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Parameter Optimization in High-Throughput Testing for Structural Materials.

Bader A, Toenjes A, Wielki N, Mändle A, Onken AK, Hehl AV, Meyer D, Brannath W, Tracht K.

Materials (Basel). 2019 Oct 21;12(20). pii: E3439. doi: 10.3390/ma12203439.


A cytonaut's guide to protein trafficking in Giardia lamblia.

Faso C, Hehl AB.

Adv Parasitol. 2019;106:105-127. doi: 10.1016/bs.apar.2019.08.001.


Roles of Phosphoinositides and Their binding Proteins in Parasitic Protozoa.

Cernikova L, Faso C, Hehl AB.

Trends Parasitol. 2019 Dec;35(12):996-1008. doi: 10.1016/ Epub 2019 Oct 12. Review.


An experimental genetically attenuated live vaccine to prevent transmission of Toxoplasma gondii by cats.

Ramakrishnan C, Maier S, Walker RA, Rehrauer H, Joekel DE, Winiger RR, Basso WU, Grigg ME, Hehl AB, Deplazes P, Smith NC.

Sci Rep. 2019 Feb 6;9(1):1474. doi: 10.1038/s41598-018-37671-8.


Five facts about Giardia lamblia.

Cernikova L, Faso C, Hehl AB.

PLoS Pathog. 2018 Sep 27;14(9):e1007250. doi: 10.1371/journal.ppat.1007250. eCollection 2018 Sep. Review. No abstract available.


Mitochondrial Glycolysis in a Major Lineage of Eukaryotes.

Río Bártulos C, Rogers MB, Williams TA, Gentekaki E, Brinkmann H, Cerff R, Liaud MF, Hehl AB, Yarlett NR, Gruber A, Kroth PG, van der Giezen M.

Genome Biol Evol. 2018 Sep 1;10(9):2310-2325. doi: 10.1093/gbe/evy164.


Veterinary parasitology teaching - Ten years of experience with the Vetsuisse curriculum.

Schnyder M, Hertzberg H, Mathis A, Schönmann M, Hehl A, Deplazes P.

Vet Parasitol. 2018 Mar 15;252:148-152. doi: 10.1016/j.vetpar.2018.01.033. Epub 2018 Feb 1.


Diversity of Entamoeba spp. in African great apes and humans: an insight from Illumina MiSeq high-throughput sequencing.

Vlčková K, Kreisinger J, Pafčo B, Čížková D, Tagg N, Hehl AB, Modrý D.

Int J Parasitol. 2018 Jun;48(7):519-530. doi: 10.1016/j.ijpara.2017.11.008. Epub 2018 Mar 10.


RNA-Seq analysis during the life cycle of Cryptosporidium parvum reveals significant differential gene expression between proliferating stages in the intestine and infectious sporozoites.

Lippuner C, Ramakrishnan C, Basso WU, Schmid MW, Okoniewski M, Smith NC, Hässig M, Deplazes P, Hehl AB.

Int J Parasitol. 2018 May;48(6):413-422. doi: 10.1016/j.ijpara.2017.10.007. Epub 2018 Feb 9.


In vitro efficacy of bumped kinase inhibitors against Besnoitia besnoiti tachyzoites.

Jiménez-Meléndez A, Ojo KK, Wallace AM, Smith TR, Hemphill A, Balmer V, Regidor-Cerrillo J, Ortega-Mora LM, Hehl AB, Fan E, Maly DJ, Van Voorhis WC, Álvarez-García G.

Int J Parasitol. 2017 Oct;47(12):811-821. doi: 10.1016/j.ijpara.2017.08.005. Epub 2017 Sep 9.


A druggable secretory protein maturase of Toxoplasma essential for invasion and egress.

Dogga SK, Mukherjee B, Jacot D, Kockmann T, Molino L, Hammoudi PM, Hartkoorn RC, Hehl AB, Soldati-Favre D.

Elife. 2017 Sep 12;6. pii: e27480. doi: 10.7554/eLife.27480.


Genome-wide analysis of gene expression and protein secretion of Babesia canis during virulent infection identifies potential pathogenicity factors.

Eichenberger RM, Ramakrishnan C, Russo G, Deplazes P, Hehl AB.

Sci Rep. 2017 Jun 13;7(1):3357. doi: 10.1038/s41598-017-03445-x.


The merozoite-specific protein, TgGRA11B, identified as a component of the Toxoplasma gondii parasitophorous vacuole in a tachyzoite expression model.

Ramakrishnan C, Walker RA, Eichenberger RM, Hehl AB, Smith NC.

Int J Parasitol. 2017 Sep;47(10-11):597-600. doi: 10.1016/j.ijpara.2017.04.001. Epub 2017 May 17.


Response to Zamponi et al.

Hehl AB, Faso C.

Trends Parasitol. 2017 Feb;33(2):76. doi: 10.1016/ Epub 2017 Jan 9. No abstract available.


Cyst-Wall-Protein-1 is fundamental for Golgi-like organelle neogenesis and cyst-wall biosynthesis in Giardia lamblia.

Ebneter JA, Heusser SD, Schraner EM, Hehl AB, Faso C.

Nat Commun. 2016 Dec 15;7:13859. doi: 10.1038/ncomms13859.


An Interactome-Centered Protein Discovery Approach Reveals Novel Components Involved in Mitosome Function and Homeostasis in Giardia lamblia.

Rout S, Zumthor JP, Schraner EM, Faso C, Hehl AB.

PLoS Pathog. 2016 Dec 7;12(12):e1006036. doi: 10.1371/journal.ppat.1006036. eCollection 2016 Dec.


Rac Regulates Giardia lamblia Encystation by Coordinating Cyst Wall Protein Trafficking and Secretion.

Krtková J, Thomas EB, Alas GC, Schraner EM, Behjatnia HR, Hehl AB, Paredez AR.

mBio. 2016 Aug 23;7(4). pii: e01003-16. doi: 10.1128/mBio.01003-16.


Static Clathrin Assemblies at the Peripheral Vacuole-Plasma Membrane Interface of the Parasitic Protozoan Giardia lamblia.

Zumthor JP, Cernikova L, Rout S, Kaech A, Faso C, Hehl AB.

PLoS Pathog. 2016 Jul 20;12(7):e1005756. doi: 10.1371/journal.ppat.1005756. eCollection 2016 Jul.


Comparative characterisation of two nitroreductases from Giardia lamblia as potential activators of nitro compounds.

Müller J, Rout S, Leitsch D, Vaithilingam J, Hehl A, Müller N.

Int J Parasitol Drugs Drug Resist. 2015 Mar 25;5(2):37-43. doi: 10.1016/j.ijpddr.2015.03.001. eCollection 2015 Aug.


Discovery of a tyrosine-rich sporocyst wall protein in Eimeria tenella.

Walker RA, Niepceron A, Ramakrishnan C, Sedano L, Hehl AB, Brossier F, Smith NC.

Parasit Vectors. 2016 Mar 2;9:124. doi: 10.1186/s13071-016-1410-z.


Serotonin promotes acinar dedifferentiation following pancreatitis-induced regeneration in the adult pancreas.

Saponara E, Grabliauskaite K, Bombardo M, Buzzi R, Silva AB, Malagola E, Tian Y, Hehl AB, Schraner EM, Seleznik GM, Zabel A, Reding T, Sonda S, Graf R.

J Pathol. 2015 Dec;237(4):495-507. doi: 10.1002/path.4595. Epub 2015 Sep 10.


RNA Seq analysis of the Eimeria tenella gametocyte transcriptome reveals clues about the molecular basis for sexual reproduction and oocyst biogenesis.

Walker RA, Sharman PA, Miller CM, Lippuner C, Okoniewski M, Eichenberger RM, Ramakrishnan C, Brossier F, Deplazes P, Hehl AB, Smith NC.

BMC Genomics. 2015 Feb 18;16:94. doi: 10.1186/s12864-015-1298-6.


Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.

Hehl AB, Basso WU, Lippuner C, Ramakrishnan C, Okoniewski M, Walker RA, Grigg ME, Smith NC, Deplazes P.

BMC Genomics. 2015 Feb 13;16:66. doi: 10.1186/s12864-015-1225-x.


The single epsin homolog in Giardia lamblia localizes to the ventral disk of trophozoites and is not associated with clathrin membrane coats.

Ebneter JA, Hehl AB.

Mol Biochem Parasitol. 2014 Oct;197(1-2):24-7. doi: 10.1016/j.molbiopara.2014.09.008. Epub 2014 Oct 5.


p21(WAF1) (/Cip1) limits senescence and acinar-to-ductal metaplasia formation during pancreatitis.

Grabliauskaite K, Hehl AB, Seleznik GM, Saponara E, Schlesinger K, Zuellig RA, Dittmann A, Bain M, Reding T, Sonda S, Graf R.

J Pathol. 2015 Feb;235(3):502-14. doi: 10.1002/path.4440. Epub 2014 Nov 6.


The Cre/loxP system in Giardia lamblia: genetic manipulations in a binucleate tetraploid protozoan.

Wampfler PB, Faso C, Hehl AB.

Int J Parasitol. 2014 Jul;44(8):497-506. doi: 10.1016/j.ijpara.2014.03.008. Epub 2014 Apr 18.


Proteomics of secretory and endocytic organelles in Giardia lamblia.

Wampfler PB, Tosevski V, Nanni P, Spycher C, Hehl AB.

PLoS One. 2014 Apr 14;9(4):e94089. doi: 10.1371/journal.pone.0094089. eCollection 2014.


The proteome landscape of Giardia lamblia encystation.

Faso C, Bischof S, Hehl AB.

PLoS One. 2013 Dec 31;8(12):e83207. doi: 10.1371/journal.pone.0083207. eCollection 2013.


Deoxysphingolipids, novel biomarkers for type 2 diabetes, are cytotoxic for insulin-producing cells.

Zuellig RA, Hornemann T, Othman A, Hehl AB, Bode H, Güntert T, Ogunshola OO, Saponara E, Grabliauskaite K, Jang JH, Ungethuem U, Wei Y, von Eckardstein A, Graf R, Sonda S.

Diabetes. 2014 Apr;63(4):1326-39. doi: 10.2337/db13-1042. Epub 2013 Dec 30.


An ER-directed transcriptional response to unfolded protein stress in the absence of conserved sensor-transducer proteins in Giardia lamblia.

Spycher C, Herman EK, Morf L, Qi W, Rehrauer H, Aquino Fournier C, Dacks JB, Hehl AB.

Mol Microbiol. 2013 May;88(4):754-71. doi: 10.1111/mmi.12218. Epub 2013 Apr 26.


Toxoplasma gondii infection in Kyrgyzstan: seroprevalence, risk factor analysis, and estimate of congenital and AIDS-related toxoplasmosis.

Minbaeva G, Schweiger A, Bodosheva A, Kuttubaev O, Hehl AB, Tanner I, Ziadinov I, Torgerson PR, Deplazes P.

PLoS Negl Trop Dis. 2013;7(2):e2043. doi: 10.1371/journal.pntd.0002043. Epub 2013 Feb 7.


Export of cyst wall material and Golgi organelle neogenesis in Giardia lamblia depend on endoplasmic reticulum exit sites.

Faso C, Konrad C, Schraner EM, Hehl AB.

Cell Microbiol. 2013 Apr;15(4):537-53. doi: 10.1111/cmi.12054. Epub 2012 Dec 2.


Serotonin regulates amylase secretion and acinar cell damage during murine pancreatitis.

Sonda S, Silva AB, Grabliauskaite K, Saponara E, Weber A, Jang JH, Züllig RA, Bain M, Reding Graf T, Hehl AB, Graf R.

Gut. 2013 Jun;62(6):890-8. doi: 10.1136/gutjnl-2011-301724. Epub 2012 May 16.


Mitosomes in trophozoites and cysts of the reptilian parasite Entamoeba invadens.

Siegesmund MA, Hehl AB, van der Giezen M.

Eukaryot Cell. 2011 Nov;10(11):1582-5. doi: 10.1128/EC.05172-11. Epub 2011 Sep 30.


Membrane trafficking and organelle biogenesis in Giardia lamblia: use it or lose it.

Faso C, Hehl AB.

Int J Parasitol. 2011 Apr;41(5):471-80. doi: 10.1016/j.ijpara.2010.12.014. Epub 2011 Feb 4. Review.


Post-transcriptional repair of a split heat shock protein 90 gene by mRNA trans-splicing.

Nageshan RK, Roy N, Hehl AB, Tatu U.

J Biol Chem. 2011 Mar 4;286(9):7116-22. doi: 10.1074/jbc.C110.208389. Epub 2011 Jan 5.


Expression of Cryptosporidium parvum Cpa135/CpCCP1 chimeras in Giardia duodenalis: organization of the protein domains affects the protein secretion pathway.

Lalle M, Rosati MA, Bien J, Hehl AB, Pozio E, Tosini F.

Exp Parasitol. 2011 Mar;127(3):680-6. doi: 10.1016/j.exppara.2010.11.009. Epub 2010 Nov 26.


The transcriptional response to encystation stimuli in Giardia lamblia is restricted to a small set of genes.

Morf L, Spycher C, Rehrauer H, Fournier CA, Morrison HG, Hehl AB.

Eukaryot Cell. 2010 Oct;9(10):1566-76. doi: 10.1128/EC.00100-10. Epub 2010 Aug 6.


Selective condensation drives partitioning and sequential secretion of cyst wall proteins in differentiating Giardia lamblia.

Konrad C, Spycher C, Hehl AB.

PLoS Pathog. 2010 Apr 8;6(4):e1000835. doi: 10.1371/journal.ppat.1000835.


The P-glycoprotein inhibitor GF120918 modulates Ca2+-dependent processes and lipid metabolism in Toxoplasma gondii.

Bottova I, Sauder U, Olivieri V, Hehl AB, Sonda S.

PLoS One. 2010 Apr 8;5(4):e10062. doi: 10.1371/journal.pone.0010062.


Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia.

Stefanić S, Spycher C, Morf L, Fabriàs G, Casas J, Schraner E, Wild P, Hehl AB, Sonda S.

J Lipid Res. 2010 Sep;51(9):2527-45. doi: 10.1194/jlr.M003392. Epub 2010 Mar 24.


Epigenetic mechanisms regulate stage differentiation in the minimized protozoan Giardia lamblia.

Sonda S, Morf L, Bottova I, Baetschmann H, Rehrauer H, Caflisch A, Hakimi MA, Hehl AB.

Mol Microbiol. 2010 Apr;76(1):48-67. doi: 10.1111/j.1365-2958.2010.07062.x. Epub 2010 Feb 1.


Stable expression of Escherichia coli beta-glucuronidase A (GusA) in Giardia lamblia: application to high-throughput drug susceptibility testing.

Müller J, Nillius D, Hehl A, Hemphill A, Müller N.

J Antimicrob Chemother. 2009 Dec;64(6):1187-91. doi: 10.1093/jac/dkp363. Epub 2009 Oct 10.


A contiguous compartment functions as endoplasmic reticulum and endosome/lysosome in Giardia lamblia.

Abodeely M, DuBois KN, Hehl A, Stefanic S, Sajid M, DeSouza W, Attias M, Engel JC, Hsieh I, Fetter RD, McKerrow JH.

Eukaryot Cell. 2009 Nov;8(11):1665-76. doi: 10.1128/EC.00123-09. Epub 2009 Sep 11.


Dual acylation accounts for the localization of {alpha}19-giardin in the ventral flagellum pair of Giardia lamblia.

Saric M, Vahrmann A, Niebur D, Kluempers V, Hehl AB, Scholze H.

Eukaryot Cell. 2009 Oct;8(10):1567-74. doi: 10.1128/EC.00136-09. Epub 2009 Aug 14.


Neogenesis and maturation of transient Golgi-like cisternae in a simple eukaryote.

Stefanic S, Morf L, Kulangara C, Regös A, Sonda S, Schraner E, Spycher C, Wild P, Hehl AB.

J Cell Sci. 2009 Aug 15;122(Pt 16):2846-56. doi: 10.1242/jcs.049411. Epub 2009 Jul 21.


Host cell P-glycoprotein is essential for cholesterol uptake and replication of Toxoplasma gondii.

Bottova I, Hehl AB, Stefanić S, Fabriàs G, Casas J, Schraner E, Pieters J, Sonda S.

J Biol Chem. 2009 Jun 26;284(26):17438-48. doi: 10.1074/jbc.M809420200. Epub 2009 Apr 22.


Identification of nucleoli in the early branching protist Giardia duodenalis.

Jiménez-García LF, Zavala G, Chávez-Munguía B, Ramos-Godínez Mdel P, López-Velázquez G, Segura-Valdez Mde L, Montañez C, Hehl AB, Argüello-García R, Ortega-Pierres G.

Int J Parasitol. 2008 Sep;38(11):1297-304. doi: 10.1016/j.ijpara.2008.04.012. Epub 2008 Jun 20.


Release of metabolic enzymes by Giardia in response to interaction with intestinal epithelial cells.

Ringqvist E, Palm JE, Skarin H, Hehl AB, Weiland M, Davids BJ, Reiner DS, Griffiths WJ, Eckmann L, Gillin FD, Svärd SG.

Mol Biochem Parasitol. 2008 Jun;159(2):85-91. doi: 10.1016/j.molbiopara.2008.02.005. Epub 2008 Feb 15.


A sphingolipid inhibitor induces a cytokinesis arrest and blocks stage differentiation in Giardia lamblia.

Sonda S, Stefanic S, Hehl AB.

Antimicrob Agents Chemother. 2008 Feb;52(2):563-9. Epub 2007 Dec 17.

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