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Items: 1 to 50 of 76

1.

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.

McGough IJ, de Groot REA, Jellett AP, Betist MC, Varandas KC, Danson CM, Heesom KJ, Korswagen HC, Cullen PJ.

Nat Commun. 2018 Sep 13;9(1):3737. doi: 10.1038/s41467-018-06114-3.

2.

Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis.

Greenhough A, Bagley C, Heesom KJ, Gurevich DB, Gay D, Bond M, Collard TJ, Paraskeva C, Martin P, Sansom OJ, Malik K, Williams AC.

EMBO Mol Med. 2018 Aug 24. pii: e8699. doi: 10.15252/emmm.201708699. [Epub ahead of print]

3.

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity.

Thomas EC, Hook SC, Gray A, Chadt A, Carling D, Al-Hasani H, Heesom KJ, Hardie DG, Tavaré JM.

Biochem J. 2018 Sep 25;475(18):2969-2983. doi: 10.1042/BCJ20180475.

PMID:
30135087
4.

Sorting nexin-21 is a scaffold for the endosomal recruitment of huntingtin.

Danson CM, Pearson N, Heesom KJ, Cullen PJ.

J Cell Sci. 2018 Sep 10;131(17). pii: jcs211672. doi: 10.1242/jcs.211672.

5.

Dysregulation of Mesenchymal Stromal Cell Antioxidant Responses in Progressive Multiple Sclerosis.

Redondo J, Sarkar P, Kemp K, Heesom KJ, Wilkins A, Scolding NJ, Rice CM.

Stem Cells Transl Med. 2018 Oct;7(10):748-758. doi: 10.1002/sctm.18-0045. Epub 2018 Jul 31.

6.

Impact of OqxR loss of function on the envelope proteome of Klebsiella pneumoniae and susceptibility to antimicrobials.

Wan Nur Ismah WAK, Takebayashi Y, Findlay J, Heesom KJ, Avison MB.

J Antimicrob Chemother. 2018 Jul 24. doi: 10.1093/jac/dky293. [Epub ahead of print]

PMID:
30053019
7.

Enhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing.

Hawksworth J, Satchwell TJ, Meinders M, Daniels DE, Regan F, Thornton NM, Wilson MC, Dobbe JG, Streekstra GJ, Trakarnsanga K, Heesom KJ, Anstee DJ, Frayne J, Toye AM.

EMBO Mol Med. 2018 Jun;10(6). pii: e8454. doi: 10.15252/emmm.201708454.

8.

Preliminary evidence of reductive stress in human cytotoxic T cells following exercise.

Wadley AJ, Holliday A, Morgan RG, Heesom KJ, Aldred S, Peters DM, Bueno AA, Coles SJ.

J Appl Physiol (1985). 2018 Aug 1;125(2):586-595. doi: 10.1152/japplphysiol.01137.2017. Epub 2018 Apr 12.

PMID:
29648517
9.

The cardiac proteome in patients with congenital ventricular septal defect: A comparative study between right atria and right ventricles.

Bond AR, Iacobazzi D, Abdul-Ghani S, Ghorbel MT, Heesom KJ, George SJ, Caputo M, Suleiman MS, Tulloh RM.

J Proteomics. 2018 Mar 20. pii: S1874-3919(18)30123-4. doi: 10.1016/j.jprot.2018.03.022. [Epub ahead of print]

10.

Transduction with BBF2H7/CREB3L2 upregulates SEC23A protein in erythroblasts and partially corrects the hypo-glycosylation phenotype associated with CDAII.

Pellegrin S, Haydn-Smith KL, Hampton-O'Neil LA, Hawley BR, Heesom KJ, Fermo E, Bianchi P, Toye AM.

Br J Haematol. 2018 Mar 14. doi: 10.1111/bjh.15189. [Epub ahead of print] No abstract available.

PMID:
29536501
11.

Secretory factors from OP9 stromal cells delay differentiation and increase the expansion potential of adult erythroid cells in vitro.

Trakarnsanga K, Wilson MC, Heesom KJ, Andrienko TN, Srisawat C, Frayne J.

Sci Rep. 2018 Jan 31;8(1):1983. doi: 10.1038/s41598-018-20491-1.

12.

Quantitative proteomics of plasma vesicles identify novel biomarkers for hemoglobin E/β-thalassemic patients.

Kittivorapart J, Crew VK, Wilson MC, Heesom KJ, Siritanaratkul N, Toye AM.

Blood Adv. 2018 Jan 23;2(2):95-104. doi: 10.1182/bloodadvances.2017011726.

13.

Prediction of Fluoroquinolone Susceptibility Directly from Whole-Genome Sequence Data by Using Liquid Chromatography-Tandem Mass Spectrometry To Identify Mutant Genotypes.

Wan Nur Ismah WAK, Takebayashi Y, Findlay J, Heesom KJ, Jiménez-Castellanos JC, Zhang J, Graham L, Bowker K, Williams OM, MacGowan AP, Avison MB.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e01814-17. doi: 10.1128/AAC.01814-17. Print 2018 Mar.

14.

In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.

Durrant TN, Hutchinson JL, Heesom KJ, Anderson KE, Stephens LR, Hawkins PT, Marshall AJ, Moore SF, Hers I.

Blood Adv. 2017 Jun 13;1(14):918-932. doi: 10.1182/bloodadvances.2017005173.

15.

Envelope proteome changes driven by RamA overproduction in Klebsiella pneumoniae that enhance acquired β-lactam resistance.

Jiménez-Castellanos JC, Wan Nur Ismah WAK, Takebayashi Y, Findlay J, Schneiders T, Heesom KJ, Avison MB.

J Antimicrob Chemother. 2018 Jan 1;73(1):88-94. doi: 10.1093/jac/dkx345.

PMID:
29029194
16.

Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR.

Simonetti B, Danson CM, Heesom KJ, Cullen PJ.

J Cell Biol. 2017 Nov 6;216(11):3695-3712. doi: 10.1083/jcb.201703015. Epub 2017 Sep 21.

17.

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

McNally KE, Faulkner R, Steinberg F, Gallon M, Ghai R, Pim D, Langton P, Pearson N, Danson CM, Nägele H, Morris LL, Singla A, Overlee BL, Heesom KJ, Sessions R, Banks L, Collins BM, Berger I, Billadeau DD, Burstein E, Cullen PJ.

Nat Cell Biol. 2017 Oct;19(10):1214-1225. doi: 10.1038/ncb3610. Epub 2017 Sep 11.

18.

Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates.

Calvopiña K, Hinchliffe P, Brem J, Heesom KJ, Johnson S, Cain R, Lohans CT, Fishwick CWG, Schofield CJ, Spencer J, Avison MB.

Mol Microbiol. 2017 Nov;106(3):492-504. doi: 10.1111/mmi.13831. Epub 2017 Sep 21.

19.

Comparison of protein expression during wild-type, and E1B-55k-deletion, adenovirus infection using quantitative time-course proteomics.

Fu YR, Turnell AS, Davis S, Heesom KJ, Evans VC, Matthews DA.

J Gen Virol. 2017 Jun;98(6):1377-1388. doi: 10.1099/jgv.0.000781. Epub 2017 Jun 20.

20.

BASP1 interacts with oestrogen receptor α and modifies the tamoxifen response.

Marsh LA, Carrera S, Shandilya J, Heesom KJ, Davidson AD, Medler KF, Roberts SG.

Cell Death Dis. 2017 May 11;8(5):e2771. doi: 10.1038/cddis.2017.179.

21.

Proteomics informed by transcriptomics for characterising active transposable elements and genome annotation in Aedes aegypti.

Maringer K, Yousuf A, Heesom KJ, Fan J, Lee D, Fernandez-Sesma A, Bessant C, Matthews DA, Davidson AD.

BMC Genomics. 2017 Jan 19;18(1):101. doi: 10.1186/s12864-016-3432-5.

22.

Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50.

Kvainickas A, Orgaz AJ, Nägele H, Diedrich B, Heesom KJ, Dengjel J, Cullen PJ, Steinberg F.

J Cell Sci. 2017 Jan 15;130(2):382-395. doi: 10.1242/jcs.196758. Epub 2016 Dec 1.

23.

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling.

Battram AM, Durrant TN, Agbani EO, Heesom KJ, Paul DS, Piatt R, Poole AW, Cullen PJ, Bergmeier W, Moore SF, Hers I.

J Biol Chem. 2017 Feb 3;292(5):1691-1704. doi: 10.1074/jbc.M116.746867. Epub 2016 Nov 30.

24.

Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins.

McMillan KJ, Gallon M, Jellett AP, Clairfeuille T, Tilley FC, McGough I, Danson CM, Heesom KJ, Wilkinson KA, Collins BM, Cullen PJ.

J Cell Biol. 2016 Aug 15;214(4):389-99. doi: 10.1083/jcb.201604057.

25.

TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion.

McCaughey J, Miller VJ, Stevenson NL, Brown AK, Budnik A, Heesom KJ, Alibhai D, Stephens DJ.

Cell Rep. 2016 May 24;15(8):1648-59. doi: 10.1016/j.celrep.2016.04.062. Epub 2016 May 12.

26.

Comparative effects of overproducing the AraC-type transcriptional regulators MarA, SoxS, RarA and RamA on antimicrobial drug susceptibility in Klebsiella pneumoniae.

Jiménez-Castellanos JC, Wan Ahmad Kamil WN, Cheung CH, Tobin MS, Brown J, Isaac SG, Heesom KJ, Schneiders T, Avison MB.

J Antimicrob Chemother. 2016 Jul;71(7):1820-5. doi: 10.1093/jac/dkw088. Epub 2016 Mar 29.

27.

Comparison of the Proteome of Adult and Cord Erythroid Cells, and Changes in the Proteome Following Reticulocyte Maturation.

Wilson MC, Trakarnsanga K, Heesom KJ, Cogan N, Green C, Toye AM, Parsons SF, Anstee DJ, Frayne J.

Mol Cell Proteomics. 2016 Jun;15(6):1938-46. doi: 10.1074/mcp.M115.057315. Epub 2016 Mar 22.

28.

Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression.

Denton RM, Pullen TJ, Armstrong CT, Heesom KJ, Rutter GA.

Biochem J. 2016 May 1;473(9):1165-78. doi: 10.1042/BCJ20160135. Epub 2016 Mar 2.

29.

Quantitative phospho-proteomics reveals the Plasmodium merozoite triggers pre-invasion host kinase modification of the red cell cytoskeleton.

Zuccala ES, Satchwell TJ, Angrisano F, Tan YH, Wilson MC, Heesom KJ, Baum J.

Sci Rep. 2016 Feb 2;6:19766. doi: 10.1038/srep19766.

30.

Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2.

Rollason R, Wherlock M, Heath JA, Heesom KJ, Saleem MA, Welsh GI.

Biosci Rep. 2016 Jan 13;36(1):e00302. doi: 10.1042/BSR20150252.

31.

Galaxy Integrated Omics: Web-based Standards-Compliant Workflows for Proteomics Informed by Transcriptomics.

Fan J, Saha S, Barker G, Heesom KJ, Ghali F, Jones AR, Matthews DA, Bessant C.

Mol Cell Proteomics. 2015 Nov;14(11):3087-93. doi: 10.1074/mcp.O115.048777. Epub 2015 Aug 12.

32.

Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected].

Palumbo V, Pellacani C, Heesom KJ, Rogala KB, Deane CM, Mottier-Pavie V, Gatti M, Bonaccorsi S, Wakefield JG.

Curr Biol. 2015 Jun 29;25(13):1777-83. doi: 10.1016/j.cub.2015.05.033. Epub 2015 Jun 18. Erratum in: Curr Biol. 2015 Aug 3;25(15):2063.

33.

Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells.

Park JH, Szemes M, Vieira GC, Melegh Z, Malik S, Heesom KJ, Von Wallwitz-Freitas L, Greenhough A, Brown KW, Zheng YG, Catchpoole D, Deery MJ, Malik K.

Mol Oncol. 2015 Mar;9(3):617-27. doi: 10.1016/j.molonc.2014.10.015. Epub 2014 Nov 15.

34.

Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling.

McGough IJ, Steinberg F, Gallon M, Yatsu A, Ohbayashi N, Heesom KJ, Fukuda M, Cullen PJ.

J Cell Sci. 2014 Nov 15;127(Pt 22):4940-53. doi: 10.1242/jcs.156299. Epub 2014 Oct 2.

35.

Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance.

Hamdollah Zadeh MA, Amin EM, Hoareau-Aveilla C, Domingo E, Symonds KE, Ye X, Heesom KJ, Salmon A, D'Silva O, Betteridge KB, Williams AC, Kerr DJ, Salmon AH, Oltean S, Midgley RS, Ladomery MR, Harper SJ, Varey AH, Bates DO.

Mol Oncol. 2015 Jan;9(1):167-78. doi: 10.1016/j.molonc.2014.07.017. Epub 2014 Aug 20.

36.

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation.

McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ.

Curr Biol. 2014 Jul 21;24(14):1678. doi: 10.1016/j.cub.2014.07.004. Epub 2014 Jul 21. No abstract available.

37.

Qualitative and quantitative comparison of the proteome of erythroid cells differentiated from human iPSCs and adult erythroid cells by multiplex TMT labelling and nanoLC-MS/MS.

Trakarnsanga K, Wilson MC, Griffiths RE, Toye AM, Carpenter L, Heesom KJ, Parsons SF, Anstee DJ, Frayne J.

PLoS One. 2014 Jul 14;9(7):e100874. doi: 10.1371/journal.pone.0100874. eCollection 2014.

38.

Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation.

McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ.

Curr Biol. 2014 Jul 21;24(14):1670-1676. doi: 10.1016/j.cub.2014.06.024. Epub 2014 Jul 3. Erratum in: Curr Biol. 2014 Jul 21;24(14):1678. Whone, Alan L [added].

39.

Cardiac phosphoproteomics during remote ischemic preconditioning: a role for the sarcomeric Z-disk proteins.

Abdul-Ghani S, Heesom KJ, Angelini GD, Suleiman MS.

Biomed Res Int. 2014;2014:767812. doi: 10.1155/2014/767812. Epub 2014 Mar 30.

40.

High-throughput quantitative proteomic analysis of dengue virus type 2 infected A549 cells.

Chiu HC, Hannemann H, Heesom KJ, Matthews DA, Davidson AD.

PLoS One. 2014 Mar 26;9(3):e93305. doi: 10.1371/journal.pone.0093305. eCollection 2014.

41.

RhoG protein regulates platelet granule secretion and thrombus formation in mice.

Goggs R, Harper MT, Pope RJ, Savage JS, Williams CM, Mundell SJ, Heesom KJ, Bass M, Mellor H, Poole AW.

J Biol Chem. 2013 Nov 22;288(47):34217-29. doi: 10.1074/jbc.M113.504100. Epub 2013 Oct 8.

42.

SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome.

Danson C, Brown E, Hemmings OJ, McGough IJ, Yarwood S, Heesom KJ, Carlton JG, Martin-Serrano J, May MT, Verkade P, Cullen PJ.

J Cell Sci. 2013 Nov 1;126(Pt 21):4885-99. doi: 10.1242/jcs.125732. Epub 2013 Aug 28.

43.

Protein distribution during human erythroblast enucleation in vitro.

Bell AJ, Satchwell TJ, Heesom KJ, Hawley BR, Kupzig S, Hazell M, Mushens R, Herman A, Toye AM.

PLoS One. 2013;8(4):e60300. doi: 10.1371/journal.pone.0060300. Epub 2013 Apr 2.

44.

A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport.

Steinberg F, Gallon M, Winfield M, Thomas EC, Bell AJ, Heesom KJ, Tavaré JM, Cullen PJ.

Nat Cell Biol. 2013 May;15(5):461-71. doi: 10.1038/ncb2721. Epub 2013 Apr 7. Erratum in: Nat Cell Biol. 2014 Aug;16(8):821.

45.

De novo derivation of proteomes from transcriptomes for transcript and protein identification.

Evans VC, Barker G, Heesom KJ, Fan J, Bessant C, Matthews DA.

Nat Methods. 2012 Dec;9(12):1207-11. doi: 10.1038/nmeth.2227. Epub 2012 Nov 11.

46.

Differential proteomic analysis of human erythroblasts undergoing apoptosis induced by epo-withdrawal.

Pellegrin S, Heesom KJ, Satchwell TJ, Hawley BR, Daniels G, van den Akker E, Toye AM.

PLoS One. 2012;7(6):e38356. doi: 10.1371/journal.pone.0038356. Epub 2012 Jun 18.

47.

The interactome of the human respiratory syncytial virus NS1 protein highlights multiple effects on host cell biology.

Wu W, Tran KC, Teng MN, Heesom KJ, Matthews DA, Barr JN, Hiscox JA.

J Virol. 2012 Aug;86(15):7777-89. doi: 10.1128/JVI.00460-12. Epub 2012 May 16.

48.

SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways.

Steinberg F, Heesom KJ, Bass MD, Cullen PJ.

J Cell Biol. 2012 Apr 16;197(2):219-30. doi: 10.1083/jcb.201111121. Epub 2012 Apr 9.

49.

Characterization of human Sec16B: indications of specialized, non-redundant functions.

Budnik A, Heesom KJ, Stephens DJ.

Sci Rep. 2011;1:77. doi: 10.1038/srep00077. Epub 2011 Aug 30.

50.

Phasic contractions of isolated human myometrium are associated with Rho-kinase (ROCK)-dependent phosphorylation of myosin phosphatase-targeting subunit (MYPT1).

Hudson CA, Heesom KJ, López Bernal A.

Mol Hum Reprod. 2012 May;18(5):265-79. doi: 10.1093/molehr/gar078. Epub 2011 Dec 8.

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