Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 169


The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis.

Abe H, Alavattam KG, Hu YC, Pang Q, Andreassen PR, Hegde RS, Namekawa SH.

Curr Biol. 2019 Dec 21. pii: S0960-9822(19)31566-0. doi: 10.1016/j.cub.2019.11.064. [Epub ahead of print]


Mechanism of ribosome stalling during translation of a poly(A) tail.

Chandrasekaran V, Juszkiewicz S, Choi J, Puglisi JD, Brown A, Shao S, Ramakrishnan V, Hegde RS.

Nat Struct Mol Biol. 2019 Dec;26(12):1132-1140. doi: 10.1038/s41594-019-0331-x. Epub 2019 Nov 25.


TTC5 mediates autoregulation of tubulin via mRNA degradation.

Lin Z, Gasic I, Chandrasekaran V, Peters N, Shao S, Mitchison TJ, Hegde RS.

Science. 2020 Jan 3;367(6473):100-104. doi: 10.1126/science.aaz4352. Epub 2019 Nov 14.


The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension.

Wang Y, Pandey RN, York AJ, Mallela J, Nichols WC, Hu YC, Molkentin JD, Wikenheiser-Brokamp KA, Hegde RS.

Nat Commun. 2019 Sep 12;10(1):4143. doi: 10.1038/s41467-019-12226-1.


Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of Tail-Anchored Proteins, Cause Rapidly Progressive Pediatric Cardiomyopathy.

Verhagen JMA, van den Born M, van der Linde HC, G J Nikkels P, Verdijk RM, Kivlen MH, van Unen LMA, Baas AF, Ter Heide H, van Osch-Gevers L, Hoogeveen-Westerveld M, Herkert JC, Bertoli-Avella AM, van Slegtenhorst MA, Wessels MW, Verheijen FW, Hassel D, Hofstra RMW, Hegde RS, van Hasselt PM, van Ham TJ, van de Laar IMBH.

Circ Genom Precis Med. 2019 Sep;12(9):397-406. doi: 10.1161/CIRCGEN.119.002507. Epub 2019 Aug 28.


Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors.

Zavodszky E, Hegde RS.

Elife. 2019 May 16;8. pii: e46740. doi: 10.7554/eLife.46740.


An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye.

Nguyen MT, Vemaraju S, Nayak G, Odaka Y, Buhr ED, Alonzo N, Tran U, Batie M, Upton BA, Darvas M, Kozmik Z, Rao S, Hegde RS, Iuvone PM, Van Gelder RN, Lang RA.

Nat Cell Biol. 2019 Apr;21(4):420-429. doi: 10.1038/s41556-019-0301-x. Epub 2019 Apr 1.


Recognition and Degradation of Mislocalized Proteins in Health and Disease.

Hegde RS, Zavodszky E.

Cold Spring Harb Perspect Biol. 2019 Nov 1;11(11). pii: a033902. doi: 10.1101/cshperspect.a033902. Review.


The Role of EMC during Membrane Protein Biogenesis.

Chitwood PJ, Hegde RS.

Trends Cell Biol. 2019 May;29(5):371-384. doi: 10.1016/j.tcb.2019.01.007. Epub 2019 Feb 27. Review.


Activation of GCN2 by the ribosomal P-stalk.

Inglis AJ, Masson GR, Shao S, Perisic O, McLaughlin SH, Hegde RS, Williams RL.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4946-4954. doi: 10.1073/pnas.1813352116. Epub 2019 Feb 25.


The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis.

Volkmar N, Thezenas ML, Louie SM, Juszkiewicz S, Nomura DK, Hegde RS, Kessler BM, Christianson JC.

J Cell Sci. 2019 Jan 16;132(2). pii: jcs223453. doi: 10.1242/jcs.223453.


EMC Is Required to Initiate Accurate Membrane Protein Topogenesis.

Chitwood PJ, Juszkiewicz S, Guna A, Shao S, Hegde RS.

Cell. 2018 Nov 29;175(6):1507-1519.e16. doi: 10.1016/j.cell.2018.10.009. Epub 2018 Nov 8.


ZNF598 Is a Quality Control Sensor of Collided Ribosomes.

Juszkiewicz S, Chandrasekaran V, Lin Z, Kraatz S, Ramakrishnan V, Hegde RS.

Mol Cell. 2018 Nov 1;72(3):469-481.e7. doi: 10.1016/j.molcel.2018.08.037. Epub 2018 Oct 4.


Quality Control of Orphaned Proteins.

Juszkiewicz S, Hegde RS.

Mol Cell. 2018 Aug 2;71(3):443-457. doi: 10.1016/j.molcel.2018.07.001. Review.


The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth.

Wang Y, Pandey RN, Riffle S, Chintala H, Wikenheiser-Brokamp KA, Hegde RS.

Mol Cancer Ther. 2018 Aug;17(8):1659-1669. doi: 10.1158/1535-7163.MCT-18-0057. Epub 2018 May 25.


Highly Sensitive Refractive Index Sensors with Plasmonic Nanoantennas-Utilization of Optimal Spectral Detuning of Fano Resonances.

Mesch M, Weiss T, Schäferling M, Hentschel M, Hegde RS, Giessen H.

ACS Sens. 2018 May 25;3(5):960-966. doi: 10.1021/acssensors.8b00003. Epub 2018 May 14.


Transmembrane Domain Recognition during Membrane Protein Biogenesis and Quality Control.

Guna A, Hegde RS.

Curr Biol. 2018 Apr 23;28(8):R498-R511. doi: 10.1016/j.cub.2018.02.004. Review.


Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum.

Anghel SA, McGilvray PT, Hegde RS, Keenan RJ.

Cell Rep. 2017 Dec 26;21(13):3708-3716. doi: 10.1016/j.celrep.2017.12.006.


The ER membrane protein complex is a transmembrane domain insertase.

Guna A, Volkmar N, Christianson JC, Hegde RS.

Science. 2018 Jan 26;359(6374):470-473. doi: 10.1126/science.aao3099. Epub 2017 Dec 14.


UBE2O is a quality control factor for orphans of multiprotein complexes.

Yanagitani K, Juszkiewicz S, Hegde RS.

Science. 2017 Aug 4;357(6350):472-475. doi: 10.1126/science.aan0178.


Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids.

Riffle S, Hegde RS.

J Exp Clin Cancer Res. 2017 Aug 3;36(1):102. doi: 10.1186/s13046-017-0570-9. Review.


Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids.

Riffle S, Pandey RN, Albert M, Hegde RS.

BMC Cancer. 2017 May 18;17(1):338. doi: 10.1186/s12885-017-3319-0.


ETS transcription factors Etv2 and Fli1b are required for tumor angiogenesis.

Baltrunaite K, Craig MP, Palencia Desai S, Chaturvedi P, Pandey RN, Hegde RS, Sumanas S.

Angiogenesis. 2017 Aug;20(3):307-323. doi: 10.1007/s10456-017-9539-8. Epub 2017 Jan 20.


Mechanistic basis for a molecular triage reaction.

Shao S, Rodrigo-Brenni MC, Kivlen MH, Hegde RS.

Science. 2017 Jan 20;355(6322):298-302. doi: 10.1126/science.aah6130.


IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses.

Chen C, Itakura E, Nelson GM, Sheng M, Laurent P, Fenk LA, Butcher RA, Hegde RS, de Bono M.

Nature. 2017 Feb 2;542(7639):43-48. doi: 10.1038/nature20818. Epub 2017 Jan 18.


Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination.

Juszkiewicz S, Hegde RS.

Mol Cell. 2017 Feb 16;65(4):743-750.e4. doi: 10.1016/j.molcel.2016.11.039. Epub 2017 Jan 5.


Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.

Shao S, Murray J, Brown A, Taunton J, Ramakrishnan V, Hegde RS.

Cell. 2016 Nov 17;167(5):1229-1240.e15. doi: 10.1016/j.cell.2016.10.046.


Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.

Itakura E, Zavodszky E, Shao S, Wohlever ML, Keenan RJ, Hegde RS.

Mol Cell. 2016 Jul 7;63(1):21-33. doi: 10.1016/j.molcel.2016.05.020. Epub 2016 Jun 23.


Toward a structural understanding of co-translational protein translocation.

Voorhees RM, Hegde RS.

Curr Opin Cell Biol. 2016 Aug;41:91-9. doi: 10.1016/ Epub 2016 May 6. Review.


The Eyes Absent Proteins in Developmental and Pathological Angiogenesis.

Wang Y, Tadjuidje E, Pandey RN, Stefater JA 3rd, Smith LE, Lang RA, Hegde RS.

Am J Pathol. 2016 Mar;186(3):568-78. doi: 10.1016/j.ajpath.2015.10.031. Epub 2016 Jan 5.


Ribosome-associated protein quality control.

Brandman O, Hegde RS.

Nat Struct Mol Biol. 2016 Jan;23(1):7-15. Review.


Structure of the Sec61 channel opened by a signal sequence.

Voorhees RM, Hegde RS.

Science. 2016 Jan 1;351(6268):88-91. doi: 10.1126/science.aad4992.


Target Selection during Protein Quality Control.

Shao S, Hegde RS.

Trends Biochem Sci. 2016 Feb;41(2):124-137. doi: 10.1016/j.tibs.2015.10.007. Epub 2015 Nov 25. Review.


Correction: A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family.

Patel K, Giese AP, Grossheim JM, Hegde RS, Delio M, Samanich J, Riazuddin S, Frolenkov GI, Cai J, Ahmed ZM, Morrow BE.

PLoS One. 2015 Oct 16;10(10):e0141259. doi: 10.1371/journal.pone.0141259. eCollection 2015. No abstract available.


A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family.

Patel K, Giese AP, Grossheim JM, Hegde RS, Delio M, Samanich J, Riazuddin S, Frolenkov GI, Cai J, Ahmed ZM, Morrow BE.

PLoS One. 2015 Oct 1;10(10):e0133082. doi: 10.1371/journal.pone.0133082. eCollection 2015. Erratum in: PLoS One. 2015;10(10):e0141259. Hegde, Rashima S [corrected to Hegde, Rashmi S].


Structural basis for stop codon recognition in eukaryotes.

Brown A, Shao S, Murray J, Hegde RS, Ramakrishnan V.

Nature. 2015 Aug 27;524(7566):493-496. doi: 10.1038/nature14896. Epub 2015 Aug 5.


Structures of the scanning and engaged states of the mammalian SRP-ribosome complex.

Voorhees RM, Hegde RS.

Elife. 2015 Jul 9;4. doi: 10.7554/eLife.07975.


BAZ1B is dispensable for H2AX phosphorylation on Tyrosine 142 during spermatogenesis.

Broering TJ, Wang YL, Pandey RN, Hegde RS, Wang SC, Namekawa SH.

Biol Open. 2015 May 15;4(7):873-84. doi: 10.1242/bio.011734.


The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon.

von der Malsburg K, Shao S, Hegde RS.

Mol Biol Cell. 2015 Jun 15;26(12):2168-80. doi: 10.1091/mbc.E15-01-0040. Epub 2015 Apr 15.


Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.

Mateja A, Paduch M, Chang HY, Szydlowska A, Kossiakoff AA, Hegde RS, Keenan RJ.

Science. 2015 Mar 6;347(6226):1152-5. doi: 10.1126/science.1261671.


Structure and assembly pathway of the ribosome quality control complex.

Shao S, Brown A, Santhanam B, Hegde RS.

Mol Cell. 2015 Feb 5;57(3):433-44. doi: 10.1016/j.molcel.2014.12.015. Epub 2015 Jan 8.


Neuropathy target esterase impairments cause Oliver-McFarlane and Laurence-Moon syndromes.

Hufnagel RB, Arno G, Hein ND, Hersheson J, Prasad M, Anderson Y, Krueger LA, Gregory LC, Stoetzel C, Jaworek TJ, Hull S, Li A, Plagnol V, Willen CM, Morgan TM, Prows CA, Hegde RS, Riazuddin S, Grabowski GA, Richardson RJ, Dieterich K, Huang T, Revesz T, Martinez-Barbera JP, Sisk RA, Jefferies C, Houlden H, Dattani MT, Fink JK, Dollfus H, Moore AT, Ahmed ZM.

J Med Genet. 2015 Feb;52(2):85-94. doi: 10.1136/jmedgenet-2014-102856. Epub 2014 Dec 5.


Cell Biology. Local synthesis and disposal.

Shao S, Hegde RS.

Science. 2014 Nov 7;346(6210):701-2. doi: 10.1126/science.1261602. No abstract available.


Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors.

Shao S, Hegde RS.

Mol Cell. 2014 Sep 18;55(6):880-890. doi: 10.1016/j.molcel.2014.07.006. Epub 2014 Aug 14.


ER stress-induced clearance of misfolded GPI-anchored proteins via the secretory pathway.

Satpute-Krishnan P, Ajinkya M, Bhat S, Itakura E, Hegde RS, Lippincott-Schwartz J.

Cell. 2014 Jul 31;158(3):522-33. doi: 10.1016/j.cell.2014.06.026.


Precision synthesis: designing hot spots over hot spots via selective gold deposition on silver octahedra edges.

Liu Y, Pedireddy S, Lee YH, Hegde RS, Tjiu WW, Cui Y, Ling XY.

Small. 2014 Dec 10;10(23):4940-50. doi: 10.1002/smll.201401242. Epub 2014 Jul 22.


Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.

Rodrigo-Brenni MC, Gutierrez E, Hegde RS.

Mol Cell. 2014 Jul 17;55(2):227-37. doi: 10.1016/j.molcel.2014.05.025. Epub 2014 Jun 26.


Structure of the mammalian ribosome-Sec61 complex to 3.4 Å resolution.

Voorhees RM, Fernández IS, Scheres SH, Hegde RS.

Cell. 2014 Jun 19;157(7):1632-43. doi: 10.1016/j.cell.2014.05.024. Epub 2014 Jun 12.


Msp1: patrolling mitochondria for lost proteins.

Hegde RS.

EMBO J. 2014 Jul 17;33(14):1509-10. doi: 10.15252/embj.201488930. Epub 2014 Jun 10. No abstract available.


An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism.

Chen C, Itakura E, Weber KP, Hegde RS, de Bono M.

PLoS Genet. 2014 Mar 6;10(3):e1004082. doi: 10.1371/journal.pgen.1004082. eCollection 2014 Mar.

Supplemental Content

Loading ...
Support Center