available.

PMID:
31545509
2.

From the pathophysiology of the human lung alveolus to epigenetic editing: Congress 2018 highlights from ERS Assembly 3 "Basic and Translational Science."

Nikolić MZ, Garrido-Martin EM, Greiffo FR, Fabre A, Heijink IH, Boots A, Greene CM, Hiemstra PS, Bartel S.

ERJ Open Res. 2019 May 10;5(2). pii: 00194-2018. doi: 10.1183/23120541.00194-2018. eCollection 2019 Apr. Review.

3.

Defective Fibrillar Collagen Organization by Fibroblasts Contributes to Airway Remodeling in Asthma.

Mostaço-Guidolin LB, Osei ET, Ullah J, Hajimohammadi S, Fouadi M, Li X, Li V, Shaheen F, Yang CX, Chu F, Cole DJ, Brandsma CA, Heijink IH, Maksym GN, Walker D, Hackett TL.

Am J Respir Crit Care Med. 2019 Aug 15;200(4):431-443. doi: 10.1164/rccm.201810-1855OC.

PMID:
30950644
4.

Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD.

Faiz A, Steiling K, Roffel MP, Postma DS, Spira A, Lenburg ME, Borggrewe M, Eijgenraam TR, Jonker MR, Koppelman GH, Pouwels SD, Liu G, Alekseyev YO, Lam S, Hiemstra PS, Sterk PJ, Timens W, Brandsma CA, Heijink IH, van den Berge M.

Eur Respir J. 2019 Apr 25;53(4). pii: 1801202. doi: 10.1183/13993003.01202-2018. Print 2019 Apr.

PMID:
30846474
5.

Pro-inflammatory effects of extracellular Hsp70 and cigarette smoke in primary airway epithelial cells from COPD patients.

Hulina-Tomašković A, Heijink IH, Jonker MR, Somborac-Bačura A, Grdić Rajković M, Rumora L.

Biochimie. 2019 Jan;156:47-58. doi: 10.1016/j.biochi.2018.09.010. Epub 2018 Sep 27.

PMID:
30268700
6.

Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.

Ng-Blichfeldt JP, Schrik A, Kortekaas RK, Noordhoek JA, Heijink IH, Hiemstra PS, Stolk J, Königshoff M, Gosens R.

EBioMedicine. 2018 Oct;36:461-474. doi: 10.1016/j.ebiom.2018.09.002. Epub 2018 Sep 17.

7.

Characterization of a lung epithelium specific E-cadherin knock-out model: Implications for obstructive lung pathology.

Post S, Heijink IH, Hesse L, Koo HK, Shaheen F, Fouadi M, Kuchibhotla VNS, Lambrecht BN, Van Oosterhout AJM, Hackett TL, Nawijn MC.

Sci Rep. 2018 Sep 5;8(1):13275. doi: 10.1038/s41598-018-31500-8.

8.

Cigarette smoke exposure decreases CFLAR expression in the bronchial epithelium, augmenting susceptibility for lung epithelial cell death and DAMP release.

Faiz A, Heijink IH, Vermeulen CJ, Guryev V, van den Berge M, Nawijn MC, Pouwels SD.

Sci Rep. 2018 Aug 20;8(1):12426. doi: 10.1038/s41598-018-30602-7.

9.

microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD.

Tasena H, Faiz A, Timens W, Noordhoek J, Hylkema MN, Gosens R, Hiemstra PS, Spira A, Postma DS, Tew GW, Grimbaldeston MA, van den Berge M, Heijink IH, Brandsma CA.

Eur Respir J. 2018 Sep 6;52(3). pii: 1701556. doi: 10.1183/13993003.01556-2017. Print 2018 Sep.

PMID:
30072506
10.

Profiling of healthy and asthmatic airway smooth muscle cells following interleukin-1β treatment: a novel role for CCL20 in chronic mucus hypersecretion.

Faiz A, Weckmann M, Tasena H, Vermeulen CJ, Van den Berge M, Ten Hacken NHT, Halayko AJ, Ward JPT, Lee TH, Tjin G, Black JL, Haghi M, Xu CJ, King GG, Farah CS, Oliver BG, Heijink IH, Burgess JK.

Eur Respir J. 2018 Aug 9;52(2). pii: 1800310. doi: 10.1183/13993003.00310-2018. Print 2018 Aug.

PMID:
29946002
11.

Impact of acute exposure to cigarette smoke on airway gene expression.

Billatos E, Faiz A, Gesthalter Y, LeClerc A, Alekseyev YO, Xiao X, Liu G, Ten Hacken NHT, Heijink IH, Timens W, Brandsma CA, Postma DS, van den Berge M, Spira A, Lenburg ME.

Physiol Genomics. 2018 Sep 1;50(9):705-713. doi: 10.1152/physiolgenomics.00092.2017. Epub 2018 Jun 22.

12.

Mesenchymal Stromal Cells to Regenerate Emphysema: On the Horizon?

Kruk DMLW, Heijink IH, Slebos DJ, Timens W, Ten Hacken NH.

Respiration. 2018;96(2):148-158. doi: 10.1159/000488149. Epub 2018 May 2. Review.

13.

Effects of fluticasone propionate and budesonide on the expression of immune defense genes in bronchial epithelial cells.

van den Berge M, Jonker MR, Miller-Larsson A, Postma DS, Heijink IH.

Pulm Pharmacol Ther. 2018 Jun;50:47-56. doi: 10.1016/j.pupt.2018.04.002. Epub 2018 Apr 5.

PMID:
29627483
14.

Nasal epithelium as a proxy for bronchial epithelium for smoking-induced gene expression and expression Quantitative Trait Loci.

Imkamp K, Berg M, Vermeulen CJ, Heijink IH, Guryev V, Kerstjens HAM, Koppelman GH, van den Berge M, Faiz A.

J Allergy Clin Immunol. 2018 Jul;142(1):314-317.e15. doi: 10.1016/j.jaci.2018.01.047. Epub 2018 Mar 6. No abstract available.

PMID:
29522853
15.

SIRT1/FoxO3 axis alteration leads to aberrant immune responses in bronchial epithelial cells.

Di Vincenzo S, Heijink IH, Noordhoek JA, Cipollina C, Siena L, Bruno A, Ferraro M, Postma DS, Gjomarkaj M, Pace E.

J Cell Mol Med. 2018 Apr;22(4):2272-2282. doi: 10.1111/jcmm.13509. Epub 2018 Feb 7.

16.

Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression.

Boudewijn IM, Faiz A, Steiling K, van der Wiel E, Telenga ED, Hoonhorst SJM, Ten Hacken NHT, Brandsma CA, Kerstjens HAM, Timens W, Heijink IH, Jonker MR, de Bruin HG, Sebastiaan Vroegop J, Pasma HR, Boersma WG, Wielders P, van den Elshout F, Mansour K, Spira A, Lenburg ME, Guryev V, Postma DS, van den Berge M.

Respir Res. 2017 Dec 21;18(1):213. doi: 10.1186/s12931-017-0696-5.

17.

Airway Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease: Role of Cigarette Smoke Exposure.

Aghapour M, Raee P, Moghaddam SJ, Hiemstra PS, Heijink IH.

Am J Respir Cell Mol Biol. 2018 Feb;58(2):157-169. doi: 10.1165/rcmb.2017-0200TR. Review.

PMID:
28933915
18.

Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress.

van Gisbergen MW, Voets AM, Biemans R, Hoffmann RF, Drittij-Reijnders MJ, Haenen GRMM, Heijink IH, Rouschop KMA, Dubois LJ, Lambin P.

PLoS One. 2017 Aug 3;12(8):e0182508. doi: 10.1371/journal.pone.0182508. eCollection 2017.

19.

Genetic variance is associated with susceptibility for cigarette smoke-induced DAMP release in mice.

Pouwels SD, Faiz A, den Boef LE, Gras R, van den Berge M, Boezen HM, Korstanje R, Ten Hacken NHT, van Oosterhout AJM, Heijink IH, Nawijn MC.

Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L559-L580. doi: 10.1152/ajplung.00466.2016. Epub 2017 Jun 8.

20.

miR-146a-5p plays an essential role in the aberrant epithelial-fibroblast cross-talk in COPD.

Osei ET, Florez-Sampedro L, Tasena H, Faiz A, Noordhoek JA, Timens W, Postma DS, Hackett TL, Heijink IH, Brandsma CA.

Eur Respir J. 2017 May 25;49(5). pii: 1602538. doi: 10.1183/13993003.02538-2016. Print 2017 May.

21.

Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD.

Song J, Heijink IH, Kistemaker LEM, Reinders-Luinge M, Kooistra W, Noordhoek JA, Gosens R, Brandsma CA, Timens W, Hiemstra PS, Rots MG, Hylkema MN.

Clin Epigenetics. 2017 Apr 24;9:42. doi: 10.1186/s13148-017-0341-7. eCollection 2017.

22.

Targeted epigenetic editing of SPDEF reduces mucus production in lung epithelial cells.

Song J, Cano-Rodriquez D, Winkle M, Gjaltema RA, Goubert D, Jurkowski TP, Heijink IH, Rots MG, Hylkema MN.

Am J Physiol Lung Cell Mol Physiol. 2017 Mar 1;312(3):L334-L347. doi: 10.1152/ajplung.00059.2016. Epub 2016 Dec 23.

23.

Viral mimic poly-(I:C) attenuates airway epithelial T-cell suppressive capacity: implications for asthma.

Schwarze J, Fitch PM, Heimweg J, Errington C, Matsuda R, de Bruin HG, van den Berge M, van Oosterhout AJ, Heijink IH.

Eur Respir J. 2016 Dec;48(6):1785-1788. doi: 10.1183/13993003.00841-2016. Epub 2016 Oct 6. No abstract available.

24.

Susceptibility for cigarette smoke-induced DAMP release and DAMP-induced inflammation in COPD.

Pouwels SD, Hesse L, Faiz A, Lubbers J, Bodha PK, Ten Hacken NH, van Oosterhout AJ, Nawijn MC, Heijink IH.

Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L881-L892. doi: 10.1152/ajplung.00135.2016. Epub 2016 Sep 9.

25.

Increased neutrophil expression of pattern recognition receptors during COPD exacerbations.

Pouwels SD, van Geffen WH, Jonker MR, Kerstjens HA, Nawijn MC, Heijink IH.

Respirology. 2017 Feb;22(2):401-404. doi: 10.1111/resp.12912. Epub 2016 Sep 27.

PMID:
27679416
26.

Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD.

Osei ET, Noordhoek JA, Hackett TL, Spanjer AI, Postma DS, Timens W, Brandsma CA, Heijink IH.

Eur Respir J. 2016 Aug;48(2):359-69. doi: 10.1183/13993003.01911-2015. Epub 2016 Jul 13.

27.

Cigarette smoke-induced epithelial expression of WNT-5B: implications for COPD.

Heijink IH, de Bruin HG, Dennebos R, Jonker MR, Noordhoek JA, Brandsma CA, van den Berge M, Postma DS.

Eur Respir J. 2016 Aug;48(2):504-15. doi: 10.1183/13993003.01541-2015. Epub 2016 Apr 28.

28.

TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8.

Spanjer AI, Baarsma HA, Oostenbrink LM, Jansen SR, Kuipers CC, Lindner M, Postma DS, Meurs H, Heijink IH, Gosens R, Königshoff M.

FASEB J. 2016 May;30(5):1823-35. doi: 10.1096/fj.201500129. Epub 2016 Feb 5.

PMID:
26849959
29.

A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis.

Spanjer AI, Menzen MH, Dijkstra AE, van den Berge M, Boezen HM, Nickle DC, Sin DD, Bossé Y, Brandsma CA, Timens W, Postma DS, Meurs H, Heijink IH, Gosens R.

Thorax. 2016 Apr;71(4):312-22. doi: 10.1136/thoraxjnl-2015-206958. Epub 2016 Jan 21.

PMID:
26797711
30.

Budesonide and fluticasone propionate differentially affect the airway epithelial barrier.

Heijink IH, Jonker MR, de Vries M, van Oosterhout AJ, Telenga E, Ten Hacken NH, Postma DS, van den Berge M.

Respir Res. 2016 Jan 6;17:2. doi: 10.1186/s12931-015-0318-z.

31.

Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice.

Pouwels SD, Zijlstra GJ, van der Toorn M, Hesse L, Gras R, Ten Hacken NH, Krysko DV, Vandenabeele P, de Vries M, van Oosterhout AJ, Heijink IH, Nawijn MC.

Am J Physiol Lung Cell Mol Physiol. 2016 Feb 15;310(4):L377-86. doi: 10.1152/ajplung.00174.2015. Epub 2015 Dec 30.

32.

Pim1 kinase activity preserves airway epithelial integrity upon house dust mite exposure.

de Vries M, Hesse L, Jonker MR, van den Berge M, van Oosterhout AJ, Heijink IH, Nawijn MC.

Am J Physiol Lung Cell Mol Physiol. 2015 Dec 1;309(11):L1344-53. doi: 10.1152/ajplung.00043.2015. Epub 2015 Oct 9.

33.

Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD.

Ngkelo A, Hoffmann RF, Durham AL, Marwick JA, Brandenburg SM, de Bruin HG, Jonker MR, Rossios C, Tsitsiou E, Caramori G, Contoli M, Casolari P, Monaco F, Andò F, Speciale G, Kilty I, Chung KF, Papi A, Lindsay MA, Ten Hacken NH, van den Berge M, Timens W, Barnes PJ, van Oosterhout AJ, Adcock IM, Kirkham PA, Heijink IH.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1112-23. doi: 10.1152/ajplung.00077.2015. Epub 2015 Aug 28.

34.

ADAM10 mediates the house dust mite-induced release of chemokine ligand CCL20 by airway epithelium.

Post S, Rozeveld D, Jonker MR, Bischoff R, van Oosterhout AJ, Heijink IH.

Allergy. 2015 Dec;70(12):1545-52. doi: 10.1111/all.12730. Epub 2015 Sep 11.

PMID:
26296735
35.

Unravelling the complexity of COPD by microRNAs: it's a small world after all.

Osei ET, Florez-Sampedro L, Timens W, Postma DS, Heijink IH, Brandsma CA.

Eur Respir J. 2015 Sep;46(3):807-18. doi: 10.1183/13993003.02139-2014. Epub 2015 Aug 6. Review.

36.

Increased serum levels of LL37, HMGB1 and S100A9 during exacerbation in COPD patients.

Pouwels SD, Nawijn MC, Bathoorn E, Riezebos-Brilman A, van Oosterhout AJ, Kerstjens HA, Heijink IH.

Eur Respir J. 2015 May;45(5):1482-5. doi: 10.1183/09031936.00158414. No abstract available.

37.

MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [(18)F]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation.

Matusiak N, van Waarde A, Rozeveld D, van Oosterhout AJ, Heijink IH, Castelli R, Overkleeft HS, Bischoff R, Dierckx RA, Elsinga PH.

Mol Imaging Biol. 2015 Oct;17(5):680-7. doi: 10.1007/s11307-015-0847-3.

PMID:
25822732
38.

Metalloproteinase Profiling in Lung Transplant Recipients With Good Outcome and Bronchiolitis Obliterans Syndrome.

Heijink IH, Rozeveld D, van der Heide S, van der Bij W, Bischoff R, van Oosterhout AJ, van der Toorn M.

Transplantation. 2015 Sep;99(9):1946-52. doi: 10.1097/TP.0000000000000602.

PMID:
25651312
39.

A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle.

Poppinga WJ, Heijink IH, Holtzer LJ, Skroblin P, Klussmann E, Halayko AJ, Timens W, Maarsingh H, Schmidt M.

Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L766-75. doi: 10.1152/ajplung.00301.2014. Epub 2015 Jan 30.

40.

Genetic variation associates with susceptibility for cigarette smoke-induced neutrophilia in mice.

Pouwels SD, Heijink IH, Brouwer U, Gras R, den Boef LE, Boezen HM, Korstanje R, van Oosterhout AJ, Nawijn MC.

Am J Physiol Lung Cell Mol Physiol. 2015 Apr 1;308(7):L693-709. doi: 10.1152/ajplung.00118.2014. Epub 2015 Jan 30.

41.

Cigarette smoke-induced damage-associated molecular pattern release from necrotic neutrophils triggers proinflammatory mediator release.

Heijink IH, Pouwels SD, Leijendekker C, de Bruin HG, Zijlstra GJ, van der Vaart H, ten Hacken NH, van Oosterhout AJ, Nawijn MC, van der Toorn M.

Am J Respir Cell Mol Biol. 2015 May;52(5):554-62. doi: 10.1165/rcmb.2013-0505OC. Erratum in: Am J Respir Cell Mol Biol. 2016 Apr;54(4):597-9.

PMID:
25192219
42.

Abnormalities in airway epithelial junction formation in chronic obstructive pulmonary disease.

Heijink IH, Noordhoek JA, Timens W, van Oosterhout AJ, Postma DS.

Am J Respir Crit Care Med. 2014 Jun 1;189(11):1439-42. doi: 10.1164/rccm.201311-1982LE. No abstract available.

PMID:
24881942
43.

Untargeted lipidomic analysis in chronic obstructive pulmonary disease. Uncovering sphingolipids.

Telenga ED, Hoffmann RF, Ruben t'Kindt, Hoonhorst SJ, Willemse BW, van Oosterhout AJ, Heijink IH, van den Berge M, Jorge L, Sandra P, Postma DS, Sandra K, ten Hacken NH.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):155-64. doi: 10.1164/rccm.201312-2210OC.

PMID:
24871890
44.

Pim1 kinase protects airway epithelial cells from cigarette smoke-induced damage and airway inflammation.

de Vries M, Heijink IH, Gras R, den Boef LE, Reinders-Luinge M, Pouwels SD, Hylkema MN, van der Toorn M, Brouwer U, van Oosterhout AJ, Nawijn MC.

Am J Physiol Lung Cell Mol Physiol. 2014 Aug 1;307(3):L240-51. doi: 10.1152/ajplung.00156.2013. Epub 2014 May 9.

45.

Protease-activated receptor-2 activation contributes to house dust mite-induced IgE responses in mice.

Post S, Heijink IH, Petersen AH, de Bruin HG, van Oosterhout AJ, Nawijn MC.

PLoS One. 2014 Mar 20;9(3):e91206. doi: 10.1371/journal.pone.0091206. eCollection 2014.

46.

Glucocorticoids induce the production of the chemoattractant CCL20 in airway epithelium.

Zijlstra GJ, Fattahi F, Rozeveld D, Jonker MR, Kliphuis NM, van den Berge M, Hylkema MN, ten Hacken NH, van Oosterhout AJ, Heijink IH.

Eur Respir J. 2014 Aug;44(2):361-70. doi: 10.1183/09031936.00209513. Epub 2014 Mar 13.

47.

Airway epithelial barrier function regulates the pathogenesis of allergic asthma.

Heijink IH, Nawijn MC, Hackett TL.

Clin Exp Allergy. 2014;44(5):620-30. doi: 10.1111/cea.12296. Review.

PMID:
24612268
48.

A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke.

Oldenburger A, Poppinga WJ, Kos F, de Bruin HG, Rijks WF, Heijink IH, Timens W, Meurs H, Maarsingh H, Schmidt M.

Am J Physiol Cell Physiol. 2014 Mar 15;306(6):C585-97. doi: 10.1152/ajpcell.00183.2013. Epub 2014 Jan 22.

49.

A specific DAMP profile identifies susceptibility to smoke-induced airway inflammation.

Pouwels SD, Heijink IH, van Oosterhout AJ, Nawijn MC.

Eur Respir J. 2014 Apr;43(4):1183-6. doi: 10.1183/09031936.00127813. Epub 2013 Dec 5. No abstract available.

50.

DAMPs activating innate and adaptive immune responses in COPD.

Pouwels SD, Heijink IH, ten Hacken NH, Vandenabeele P, Krysko DV, Nawijn MC, van Oosterhout AJ.

Mucosal Immunol. 2014 Mar;7(2):215-26. doi: 10.1038/mi.2013.77. Epub 2013 Oct 23. Review.

PMID:
24150257

Supplemental Content

Loading ...
Support Center