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Items: 1 to 50 of 475

1.

CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression.

Fousek K, Watanabe J, Joseph SK, George A, An X, Byrd TT, Morris JS, Luong A, Martínez-Paniagua MA, Sanber K, Navai SA, Gad AZ, Salsman VS, Mathew PR, Kim HN, Wagner DL, Brunetti L, Jang A, Baker ML, Varadarajan N, Hegde M, Kim YM, Heisterkamp N, Abdel-Azim H, Ahmed N.

Leukemia. 2020 Mar 24. doi: 10.1038/s41375-020-0792-2. [Epub ahead of print]

PMID:
32205861
2.

Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis.

Chakraborty A, Tapryal N, Venkova T, Mitra J, Vasquez V, Sarker AH, Duarte-Silva S, Huai W, Ashizawa T, Ghosh G, Maciel P, Sarkar PS, Hegde ML, Chen X, Hazra TK.

Proc Natl Acad Sci U S A. 2020 Mar 23. pii: 201917280. doi: 10.1073/pnas.1917280117. [Epub ahead of print]

PMID:
32205441
3.

Design and Reporting Considerations for Genetic Screening Tests.

Hagenkord J, Funke B, Qian E, Hegde M, Jacobs KB, Ferber M, Lebo M, Buchanan A, Bick D.

J Mol Diagn. 2020 Feb 22. pii: S1525-1578(20)30038-6. doi: 10.1016/j.jmoldx.2020.01.014. [Epub ahead of print] Review.

PMID:
32092541
4.

The prevalence of myocardial bridging on multidetector computed tomography and its relation to coronary plaques.

Rajendran R, Hegde M.

Pol J Radiol. 2019 Nov 21;84:e478-e483. doi: 10.5114/pjr.2019.90370. eCollection 2019.

5.

Mesial temporal resection following long-term ambulatory intracranial EEG monitoring with a direct brain-responsive neurostimulation system.

Hirsch LJ, Mirro EA, Salanova V, Witt TC, Drees CN, Brown MG, Lee RW, Sadler TL, Felton EA, Rutecki P, Shin HW, Hadar E, Hegde M, Rao VR, Mnatsakanyan L, Madhavan DS, Zakaria TJ, Liu AA, Heck CN, Greenwood JE, Bigelow JK, Nair DR, Alexopoulos AV, Mackow M, Edwards JC, Sotudeh N, Kuzniecky RI, Gwinn RP, Doherty MJ, Geller EB, Morrell MJ.

Epilepsia. 2020 Mar;61(3):408-420. doi: 10.1111/epi.16442. Epub 2020 Feb 18.

PMID:
32072621
6.

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle.

Dharmalingam P, Talakatta G, Mitra J, Wang H, Derry PJ, Nilewski LG, McHugh EA, Fabian RH, Mendoza K, Vasquez V, Hegde PM, Kakadiaris E, Roy T, Boldogh I, Hegde VL, Mitra S, Tour JM, Kent TA, Hegde ML.

ACS Nano. 2020 Mar 24;14(3):2827-2846. doi: 10.1021/acsnano.9b05821. Epub 2020 Feb 21.

PMID:
32049495
7.

Strong graphene oxide nanocomposites from aqueous hybrid liquid crystals.

Hegde M, Yang L, Vita F, Fox RJ, van de Watering R, Norder B, Lafont U, Francescangeli O, Madsen LA, Picken SJ, Samulski ET, Dingemans TJ.

Nat Commun. 2020 Feb 11;11(1):830. doi: 10.1038/s41467-020-14618-0.

8.

Genetic screens in isogenic mammalian cell lines without single cell cloning.

DeWeirdt PC, Sangree AK, Hanna RE, Sanson KR, Hegde M, Strand C, Persky NS, Doench JG.

Nat Commun. 2020 Feb 6;11(1):752. doi: 10.1038/s41467-020-14620-6.

9.

3D Printing Latex: A Route to Complex Geometries of High Molecular Weight Polymers.

Scott PJ, Meenakshisundaram V, Hegde M, Kasprzak CR, Winkler CR, Feller KD, Williams CB, Long TE.

ACS Appl Mater Interfaces. 2020 Mar 4;12(9):10918-10928. doi: 10.1021/acsami.9b19986. Epub 2020 Feb 20.

PMID:
32028758
10.

Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity.

Wertz MH, Mitchem MR, Pineda SS, Hachigian LJ, Lee H, Lau V, Powers A, Kulicke R, Madan GK, Colic M, Therrien M, Vernon A, Beja-Glasser VF, Hegde M, Gao F, Kellis M, Hart T, Doench JG, Heiman M.

Neuron. 2020 Jan 24. pii: S0896-6273(20)30004-0. doi: 10.1016/j.neuron.2020.01.004. [Epub ahead of print]

PMID:
32004439
11.

The Latin American experience with a next generation sequencing genetic panel for recessive limb-girdle muscular weakness and Pompe disease.

Bevilacqua JA, Guecaimburu Ehuletche MDR, Perna A, Dubrovsky A, Franca MC Jr, Vargas S, Hegde M, Claeys KG, Straub V, Daba N, Faria R, Periquet M, Sparks S, Thibault N, Araujo R.

Orphanet J Rare Dis. 2020 Jan 13;15(1):11. doi: 10.1186/s13023-019-1291-2.

12.

A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson's disease: Emerging concepts and challenges.

Vasquez V, Mitra J, Wang H, Hegde PM, Rao KS, Hegde ML.

Prog Neurobiol. 2020 Feb;185:101729. doi: 10.1016/j.pneurobio.2019.101729. Epub 2019 Dec 18. Review.

PMID:
31863801
13.

Evaluation of surface integrity of root end cavities prepared using conventional and piezoelectric devices: A scanning electron microscopy study.

Hegde MN, Honap MN, Narayanan S.

Indian J Dent Res. 2019 Sep-Oct;30(5):772-776. doi: 10.4103/ijdr.IJDR_237_18.

PMID:
31854372
14.

Comparative evaluation of the pushout bond strength of two root-end materials: An in vitro study.

Hegde N, Hegde MN, Bhat GS.

J Conserv Dent. 2019 Jul-Aug;22(4):340-343. doi: 10.4103/JCD.JCD_563_18.

15.

RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease.

Wang H, Rangaswamy S, Kodavati M, Mitra J, Guo W, Guerrero EN, Van Den Bosch L, Hegde ML.

Mol Brain. 2019 Dec 4;12(1):103. doi: 10.1186/s13041-019-0526-4.

16.

Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis.

Lakey-Beitia J, Kumar D J, Hegde ML, Rao KS.

Int J Mol Sci. 2019 Nov 7;20(22). pii: E5553. doi: 10.3390/ijms20225553. Review.

17.

A Commentary on TDP-43 and DNA Damage Response in Amyotrophic Lateral Sclerosis.

Mitra J, Hegde ML.

J Exp Neurosci. 2019 Oct 10;13:1179069519880166. doi: 10.1177/1179069519880166. eCollection 2019.

18.

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective.

Derry PJ, Hegde ML, Jackson GR, Kayed R, Tour JM, Tsai AL, Kent TA.

Prog Neurobiol. 2020 Jan;184:101716. doi: 10.1016/j.pneurobio.2019.101716. Epub 2019 Oct 8. Review.

PMID:
31604111
19.

Hexahydropyrrolo[2,3-b]indole Compounds as Potential Therapeutics for Alzheimer's Disease.

Doens D, Valdés-Tresanco ME, Vasquez V, Carreira MB, De La Guardia Y, Stephens DE, Nguyen VD, Nguyen VT, Gu J, Hegde ML, Larionov OV, Valiente PA, Lleonart R, Fernández PL.

ACS Chem Neurosci. 2019 Oct 16;10(10):4250-4263. doi: 10.1021/acschemneuro.9b00297. Epub 2019 Oct 7.

PMID:
31545596
20.

Type 2 diabetes differentially affects the substrate saturation kinetic attributes of erythrocyte hexokinase and phosphofructokinase.

Bhise S, Rao J, Hegde M, Katyare S.

FEBS Lett. 2020 Jan;594(2):240-250. doi: 10.1002/1873-3468.13604. Epub 2019 Sep 25.

PMID:
31520487
21.

Isolated Partial Anomalous Pulmonary Venous Connection: Development of Volume Overload and Elevated Estimated Pulmonary Pressure in Adults.

Hegde M, Manjunath SC, Usha MK.

J Clin Imaging Sci. 2019 Jun 14;9:29. doi: 10.25259/JCIS-8-2019. eCollection 2019.

22.

Nanofibrillar Ionic Polymer Composites Enable High-Modulus Ion-Conducting Membranes.

Fox RJ, Yu D, Hegde M, Kumbhar AS, Madsen LA, Dingemans TJ.

ACS Appl Mater Interfaces. 2019 Oct 30;11(43):40551-40563. doi: 10.1021/acsami.9b10921. Epub 2019 Sep 30.

PMID:
31507155
23.

Immunotherapy for pediatric brain tumors: past and present.

Foster JB, Madsen PJ, Hegde M, Ahmed N, Cole KA, Maris JM, Resnick AC, Storm PB, Waanders AJ.

Neuro Oncol. 2019 Oct 9;21(10):1226-1238. doi: 10.1093/neuonc/noz077.

PMID:
31504801
24.

Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis.

Guerrero EN, Mitra J, Wang H, Rangaswamy S, Hegde PM, Basu P, Rao KS, Hegde ML.

Hum Mol Genet. 2019 Sep 15;28(18):3161-3162. doi: 10.1093/hmg/ddz141. No abstract available.

25.

Faceting-Controlled Zeeman Splitting in Plasmonic TiO2 Nanocrystals.

Yin P, Hegde M, Garnet NS, Tan Y, Radovanovic PV.

Nano Lett. 2019 Sep 11;19(9):6695-6702. doi: 10.1021/acs.nanolett.9b03128. Epub 2019 Aug 29.

PMID:
31448925
26.

Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group.

Roberts RD, Lizardo MM, Reed DR, Hingorani P, Glover J, Allen-Rhoades W, Fan T, Khanna C, Sweet-Cordero EA, Cash T, Bishop MW, Hegde M, Sertil AR, Koelsche C, Mirabello L, Malkin D, Sorensen PH, Meltzer PS, Janeway KA, Gorlick R, Crompton BD.

Cancer. 2019 Oct 15;125(20):3514-3525. doi: 10.1002/cncr.32351. Epub 2019 Jul 29. Review.

PMID:
31355930
27.

Oral candidal carriage correlates with CD4+ cell count but not with HIV and highly active antiretroviral therapy status.

Sah P, Patel P, Chandrashekar C, Martena S, Ballal M, Hegde M, Guddattu V, Murdoch C, Sharma M, Radhakrishnan R.

J Investig Clin Dent. 2019 Nov;10(4):e12438. doi: 10.1111/jicd.12438. Epub 2019 Jul 17.

PMID:
31313889
28.

Protection of wear resistance behaviour of enamel against electron beam irradiation.

Hegde MN, Gatti P, Hegde ND.

BDJ Open. 2019 Jul 11;5:11. doi: 10.1038/s41405-019-0021-0. eCollection 2019.

29.

Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape.

Hegde M, Mukherjee M, Grada Z, Pignata A, Landi D, Navai SA, Wakefield A, Fousek K, Bielamowicz K, Chow KK, Brawley VS, Byrd TT, Krebs S, Gottschalk S, Wels WS, Baker ML, Dotti G, Mamonkin M, Brenner MK, Orange JS, Ahmed N.

J Clin Invest. 2019 Jul 2;129(8):3464. doi: 10.1172/JCI131246. eCollection 2019 Jul 2. No abstract available.

30.

New Mechanisms of DNA Repair Defects in Fused in Sarcoma-Associated Neurodegeneration: Stage Set for DNA Repair-Based Therapeutics?

Wang H, Hegde ML.

J Exp Neurosci. 2019 Jun 10;13:1179069519856358. doi: 10.1177/1179069519856358. eCollection 2019.

32.

Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis.

Guerrero EN, Mitra J, Wang H, Rangaswamy S, Hegde PM, Basu P, Rao KS, Hegde ML.

Hum Mol Genet. 2019 Aug 1;28(5):2459-2476. doi: 10.1093/hmg/ddz062. Epub 2019 Apr 1. Erratum in: Hum Mol Genet. 2019 Sep 15;28(18):3161-3162.

PMID:
31067307
33.

Differential sensitivity of structural, diffusion, and resting-state functional MRI for detecting brain alterations and verbal memory impairment in temporal lobe epilepsy.

Chang YA, Marshall A, Bahrami N, Mathur K, Javadi SS, Reyes A, Hegde M, Shih JJ, Paul BM, Hagler DJ Jr, McDonald CR.

Epilepsia. 2019 May;60(5):935-947. doi: 10.1111/epi.14736. Epub 2019 Apr 25.

PMID:
31020649
34.

Correction of pseudoexon splicing caused by a novel intronic dysferlin mutation.

Dominov JA, Uyan Ö, McKenna-Yasek D, Nallamilli BRR, Kergourlay V, Bartoli M, Levy N, Hudson J, Evangelista T, Lochmuller H, Krahn M, Rufibach L, Hegde M, Brown RH Jr.

Ann Clin Transl Neurol. 2019 Mar 3;6(4):642-654. doi: 10.1002/acn3.738. eCollection 2019 Apr.

35.

Clinical utility of RNA sequencing to resolve unusual GNE myopathy with a novel promoter deletion.

Chakravorty S, Berger K, Arafat D, Nallamilli BRR, Subramanian HP, Joseph S, Anderson ME, Campbell KP, Glass J, Gibson G, Hegde M.

Muscle Nerve. 2019 Jul;60(1):98-103. doi: 10.1002/mus.26486. Epub 2019 Apr 29.

PMID:
30990900
36.

Cognitive phenotypes in temporal lobe epilepsy are associated with distinct patterns of white matter network abnormalities.

Reyes A, Kaestner E, Bahrami N, Balachandra A, Hegde M, Paul BM, Hermann B, McDonald CR.

Neurology. 2019 Apr 23;92(17):e1957-e1968. doi: 10.1212/WNL.0000000000007370. Epub 2019 Mar 27.

PMID:
30918094
37.

Asymmetric confinement for defining outgrowth directionality.

Holloway PM, Hallinan GI, Hegde M, Lane SIR, Deinhardt K, West J.

Lab Chip. 2019 Apr 9;19(8):1484-1489. doi: 10.1039/c9lc00078j.

PMID:
30899932
38.

Saliva as a biomarker for dental caries: A systematic review.

Hegde MN, Attavar SH, Shetty N, Hegde ND, Hegde NN.

J Conserv Dent. 2019 Jan-Feb;22(1):2-6. doi: 10.4103/JCD.JCD_531_18. Review.

39.

Retraction Note: A homing system targets therapeutic T cells to brain cancer.

Samaha H, Pignata A, Fousek K, Ren J, Lam FW, Stossi F, Dubrulle J, Salsman VS, Krishnan S, Hong SH, Baker ML, Shree A, Gad AZ, Shum T, Fukumura D, Byrd TT, Mukherjee M, Marrelli SP, Orange JS, Joseph SK, Sorensen PH, Taylor MD, Hegde M, Mamonkin M, Jain RK, El-Naggar S, Ahmed N.

Nature. 2019 Mar;567(7746):132. doi: 10.1038/s41586-019-0967-z.

40.

Double helical conformation and extreme rigidity in a rodlike polyelectrolyte.

Wang Y, He Y, Yu Z, Gao J, Ten Brinck S, Slebodnick C, Fahs GB, Zanelotti CJ, Hegde M, Moore RB, Ensing B, Dingemans TJ, Qiao R, Madsen LA.

Nat Commun. 2019 Feb 18;10(1):801. doi: 10.1038/s41467-019-08756-3.

41.

Anticancer and antimetastatic potential of enterolactone: Clinical, preclinical and mechanistic perspectives.

Mali AV, Padhye SB, Anant S, Hegde MV, Kadam SS.

Eur J Pharmacol. 2019 Jun 5;852:107-124. doi: 10.1016/j.ejphar.2019.02.022. Epub 2019 Feb 14. Review.

PMID:
30771348
42.

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects.

Mitra J, Guerrero EN, Hegde PM, Liachko NF, Wang H, Vasquez V, Gao J, Pandey A, Taylor JP, Kraemer BC, Wu P, Boldogh I, Garruto RM, Mitra S, Rao KS, Hegde ML.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4696-4705. doi: 10.1073/pnas.1818415116. Epub 2019 Feb 15.

43.

Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome.

Berauer JP, Mezina AI, Okou DT, Sabo A, Muzny DM, Gibbs RA, Hegde MR, Chopra P, Cutler DJ, Perlmutter DH, Bull LN, Thompson RJ, Loomes KM, Spinner NB, Rajagopalan R, Guthery SL, Moore B, Yandell M, Harpavat S, Magee JC, Kamath BM, Molleston JP, Bezerra JA, Murray KF, Alonso EM, Rosenthal P, Squires RH, Wang KS, Finegold MJ, Russo P, Sherker AH, Sokol RJ, Karpen SJ; Childhood Liver Disease Research Network (ChiLDReN).

Hepatology. 2019 Sep;70(3):899-910. doi: 10.1002/hep.30515. Epub 2019 Mar 21.

PMID:
30664273
44.

Evidence-Based Consensus and Systematic Review on Reducing the Time to Diagnosis of Duchenne Muscular Dystrophy.

Aartsma-Rus A, Hegde M, Ben-Omran T, Buccella F, Ferlini A, Gallano P, Howell RR, Leturcq F, Martin AS, Potulska-Chromik A, Saute JA, Schmidt WM, Sejersen T, Tuffery-Giraud S, Uyguner ZO, Witcomb LA, Yau S, Nelson SF.

J Pediatr. 2019 Jan;204:305-313.e14. doi: 10.1016/j.jpeds.2018.10.043. No abstract available.

45.

Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities.

Sanson KR, Hanna RE, Hegde M, Donovan KF, Strand C, Sullender ME, Vaimberg EW, Goodale A, Root DE, Piccioni F, Doench JG.

Nat Commun. 2018 Dec 21;9(1):5416. doi: 10.1038/s41467-018-07901-8.

46.

Genetic landscape and novel disease mechanisms from a large LGMD cohort of 4656 patients.

Nallamilli BRR, Chakravorty S, Kesari A, Tanner A, Ankala A, Schneider T, da Silva C, Beadling R, Alexander JJ, Askree SH, Whitt Z, Bean L, Collins C, Khadilkar S, Gaitonde P, Dastur R, Wicklund M, Mozaffar T, Harms M, Rufibach L, Mittal P, Hegde M.

Ann Clin Transl Neurol. 2018 Dec 1;5(12):1574-1587. doi: 10.1002/acn3.649. eCollection 2018 Dec.

47.
48.

Beyond depression: The impact of executive functioning on quality of life in patients with temporal lobe epilepsy.

Ehrlich T, Reyes A, Paul BM, Uttarwar V, Hartman S, Mathur K, Chang YA, Hegde M, Shih JJ, McDonald CR.

Epilepsy Res. 2019 Jan;149:30-36. doi: 10.1016/j.eplepsyres.2018.11.004. Epub 2018 Nov 13.

49.

Reverse rotary instrumentation in the apical third of the root canal system: An scanning electron microscope analysis.

Bhat R, Hegde MN.

Indian J Dent Res. 2018 Sep-Oct;29(5):594-599. doi: 10.4103/ijdr.IJDR_143_15.

50.

Cannabinoid exposure during pregnancy and its impact on immune function.

Dong C, Chen J, Harrington A, Vinod KY, Hegde ML, Hegde VL.

Cell Mol Life Sci. 2019 Feb;76(4):729-743. doi: 10.1007/s00018-018-2955-0. Epub 2018 Oct 29. Review.

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