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Items: 1 to 50 of 125

1.

TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression.

Ottaviani S, Stebbing J, Frampton AE, Zagorac S, Krell J, de Giorgio A, Trabulo SM, Nguyen VTM, Magnani L, Feng H, Giovannetti E, Funel N, Gress TM, Jiao LR, Lombardo Y, Lemoine NR, Heeschen C, Castellano L.

Nat Commun. 2018 May 10;9(1):1845. doi: 10.1038/s41467-018-03962-x.

2.

The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1.

Cioffi M, Trabulo SM, Vallespinos M, Raj D, Kheir TB, Lin ML, Begum J, Baker AM, Amgheib A, Saif J, Perez M, Soriano J, Desco M, Gomez-Gaviro MV, Cusso L, Megias D, Aicher A, Heeschen C.

Oncotarget. 2017 Mar 28;8(13):21609-21625. doi: 10.18632/oncotarget.15450.

3.

Multifunctionalized iron oxide nanoparticles for selective targeting of pancreatic cancer cells.

Trabulo S, Aires A, Aicher A, Heeschen C, Cortajarena AL.

Biochim Biophys Acta. 2017 Jun;1861(6):1597-1605. doi: 10.1016/j.bbagen.2017.01.035. Epub 2017 Feb 1.

PMID:
28161480
4.

ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation.

Dumartin L, Alrawashdeh W, Trabulo SM, Radon TP, Steiger K, Feakins RM, di Magliano MP, Heeschen C, Esposito I, Lemoine NR, Crnogorac-Jurcevic T.

Oncogene. 2017 Jun 1;36(22):3094-3103. doi: 10.1038/onc.2016.459. Epub 2016 Dec 12.

5.

More challenges ahead-metabolic heterogeneity of pancreatic cancer stem cells.

Heeschen C, Sancho P.

Mol Cell Oncol. 2016 Mar 16;3(2):e1105353. doi: 10.1080/23723556.2015.1105353. eCollection 2016 Mar.

6.

DNMT1 Inhibition Reprograms Pancreatic Cancer Stem Cells via Upregulation of the miR-17-92 Cluster.

Zagorac S, Alcala S, Fernandez Bayon G, Bou Kheir T, Schoenhals M, González-Neira A, Fernandez Fraga M, Aicher A, Heeschen C, Sainz B Jr.

Cancer Res. 2016 Aug 1;76(15):4546-58. doi: 10.1158/0008-5472.CAN-15-3268. Epub 2016 Jun 3.

7.

Hallmarks of cancer stem cell metabolism.

Sancho P, Barneda D, Heeschen C.

Br J Cancer. 2016 Jun 14;114(12):1305-12. doi: 10.1038/bjc.2016.152. Epub 2016 May 24. Review.

8.

Circulating cancer stem cells: the importance to select.

Yang MH, Imrali A, Heeschen C.

Chin J Cancer Res. 2015 Oct;27(5):437-49. doi: 10.3978/j.issn.1000-9604.2015.04.08. Review.

9.

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells.

Sancho P, Burgos-Ramos E, Tavera A, Bou Kheir T, Jagust P, Schoenhals M, Barneda D, Sellers K, Campos-Olivas R, Graña O, Viera CR, Yuneva M, Sainz B Jr, Heeschen C.

Cell Metab. 2015 Oct 6;22(4):590-605. doi: 10.1016/j.cmet.2015.08.015. Epub 2015 Sep 10.

10.

MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3.

Cioffi M, Vallespinos-Serrano M, Trabulo SM, Fernandez-Marcos PJ, Firment AN, Vazquez BN, Vieira CR, Mulero F, Camara JA, Cronin UP, Perez M, Soriano J, G Galvez B, Castells-Garcia A, Haage V, Raj D, Megias D, Hahn S, Serrano L, Moon A, Aicher A, Heeschen C.

Cell Rep. 2015 Sep 8;12(10):1594-605. doi: 10.1016/j.celrep.2015.08.006. Epub 2015 Aug 28.

11.

Concise Review: Stem Cells in Pancreatic Cancer: From Concept to Translation.

Raj D, Aicher A, Heeschen C.

Stem Cells. 2015 Oct;33(10):2893-902. doi: 10.1002/stem.2114. Epub 2015 Aug 14. Review.

12.

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies.

Lonardo E, Cioffi M, Sancho P, Crusz S, Heeschen C.

J Vis Exp. 2015 Jun 20;(100):e52801. doi: 10.3791/52801.

13.

The miR-17-92 cluster counteracts quiescence and chemoresistance in a distinct subpopulation of pancreatic cancer stem cells.

Cioffi M, Trabulo SM, Sanchez-Ripoll Y, Miranda-Lorenzo I, Lonardo E, Dorado J, Reis Vieira C, Ramirez JC, Hidalgo M, Aicher A, Hahn S, Sainz B Jr, Heeschen C.

Gut. 2015 Dec;64(12):1936-48. doi: 10.1136/gutjnl-2014-308470. Epub 2015 Apr 17. Erratum in: Gut. 2016 Jul;65(7):1224.

14.

Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment.

Sainz B Jr, Alcala S, Garcia E, Sanchez-Ripoll Y, Azevedo MM, Cioffi M, Tatari M, Miranda-Lorenzo I, Hidalgo M, Gomez-Lopez G, Cañamero M, Erkan M, Kleeff J, García-Silva S, Sancho P, Hermann PC, Heeschen C.

Gut. 2015 Dec;64(12):1921-35. doi: 10.1136/gutjnl-2014-308935. Epub 2015 Apr 3.

PMID:
25841238
15.

The fuss over lipo"fuss"cin: not all autofluorescence is the same.

Sainz B Jr, Miranda-Lorenzo I, Heeschen C.

Eur J Histochem. 2015 Mar 12;59(1):2512. doi: 10.4081/ejh.2015.2512.

16.

Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual Mechanisms.

Cioffi M, Trabulo S, Hidalgo M, Costello E, Greenhalf W, Erkan M, Kleeff J, Sainz B Jr, Heeschen C.

Clin Cancer Res. 2015 May 15;21(10):2325-37. doi: 10.1158/1078-0432.CCR-14-1399. Epub 2015 Feb 23.

17.

ISG15 is a critical microenvironmental factor for pancreatic cancer stem cells.

Sainz B Jr, Martín B, Tatari M, Heeschen C, Guerra S.

Cancer Res. 2014 Dec 15;74(24):7309-20. doi: 10.1158/0008-5472.CAN-14-1354. Epub 2014 Nov 3.

18.

K-RasV14I recapitulates Noonan syndrome in mice.

Hernández-Porras I, Fabbiano S, Schuhmacher AJ, Aicher A, Cañamero M, Cámara JA, Cussó L, Desco M, Heeschen C, Mulero F, Bustelo XR, Guerra C, Barbacid M.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16395-400. doi: 10.1073/pnas.1418126111. Epub 2014 Oct 30.

19.

Intracellular autofluorescence: a biomarker for epithelial cancer stem cells.

Miranda-Lorenzo I, Dorado J, Lonardo E, Alcala S, Serrano AG, Clausell-Tormos J, Cioffi M, Megias D, Zagorac S, Balic A, Hidalgo M, Erkan M, Kleeff J, Scarpa A, Sainz B Jr, Heeschen C.

Nat Methods. 2014 Nov;11(11):1161-9. doi: 10.1038/nmeth.3112. Epub 2014 Sep 28.

PMID:
25262208
20.

Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

Hermann PC, Sancho P, Cañamero M, Martinelli P, Madriles F, Michl P, Gress T, de Pascual R, Gandia L, Guerra C, Barbacid M, Wagner M, Vieira CR, Aicher A, Real FX, Sainz B Jr, Heeschen C.

Gastroenterology. 2014 Nov;147(5):1119-33.e4. doi: 10.1053/j.gastro.2014.08.002. Epub 2014 Aug 12.

PMID:
25127677
21.

Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling.

Balic A, Sørensen MD, Trabulo SM, Sainz B Jr, Cioffi M, Vieira CR, Miranda-Lorenzo I, Hidalgo M, Kleeff J, Erkan M, Heeschen C.

Mol Cancer Ther. 2014 Jul;13(7):1758-71. doi: 10.1158/1535-7163.MCT-13-0948. Epub 2014 Apr 30.

22.

Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells.

Lonardo E, Cioffi M, Sancho P, Sanchez-Ripoll Y, Trabulo SM, Dorado J, Balic A, Hidalgo M, Heeschen C.

PLoS One. 2013 Oct 18;8(10):e76518. doi: 10.1371/journal.pone.0076518. eCollection 2013.

23.

Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts.

Hermann PC, Trabulo SM, Sainz B Jr, Balic A, Garcia E, Hahn SA, Vandana M, Sahoo SK, Tunici P, Bakker A, Hidalgo M, Heeschen C.

PLoS One. 2013 Jun 18;8(6):e66371. doi: 10.1371/journal.pone.0066371. Print 2013.

24.

Standing out from the crowd: cancer stem cells in hepatocellular carcinoma.

Sainz B Jr, Heeschen C.

Cancer Cell. 2013 Apr 15;23(4):431-3. doi: 10.1016/j.ccr.2013.03.023.

25.

Stem cells & pancreatic cancer.

García-Silva S, Frias-Aldeguer J, Heeschen C.

Pancreatology. 2013 Mar-Apr;13(2):110-3. doi: 10.1016/j.pan.2012.12.003.

PMID:
23561967
26.

Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1).

Trakala M, Fernández-Miranda G, Pérez de Castro I, Heeschen C, Malumbres M.

Cell Cycle. 2013 Apr 1;12(7):1030-41. doi: 10.4161/cc.24004. Epub 2013 Feb 21.

27.

Metastatic cancer stem cells--quo vadis?

Hermann PC, Heeschen C.

Clin Chem. 2013 Aug;59(8):1268-9. doi: 10.1373/clinchem.2012.197830. Epub 2013 Jan 3. No abstract available.

28.
29.

Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness.

Lonardo E, Frias-Aldeguer J, Hermann PC, Heeschen C.

Cell Cycle. 2012 Apr 1;11(7):1282-90. doi: 10.4161/cc.19679. Epub 2012 Apr 1.

PMID:
22421149
30.

Vascular incorporation of endothelial colony-forming cells is essential for functional recovery of murine ischemic tissue following cell therapy.

Schwarz TM, Leicht SF, Radic T, Rodriguez-Arabaolaza I, Hermann PC, Berger F, Saif J, Böcker W, Ellwart JW, Aicher A, Heeschen C.

Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):e13-21. doi: 10.1161/ATVBAHA.111.239822. Epub 2011 Dec 22. Erratum in: Arterioscler Thromb Vasc Biol. 2015 Aug;35(8):e36.

31.

Stem cells as the root of pancreatic ductal adenocarcinoma.

Balic A, Dorado J, Alonso-Gómez M, Heeschen C.

Exp Cell Res. 2012 Apr 1;318(6):691-704. doi: 10.1016/j.yexcr.2011.11.007. Epub 2011 Nov 15. Review.

PMID:
22119145
32.

EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells.

Cioffi M, Dorado J, Baeuerle PA, Heeschen C.

Clin Cancer Res. 2012 Jan 15;18(2):465-74. doi: 10.1158/1078-0432.CCR-11-1270. Epub 2011 Nov 17.

33.

Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.

Lonardo E, Hermann PC, Mueller MT, Huber S, Balic A, Miranda-Lorenzo I, Zagorac S, Alcala S, Rodriguez-Arabaolaza I, Ramirez JC, Torres-Ruíz R, Garcia E, Hidalgo M, Cebrián DÁ, Heuchel R, Löhr M, Berger F, Bartenstein P, Aicher A, Heeschen C.

Cell Stem Cell. 2011 Nov 4;9(5):433-46. doi: 10.1016/j.stem.2011.10.001. Erratum in: Cell Stem Cell. 2012 Jan 6;10(1):104.

34.

Pancreatic cancer stem cells: new insights and perspectives.

Dorado J, Lonardo E, Miranda-Lorenzo I, Heeschen C.

J Gastroenterol. 2011 Aug;46(8):966-73. doi: 10.1007/s00535-011-0422-x. Epub 2011 Jun 23. Review.

PMID:
21698355
35.

Multimarker risk model containing troponin-T, interleukin 10, myeloperoxidase and placental growth factor predicts long-term cardiovascular risk after non-ST-segment elevation acute coronary syndrome.

Oemrawsingh RM, Lenderink T, Akkerhuis KM, Heeschen C, Baldus S, Fichtlscherer S, Hamm CW, Simoons ML, Boersma E; CAPTURE investigators.

Heart. 2011 Jul;97(13):1061-6. doi: 10.1136/hrt.2010.197392. Epub 2011 May 10.

PMID:
21558475
36.

Inhibition of ataxia telangiectasia- and Rad3-related function abrogates the in vitro and in vivo tumorigenicity of human colon cancer cells through depletion of the CD133(+) tumor-initiating cell fraction.

Gallmeier E, Hermann PC, Mueller MT, Machado JG, Ziesch A, De Toni EN, Palagyi A, Eisen C, Ellwart JW, Rivera J, Rubio-Viqueira B, Hidalgo M, Bunz F, Göke B, Heeschen C.

Stem Cells. 2011 Mar;29(3):418-29. doi: 10.1002/stem.595.

37.

Adiponectin pretreatment counteracts the detrimental effect of a diabetic environment on endothelial progenitors.

Leicht SF, Schwarz TM, Hermann PC, Seissler J, Aicher A, Heeschen C.

Diabetes. 2011 Feb;60(2):652-61. doi: 10.2337/db10-0240.

38.

Combination of injectable multiple growth factor-releasing scaffolds and cell therapy as an advanced modality to enhance tissue neovascularization.

Saif J, Schwarz TM, Chau DY, Henstock J, Sami P, Leicht SF, Hermann PC, Alcala S, Mulero F, Shakesheff KM, Heeschen C, Aicher A.

Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1897-904. doi: 10.1161/ATVBAHA.110.207928. Epub 2010 Aug 5.

39.

Pancreatic cancer stem cells - update and future perspectives.

Lonardo E, Hermann PC, Heeschen C.

Mol Oncol. 2010 Oct;4(5):431-42. doi: 10.1016/j.molonc.2010.06.002. Epub 2010 Jun 9. Review.

40.

Cancer stem cells in solid tumors.

Hermann PC, Bhaskar S, Cioffi M, Heeschen C.

Semin Cancer Biol. 2010 Apr;20(2):77-84. doi: 10.1016/j.semcancer.2010.03.004. Epub 2010 Apr 3. Review.

PMID:
20371287
41.

Cancer stem cells as new therapeutic target to prevent tumour progression and metastasis.

Mueller MT, Hermann PC, Heeschen C.

Front Biosci (Elite Ed). 2010 Jan 1;2:602-13. Review.

PMID:
20036905
42.

Pancreatic cancer stem cells--insights and perspectives.

Hermann PC, Mueller MT, Heeschen C.

Expert Opin Biol Ther. 2009 Oct;9(10):1271-8. doi: 10.1517/14712590903246362. Review.

PMID:
19723015
43.

Add some fat to vascular progenitor cell therapy.

Saif J, Heeschen C, Aicher A.

Circ Res. 2009 Jun 19;104(12):1330-2. doi: 10.1161/CIRCRESAHA.109.200469. No abstract available.

44.

Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer.

Mueller MT, Hermann PC, Witthauer J, Rubio-Viqueira B, Leicht SF, Huber S, Ellwart JW, Mustafa M, Bartenstein P, D'Haese JG, Schoenberg MH, Berger F, Jauch KW, Hidalgo M, Heeschen C.

Gastroenterology. 2009 Sep;137(3):1102-13. doi: 10.1053/j.gastro.2009.05.053. Epub 2009 Jun 6.

PMID:
19501590
45.

cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal vasculogenesis.

Aicher A, Heeschen C, Feil S, Hofmann F, Mendelsohn ME, Feil R, Dimmeler S.

PLoS One. 2009;4(3):e4879. doi: 10.1371/journal.pone.0004879. Epub 2009 Mar 16.

46.

Prostaglandin E positively modulates endothelial progenitor cell homeostasis: an advanced treatment modality for autologous cell therapy.

Herrler T, Leicht SF, Huber S, Hermann PC, Schwarz TM, Kopp R, Heeschen C.

J Vasc Res. 2009;46(4):333-46. doi: 10.1159/000189794. Epub 2009 Jan 10.

47.

The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche.

Aicher A, Kollet O, Heeschen C, Liebner S, Urbich C, Ihling C, Orlandi A, Lapidot T, Zeiher AM, Dimmeler S.

Circ Res. 2008 Oct 10;103(8):796-803. doi: 10.1161/CIRCRESAHA.107.172718. Epub 2008 Sep 5.

48.

More good reasons for adherence to statin therapy during acute coronary syndromes.

Herrler T, Böhm M, Heeschen C.

Eur Heart J. 2008 Sep;29(17):2061-3. doi: 10.1093/eurheartj/ehn348. Epub 2008 Aug 1. No abstract available.

PMID:
18676969
49.

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer.

Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, Guba M, Bruns CJ, Heeschen C.

Cell Stem Cell. 2007 Sep 13;1(3):313-23. doi: 10.1016/j.stem.2007.06.002.

50.

Concentration of bone marrow total nucleated cells by a point-of-care device provides a high yield and preserves their functional activity.

Hermann PC, Huber SL, Herrler T, von Hesler C, Andrassy J, Kevy SV, Jacobson MS, Heeschen C.

Cell Transplant. 2008;16(10):1059-69.

PMID:
18351022

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