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Items: 33


Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs.

Strnadel J, Carromeu C, Bardy C, Navarro M, Platoshyn O, Glud AN, Marsala S, Kafka J, Miyanohara A, Kato T Jr, Tadokoro T, Hefferan MP, Kamizato K, Yoshizumi T, Juhas S, Juhasova J, Ho CS, Kheradmand T, Chen P, Bohaciakova D, Hruska-Plochan M, Todd AJ, Driscoll SP, Glenn TD, Pfaff SL, Klima J, Ciacci J, Curtis E, Gage FH, Bui J, Yamada K, Muotri AR, Marsala M.

Sci Transl Med. 2018 May 9;10(440). pii: eaam6651. doi: 10.1126/scitranslmed.aam6651.


Amelioration of Penetrating Ballistic-Like Brain Injury Induced Cognitive Deficits after Neuronal Differentiation of Transplanted Human Neural Stem Cells.

Spurlock MS, Ahmed AI, Rivera KN, Yokobori S, Lee SW, Sam PN, Shear DA, Hefferan MP, Hazel TG, Johe KK, Gajavelli S, Tortella FC, Bullock RM.

J Neurotrauma. 2017 Jun 1;34(11):1981-1995. doi: 10.1089/neu.2016.4602. Epub 2017 Mar 23.


Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain.

Leinders M, Koehrn FJ, Bartok B, Boyle DL, Shubayev V, Kalcheva I, Yu NK, Park J, Kaang BK, Hefferan MP, Firestein GS, Sorkin LS.

Pain. 2014 Jun;155(6):1150-60. doi: 10.1016/j.pain.2014.03.003. Epub 2014 Mar 12.


Pig models of neurodegenerative disorders: Utilization in cell replacement-based preclinical safety and efficacy studies.

Dolezalova D, Hruska-Plochan M, Bjarkam CR, Sørensen JC, Cunningham M, Weingarten D, Ciacci JD, Juhas S, Juhasova J, Motlik J, Hefferan MP, Hazel T, Johe K, Carromeu C, Muotri A, Bui J, Strnadel J, Marsala M.

J Comp Neurol. 2014 Aug 15;522(12):2784-801. doi: 10.1002/cne.23575. Epub 2014 Apr 12. Review.


Effective long-term immunosuppression in rats by subcutaneously implanted sustained-release tacrolimus pellet: effect on spinally grafted human neural precursor survival.

Sevc J, Goldberg D, van Gorp S, Leerink M, Juhas S, Juhasova J, Marsala S, Hruska-Plochan M, Hefferan MP, Motlik J, Rypacek F, Machova L, Kakinohana O, Santucci C, Johe K, Lukacova N, Yamada K, Bui JD, Marsala M.

Exp Neurol. 2013 Oct;248:85-99. doi: 10.1016/j.expneurol.2013.05.017. Epub 2013 Jun 5.


Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation.

Hefferan MP, Galik J, Kakinohana O, Sekerkova G, Santucci C, Marsala S, Navarro R, Hruska-Plochan M, Johe K, Feldman E, Cleveland DW, Marsala M.

PLoS One. 2012;7(8):e42614. doi: 10.1371/journal.pone.0042614. Epub 2012 Aug 20.


Combinational spinal GAD65 gene delivery and systemic GABA-mimetic treatment for modulation of spasticity.

Kakinohana O, Hefferan MP, Miyanohara A, Nejime T, Marsala S, Juhas S, Juhasova J, Motlik J, Kucharova K, Strnadel J, Platoshyn O, Lazar P, Galik J, Vinay L, Marsala M.

PLoS One. 2012;7(1):e30561. doi: 10.1371/journal.pone.0030561. Epub 2012 Jan 23.


Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.

Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS.

Nature. 2012 Jan 25;482(7384):216-20. doi: 10.1038/nature10821.


Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia.

Fuchigami T, Kakinohana O, Hefferan MP, Lukacova N, Marsala S, Platoshyn O, Sugahara K, Yaksh TL, Marsala M.

Neuroscience. 2011 Oct 27;194:160-9. doi: 10.1016/j.neuroscience.2011.08.022. Epub 2011 Aug 16.


Transplantation of rat synapsin-EGFP-labeled embryonic neurons into the intact and ischemic CA1 hippocampal region: distribution, phenotype, and axodendritic sprouting.

Kucharova K, Hefferan MP, Patel P, Marsala S, Nejime T, Miyanohara A, Marsala M, Drummond JC.

Cell Transplant. 2011;20(8):1163-78. doi: 10.3727/096368910X564544. Epub 2011 Jun 9.


Optimization of immunosuppressive therapy for spinal grafting of human spinal stem cells in a rat model of ALS.

Hefferan MP, Johe K, Hazel T, Feldman EL, Lunn JS, Marsala M.

Cell Transplant. 2011;20(8):1153-61. doi: 10.3727/096368910X564553. Epub 2011 Jun 9.


Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells.

Yuan SH, Martin J, Elia J, Flippin J, Paramban RI, Hefferan MP, Vidal JG, Mu Y, Killian RL, Israel MA, Emre N, Marsala S, Marsala M, Gage FH, Goldstein LS, Carson CT.

PLoS One. 2011 Mar 2;6(3):e17540. doi: 10.1371/journal.pone.0017540.


Suppression of stretch reflex activity after spinal or systemic treatment with AMPA receptor antagonist NGX424 in rats with developed baclofen tolerance.

Oshiro M, Hefferan MP, Kakinohana O, Lukacova N, Sugahara K, Yaksh TL, Marsala M.

Br J Pharmacol. 2010 Nov;161(5):976-85. doi: 10.1111/j.1476-5381.2010.00954.x.


The ROCK inhibitor Y-27632 improves recovery of human embryonic stem cells after fluorescence-activated cell sorting with multiple cell surface markers.

Emre N, Vidal JG, Elia J, O'Connor ED, Paramban RI, Hefferan MP, Navarro R, Goldberg DS, Varki NM, Marsala M, Carson CT.

PLoS One. 2010 Aug 13;5(8):e12148. doi: 10.1371/journal.pone.0012148.


Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immunosuppressed minipigs.

Usvald D, Vodicka P, Hlucilova J, Prochazka R, Motlik J, Kuchorova K, Johe K, Marsala S, Scadeng M, Kakinohana O, Navarro R, Santa M, Hefferan MP, Yaksh TL, Marsala M.

Cell Transplant. 2010;19(9):1103-22. doi: 10.3727/096368910X503406. Epub 2010 Apr 21.


Stem cells: comprehensive treatments for amyotrophic lateral sclerosis in conjunction with growth factor delivery.

Lunn JS, Hefferan MP, Marsala M, Feldman EL.

Growth Factors. 2009 Jun;27(3):133-40. doi: 10.1080/08977190902814855. Review.


The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord.

Codeluppi S, Svensson CI, Hefferan MP, Valencia F, Silldorff MD, Oshiro M, Marsala M, Pasquale EB.

J Neurosci. 2009 Jan 28;29(4):1093-104. doi: 10.1523/JNEUROSCI.4103-08.2009.


Spinal p38 mitogen-activated protein kinase mediates allodynia induced by first-degree burn in the rat.

Sorkin L, Svensson CI, Jones-Cordero TL, Hefferan MP, Campana WM.

J Neurosci Res. 2009 Mar;87(4):948-55. doi: 10.1002/jnr.21905.


Inhibition of spinal cytosolic phospholipase A(2) expression by an antisense oligonucleotide attenuates tissue injury-induced hyperalgesia.

Kim DH, Fitzsimmons B, Hefferan MP, Svensson CI, Wancewicz E, Monia BP, Hung G, Butler M, Marsala M, Hua XY, Yaksh TL.

Neuroscience. 2008 Jun 26;154(3):1077-87. doi: 10.1016/j.neuroscience.2008.04.033. Epub 2008 Apr 30.


Spinal astrocyte glutamate receptor 1 overexpression after ischemic insult facilitates behavioral signs of spasticity and rigidity.

Hefferan MP, Kucharova K, Kinjo K, Kakinohana O, Sekerkova G, Nakamura S, Fuchigami T, Tomori Z, Yaksh TL, Kurtz N, Marsala M.

J Neurosci. 2007 Oct 17;27(42):11179-91.


Cell therapy and stem cells in animal models of motor neuron disorders.

Hedlund E, Hefferan MP, Marsala M, Isacson O.

Eur J Neurosci. 2007 Oct;26(7):1721-37. Review.


Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells.

Cizkova D, Kakinohana O, Kucharova K, Marsala S, Johe K, Hazel T, Hefferan MP, Marsala M.

Neuroscience. 2007 Jun 29;147(2):546-60. Epub 2007 May 23.


Low-speed subcellular fractionation method for determining noxious stimulus-evoked spinal neurokinin-1 receptor internalization.

Jones TL, Hefferan MP, Marsala M, Sorkin LS.

J Neurosci Methods. 2007 Mar 30;161(1):23-31. Epub 2006 Nov 2.


Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study.

Kakinohana O, Hefferan MP, Nakamura S, Kakinohana M, Galik J, Tomori Z, Marsala J, Yaksh TL, Marsala M.

Neuroscience. 2006 Sep 1;141(3):1569-83. Epub 2006 Jun 22.


Spatiotemporal alterations of the NO/NOS neuronal pools following transient abdominal aorta occlusion: morphological and biochemical studies in the rabbit.

Kucharova K, Lukacova N, Pavel J, Radonak J, Hefferan MP, Kolesar D, Kolesarova M, Marsala M, Marsala J.

Cell Mol Neurobiol. 2006 Oct-Nov;26(7-8):1295-310. Epub 2006 Jun 20.


Development of baclofen tolerance in a rat model of chronic spasticity and rigidity.

Hefferan MP, Fuchigami T, Marsala M.

Neurosci Lett. 2006 Jul 31;403(1-2):195-200. Epub 2006 May 22.


Synaptogenesis and amino acid release from long term embryonic rat spinal cord neuronal culture using tissue culture inserts.

Marsala M, Kakinohana O, Hefferan MP, Cizkova D, Kinjoh K, Marsala S.

J Neurosci Methods. 2005 Jan 30;141(1):21-7.


Interaction of spinal nitric oxide and prostaglandins after L5-L6 spinal nerve ligation in the rat: an isobolographic analysis.

Hefferan MP, Loomis CW.

Anesthesiology. 2004 Jun;100(6):1611-4. No abstract available.


Coadministration of intrathecal strychnine and bicuculline effects synergistic allodynia in the rat: an isobolographic analysis.

Loomis CW, Khandwala H, Osmond G, Hefferan MP.

J Pharmacol Exp Ther. 2001 Mar;296(3):756-61.

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