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Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp.

Cheng HW, Onder L, Novkovic M, Soneson C, Lütge M, Pikor N, Scandella E, Robinson MD, Miyazaki JI, Tersteegen A, Sorg U, Pfeffer K, Rülicke T, Hehlgans T, Ludewig B.

Nat Commun. 2019 Apr 15;10(1):1739. doi: 10.1038/s41467-019-09728-3.


Chronic Inflammation Increases the Sensitivity of Mouse Treg for TNFR2 Costimulation.

Schmid T, Falter L, Weber S, Müller N, Molitor K, Zeller D, Weber-Steffens D, Hehlgans T, Wajant H, Mostböck S, Männel DN.

Front Immunol. 2017 Nov 7;8:1471. doi: 10.3389/fimmu.2017.01471. eCollection 2017.


The association between acute graft-versus-host disease and antimicrobial peptide expression in the gastrointestinal tract after allogeneic stem cell transplantation.

Weber D, Frauenschläger K, Ghimire S, Peter K, Panzer I, Hiergeist A, Weber M, Kutny D, Wolff D, Grube M, Huber E, Oefner P, Gessner A, Hehlgans T, Herr W, Holler E.

PLoS One. 2017 Sep 21;12(9):e0185265. doi: 10.1371/journal.pone.0185265. eCollection 2017.


Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis.

Onder L, Mörbe U, Pikor N, Novkovic M, Cheng HW, Hehlgans T, Pfeffer K, Becher B, Waisman A, Rülicke T, Gommerman J, Mueller CG, Sawa S, Scandella E, Ludewig B.

Immunity. 2017 Jul 18;47(1):80-92.e4. doi: 10.1016/j.immuni.2017.05.008. Epub 2017 Jul 11.


Human beta-defensin-2 and -3 enhance pro-inflammatory cytokine expression induced by TLR ligands via ATP-release in a P2X7R dependent manner.

Wanke D, Mauch-Mücke K, Holler E, Hehlgans T.

Immunobiology. 2016 Nov;221(11):1259-65. doi: 10.1016/j.imbio.2016.06.006. Epub 2016 Jun 19.


IL-10 from marginal zone precursor B cells controls the differentiation of Th17, Tfh and Tfr cells in transplantation tolerance.

Lal G, Kulkarni N, Nakayama Y, Singh AK, Sethi A, Burrell BE, Brinkman CC, Iwami D, Zhang T, Hehlgans T, Bromberg JS.

Immunol Lett. 2016 Feb;170:52-63. doi: 10.1016/j.imlet.2016.01.002. Epub 2016 Jan 6.


Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B-cell activation and proliferation.

Heinig K, Gätjen M, Grau M, Stache V, Anagnostopoulos I, Gerlach K, Niesner RA, Cseresnyes Z, Hauser AE, Lenz P, Hehlgans T, Brink R, Westermann J, Dörken B, Lipp M, Lenz G, Rehm A, Höpken UE.

Cancer Discov. 2014 Dec;4(12):1448-65. doi: 10.1158/2159-8290.CD-14-0096. Epub 2014 Sep 24.


Metagenomic analysis of the stool microbiome in patients receiving allogeneic stem cell transplantation: loss of diversity is associated with use of systemic antibiotics and more pronounced in gastrointestinal graft-versus-host disease.

Holler E, Butzhammer P, Schmid K, Hundsrucker C, Koestler J, Peter K, Zhu W, Sporrer D, Hehlgans T, Kreutz M, Holler B, Wolff D, Edinger M, Andreesen R, Levine JE, Ferrara JL, Gessner A, Spang R, Oefner PJ.

Biol Blood Marrow Transplant. 2014 May;20(5):640-5. doi: 10.1016/j.bbmt.2014.01.030. Epub 2014 Jan 31.


LTβR expression on hematopoietic cells regulates acute inflammation and influences maturation of myeloid subpopulations.

Wege AK, Huber B, Wimmer N, Männel DN, Hehlgans T.

Innate Immun. 2014 Jul;20(5):461-70. doi: 10.1177/1753425913497242. Epub 2013 Aug 12.


Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity.

Chai Q, Onder L, Scandella E, Gil-Cruz C, Perez-Shibayama C, Cupovic J, Danuser R, Sparwasser T, Luther SA, Thiel V, Rülicke T, Stein JV, Hehlgans T, Ludewig B.

Immunity. 2013 May 23;38(5):1013-24. doi: 10.1016/j.immuni.2013.03.012. Epub 2013 Apr 25.


Endothelial cell-specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation.

Onder L, Danuser R, Scandella E, Firner S, Chai Q, Hehlgans T, Stein JV, Ludewig B.

J Exp Med. 2013 Mar 11;210(3):465-73. doi: 10.1084/jem.20121462. Epub 2013 Feb 18.


Beta-defensins activate macrophages and synergize in pro-inflammatory cytokine expression induced by TLR ligands.

Barabas N, Röhrl J, Holler E, Hehlgans T.

Immunobiology. 2013 Jul;218(7):1005-11. doi: 10.1016/j.imbio.2012.11.007. Epub 2012 Nov 29.


Lymphotoxin-beta receptor signalling regulates cytokine expression via TRIM30α in a TRAF3-dependent manner.

Wimmer N, Heigl U, Klingseisen L, Schneider-Brachert W, Hehlgans T.

Mol Immunol. 2013 May;54(1):40-7. doi: 10.1016/j.molimm.2012.10.036. Epub 2012 Dec 3.


Friend or foe: A novel role of β-defensins in tumor development.

Röhrl J, Geissler EK, Hehlgans T.

Oncoimmunology. 2012 Oct 1;1(7):1159-1160.


E3-14.7K is recruited to TNF-receptor 1 and blocks TNF cytolysis independent from interaction with optineurin.

Klingseisen L, Ehrenschwender M, Heigl U, Wajant H, Hehlgans T, Schütze S, Schneider-Brachert W.

PLoS One. 2012;7(6):e38348. doi: 10.1371/journal.pone.0038348. Epub 2012 Jun 4.


Mouse β-defensin 14 (Defb14) promotes tumor growth by inducing angiogenesis in a CCR6-dependent manner.

Röhrl J, Huber B, Koehl GE, Geissler EK, Hehlgans T.

J Immunol. 2012 May 15;188(10):4931-9. doi: 10.4049/jimmunol.1102442. Epub 2012 Apr 13.


Mechanisms of immune complex-mediated experimental glomerulonephritis: possible role of the balance between endogenous TNF and soluble TNF receptor type 2.

Pfeifer E, Polz J, Grieβl S, Mostböck S, Hehlgans T, Männel DN.

Eur Cytokine Netw. 2012 Mar 1;23(1):15-20. doi: 10.1684/ecn.2012.0299.


Lymphotoxin-beta receptor activation on macrophages ameliorates acute DSS-induced intestinal inflammation in a TRIM30α-dependent manner.

Wimmer N, Huber B, Wege AK, Barabas N, Röhrl J, Pfeffer K, Hehlgans T.

Mol Immunol. 2012 Jun;51(2):128-35. doi: 10.1016/j.molimm.2012.02.118. Epub 2012 Mar 20.


Lymphotoxin β receptor activation on macrophages induces cross-tolerance to TLR4 and TLR9 ligands.

Wimmer N, Huber B, Barabas N, Röhrl J, Pfeffer K, Hehlgans T.

J Immunol. 2012 Apr 1;188(7):3426-33. doi: 10.4049/jimmunol.1103324. Epub 2012 Feb 22.


RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.

Powolny-Budnicka I, Riemann M, Tänzer S, Schmid RM, Hehlgans T, Weih F.

Immunity. 2011 Mar 25;34(3):364-74. doi: 10.1016/j.immuni.2011.02.019.


Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.

Röhrl J, Yang D, Oppenheim JJ, Hehlgans T.

J Immunol. 2010 Jun 15;184(12):6688-94. doi: 10.4049/jimmunol.0903984. Epub 2010 May 17.


Lymphotoxin-β receptor activation by lymphotoxin-α(1)β(2) and LIGHT promotes tumor growth in an NFκB-dependent manner.

Daller B, Müsch W, Röhrl J, Tumanov AV, Nedospasov SA, Männel DN, Schneider-Brachert W, Hehlgans T.

Int J Cancer. 2011 Mar 15;128(6):1363-70. doi: 10.1002/ijc.25456.


Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells on combined tumor necrosis factor receptor-1/lymphotoxin beta-receptor NF-kappaB signaling.

Lötzer K, Döpping S, Connert S, Gräbner R, Spanbroek R, Lemser B, Beer M, Hildner M, Hehlgans T, van der Wall M, Mebius RE, Lovas A, Randolph GJ, Weih F, Habenicht AJ.

Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):395-402. doi: 10.1161/ATVBAHA.109.191395. Epub 2010 Feb 5.


Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells.

Röhrl J, Yang D, Oppenheim JJ, Hehlgans T.

J Biol Chem. 2010 Mar 5;285(10):7028-34. doi: 10.1074/jbc.M109.091090. Epub 2010 Jan 12.


Neutralization of LIGHT ameliorates acute dextran sodium sulphate-induced intestinal inflammation.

Jungbeck M, Daller B, Federhofer J, Wege AK, Wimmer N, Männel DN, Hehlgans T.

Immunology. 2009 Nov;128(3):451-8. doi: 10.1111/j.1365-2567.2009.03131.x.


Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice.

Gräbner R, Lötzer K, Döpping S, Hildner M, Radke D, Beer M, Spanbroek R, Lippert B, Reardon CA, Getz GS, Fu YX, Hehlgans T, Mebius RE, van der Wall M, Kruspe D, Englert C, Lovas A, Hu D, Randolph GJ, Weih F, Habenicht AJ.

J Exp Med. 2009 Jan 16;206(1):233-48. doi: 10.1084/jem.20080752. Epub 2009 Jan 12.


Enhanced susceptibility to Con A-induced liver injury in mice transgenic for the intracellular isoform of human TNF receptor type 2.

Bäumel M, Lechner A, Hehlgans T, Männel DN.

J Leukoc Biol. 2008 Jul;84(1):162-9. doi: 10.1189/jlb.1007713. Epub 2008 Apr 24.


Generation and characterization of alpha-chymase-Cre transgenic mice.

Müsch W, Wege AK, Männel DN, Hehlgans T.

Genesis. 2008 Mar;46(3):163-6. doi: 10.1002/dvg.20378.


Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3.

Röhrl J, Yang D, Oppenheim JJ, Hehlgans T.

J Biol Chem. 2008 Feb 29;283(9):5414-9. doi: 10.1074/jbc.M709103200. Epub 2007 Dec 31.


Blocking lymphotoxin beta receptor signalling exacerbates acute DSS-induced intestinal inflammation--opposite functions for surface lymphotoxin expressed by T and B lymphocytes.

Jungbeck M, Stopfer P, Bataille F, Nedospasov SA, Männel DN, Hehlgans T.

Mol Immunol. 2008 Jan;45(1):34-41. Epub 2007 Jun 27.


Characterization of TNF receptor type 2 isoform in the mouse.

Hauser A, Hehlgans T, Männel DN.

Mol Immunol. 2007 Jul;44(14):3563-70. Epub 2007 May 7.


Localization of the mouse defense lectin ficolin B in lysosomes of activated macrophages.

Runza VL, Hehlgans T, Echtenacher B, Zähringer U, Schwaeble WJ, Männel DN.

J Endotoxin Res. 2006;12(2):120-6.


Colocalization of endogenous TNF with a functional intracellular splice form of human TNF receptor type 2.

Scherübl C, Schneider-Brachert W, Schütze S, Hehlgans T, Männel DN.

J Inflamm (Lond). 2005 Jul 4;2:7.


Role of CREB1 and NF{kappa}B-p65 in the down-regulation of renin gene expression by tumor necrosis factor {alpha}.

Todorov VT, Völkl S, Friedrich J, Kunz-Schughart LA, Hehlgans T, Vermeulen L, Haegeman G, Schmitz ML, Kurtz A.

J Biol Chem. 2005 Jul 1;280(26):24356-62. Epub 2005 Apr 27.


From "junk" to gene: curriculum vitae of a primate receptor isoform gene.

Singer SS, Männel DN, Hehlgans T, Brosius J, Schmitz J.

J Mol Biol. 2004 Aug 20;341(4):883-6.


Involvement of the lectin pathway of complement activation in antimicrobial immune defense during experimental septic peritonitis.

Windbichler M, Echtenacher B, Hehlgans T, Jensenius JC, Schwaeble W, Männel DN.

Infect Immun. 2004 Sep;72(9):5247-52.


Tumor necrosis factor-alpha activates NFkappaB to inhibit renin transcription by targeting cAMP-responsive element.

Todorov VT, Völkl S, Müller M, Bohla A, Klar J, Kunz-Schughart LA, Hehlgans T, Kurtz A.

J Biol Chem. 2004 Jan 9;279(2):1458-67. Epub 2003 Oct 16.


The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes.

Ehlers S, Hölscher C, Scheu S, Tertilt C, Hehlgans T, Suwinski J, Endres R, Pfeffer K.

J Immunol. 2003 May 15;170(10):5210-8.


The TNF-TNF receptor system.

Hehlgans T, Männel DN.

Biol Chem. 2002 Oct;383(10):1581-5. Review.


Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria.

Stoelcker B, Hehlgans T, Weigl K, Bluethmann H, Grau GE, Männel DN.

Infect Immun. 2002 Oct;70(10):5857-9.


Lymphotoxin-beta receptor immune interaction promotes tumor growth by inducing angiogenesis.

Hehlgans T, Stoelcker B, Stopfer P, Müller P, Cernaianu G, Guba M, Steinbauer M, Nedospasov SA, Pfeffer K, Männel DN.

Cancer Res. 2002 Jul 15;62(14):4034-40.


Hypoxic upregulation of TNF receptor type 2 expression involves NF-IL-6 and is independent of HIF-1 or HIF-2.

Hehlgans T, Seitz C, Lewis C, Männel DN.

J Interferon Cytokine Res. 2001 Sep;21(9):757-62.


Antimetastatic effect of CpG DNA mediated by type I IFN.

Hafner M, Zawatzky R, Hirtreiter C, Buurman WA, Echtenacher B, Hehlgans T, Männel DN.

Cancer Res. 2001 Jul 15;61(14):5523-8.


Functional characterization of the mouse lymphotoxin-beta receptor promoter.

Muller P, Männel DN, Hehlgans T.

Eur Cytokine Netw. 2001 Apr-Jun;12(2):325-30.


Development of allergic contact dermatitis requires activation of both tumor necrosis factor-receptors.

Becke FM, Hehlgans T, Brockhoff G, Männel DN.

Eur Cytokine Netw. 2001 Mar;12(1):45-50.

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