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Items: 1 to 50 of 163

1.

Crystal structure of the red light-activated channelrhodopsin Chrimson.

Oda K, Vierock J, Oishi S, Rodriguez-Rozada S, Taniguchi R, Yamashita K, Wiegert JS, Nishizawa T, Hegemann P, Nureki O.

Nat Commun. 2018 Sep 26;9(1):3949. doi: 10.1038/s41467-018-06421-9.

2.

Electrical properties, substrate specificity and optogenetic potential of the engineered light-driven sodium pump eKR2.

Grimm C, Silapetere A, Vogt A, Bernal Sierra YA, Hegemann P.

Sci Rep. 2018 Jun 18;8(1):9316. doi: 10.1038/s41598-018-27690-w.

3.

Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain.

Scheib U, Broser M, Constantin OM, Yang S, Gao S, Mukherjee S, Stehfest K, Nagel G, Gee CE, Hegemann P.

Nat Commun. 2018 May 24;9(1):2046. doi: 10.1038/s41467-018-04428-w.

4.

Author Correction: Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior.

Wietek J, Rodriguez-Rozada S, Tutas J, Tenedini F, Grimm C, Oertner TG, Soba P, Hegemann P, Wiegert JS.

Sci Rep. 2018 Mar 14;8(1):4765. doi: 10.1038/s41598-018-23001-5.

5.

The femtosecond-to-second photochemistry of red-shifted fast-closing anion channelrhodopsin PsACR1.

Hontani Y, Broser M, Silapetere A, Krause BS, Hegemann P, Kennis JTM.

Phys Chem Chem Phys. 2017 Nov 22;19(45):30402-30409. doi: 10.1039/c7cp06414d.

PMID:
29125160
6.

Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior.

Wietek J, Rodriguez-Rozada S, Tutas J, Tenedini F, Grimm C, Oertner TG, Soba P, Hegemann P, Wiegert JS.

Sci Rep. 2017 Nov 2;7(1):14957. doi: 10.1038/s41598-017-14330-y. Erratum in: Sci Rep. 2018 Mar 14;8(1):4765.

7.

Optogenetic Tools for Subcellular Applications in Neuroscience.

Rost BR, Schneider-Warme F, Schmitz D, Hegemann P.

Neuron. 2017 Nov 1;96(3):572-603. doi: 10.1016/j.neuron.2017.09.047. Review.

PMID:
29096074
8.
9.

Targeting of Photoreceptor Genes in Chlamydomonas reinhardtii via Zinc-Finger Nucleases and CRISPR/Cas9.

Greiner A, Kelterborn S, Evers H, Kreimer G, Sizova I, Hegemann P.

Plant Cell. 2017 Oct;29(10):2498-2518. doi: 10.1105/tpc.17.00659. Epub 2017 Oct 4.

10.

Heterogeneity of the Transmembrane Protein Conformation in Purple Membranes Identified by Infrared Nanospectroscopy.

Giliberti V, Badioli M, Nucara A, Calvani P, Ritter E, Puskar L, Aziz EF, Hegemann P, Schade U, Ortolani M, Baldassarre L.

Small. 2017 Nov;13(44). doi: 10.1002/smll.201701181. Epub 2017 Sep 27.

PMID:
28960799
11.

The form and function of channelrhodopsin.

Deisseroth K, Hegemann P.

Science. 2017 Sep 15;357(6356). pii: eaan5544. doi: 10.1126/science.aan5544. Review.

12.

Molecular determinants of proton selectivity and gating in the red-light activated channelrhodopsin Chrimson.

Vierock J, Grimm C, Nitzan N, Hegemann P.

Sci Rep. 2017 Aug 30;7(1):9928. doi: 10.1038/s41598-017-09600-8.

13.

The two parallel photocycles of the Chlamydomonas sensory photoreceptor histidine kinase rhodopsin 1.

Luck M, Hegemann P.

J Plant Physiol. 2017 Oct;217:77-84. doi: 10.1016/j.jplph.2017.07.008. Epub 2017 Jul 13. Review.

PMID:
28784569
14.

Reaction dynamics of the chimeric channelrhodopsin C1C2.

Hontani Y, Marazzi M, Stehfest K, Mathes T, van Stokkum IHM, Elstner M, Hegemann P, Kennis JTM.

Sci Rep. 2017 Aug 3;7(1):7217. doi: 10.1038/s41598-017-07363-w.

15.

Proton transfer reactions in the red light-activatable channelrhodopsin variant ReaChR and their relevance for its function.

Kaufmann JCD, Krause BS, Grimm C, Ritter E, Hegemann P, Bartl FJ.

J Biol Chem. 2017 Aug 25;292(34):14205-14216. doi: 10.1074/jbc.M117.779629. Epub 2017 Jun 28.

16.

Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins.

Grimm C, Vierock J, Hegemann P, Wietek J.

J Vis Exp. 2017 May 22;(123). doi: 10.3791/55497.

PMID:
28570519
17.

Complex Photochemistry within the Green-Absorbing Channelrhodopsin ReaChR.

Krause BS, Grimm C, Kaufmann JCD, Schneider F, Sakmar TP, Bartl FJ, Hegemann P.

Biophys J. 2017 Mar 28;112(6):1166-1175. doi: 10.1016/j.bpj.2017.02.001.

18.

An Efficient Visual Screen for CRISPR/Cas9 Activity in Arabidopsis thaliana.

Hahn F, Mantegazza O, Greiner A, Hegemann P, Eisenhut M, Weber AP.

Front Plant Sci. 2017 Jan 24;8:39. doi: 10.3389/fpls.2017.00039. eCollection 2017.

19.

Active cortical dendrites modulate perception.

Takahashi N, Oertner TG, Hegemann P, Larkum ME.

Science. 2016 Dec 23;354(6319):1587-1590. doi: 10.1126/science.aah6066.

PMID:
28008068
20.

Photoadduct Formation from the FMN Singlet Excited State in the LOV2 Domain of Chlamydomonas reinhardtii Phototropin.

Zhu J, Mathes T, Hontani Y, Alexandre MT, Toh KC, Hegemann P, Kennis JT.

J Phys Chem Lett. 2016 Nov 3;7(21):4380-4384. Epub 2016 Oct 25.

21.

A blue-light photoreceptor mediates the feedback regulation of photosynthesis.

Petroutsos D, Tokutsu R, Maruyama S, Flori S, Greiner A, Magneschi L, Cusant L, Kottke T, Mittag M, Hegemann P, Finazzi G, Minagawa J.

Nature. 2016 Sep 22;537(7621):563-566. doi: 10.1038/nature19358. Epub 2016 Sep 14.

PMID:
27626383
22.

Unfolding of the C-Terminal Jα Helix in the LOV2 Photoreceptor Domain Observed by Time-Resolved Vibrational Spectroscopy.

Konold PE, Mathes T, Weiβenborn J, Groot ML, Hegemann P, Kennis JT.

J Phys Chem Lett. 2016 Sep 1;7(17):3472-6. doi: 10.1021/acs.jpclett.6b01484. Epub 2016 Aug 22.

23.

Active site structure and absorption spectrum of channelrhodopsin-2 wild-type and C128T mutant.

Guo Y, Beyle FE, Bold BM, Watanabe HC, Koslowski A, Thiel W, Hegemann P, Marazzi M, Elstner M.

Chem Sci. 2016 Jun 1;7(6):3879-3891. doi: 10.1039/c6sc00468g. Epub 2016 Feb 26.

24.

Optogenetic approaches addressing extracellular modulation of neural excitability.

Ferenczi EA, Vierock J, Atsuta-Tsunoda K, Tsunoda SP, Ramakrishnan C, Gorini C, Thompson K, Lee SY, Berndt A, Perry C, Minniberger S, Vogt A, Mattis J, Prakash R, Delp S, Deisseroth K, Hegemann P.

Sci Rep. 2016 Apr 5;6:23947. doi: 10.1038/srep23947.

25.

Identification of a Natural Green Light Absorbing Chloride Conducting Channelrhodopsin from Proteomonas sulcata.

Wietek J, Broser M, Krause BS, Hegemann P.

J Biol Chem. 2016 Feb 19;291(8):4121-7. doi: 10.1074/jbc.M115.699637. Epub 2016 Jan 6.

26.

Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity.

Berndt A, Lee SY, Wietek J, Ramakrishnan C, Steinberg EE, Rashid AJ, Kim H, Park S, Santoro A, Frankland PW, Iyer SM, Pak S, Ährlund-Richter S, Delp SL, Malenka RC, Josselyn SA, Carlén M, Hegemann P, Deisseroth K.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):822-9. doi: 10.1073/pnas.1523341113. Epub 2015 Dec 22.

27.

Light-Induced Rearrangement of the β5 Strand in the BLUF Photoreceptor SyPixD (Slr1694).

Mehlhorn J, Lindtner T, Richter F, Glass K, Steinocher H, Beck S, Hegemann P, Kennis JT, Mathes T.

J Phys Chem Lett. 2015 Dec 3;6(23):4749-53. doi: 10.1021/acs.jpclett.5b02245. Epub 2015 Nov 17.

PMID:
26631358
28.

Conversion of a light-driven proton pump into a light-gated ion channel.

Vogt A, Guo Y, Tsunoda SP, Kateriya S, Elstner M, Hegemann P.

Sci Rep. 2015 Nov 24;5:16450. doi: 10.1038/srep16450.

29.

Optogenetic acidification of synaptic vesicles and lysosomes.

Rost BR, Schneider F, Grauel MK, Wozny C, Bentz C, Blessing A, Rosenmund T, Jentsch TJ, Schmitz D, Hegemann P, Rosenmund C.

Nat Neurosci. 2015 Dec;18(12):1845-1852. doi: 10.1038/nn.4161. Epub 2015 Nov 9.

30.

An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo.

Wietek J, Beltramo R, Scanziani M, Hegemann P, Oertner TG, Wiegert JS.

Sci Rep. 2015 Oct 7;5:14807. doi: 10.1038/srep14807.

31.

Optogenetics: 10 years after ChR2 in neurons--views from the community.

Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, Janak PH, Johnston D, Josselyn SA, Koch C, Kreitzer AC, Lüscher C, Malenka RC, Miesenböck G, Nagel G, Roska B, Schnitzer MJ, Shenoy KV, Soltesz I, Sternson SM, Tsien RW, Tsien RY, Turrigiano GG, Tye KM, Wilson RI.

Nat Neurosci. 2015 Sep;18(9):1202-12. doi: 10.1038/nn.4106. Review. No abstract available.

PMID:
26308981
32.

Photoactivated cyclases: In memoriam Masakatsu Watanabe.

Hegemann P.

Photochem Photobiol Sci. 2015 Oct;14(10):1781-6. doi: 10.1039/c5pp00233h. Review. No abstract available.

PMID:
26270352
33.

The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling.

Scheib U, Stehfest K, Gee CE, Körschen HG, Fudim R, Oertner TG, Hegemann P.

Sci Signal. 2015 Aug 11;8(389):rs8. doi: 10.1126/scisignal.aab0611.

PMID:
26268609
34.

Light-Dark Adaptation of Channelrhodopsin Involves Photoconversion between the all-trans and 13-cis Retinal Isomers.

Bruun S, Stoeppler D, Keidel A, Kuhlmann U, Luck M, Diehl A, Geiger MA, Woodmansee D, Trauner D, Hegemann P, Oschkinat H, Hildebrandt P, Stehfest K.

Biochemistry. 2015 Sep 8;54(35):5389-400. doi: 10.1021/acs.biochem.5b00597. Epub 2015 Aug 20.

PMID:
26237332
35.

Time-resolved infrared spectroscopic techniques as applied to channelrhodopsin.

Ritter E, Puskar L, Bartl FJ, Aziz EF, Hegemann P, Schade U.

Front Mol Biosci. 2015 Jul 7;2:38. doi: 10.3389/fmolb.2015.00038. eCollection 2015. Review.

36.

Biophysics of Channelrhodopsin.

Schneider F, Grimm C, Hegemann P.

Annu Rev Biophys. 2015;44:167-86. doi: 10.1146/annurev-biophys-060414-034014. Review.

PMID:
26098512
37.

Photochemical chromophore isomerization in histidine kinase rhodopsin HKR1.

Luck M, Bruun S, Keidel A, Hegemann P, Hildebrandt P.

FEBS Lett. 2015 Apr 28;589(10):1067-71. doi: 10.1016/j.febslet.2015.03.024. Epub 2015 Mar 31.

38.

Erratum: Synthetic retinal analogs modify the spectral and kinetic characteristics of microbial rhodopsin optogenetic tools.

AzimiHashemi N, Erbguth K, Vogt A, Riemensperger T, Rauch E, Woodmansee D, Nagpal J, Brauner M, Sheves M, Fiala A, Kattner L, Trauner D, Hegemann P, Gottschalk A, Liewald JF.

Nat Commun. 2015 Feb 25;6:6458. doi: 10.1038/ncomms7458. No abstract available.

PMID:
25711720
39.

Controlling fertilization and cAMP signaling in sperm by optogenetics.

Jansen V, Alvarez L, Balbach M, Strünker T, Hegemann P, Kaupp UB, Wachten D.

Elife. 2015 Jan 20;4. doi: 10.7554/eLife.05161.

40.

Early formation of the ion-conducting pore in channelrhodopsin-2.

Kuhne J, Eisenhauer K, Ritter E, Hegemann P, Gerwert K, Bartl F.

Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4953-7. doi: 10.1002/anie.201410180. Epub 2014 Dec 23.

PMID:
25537168
41.

Synthetic retinal analogues modify the spectral and kinetic characteristics of microbial rhodopsin optogenetic tools.

AzimiHashemi N, Erbguth K, Vogt A, Riemensperger T, Rauch E, Woodmansee D, Nagpal J, Brauner M, Sheves M, Fiala A, Kattner L, Trauner D, Hegemann P, Gottschalk A, Liewald JF.

Nat Commun. 2014 Dec 15;5:5810. doi: 10.1038/ncomms6810.

PMID:
25503804
42.

Upgrading a microplate reader for photobiology and all-optical experiments.

Richter F, Scheib US, Mehlhorn J, Schubert R, Wietek J, Gernetzki O, Hegemann P, Mathes T, Möglich A.

Photochem Photobiol Sci. 2015 Feb;14(2):270-9. doi: 10.1039/c4pp00361f.

PMID:
25373866
43.

Absorption and emission spectroscopic characterization of photo-dynamics of photoactivated adenylyl cyclase mutant bPAC-Y7F of Beggiatoa sp.

Penzkofer A, Stierl M, Mathes T, Hegemann P.

J Photochem Photobiol B. 2014 Nov;140:182-93. doi: 10.1016/j.jphotobiol.2014.06.017. Epub 2014 Aug 7.

PMID:
25154810
44.

Key residues for the light regulation of the blue light-activated adenylyl cyclase from Beggiatoa sp.

Stierl M, Penzkofer A, Kennis JT, Hegemann P, Mathes T.

Biochemistry. 2014 Aug 12;53(31):5121-30. doi: 10.1021/bi500479v. Epub 2014 Jul 28.

PMID:
25046330
45.

Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase.

Gasser C, Taiber S, Yeh CM, Wittig CH, Hegemann P, Ryu S, Wunder F, Möglich A.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8803-8. doi: 10.1073/pnas.1321600111. Epub 2014 Jun 2.

46.

Conversion of channelrhodopsin into a light-gated chloride channel.

Wietek J, Wiegert JS, Adeishvili N, Schneider F, Watanabe H, Tsunoda SP, Vogt A, Elstner M, Oertner TG, Hegemann P.

Science. 2014 Apr 25;344(6182):409-12. doi: 10.1126/science.1249375. Epub 2014 Mar 27.

47.

Bistable retinal schiff base photodynamics of histidine kinase rhodopsin HKR1 from Chlamydomonas reinhardtii.

Penzkofer A, Luck M, Mathes T, Hegemann P.

Photochem Photobiol. 2014 Jul-Aug;90(4):773-85. doi: 10.1111/php.12246. Epub 2014 Mar 8.

PMID:
24460585
48.

Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.

Ernst OP, Lodowski DT, Elstner M, Hegemann P, Brown LS, Kandori H.

Chem Rev. 2014 Jan 8;114(1):126-63. doi: 10.1021/cr4003769. Epub 2013 Dec 23. Review. No abstract available.

49.

A set of engineered Escherichia coli expression strains for selective isotope and reactivity labeling of amino acid side chains and flavin cofactors.

Mehlhorn J, Steinocher H, Beck S, Kennis JT, Hegemann P, Mathes T.

PLoS One. 2013 Nov 1;8(11):e79006. doi: 10.1371/journal.pone.0079006. eCollection 2013.

50.

Gloeobacter rhodopsin, limitation of proton pumping at high electrochemical load.

Vogt A, Wietek J, Hegemann P.

Biophys J. 2013 Nov 5;105(9):2055-63. doi: 10.1016/j.bpj.2013.08.031.

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