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GSK3β-SCFFBXW7α mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover.

Garvin AJ, Khalaf AHA, Rettino A, Xicluna J, Butler L, Morris JR, Heery DM, Clarke NM.

Nucleic Acids Res. 2019 May 21;47(9):4476-4494. doi: 10.1093/nar/gkz163.


Predicting puberty in partial androgen insensitivity syndrome: Use of clinical and functional androgen receptor indices.

Lek N, Tadokoro-Cuccaro R, Whitchurch JB, Mazumder B, Miles H, Prentice P, Bunch T, Zielińska K, Metzler V, Mongan NP, Heery DM, Hughes IA.

EBioMedicine. 2018 Oct;36:401-409. doi: 10.1016/j.ebiom.2018.09.047. Epub 2018 Oct 11.


Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system.

Lee JB, Zgair A, Malec J, Kim TH, Kim MG, Ali J, Qin C, Feng W, Chiang M, Gao X, Voronin G, Garces AE, Lau CL, Chan TH, Hume A, McIntosh TM, Soukarieh F, Al-Hayali M, Cipolla E, Collins HM, Heery DM, Shin BS, Yoo SD, Kagan L, Stocks MJ, Bradshaw TD, Fischer PM, Gershkovich P.

J Control Release. 2018 Sep 28;286:10-19. doi: 10.1016/j.jconrel.2018.07.022. Epub 2018 Jul 18.


A fellowship of Ring1 maintains AML stem cells.

Heery DM.

Blood. 2018 Apr 19;131(16):1771-1773. doi: 10.1182/blood-2018-02-832121. No abstract available.


Corrigendum: Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with polycystic ovary syndrome.

Atiomo W, Shafiee MN, Chapman C, Metzler VM, Abouzeid J, Latif A, Chadwick A, Kitson S, Sivalingam VN, Stratford IJ, Rutland CS, Persson JL, Ødum N, Fuentes-Utrilla P, Jeyapalan JN, Heery DM, Crosbie EJ, Mongan NP.

Clin Endocrinol (Oxf). 2017 Dec;87(6):886. doi: 10.1111/cen.13515. No abstract available.


H-IPSE Is a Pathogen-Secreted Host Nucleus-Infiltrating Protein (Infiltrin) Expressed Exclusively by the Schistosoma haematobium Egg Stage.

Pennington LF, Alouffi A, Mbanefo EC, Ray D, Heery DM, Jardetzky TS, Hsieh MH, Falcone FH.

Infect Immun. 2017 Nov 17;85(12). pii: e00301-17. doi: 10.1128/IAI.00301-17. Print 2017 Dec.


Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with polycystic ovary syndrome.

Atiomo W, Shafiee MN, Chapman C, Metzler VM, Abouzeid J, Latif A, Chadwick A, Kitson S, Sivalingam VN, Stratford IJ, Rutland CS, Persson JL, Ødum N, Fuentes-Utrilla P, Jeyapalan JN, Heery DM, Crosbie EJ, Mongan NP.

Clin Endocrinol (Oxf). 2017 Nov;87(5):557-565. doi: 10.1111/cen.13436. Epub 2017 Aug 18. Erratum in: Clin Endocrinol (Oxf). 2017 Dec;87(6):886.


Abnormal Clock Gene Expression and Locomotor Activity Rhythms in Two Month-Old Female APPSwe/PS1dE9 Mice.

Oyegbami O, Collins HM, Pardon MC, Ebling FJP, Heery DM, Moran PM.

Curr Alzheimer Res. 2017;14(8):850-860. doi: 10.2174/1567205014666170317113159.


Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ) are disrupted by retinal disease-associated mutations.

Fulton J, Mazumder B, Whitchurch JB, Monteiro CJ, Collins HM, Chan CM, Clemente MP, Hernandez-Quiles M, Stewart EA, Amoaku WM, Moran PM, Mongan NP, Persson JL, Ali S, Heery DM.

Cell Death Dis. 2017 Mar 16;8(3):e2677. doi: 10.1038/cddis.2017.98.


Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development.

Metzler VM, de Brot S, Robinson RS, Jeyapalan JN, Rakha E, Walton T, Gardner DS, Lund EF, Whitchurch J, Haigh D, Lochray JM, Robinson BD, Allegrucci C, Fray RG, Persson JL, Ødum N, Miftakhova RR, Rizvanov AA, Hughes IA, Tadokoro-Cuccaro R, Heery DM, Rutland CS, Mongan NP.

Placenta. 2017 Aug;56:79-85. doi: 10.1016/j.placenta.2017.02.018. Epub 2017 Feb 20. Review.


Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells.

Sarwar M, Semenas J, Miftakhova R, Simoulis A, Robinson B, Gjörloff Wingren A, Mongan NP, Heery DM, Johnsson H, Abrahamsson PA, Dizeyi N, Luo J, Persson JL.

Oncotarget. 2016 Sep 27;7(39):63065-63081. doi: 10.18632/oncotarget.11757.


Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow.

Miftakhova R, Hedblom A, Semenas J, Robinson B, Simoulis A, Malm J, Rizvanov A, Heery DM, Mongan NP, Maitland NJ, Allegrucci C, Persson JL.

Cancer Res. 2016 Apr 15;76(8):2453-64. doi: 10.1158/0008-5472.CAN-15-2340. Epub 2016 Feb 26.


MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators.

Nilsson EM, Laursen KB, Whitchurch J, McWilliam A, Ødum N, Persson JL, Heery DM, Gudas LJ, Mongan NP.

Oncotarget. 2015 Nov 3;6(34):35710-25. doi: 10.18632/oncotarget.5958.


Correction: PRAME Is a Golgi-Targeted Protein That Associates with the Elongin BC Complex and Is Upregulated by Interferon-Gamma and Bacterial PAMPs.

Wadelin FR, Fulton J, Collins HM, Tertipis N, Bottley A, Spriggs KA, Falcone FH, Heery DM.

PLoS One. 2015 Jun 12;10(6):e0129297. doi: 10.1371/journal.pone.0129297. eCollection 2015. No abstract available.


Regulation of vascular endothelial growth factor in prostate cancer.

de Brot S, Ntekim A, Cardenas R, James V, Allegrucci C, Heery DM, Bates DO, Ødum N, Persson JL, Mongan NP.

Endocr Relat Cancer. 2015 Jun;22(3):R107-23. doi: 10.1530/ERC-15-0123. Epub 2015 Apr 13. Review.


Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2)-deficient mice: do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms?

O'Callaghan MJ, Bay-Richter C, O'Tuathaigh CM, Heery DM, Waddington JL, Moran PM.

J Psychopharmacol. 2014 Oct;28(10):973-7. doi: 10.1177/0269881114544774. Epub 2014 Aug 13.


The double PHD finger domain of MOZ/MYST3 induces α-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification.

Dreveny I, Deeves SE, Fulton J, Yue B, Messmer M, Bhattacharya A, Collins HM, Heery DM.

Nucleic Acids Res. 2014 Jan;42(2):822-35. doi: 10.1093/nar/gkt931. Epub 2013 Oct 22.


A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.

Chan CM, Fulton J, Montiel-Duarte C, Collins HM, Bharti N, Wadelin FR, Moran PM, Mongan NP, Heery DM.

Nucleic Acids Res. 2013 Nov;41(21):9663-79. doi: 10.1093/nar/gkt761. Epub 2013 Aug 23.


PRAME is a golgi-targeted protein that associates with the Elongin BC complex and is upregulated by interferon-gamma and bacterial PAMPs.

Wadelin FR, Fulton J, Collins HM, Tertipis N, Bottley A, Spriggs KA, Falcone FH, Heery DM.

PLoS One. 2013;8(2):e58052. doi: 10.1371/journal.pone.0058052. Epub 2013 Feb 27. Erratum in: PLoS One. 2015;10(6):e0129297.


D-amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors.

Bay-Richter C, O'Callaghan MJ, Mathur N, O'Tuathaigh CM, Heery DM, Fone KC, Waddington JL, Moran PM.

Neuropsychopharmacology. 2013 Jul;38(8):1512-20. doi: 10.1038/npp.2013.50. Epub 2013 Feb 19.


Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells.

Collins HM, Abdelghany MK, Messmer M, Yue B, Deeves SE, Kindle KB, Mantelingu K, Aslam A, Winkler GS, Kundu TK, Heery DM.

BMC Cancer. 2013 Jan 29;13:37. doi: 10.1186/1471-2407-13-37.


Interleukin-4-inducing principle from Schistosoma mansoni eggs contains a functional C-terminal nuclear localization signal necessary for nuclear translocation in mammalian cells but not for its uptake.

Kaur I, Schramm G, Everts B, Scholzen T, Kindle KB, Beetz C, Montiel-Duarte C, Blindow S, Jones AT, Haas H, Stolnik S, Heery DM, Falcone FH.

Infect Immun. 2011 Apr;79(4):1779-88. doi: 10.1128/IAI.01048-10. Epub 2011 Jan 10.


Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia.

Wadelin F, Fulton J, McEwan PA, Spriggs KA, Emsley J, Heery DM.

Mol Cancer. 2010 Aug 27;9:226. doi: 10.1186/1476-4598-9-226. Review.


MOZ-TIF2-mediated destruction of CBP/p300 is blocked by calpain inhibitor 2.

Kindle KB, Collins HM, Heery DM.

Leukemia. 2010 Jul;24(7):1359-61. doi: 10.1038/leu.2010.92. Epub 2010 May 20. No abstract available.


p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.

Cannell IG, Kong YW, Johnston SJ, Chen ML, Collins HM, Dobbyn HC, Elia A, Kress TR, Dickens M, Clemens MJ, Heery DM, Gaestel M, Eilers M, Willis AE, Bushell M.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5375-80. doi: 10.1073/pnas.0910015107. Epub 2010 Mar 8.


SUMOylation regulates the nuclear mobility of CREB binding protein and its association with nuclear bodies in live cells.

Ryan CM, Kindle KB, Collins HM, Heery DM.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):1136-41. doi: 10.1016/j.bbrc.2009.12.040. Epub 2009 Dec 16.


Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome.

Elsheikh SE, Green AR, Rakha EA, Powe DG, Ahmed RA, Collins HM, Soria D, Garibaldi JM, Paish CE, Ammar AA, Grainge MJ, Ball GR, Abdelghany MK, Martinez-Pomares L, Heery DM, Ellis IO.

Cancer Res. 2009 May 1;69(9):3802-9. doi: 10.1158/0008-5472.CAN-08-3907. Epub 2009 Apr 14.


Enhanced latent inhibition in dopamine receptor-deficient mice is sex-specific for the D1 but not D2 receptor subtype: implications for antipsychotic drug action.

Bay-Richter C, O'Tuathaigh CM, O'Sullivan G, Heery DM, Waddington JL, Moran PM.

Int J Neuropsychopharmacol. 2009 Apr;12(3):403-14. doi: 10.1017/S1461145708009656. Epub 2008 Nov 17.


Pharmacological targeting of lysine acetyltransferases in human disease: a progress report.

Heery DM, Fischer PM.

Drug Discov Today. 2007 Jan;12(1-2):88-99. Epub 2006 Dec 1. Review.


ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases.

Lopez-Garcia J, Periyasamy M, Thomas RS, Christian M, Leao M, Jat P, Kindle KB, Heery DM, Parker MG, Buluwela L, Kamalati T, Ali S.

Nucleic Acids Res. 2006;34(21):6126-36. Epub 2006 Nov 3.


Functional interaction of CREB binding protein (CBP) with nuclear transport proteins and modulation by HDAC inhibitors.

Ryan CM, Harries JC, Kindle KB, Collins HM, Heery DM.

Cell Cycle. 2006 Sep;5(18):2146-52. Epub 2006 Sep 15.


Effects of glucocorticoids on STAT4 activation in human T cells are stimulus-dependent.

Fahey AJ, Robins RA, Kindle KB, Heery DM, Constantinescu CS.

J Leukoc Biol. 2006 Jul;80(1):133-44. Epub 2006 May 2.


MOZ fusion proteins in acute myeloid leukaemia.

Troke PJ, Kindle KB, Collins HM, Heery DM.

Biochem Soc Symp. 2006;(73):23-39. Review.


MOZ-TIF2 alters cofactor recruitment and histone modification at the RARbeta2 promoter: differential effects of MOZ fusion proteins on CBP- and MOZ-dependent activators.

Collins HM, Kindle KB, Matsuda S, Ryan C, Troke PJ, Kalkhoven E, Heery DM.

J Biol Chem. 2006 Jun 23;281(25):17124-33. Epub 2006 Apr 13.


Structural diversity in p160/CREB-binding protein coactivator complexes.

Waters L, Yue B, Veverka V, Renshaw P, Bramham J, Matsuda S, Frenkiel T, Kelly G, Muskett F, Carr M, Heery DM.

J Biol Chem. 2006 May 26;281(21):14787-95. Epub 2006 Mar 15.


T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif.

Lucey MJ, Chen D, Lopez-Garcia J, Hart SM, Phoenix F, Al-Jehani R, Alao JP, White R, Kindle KB, Losson R, Chambon P, Parker MG, Schär P, Heery DM, Buluwela L, Ali S.

Nucleic Acids Res. 2005 Nov 10;33(19):6393-404. Print 2005.


MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function.

Kindle KB, Troke PJ, Collins HM, Matsuda S, Bossi D, Bellodi C, Kalkhoven E, Salomoni P, Pelicci PG, Minucci S, Heery DM.

Mol Cell Biol. 2005 Feb;25(3):988-1002.


A Conserved alpha-helical motif mediates the binding of diverse nuclear proteins to the SRC1 interaction domain of CBP.

Matsuda S, Harries JC, Viskaduraki M, Troke PJ, Kindle KB, Ryan C, Heery DM.

J Biol Chem. 2004 Apr 2;279(14):14055-64. Epub 2004 Jan 13.


An extended LXXLL motif sequence determines the nuclear receptor binding specificity of TRAP220.

Coulthard VH, Matsuda S, Heery DM.

J Biol Chem. 2003 Mar 28;278(13):10942-51. Epub 2003 Jan 29.


Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.

Giraud S, Bienvenu F, Avril S, Gascan H, Heery DM, Coqueret O.

J Biol Chem. 2002 Mar 8;277(10):8004-11. Epub 2001 Dec 31.


Yeast two-hybrid screening for proteins that interact with nuclear hormone receptors.

Le Douarin B, Heery DM, Gaudon C, vom Baur E, Losson R.

Methods Mol Biol. 2001;176:227-48. Review. No abstract available.


Core LXXLL motif sequences in CREB-binding protein, SRC1, and RIP140 define affinity and selectivity for steroid and retinoid receptors.

Heery DM, Hoare S, Hussain S, Parker MG, Sheppard H.

J Biol Chem. 2001 Mar 2;276(9):6695-702. Epub 2000 Nov 14.


The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1.

Bevan CL, Hoare S, Claessens F, Heery DM, Parker MG.

Mol Cell Biol. 1999 Dec;19(12):8383-92.


A signature motif in transcriptional co-activators mediates binding to nuclear receptors.

Heery DM, Kalkhoven E, Hoare S, Parker MG.

Nature. 1997 Jun 12;387(6634):733-6.


RIP-140 interacts with multiple nuclear receptors by means of two distinct sites.

L'Horset F, Dauvois S, Heery DM, Cavaillès V, Parker MG.

Mol Cell Biol. 1996 Nov;16(11):6029-36.


Construction and characterization of recA mutant strains of Corynebacterium glutamicum and Brevibacterium lactofermentum.

Fitzpatrick R, O'Donohue M, Joy J, Heery DM, Dunican LK.

Appl Microbiol Biotechnol. 1994 Dec;42(4):575-80.


A sequence from a tryptophan-hyperproducing strain of Corynebacterium glutamicum encoding resistance to 5-methyltryptophan.

Heery DM, Fitzpatrick R, Dunican LK.

Biochem Biophys Res Commun. 1994 Jun 30;201(3):1255-62.


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