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Items: 1 to 50 of 719

1.

Ambroxol as a novel disease-modifying treatment for Parkinson's disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial.

Silveira CRA, MacKinley J, Coleman K, Li Z, Finger E, Bartha R, Morrow SA, Wells J, Borrie M, Tirona RG, Rupar CA, Zou G, Hegele RA, Mahuran D, MacDonald P, Jenkins ME, Jog M, Pasternak SH.

BMC Neurol. 2019 Feb 9;19(1):20. doi: 10.1186/s12883-019-1252-3.

2.

Lipid-Lowering Agents.

Hegele RA, Tsimikas S.

Circ Res. 2019 Feb;124(3):386-404. doi: 10.1161/CIRCRESAHA.118.313171.

PMID:
30702996
3.

Cholesterol-Lowering Agents.

Rosenson RS, Hegele RA, Koenig W.

Circ Res. 2019 Feb;124(3):364-385. doi: 10.1161/CIRCRESAHA.118.313238.

PMID:
30702994
4.

The evolution of genetic-based risk scores for lipids and cardiovascular disease.

Dron JS, Hegele RA.

Curr Opin Lipidol. 2019 Jan 22. doi: 10.1097/MOL.0000000000000576. [Epub ahead of print]

PMID:
30676533
5.

Editorial: designing targeted sequencing panels for dyslipidemia.

Hegele RA.

Curr Opin Lipidol. 2019 Jan 16. doi: 10.1097/MOL.0000000000000579. [Epub ahead of print] No abstract available.

PMID:
30664017
6.

Progress in finding pathogenic DNA copy number variations in dyslipidemia.

Iacocca MA, Dron JS, Hegele RA.

Curr Opin Lipidol. 2019 Jan 16. doi: 10.1097/MOL.0000000000000581. [Epub ahead of print]

PMID:
30664016
7.

Chylomicronemia: Differences between familial chylomicronemia syndrome and multifactorial chylomicronemia.

Paquette M, Bernard S, Hegele RA, Baass A.

Atherosclerosis. 2018 Dec 28. pii: S0021-9150(18)31550-8. doi: 10.1016/j.atherosclerosis.2018.12.019. [Epub ahead of print]

PMID:
30655019
8.

Cannabis effects on lipoproteins.

Lazarte J, Hegele RA.

Curr Opin Lipidol. 2019 Jan 14. doi: 10.1097/MOL.0000000000000575. [Epub ahead of print]

PMID:
30649023
9.

Cholesterol Lowering and Prevention of Stroke.

Hackam DG, Hegele RA.

Stroke. 2019 Feb;50(2):537-541. doi: 10.1161/STROKEAHA.118.023167. No abstract available.

PMID:
30602355
10.

Update on the diagnosis, treatment and management of rare genetic lipid disorders.

Ng DM, Burnett JR, Bell DA, Hegele RA, Hooper AJ.

Pathology. 2019 Feb;51(2):193-201. doi: 10.1016/j.pathol.2018.11.005. Epub 2018 Dec 28. Review.

PMID:
30598327
11.

Lipids and cardiovascular disease.

Burnett JR, Hooper AJ, Hegele RA.

Pathology. 2019 Feb;51(2):129-130. doi: 10.1016/j.pathol.2018.12.001. Epub 2018 Dec 27. No abstract available.

PMID:
30595506
12.

Whole-exome sequencing identifies a novel IHH insertion in an Ontario family with brachydactyly type A1.

Ho R, McIntyre AD, Kennedy BA, Hegele RA.

SAGE Open Med Case Rep. 2018 Dec 10;6:2050313X18818711. doi: 10.1177/2050313X18818711. eCollection 2018.

13.

The role of genetic testing in dyslipidaemia.

Berberich AJ, Hegele RA.

Pathology. 2019 Feb;51(2):184-192. doi: 10.1016/j.pathol.2018.10.014. Epub 2018 Dec 14. Review.

PMID:
30558903
14.

Canadian Cardiovascular Society Position Statement on Familial Hypercholesterolemia: Update 2018.

Brunham LR, Ruel I, Aljenedil S, Rivière JB, Baass A, Tu JV, Mancini GBJ, Raggi P, Gupta M, Couture P, Pearson GJ, Bergeron J, Francis GA, McCrindle BW, Morrison K, St-Pierre J, Henderson M, Hegele RA, Genest J, Goguen J, Gaudet D, Paré G, Romney J, Ransom T, Bernard S, Katz P, Joy TR, Bewick D, Brophy J.

Can J Cardiol. 2018 Dec;34(12):1553-1563. doi: 10.1016/j.cjca.2018.09.005.

PMID:
30527143
15.

GPIHBP1 autoantibody syndrome during interferon β1a treatment.

Eguchi J, Miyashita K, Fukamachi I, Nakajima K, Murakami M, Kawahara Y, Yamashita T, Ohta Y, Abe K, Nakatsuka A, Mino M, Takase S, Okazaki H, Hegele RA, Ploug M, Hu X, Wada J, Young SG, Beigneux AP.

J Clin Lipidol. 2018 Oct 24. pii: S1933-2874(18)30424-0. doi: 10.1016/j.jacl.2018.10.004. [Epub ahead of print]

PMID:
30514621
16.

Severe hypertriglyceridemia is primarily polygenic.

Dron JS, Wang J, Cao H, McIntyre AD, Iacocca MA, Menard JR, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA.

J Clin Lipidol. 2018 Oct 24. pii: S1933-2874(18)30426-4. doi: 10.1016/j.jacl.2018.10.006. [Epub ahead of print]

17.

Variants at the APOE /C1/C2/C4 Locus Modulate Cholesterol Efflux Capacity Independently of High-Density Lipoprotein Cholesterol.

Low-Kam C, Rhainds D, Lo KS, Barhdadi A, Boulé M, Alem S, Pedneault-Gagnon V, Rhéaume E, Dubé MP, Busseuil D, Hegele RA, Lettre G, Tardif JC.

J Am Heart Assoc. 2018 Aug 21;7(16):e009545. doi: 10.1161/JAHA.118.009545.

18.

A Young Male with Parafibromin-Deficient Parathyroid Carcinoma Due to a Rare Germline HRPT2/CDC73 Mutation.

Kapur A, Singh N, Mete O, Hegele RA, Fantus IG.

Endocr Pathol. 2018 Dec;29(4):374-379. doi: 10.1007/s12022-018-9552-5.

PMID:
30361844
19.

Abetalipoproteinemia.

Burnett JR, Hooper AJ, Hegele RA.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019.
2018 Oct 25.

20.

Recent Highlights of ATVB.

Dron JS, Lazarte J, Hegele RA.

Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):e185-e197. doi: 10.1161/ATVBAHA.118.311581. No abstract available.

PMID:
30354244
21.

Reporting Sex and Sex Differences in Preclinical Studies.

Lu HS, Schmidt AM, Hegele RA, Mackman N, Rader DJ, Weber C, Daugherty A.

Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):e171-e184. doi: 10.1161/ATVBAHA.118.311717. No abstract available.

PMID:
30354222
22.

Extreme hypertriglyceridemia: Genetic diversity, pancreatitis, pregnancy, and prevalence.

Chyzhyk V, Kozmic S, Brown AS, Hudgins LC, Starc TJ, Davila AD, Blevins TC, Diffenderfer MR, He L, Geller AS, Rush C, Hegele RA, Schaefer EJ.

J Clin Lipidol. 2018 Sep 18. pii: S1933-2874(18)30405-7. doi: 10.1016/j.jacl.2018.09.007. [Epub ahead of print]

PMID:
30352774
23.

Genetic and secondary causes of severe HDL deficiency and cardiovascular disease.

Geller AS, Polisecki EY, Diffenderfer MR, Asztalos BF, Karathanasis SK, Hegele RA, Schaefer EJ.

J Lipid Res. 2018 Dec;59(12):2421-2435. doi: 10.1194/jlr.M088203. Epub 2018 Oct 17.

PMID:
30333156
24.

ClinVar database of global familial hypercholesterolemia-associated DNA variants.

Iacocca MA, Chora JR, Carrié A, Freiberger T, Leigh SE, Defesche JC, Kurtz CL, DiStefano MT, Santos RD, Humphries SE, Mata P, Jannes CE, Hooper AJ, Wilemon KA, Benlian P, O'Connor R, Garcia J, Wand H, Tichy L, Sijbrands EJ, Hegele RA, Bourbon M, Knowles JW; ClinGen FH Variant Curation Expert Panel.

Hum Mutat. 2018 Nov;39(11):1631-1640. doi: 10.1002/humu.23634.

PMID:
30311388
25.

Multiple Symmetric Lipomatosis (Madelung Disease) in a Large Canadian Family With the Mitochondrial MTTK c.8344A>G Variant.

Perera U, Kennedy BA, Hegele RA.

J Investig Med High Impact Case Rep. 2018 Sep 29;6:2324709618802867. doi: 10.1177/2324709618802867. eCollection 2018 Jan-Dec.

26.

Complex effects of laminopathy mutations on nuclear structure and function.

Ho R, Hegele RA.

Clin Genet. 2019 Feb;95(2):199-209. doi: 10.1111/cge.13455. Epub 2018 Oct 23. Review.

PMID:
30280378
27.

Familial hypercholesterolemia in Canada: Initial results from the FH Canada national registry.

Brunham LR, Ruel I, Khoury E, Hegele RA, Couture P, Bergeron J, Baass A, Dufour R, Francis GA, Cermakova L, Mancini GBJ, Brophy JM, Brisson D, Gaudet D, Genest J.

Atherosclerosis. 2018 Oct;277:419-424. doi: 10.1016/j.atherosclerosis.2018.05.040.

PMID:
30270080
28.

Unusual genetic variants associated with hypercholesterolemia in Argentina.

Corral P, Geller AS, Polisecki EY, Lopez GI, Bañares VG, Cacciagiu L, Berg G, Hegele RA, Schaefer EJ, Schreier LE.

Atherosclerosis. 2018 Oct;277:256-261. doi: 10.1016/j.atherosclerosis.2018.06.009.

PMID:
30270055
29.

Whole-Gene Duplication of PCSK9 as a Novel Genetic Mechanism for Severe Familial Hypercholesterolemia.

Iacocca MA, Wang J, Sarkar S, Dron JS, Lagace T, McIntyre AD, Lau P, Robinson JF, Yang P, Knoll JH, Cao H, McPherson R, Hegele RA.

Can J Cardiol. 2018 Oct;34(10):1316-1324. doi: 10.1016/j.cjca.2018.07.479. Epub 2018 Aug 4.

30.

Erratum to "Dyslipidemia": Canadian Journal of Diabetes 2018;42(S1):S178-S185.

Mancini GBJ, Hegele RA, Leiter LA.

Can J Diabetes. 2018 Oct;42(5):574. doi: 10.1016/j.jcjd.2018.08.194. No abstract available.

PMID:
30268230
31.

Simplified Canadian Definition for Familial Hypercholesterolemia.

Ruel I, Brisson D, Aljenedil S, Awan Z, Baass A, Bélanger A, Bergeron J, Bewick D, Brophy JM, Brunham LR, Couture P, Dufour R, Francis GA, Frohlich J, Gagné C, Gaudet D, Grégoire JC, Gupta M, Hegele RA, Mancini GBJ, McCrindle BW, Pang J, Raggi P, Tu JV, Watts GF, Genest J.

Can J Cardiol. 2018 Sep;34(9):1210-1214. doi: 10.1016/j.cjca.2018.05.015. Epub 2018 May 19.

32.

Getting Real With PCSK9 Inhibitors in Familial Hypercholesterolemia.

Baass A, Hegele RA.

Can J Cardiol. 2018 Aug;34(8):959-961. doi: 10.1016/j.cjca.2018.05.006. Epub 2018 May 9. No abstract available.

PMID:
30056849
33.

A De Novo POLD1 Mutation Associated With Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy Syndrome in a Family With Werner Syndrome.

Wang LR, Radonjic A, Dilliott AA, McIntyre AD, Hegele RA.

J Investig Med High Impact Case Rep. 2018 Jul 12;6:2324709618786770. doi: 10.1177/2324709618786770. eCollection 2018 Jan-Dec.

34.

The Evolving Future of PCSK9 Inhibitors.

Rosenson RS, Hegele RA, Fazio S, Cannon CP.

J Am Coll Cardiol. 2018 Jul 17;72(3):314-329. doi: 10.1016/j.jacc.2018.04.054. Epub 2018 Jul 9. Review.

PMID:
30012326
35.

The complex molecular genetics of familial hypercholesterolaemia.

Berberich AJ, Hegele RA.

Nat Rev Cardiol. 2019 Jan;16(1):9-20. doi: 10.1038/s41569-018-0052-6. Review.

PMID:
29973710
36.

Co-occurrence of heterozygous CREB3L3 and APOA5 nonsense variants and polygenic risk in a patient with severe hypertriglyceridemia exacerbated by estrogen administration.

Wójcik C, Fazio S, McIntyre AD, Hegele RA.

J Clin Lipidol. 2018 Sep - Oct;12(5):1146-1150. doi: 10.1016/j.jacl.2018.05.014. Epub 2018 Jun 1.

PMID:
29954705
37.

PCSK9 inhibitors in familial hypercholesterolemia: What is the evidence?

Paquette M, Hegele RA, Baass A.

J Clin Lipidol. 2018 Sep - Oct;12(5):1106-1108. doi: 10.1016/j.jacl.2018.05.010. Epub 2018 May 26. No abstract available.

PMID:
29909976
38.

Large-scale deletions of the ABCA1 gene in patients with hypoalphalipoproteinemia.

Dron JS, Wang J, Berberich AJ, Iacocca MA, Cao H, Yang P, Knoll J, Tremblay K, Brisson D, Netzer C, Gouni-Berthold I, Gaudet D, Hegele RA.

J Lipid Res. 2018 Aug;59(8):1529-1535. doi: 10.1194/jlr.P086280. Epub 2018 Jun 4.

39.

Response by Daugherty et al to Letter Regarding Article, "Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies: A Statement From the Arteriosclerosis, Thrombosis, and Vascular Biology Council".

Daugherty A, Lu HS, Hegele RA, Mackman N, Rader DJ, Schmidt AM, Weber C.

Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):e101-e102. doi: 10.1161/ATVBAHA.118.310988. No abstract available.

PMID:
29793996
40.

Clinical and biochemical features of different molecular etiologies of familial chylomicronemia.

Hegele RA, Berberich AJ, Ban MR, Wang J, Digenio A, Alexander VJ, D'Erasmo L, Arca M, Jones A, Bruckert E, Stroes ES, Bergeron J, Civeira F, Witztum JL, Gaudet D.

J Clin Lipidol. 2018 Jul - Aug;12(4):920-927.e4. doi: 10.1016/j.jacl.2018.03.093. Epub 2018 Apr 4.

41.

Can We Eliminate Low-Density Lipoprotein Cholesterol-Related Cardiovascular Events Through More Aggressive Primary Prevention Therapy?

Mancini GBJ, Hegele RA.

Can J Cardiol. 2018 May;34(5):546-551. doi: 10.1016/j.cjca.2018.02.027. Epub 2018 Mar 2.

PMID:
29731018
42.

Type 2 Diabetes and the Reduction of Cardiovascular Risk: Sorting Out the Actors and the Roles.

Feldman RD, Fitchett D, Hegele RA, Poulter NR.

Can J Cardiol. 2018 May;34(5):532-535. doi: 10.1016/j.cjca.2018.01.091. Epub 2018 Feb 6. No abstract available.

PMID:
29731015
43.

Hypertension Canada's 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children.

Nerenberg KA, Zarnke KB, Leung AA, Dasgupta K, Butalia S, McBrien K, Harris KC, Nakhla M, Cloutier L, Gelfer M, Lamarre-Cliche M, Milot A, Bolli P, Tremblay G, McLean D, Padwal RS, Tran KC, Grover S, Rabkin SW, Moe GW, Howlett JG, Lindsay P, Hill MD, Sharma M, Field T, Wein TH, Shoamanesh A, Dresser GK, Hamet P, Herman RJ, Burgess E, Gryn SE, Grégoire JC, Lewanczuk R, Poirier L, Campbell TS, Feldman RD, Lavoie KL, Tsuyuki RT, Honos G, Prebtani APH, Kline G, Schiffrin EL, Don-Wauchope A, Tobe SW, Gilbert RE, Leiter LA, Jones C, Woo V, Hegele RA, Selby P, Pipe A, McFarlane PA, Oh P, Gupta M, Bacon SL, Kaczorowski J, Trudeau L, Campbell NRC, Hiremath S, Roerecke M, Arcand J, Ruzicka M, Prasad GVR, Vallée M, Edwards C, Sivapalan P, Penner SB, Fournier A, Benoit G, Feber J, Dionne J, Magee LA, Logan AG, Côté AM, Rey E, Firoz T, Kuyper LM, Gabor JY, Townsend RR, Rabi DM, Daskalopoulou SS; Hypertension Canada.

Can J Cardiol. 2018 May;34(5):506-525. doi: 10.1016/j.cjca.2018.02.022. Epub 2018 Mar 1.

PMID:
29731013
44.

Adverse effects of statin therapy: perception vs. the evidence - focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract.

Mach F, Ray KK, Wiklund O, Corsini A, Catapano AL, Bruckert E, De Backer G, Hegele RA, Hovingh GK, Jacobson TA, Krauss RM, Laufs U, Leiter LA, März W, Nordestgaard BG, Raal FJ, Roden M, Santos RD, Stein EA, Stroes ES, Thompson PD, Tokgözoglu L, Vladutiu GD, Gencer B, Stock JK, Ginsberg HN, Chapman MJ; European Atherosclerosis Society Consensus Panel.

Eur Heart J. 2018 Jul 14;39(27):2526-2539. doi: 10.1093/eurheartj/ehy182.

45.

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease.

Dilliott AA, Farhan SMK, Ghani M, Sato C, Liang E, Zhang M, McIntyre AD, Cao H, Racacho L, Robinson JF, Strong MJ, Masellis M, Bulman DE, Rogaeva E, Lang A, Tartaglia C, Finger E, Zinman L, Turnbull J, Freedman M, Swartz R, Black SE, Hegele RA.

J Vis Exp. 2018 Apr 4;(134). doi: 10.3791/57266.

46.

Dyslipidemia.

Diabetes Canada Clinical Practice Guidelines Expert Committee, Mancini GBJ, Hegele RA, Leiter LA.

Can J Diabetes. 2018 Apr;42 Suppl 1:S178-S185. doi: 10.1016/j.jcjd.2017.10.019. No abstract available. Erratum in: Can J Diabetes. 2018 Oct;42(5):574.

PMID:
29650093
47.

Genetic polymorphisms are associated with exposure biomarkers for metals and persistent organic pollutants among Inuit from the Inuvialuit Settlement Region, Canada.

Parajuli RP, Goodrich JM, Chan LHM, Ayotte P, Lemire M, Hegele RA, Basu N.

Sci Total Environ. 2018 Sep 1;634:569-578. doi: 10.1016/j.scitotenv.2018.03.331. Epub 2018 Apr 7.

PMID:
29635199
48.

Complex genetic architecture in severe hypobetalipoproteinemia.

Wang LR, McIntyre AD, Hegele RA.

Lipids Health Dis. 2018 Mar 14;17(1):48. doi: 10.1186/s12944-018-0680-1.

49.

Fatty liver in a non-obese patient.

Jackson C, Geraghty MT, Hegele RA, El Demellawy D, Jimenez-Rivera C.

Paediatr Child Health. 2017 May;22(2):59-60. doi: 10.1093/pch/pxx034. Epub 2017 Apr 13. No abstract available.

50.

The Atherogenic Dyslipidemia Complex and Novel Approaches to Cardiovascular Disease Prevention in Diabetes.

Stahel P, Xiao C, Hegele RA, Lewis GF.

Can J Cardiol. 2018 May;34(5):595-604. doi: 10.1016/j.cjca.2017.12.007. Epub 2017 Dec 15. Review.

PMID:
29459241

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