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Items: 1 to 50 of 64

1.

Targeting Host Cell Surface Nucleolin for RSV Therapy: Challenges and Opportunities.

Mastrangelo P, Norris MJ, Duan W, Barrett EG, Moraes TJ, Hegele RG.

Vaccines (Basel). 2017 Sep 19;5(3). pii: E27. doi: 10.3390/vaccines5030027.

2.

Performance of residents using digital images versus glass slides on certification examination in anatomical pathology: a mixed methods pilot study.

Mirham L, Naugler C, Hayes M, Ismiil N, Belisle A, Sade S, Streutker C, MacMillan C, Rasty G, Popovic S, Joseph M, Gabril M, Barnes P, Hegele RG, Carter B, Yousef GM.

CMAJ Open. 2016 Feb 25;4(1):E88-94. doi: 10.9778/cmajo.20140075. eCollection 2016 Jan-Mar.

3.

Loss of GD1-positive Lactobacillus correlates with inflammation in human lungs with COPD.

Sze MA, Utokaparch S, Elliott WM, Hogg JC, Hegele RG.

BMJ Open. 2015 Feb 4;5(2):e006677. doi: 10.1136/bmjopen-2014-006677.

4.

The Canadian healthy infant longitudinal development birth cohort study: biological samples and biobanking.

Moraes TJ, Lefebvre DL, Chooniedass R, Becker AB, Brook JR, Denburg J, HayGlass KT, Hegele RG, Kollmann TR, Macri J, Mandhane PJ, Scott JA, Subbarao P, Takaro TK, Turvey SE, Duncan JD, Sears MR, Befus AD; CHILD Study Investigators.

Paediatr Perinat Epidemiol. 2015 Jan;29(1):84-92. doi: 10.1111/ppe.12161. Epub 2014 Nov 18.

PMID:
25405552
5.

Respiratory syncytial virus receptor expression in the mouse and viral tropism.

Shakeri A, Mastrangelo P, Griffin JK, Moraes TJ, Hegele RG.

Histol Histopathol. 2015 Apr;30(4):401-11. doi: 10.14670/HH-30.401. Epub 2014 Nov 6. Review.

PMID:
25374027
6.

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity.

Marchant DJ, Bellac CL, Moraes TJ, Wadsworth SJ, Dufour A, Butler GS, Bilawchuk LM, Hendry RG, Robertson AG, Cheung CT, Ng J, Ang L, Luo Z, Heilbron K, Norris MJ, Duan W, Bucyk T, Karpov A, Devel L, Georgiadis D, Hegele RG, Luo H, Granville DJ, Dive V, McManus BM, Overall CM.

Nat Med. 2014 May;20(5):493-502. doi: 10.1038/nm.3508. Epub 2014 Apr 28.

PMID:
24784232
7.

Virus-induced signaling influences endosome trafficking, virus entry, and replication.

Marchant DJ, Bilawchuk L, Nish G, Hegele RG.

Methods Enzymol. 2014;534:65-76. doi: 10.1016/B978-0-12-397926-1.00004-4.

PMID:
24359948
8.

Respiratory viral detection and small airway inflammation in lung tissue of patients with stable, mild COPD.

Utokaparch S, Sze MA, Gosselink JV, McDonough JE, Elliott WM, Hogg JC, Hegele RG.

COPD. 2014 Apr;11(2):197-203. doi: 10.3109/15412555.2013.836166. Epub 2013 Oct 2.

PMID:
24088037
9.

RSV fusion: time for a new model.

Mastrangelo P, Hegele RG.

Viruses. 2013 Mar 19;5(3):873-85. doi: 10.3390/v5030873. Review.

10.

Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia.

Ali S, Hirschfeld AF, Mayer ML, Fortuno ES 3rd, Corbett N, Kaplan M, Wang S, Schneiderman J, Fjell CD, Yan J, Akhabir L, Aminuddin F, Marr N, Lacaze-Masmonteil T, Hegele RG, Becker A, Chan-Yeung M, Hancock RE, Kollmann TR, Daley D, Sandford AJ, Lavoie PM, Turvey SE.

J Immunol. 2013 Apr 15;190(8):3949-58. doi: 10.4049/jimmunol.1201015. Epub 2013 Mar 13.

11.

Formation of a stable mimic of ambient particulate matter containing viable infectious respiratory syncytial virus and its dry-deposition directly onto cell cultures.

Cruz-Sanchez TM, Haddrell AE, Hackett TL, Singhera GK, Marchant D, Lekivetz R, Meredith A, Horne D, Knight DA, van Eeden SF, Bai TR, Hegele RG, Dorscheid DR, Agnes GR.

Anal Chem. 2013 Jan 15;85(2):898-906. doi: 10.1021/ac302174y. Epub 2012 Dec 19.

PMID:
23205519
12.

Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes.

Daley D, Park JE, He JQ, Yan J, Akhabir L, Stefanowicz D, Becker AB, Chan-Yeung M, Bossé Y, Kozyrskyj AL, James AL, Musk AW, Laprise C, Hegele RG, Paré PD, Sandford AJ.

J Allergy Clin Immunol. 2012 Dec;130(6):1284-93. doi: 10.1016/j.jaci.2012.07.051. Epub 2012 Oct 9.

PMID:
23063165
13.

The RSV fusion receptor: not what everyone expected it to be.

Mastrangelo P, Hegele RG.

Microbes Infect. 2012 Nov;14(13):1205-10. doi: 10.1016/j.micinf.2012.07.015. Epub 2012 Jul 31. Review.

PMID:
22884716
14.

Identifying targets in the hunt for effective respiratory syncytial virus interventions.

Tayyari F, Hegele RG.

Expert Rev Respir Med. 2012 Apr;6(2):215-22. doi: 10.1586/ers.12.8. Review.

PMID:
22455493
15.

Making sense of cell surface nucleolin: implications for respiratory syncytial virus prophylaxis and therapy.

Hegele RG.

Cell Cycle. 2012 Jan 1;11(1):1-2. doi: 10.4161/cc.11.1.18466. Epub 2012 Jan 1. No abstract available.

PMID:
22185777
16.

Is thrombotic microangiopathy a paraneoplastic phenomenon? Case report and review of the literature.

Houston SA, Hegele RG, Sugar L, Colak E, Pavenski K, Allo G, Perl J.

NDT Plus. 2011 Oct;4(5):292-4. doi: 10.1093/ndtplus/sfr085. Epub 2011 Jul 27.

17.

Identification of nucleolin as a cellular receptor for human respiratory syncytial virus.

Tayyari F, Marchant D, Moraes TJ, Duan W, Mastrangelo P, Hegele RG.

Nat Med. 2011 Aug 14;17(9):1132-5. doi: 10.1038/nm.2444.

PMID:
21841784
18.

Respiratory syncytial virus therapy and prophylaxis: have we finally turned the corner?

Hegele RG.

Eur Respir J. 2011 Aug;38(2):246-7. doi: 10.1183/09031936.00012011. No abstract available.

19.

Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to respiratory syncytial virus and air pollution.

Hackett TL, Singhera GK, Shaheen F, Hayden P, Jackson GR, Hegele RG, Van Eeden S, Bai TR, Dorscheid DR, Knight DA.

Am J Respir Cell Mol Biol. 2011 Nov;45(5):1090-100. doi: 10.1165/rcmb.2011-0031OC. Epub 2011 Jun 3.

PMID:
21642587
20.

The relationship between respiratory viral loads and diagnosis in children presenting to a pediatric hospital emergency department.

Utokaparch S, Marchant D, Gosselink JV, McDonough JE, Thomas EE, Hogg JC, Hegele RG.

Pediatr Infect Dis J. 2011 Feb;30(2):e18-23. doi: 10.1097/INF.0b013e3181ff2fac.

PMID:
20980931
21.

Viruses and lower respiratory tract infections: does more mean worse?

Hegele RG.

Respiration. 2010;80(6):443-4. doi: 10.1159/000320329. Epub 2010 Aug 20. No abstract available.

22.

Toll-like receptor 4-mediated activation of p38 mitogen-activated protein kinase is a determinant of respiratory virus entry and tropism.

Marchant D, Singhera GK, Utokaparch S, Hackett TL, Boyd JH, Luo Z, Si X, Dorscheid DR, McManus BM, Hegele RG.

J Virol. 2010 Nov;84(21):11359-73. doi: 10.1128/JVI.00804-10. Epub 2010 Aug 11.

23.

Rosai-Dorfman disease involving the neurohypophysis.

Rotondo F, Munoz DG, Hegele RG, Gray B, Khatun N, Bonert M, Kovacs K.

Pituitary. 2010 Sep;13(3):256-9. doi: 10.1007/s11102-010-0228-5.

PMID:
20405324
24.

Evolutionary concepts in biobanking - the BC BioLibrary.

Watson PH, Wilson-McManus JE, Barnes RO, Giesz SC, Png A, Hegele RG, Brinkman JN, Mackenzie IR, Huntsman DG, Junker A, Gilks B, Skarsgard E, Burgess M, Aparicio S, McManus BM.

J Transl Med. 2009 Nov 12;7:95. doi: 10.1186/1479-5876-7-95.

25.

ERK MAP kinase-activated Arf6 trafficking directs coxsackievirus type B3 into an unproductive compartment during virus host-cell entry.

Marchant D, Sall A, Si X, Abraham T, Wu W, Luo Z, Petersen T, Hegele RG, McManus BM.

J Gen Virol. 2009 Apr;90(Pt 4):854-62. doi: 10.1099/vir.0.005868-0. Epub 2009 Mar 4.

PMID:
19264606
26.

Bosentan enhances viral load via endothelin-1 receptor type-A-mediated p38 mitogen-activated protein kinase activation while improving cardiac function during coxsackievirus-induced myocarditis.

Marchant D, Dou Y, Luo H, Garmaroudi FS, McDonough JE, Si X, Walker E, Luo Z, Arner A, Hegele RG, Laher I, McManus BM.

Circ Res. 2009 Mar 27;104(6):813-21. doi: 10.1161/CIRCRESAHA.108.191171. Epub 2009 Feb 12.

PMID:
19213955
27.

Early environmental determinants of asthma risk in a high-risk birth cohort.

Chan-Yeung M, Hegele RG, Dimich-Ward H, Ferguson A, Schulzer M, Chan H, Watson W, Becker A.

Pediatr Allergy Immunol. 2008 Sep;19(6):482-9. doi: 10.1111/j.1399-3038.2007.00689.x. Epub 2008 Feb 6.

PMID:
18266835
28.
29.

Relationship of early childhood viral exposures to respiratory symptoms, onset of possible asthma and atopy in high risk children: the Canadian Asthma Primary Prevention Study.

Lee KK, Hegele RG, Manfreda J, Wooldrage K, Becker AB, Ferguson AC, Dimich-Ward H, Watson WT, Chan-Yeung M.

Pediatr Pulmonol. 2007 Mar;42(3):290-7.

PMID:
17245731
30.

CpG-oligodeoxynucleotides inhibit RSV-enhanced allergic sensitisation in guinea pigs.

Tayyari F, Sutton TC, Manson HE, Hegele RG.

Eur Respir J. 2005 Feb;25(2):295-302.

31.

Persistent airway inflammation after resolution of respiratory syncytial virus infection in rats.

Piedimonte G, Hegele RG, Auais A.

Pediatr Res. 2004 Apr;55(4):657-65. Epub 2004 Jan 7.

PMID:
14711892
32.
33.
34.

Interaction between respiratory syncytial virus and particulate matter in guinea pig alveolar macrophages.

Kaan PM, Hegele RG.

Am J Respir Cell Mol Biol. 2003 Jun;28(6):697-704.

PMID:
12760967
35.

Does antigen-specific cytokine response correlate with the experience of oculorespiratory syndrome after influenza vaccine?

Skowronski DM, Lu H, Warrington R, Hegele RG, De Serres G, HayGlass K, Stark D, White R, Macnabb J, Li Y, Manson HE, Brunham RC.

J Infect Dis. 2003 Feb 1;187(3):495-9. Epub 2003 Jan 24.

PMID:
12552434
36.

Comparison of three methods for respiratory virus detection between induced sputum and nasopharyngeal aspirate specimens in acute asthma.

Xiang X, Qiu D, Chan KP, Chan SH, Hegele RG, Tan WC.

J Virol Methods. 2002 Mar;101(1-2):127-33.

PMID:
11849691
37.

The association between respiratory viruses and symptoms in 2-week-old infants at high risk for asthma and allergy.

Hegele RG, Ahmad HY, Becker AB, Dimich-Ward H, Ferguson AC, Manfreda J, Watson WT, Chan-Yeung M.

J Pediatr. 2001 Jun;138(6):831-7.

PMID:
11391325
38.

The pathology of asthma: brief review.

Hegele RG.

Immunopharmacology. 2000 Jul 25;48(3):257-62. Review.

PMID:
10960666
39.

Effects of respiratory syncytial virus persistence on airway responsiveness and inflammation in guinea-pigs.

Bramley AM, Vitalis TZ, Wiggs BR, Hegele RG.

Eur Respir J. 1999 Nov;14(5):1061-7.

40.
41.

Role of viruses in the onset of asthma and allergy: lessons from animal models.

Hegele RG.

Clin Exp Allergy. 1999 Jun;29 Suppl 2:78-81. Review.

PMID:
10421827
42.

Effect of respiratory syncytial virus on subsequent allergic sensitization to ovalbumin in guinea-pigs.

Dakhama A, Bramley AM, Chan NG, McKay KO, Schellenberg RR, Hegele RG.

Eur Respir J. 1999 May;13(5):976-82.

43.

PCR detection of viral nucleic acid in fatal asthma: is the lower respiratory tract a reservoir for common viruses?

Macek V, Dakhama A, Hogg JC, Green FH, Rubin BK, Hegele RG.

Can Respir J. 1999 Jan-Feb;6(1):37-43.

44.

Common respiratory viruses in lower airways of patients with acute hypersensitivity pneumonitis.

Dakhama A, Hegele RG, Laflamme G, Israël-Assayag E, Cormier Y.

Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1316-22.

PMID:
10194183
45.

Usefulness of bronchoalveolar lavage for diagnosis of acute and persistent respiratory syncytial virus lung infections in guinea pigs.

Dakhama A, Chan NG, Ahmad HY, Bramley AM, Vitalis TZ, Hegele RG.

Pediatr Pulmonol. 1998 Dec;26(6):396-404.

PMID:
9888214
46.
47.

Two enteropathogenic Escherichia coli type III secreted proteins, EspA and EspB, are virulence factors.

Abe A, Heczko U, Hegele RG, Brett Finlay B.

J Exp Med. 1998 Nov 16;188(10):1907-16.

48.

Comment on the workshop on Airway Inflammation and Remodelling in Asthma: implication for asthma therapy.

Chan NG, Bramley AM, Hegele RG.

Can Respir J. 1998 May-Jun;5(3):226,231. No abstract available.

PMID:
9729109
49.

Allergic sensitization increases airway reactivity in guinea pigs with respiratory syncytial virus bronchiolitis.

Robinson PJ, Hegele RG, Schellenberg RR.

J Allergy Clin Immunol. 1997 Oct;100(4):492-8.

PMID:
9338543
50.

Inflammation of small airways in asthma.

Hamid Q, Song Y, Kotsimbos TC, Minshall E, Bai TR, Hegele RG, Hogg JC.

J Allergy Clin Immunol. 1997 Jul;100(1):44-51.

PMID:
9257786

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