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Items: 1 to 50 of 72

1.

ATP-dependent helicase activity is dispensable for the physiological functions of Recql4.

Castillo-Tandazo W, Smeets MF, Murphy V, Liu R, Hodson C, Heierhorst J, Deans AJ, Walkley CR.

PLoS Genet. 2019 Jul 5;15(7):e1008266. doi: 10.1371/journal.pgen.1008266. eCollection 2019 Jul.

2.

Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar Dynein function in primary cilia.

King A, Hoch NC, McGregor NE, Sims NA, Smyth IM, Heierhorst J.

Hum Mol Genet. 2019 Apr 22. pii: ddz083. doi: 10.1093/hmg/ddz083. [Epub ahead of print]

PMID:
31009951
3.

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity.

Becker JR, Cuella-Martin R, Barazas M, Liu R, Oliveira C, Oliver AW, Bilham K, Holt AB, Blackford AN, Heierhorst J, Jonkers J, Rottenberg S, Chapman JR.

Nat Commun. 2018 Dec 17;9(1):5406. doi: 10.1038/s41467-018-07855-x.

4.

Multivalency regulates activity in an intrinsically disordered transcription factor.

Clark S, Myers JB, King A, Fiala R, Novacek J, Pearce G, Heierhorst J, Reichow SL, Barbar EJ.

Elife. 2018 Aug 3;7. pii: e40684. doi: 10.7554/eLife.40684.

5.

Multivalency regulates activity in an intrinsically disordered transcription factor.

Clark S, Myers JB, King A, Fiala R, Novacek J, Pearce G, Heierhorst J, Reichow SL, Barbar EJ.

Elife. 2018 May 1;7. pii: e36258. doi: 10.7554/eLife.36258. Erratum in: Elife. 2018 Aug 03;7:.

6.

Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.

Liu R, King A, Bouillet P, Tarlinton DM, Strasser A, Heierhorst J.

Front Immunol. 2018 Mar 22;9:592. doi: 10.3389/fimmu.2018.00592. eCollection 2018.

7.

Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms.

King A, Li L, Wong DM, Liu R, Bamford R, Strasser A, Tarlinton DM, Heierhorst J.

PLoS Genet. 2017 Sep 18;13(9):e1007010. doi: 10.1371/journal.pgen.1007010. eCollection 2017 Sep.

8.

ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress.

Liu R, King A, Hoch NC, Chang C, Kelly GL, Deans AJ, Heierhorst J.

DNA Repair (Amst). 2017 Sep;57:29-34. doi: 10.1016/j.dnarep.2017.06.022. Epub 2017 Jun 17.

9.

Quantitative Analysis of Yeast Checkpoint Protein Kinase Activity by Combined Mass Spectrometry Enzyme Assays.

Hoch NC, Chen ES, Tsai MD, Heierhorst J.

Methods Enzymol. 2017;586:143-164. doi: 10.1016/bs.mie.2016.09.032. Epub 2016 Nov 2.

PMID:
28137560
10.

Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway.

van Twest S, Murphy VJ, Hodson C, Tan W, Swuec P, O'Rourke JJ, Heierhorst J, Crismani W, Deans AJ.

Mol Cell. 2017 Jan 19;65(2):247-259. doi: 10.1016/j.molcel.2016.11.005. Epub 2016 Dec 13.

11.

The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma.

Wong DM, Li L, Jurado S, King A, Bamford R, Wall M, Walia MK, Kelly GL, Walkley CR, Tarlinton DM, Strasser A, Heierhorst J.

Cell Rep. 2016 Feb 16;14(6):1488-1499. doi: 10.1016/j.celrep.2016.01.012. Epub 2016 Jan 28.

12.

S100A1 and S100B are dispensable for endochondral ossification during skeletal development.

Mori Y, Mori D, Chung UI, Tanaka S, Heierhorst J, Buchou T, Baudier J, Kawaguchi H, Saito T.

Biomed Res. 2014;35(4):243-50.

13.

The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.

Smeets MF, DeLuca E, Wall M, Quach JM, Chalk AM, Deans AJ, Heierhorst J, Purton LE, Izon DJ, Walkley CR.

J Clin Invest. 2014 Aug;124(8):3551-65. doi: 10.1172/JCI75334. Epub 2014 Jun 24.

14.

The novel zinc finger protein dASCIZ regulates mitosis in Drosophila via an essential role in dynein light-chain expression.

Zaytseva O, Tenis N, Mitchell N, Kanno S, Yasui A, Heierhorst J, Quinn LM.

Genetics. 2014 Feb;196(2):443-53. doi: 10.1534/genetics.113.159541. Epub 2013 Dec 13.

15.

Use of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.

Chen ES, Hoch NC, Wang SC, Pellicioli A, Heierhorst J, Tsai MD.

Mol Cell Proteomics. 2014 Feb;13(2):551-65. doi: 10.1074/mcp.M113.034058. Epub 2013 Dec 3.

16.

Yeast hEST1A/B (SMG5/6)-like proteins contribute to environment-sensing adaptive gene expression responses.

Lai X, Beilharz T, Au WC, Hammet A, Preiss T, Basrai MA, Heierhorst J.

G3 (Bethesda). 2013 Oct 3;3(10):1649-59. doi: 10.1534/g3.113.006924.

17.

Molecular basis of the essential s phase function of the rad53 checkpoint kinase.

Hoch NC, Chen ES, Buckland R, Wang SC, Fazio A, Hammet A, Pellicioli A, Chabes A, Tsai MD, Heierhorst J.

Mol Cell Biol. 2013 Aug;33(16):3202-13. doi: 10.1128/MCB.00474-13. Epub 2013 Jun 10.

18.

Suppression of chromosome healing and anticheckpoint pathways in yeast postsenescence survivors.

Lai X, Heierhorst J.

Genetics. 2013 Jun;194(2):403-8. doi: 10.1534/genetics.113.150813. Epub 2013 Mar 27.

19.

Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2.

Shi W, Bain AL, Schwer B, Al-Ejeh F, Smith C, Wong L, Chai H, Miranda MS, Ho U, Kawaguchi M, Miura Y, Finnie JW, Wall M, Heierhorst J, Wicking C, Spring KJ, Alt FW, Khanna KK.

PLoS Genet. 2013;9(2):e1003298. doi: 10.1371/journal.pgen.1003298. Epub 2013 Feb 7.

20.

Genomic stability disorders: from budding yeast to humans.

Hoch NC, Lai X, Heierhorst J.

Front Biosci (Schol Ed). 2013 Jan 1;5:396-411. Review.

PMID:
23277058
21.

The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim.

Jurado S, Gleeson K, O'Donnell K, Izon DJ, Walkley CR, Strasser A, Tarlinton DM, Heierhorst J.

J Exp Med. 2012 Aug 27;209(9):1629-39. doi: 10.1084/jem.20120785. Epub 2012 Aug 13.

22.

ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression.

Jurado S, Conlan LA, Baker EK, Ng JL, Tenis N, Hoch NC, Gleeson K, Smeets M, Izon D, Heierhorst J.

J Biol Chem. 2012 Jan 27;287(5):3156-64. doi: 10.1074/jbc.M111.306019. Epub 2011 Dec 13.

23.

A breathtaking phenotype: unexpected roles of the DNA base damage response protein ASCIZ as a key regulator of early lung development.

Heierhorst J, Smyth I, Jurado S.

Cell Cycle. 2011 Apr 15;10(8):1222-4. Epub 2011 Apr 15.

PMID:
21415597
24.

Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis.

Jurado S, Smyth I, van Denderen B, Tenis N, Hammet A, Hewitt K, Ng JL, McNees CJ, Kozlov SV, Oka H, Kobayashi M, Conlan LA, Cole TJ, Yamamoto K, Taniguchi Y, Takeda S, Lavin MF, Heierhorst J.

PLoS Genet. 2010 Oct 21;6(10):e1001170. doi: 10.1371/journal.pgen.1001170. Erratum in: PLoS Genet. 2010;6(11). doi: 10.1371/annotation/bce92e15-60b4-493b-89de-28529386f4ac.

25.

The yeast PUF protein Puf5 has Pop2-independent roles in response to DNA replication stress.

Traven A, Lo TL, Lithgow T, Heierhorst J.

PLoS One. 2010 May 14;5(5):e10651. doi: 10.1371/journal.pone.0010651.

26.

Molecular basis for lysine specificity in the yeast ubiquitin-conjugating enzyme Cdc34.

Sadowski M, Suryadinata R, Lai X, Heierhorst J, Sarcevic B.

Mol Cell Biol. 2010 May;30(10):2316-29. doi: 10.1128/MCB.01094-09. Epub 2010 Mar 1.

27.

Dual functions of Mdt1 in genome maintenance and cell integrity pathways in Saccharomyces cerevisiae.

Traven A, Lo TL, Pike BL, Friesen H, Guzzo J, Andrews B, Heierhorst J.

Yeast. 2010 Jan;27(1):41-52. doi: 10.1002/yea.1730.

28.

The Ccr4-Pop2-NOT mRNA deadenylase contributes to septin organization in Saccharomyces cerevisiae.

Traven A, Beilharz TH, Lo TL, Lueder F, Preiss T, Heierhorst J.

Genetics. 2009 Aug;182(4):955-66. doi: 10.1534/genetics.109.104414. Epub 2009 Jun 1.

29.

Mdt1/ASCIZ: a new DNA damage response protein family.

Heierhorst J.

Cell Cycle. 2008 Sep 1;7(17):2654-60. Epub 2008 Sep 12. Review.

PMID:
18728389
30.

Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade.

Lee H, Yuan C, Hammet A, Mahajan A, Chen ES, Wu MR, Su MI, Heierhorst J, Tsai MD.

Mol Cell. 2008 Jun 20;30(6):767-78. doi: 10.1016/j.molcel.2008.05.013.

31.

DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion.

Oka H, Sakai W, Sonoda E, Nakamura J, Asagoshi K, Wilson SH, Kobayashi M, Yamamoto K, Heierhorst J, Takeda S, Taniguchi Y.

Biochem Biophys Res Commun. 2008 Jun 27;371(2):225-9. doi: 10.1016/j.bbrc.2008.04.052. Epub 2008 Apr 21. Erratum in: Biochem Biophys Res Commun. 2008 Dec 5;377(1):326.

PMID:
18433721
32.

Location-specific functions of the two forkhead-associated domains in Rad53 checkpoint kinase signaling.

Tam AT, Pike BL, Heierhorst J.

Biochemistry. 2008 Mar 25;47(12):3912-6. doi: 10.1021/bi800027t. Epub 2008 Feb 27.

PMID:
18302321
33.

Endothelial S100A1 modulates vascular function via nitric oxide.

Pleger ST, Harris DM, Shan C, Vinge LE, Chuprun JK, Berzins B, Pleger W, Druckman C, Völkers M, Heierhorst J, Øie E, Remppis A, Katus HA, Scalia R, Eckhart AD, Koch WJ, Most P.

Circ Res. 2008 Apr 11;102(7):786-94. doi: 10.1161/CIRCRESAHA.108.172031. Epub 2008 Feb 21.

PMID:
18292599
34.

Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast.

Hammet A, Magill C, Heierhorst J, Jackson SP.

EMBO Rep. 2007 Sep;8(9):851-7. Epub 2007 Aug 3.

35.
36.

Telomere-related functions of yeast KU in the repair of bleomycin-induced DNA damage.

Tam AT, Pike BL, Hammet A, Heierhorst J.

Biochem Biophys Res Commun. 2007 Jun 8;357(3):800-3. Epub 2007 Apr 10.

PMID:
17442269
37.

Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction.

Most P, Seifert H, Gao E, Funakoshi H, Völkers M, Heierhorst J, Remppis A, Pleger ST, DeGeorge BR Jr, Eckhart AD, Feldman AM, Koch WJ.

Circulation. 2006 Sep 19;114(12):1258-68. Epub 2006 Sep 4.

PMID:
16952982
38.

Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers.

Deans AJ, Khanna KK, McNees CJ, Mercurio C, Heierhorst J, McArthur GA.

Cancer Res. 2006 Aug 15;66(16):8219-26.

39.

FHA domain-ligand interactions: importance of integrating chemical and biological approaches.

Mahajan A, Yuan C, Pike BL, Heierhorst J, Chang CF, Tsai MD.

J Am Chem Soc. 2005 Oct 26;127(42):14572-3.

PMID:
16231900
40.

ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage.

McNees CJ, Conlan LA, Tenis N, Heierhorst J.

EMBO J. 2005 Jul 6;24(13):2447-57. Epub 2005 Jun 2.

41.
42.

Ccr4-not complex mRNA deadenylase activity contributes to DNA damage responses in Saccharomyces cerevisiae.

Traven A, Hammet A, Tenis N, Denis CL, Heierhorst J.

Genetics. 2005 Jan;169(1):65-75. Epub 2004 Sep 30.

43.

Rad53 kinase activation-independent replication checkpoint function of the N-terminal forkhead-associated (FHA1) domain.

Pike BL, Tenis N, Heierhorst J.

J Biol Chem. 2004 Sep 17;279(38):39636-44. Epub 2004 Jul 22.

44.
45.

Proteasome-dependent dispersal of PML nuclear bodies in response to alkylating DNA damage.

Conlan LA, McNees CJ, Heierhorst J.

Oncogene. 2004 Jan 8;23(1):307-10.

PMID:
14712236
46.

Diverse but overlapping functions of the two forkhead-associated (FHA) domains in Rad53 checkpoint kinase activation.

Pike BL, Yongkiettrakul S, Tsai MD, Heierhorst J.

J Biol Chem. 2003 Aug 15;278(33):30421-4. Epub 2003 Jun 12.

47.

Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance.

Most P, Remppis A, Pleger ST, Löffler E, Ehlermann P, Bernotat J, Kleuss C, Heierhorst J, Ruiz P, Witt H, Karczewski P, Mao L, Rockman HA, Duncan SJ, Katus HA, Koch WJ.

J Biol Chem. 2003 Sep 5;278(36):33809-17. Epub 2003 May 30.

48.

FHA domains as phospho-threonine binding modules in cell signaling.

Hammet A, Pike BL, McNees CJ, Conlan LA, Tenis N, Heierhorst J.

IUBMB Life. 2003 Jan;55(1):23-7. Review.

49.
50.

Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient mice.

Du XJ, Cole TJ, Tenis N, Gao XM, Köntgen F, Kemp BE, Heierhorst J.

Mol Cell Biol. 2002 Apr;22(8):2821-9.

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