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Items: 15


Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma.

Scanlon SE, Hegan DC, Sulkowski PL, Glazer PM.

Oncotarget. 2017 Dec 19;9(4):4647-4660. doi: 10.18632/oncotarget.23470. eCollection 2018 Jan 12.


A cell-penetrating antibody inhibits human RAD51 via direct binding.

Turchick A, Hegan DC, Jensen RB, Glazer PM.

Nucleic Acids Res. 2017 Nov 16;45(20):11782-11799. doi: 10.1093/nar/gkx871.


Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells.

Scanlon SE, Scanlon CD, Hegan DC, Sulkowski PL, Glazer PM.

Carcinogenesis. 2017 Jun 1;38(6):627-637. doi: 10.1093/carcin/bgx038.


2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.

Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS.

Sci Transl Med. 2017 Feb 1;9(375). pii: eaal2463. doi: 10.1126/scitranslmed.aal2463.


Mechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines.

Colis LC, Hegan DC, Kaneko M, Glazer PM, Herzon SB.

J Am Chem Soc. 2015 May 6;137(17):5741-7. doi: 10.1021/ja513117p. Epub 2015 Apr 22.


The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA.

Colis LC, Woo CM, Hegan DC, Li Z, Glazer PM, Herzon SB.

Nat Chem. 2014 Jun;6(6):504-10. doi: 10.1038/nchem.1944. Epub 2014 May 11.


Hypoxia and DNA repair.

Glazer PM, Hegan DC, Lu Y, Czochor J, Scanlon SE.

Yale J Biol Med. 2013 Dec 13;86(4):443-51.


Targeting cancer with a lupus autoantibody.

Hansen JE, Chan G, Liu Y, Hegan DC, Dalal S, Dray E, Kwon Y, Xu Y, Xu X, Peterson-Roth E, Geiger E, Liu Y, Gera J, Sweasy JB, Sung P, Rockwell S, Nishimura RN, Weisbart RH, Glazer PM.

Sci Transl Med. 2012 Oct 24;4(157):157ra142. doi: 10.1126/scitranslmed.3004385.


Targeted gene modification of hematopoietic progenitor cells in mice following systemic administration of a PNA-peptide conjugate.

Rogers FA, Lin SS, Hegan DC, Krause DS, Glazer PM.

Mol Ther. 2012 Jan;20(1):109-18. doi: 10.1038/mt.2011.163. Epub 2011 Aug 9.


Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.

Hegan DC, Lu Y, Stachelek GC, Crosby ME, Bindra RS, Glazer PM.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2201-6. doi: 10.1073/pnas.0904783107. Epub 2010 Jan 19.


Triplex-stimulated intermolecular recombination at a single-copy genomic target.

Knauert MP, Kalish JM, Hegan DC, Glazer PM.

Mol Ther. 2006 Sep;14(3):392-400. Epub 2006 May 30.


Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6.

Hegan DC, Narayanan L, Jirik FR, Edelmann W, Liskay RM, Glazer PM.

Carcinogenesis. 2006 Dec;27(12):2402-8. Epub 2006 May 25.


Induction of aberrant crypt foci in DNA mismatch repair-deficient mice by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP).

Smith-Roe SL, Löhr CV, Bildfell RJ, Fischer KA, Hegan DC, Glazer PM, Buermeyer AB.

Cancer Lett. 2006 Nov 28;244(1):79-85. Epub 2006 Jan 20.


Overexpression of the DNA mismatch repair factor, PMS2, confers hypermutability and DNA damage tolerance.

Gibson SL, Narayanan L, Hegan DC, Buermeyer AB, Liskay RM, Glazer PM.

Cancer Lett. 2006 Dec 8;244(2):195-202. Epub 2006 Jan 19.


Mlh1-dependent suppression of specific mutations induced in vivo by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP).

Smith-Roe SL, Hegan DC, Glazer PM, Buermeyer AB.

Mutat Res. 2006 Feb 22;594(1-2):101-12. Epub 2005 Oct 26.


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