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Items: 1 to 50 of 158

1.

CD27+CD38hi B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients.

von Borstel A, Land J, Abdulahad WH, Rutgers A, Stegeman CA, Diepstra A, Heeringa P, Sanders JS.

Front Immunol. 2019 Sep 24;10:2221. doi: 10.3389/fimmu.2019.02221. eCollection 2019.

2.

Increased miR-142-3p Expression Might Explain Reduced Regulatory T Cell Function in Granulomatosis With Polyangiitis.

Dekkema GJ, Bijma T, Jellema PG, Van Den Berg A, Kroesen BJ, Stegeman CA, Heeringa P, Abdulahad WH, Sanders JS.

Front Immunol. 2019 Sep 12;10:2170. doi: 10.3389/fimmu.2019.02170. eCollection 2019.

3.

Decreased Expression of Negative Immune Checkpoint VISTA by CD4+ T Cells Facilitates T Helper 1, T Helper 17, and T Follicular Helper Lineage Differentiation in GCA.

Hid Cadena R, Reitsema RD, Huitema MG, van Sleen Y, van der Geest KSM, Heeringa P, Boots AMH, Abdulahad WH, Brouwer E.

Front Immunol. 2019 Jul 16;10:1638. doi: 10.3389/fimmu.2019.01638. eCollection 2019.

4.

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity.

Ooi JD, Jiang JH, Eggenhuizen PJ, Chua LL, van Timmeren M, Loh KL, O'Sullivan KM, Gan PY, Zhong Y, Tsyganov K, Shochet LR, Ryan J, Stegeman CA, Fugger L, Reid HH, Rossjohn J, Heeringa P, Holdsworth SR, Peleg AY, Kitching AR.

Nat Commun. 2019 Jul 29;10(1):3392. doi: 10.1038/s41467-019-11255-0.

5.

Evidence for enhanced Bruton's tyrosine kinase activity in transitional and naïve B cells of patients with granulomatosis with polyangiitis.

von Borstel A, Abdulahad WH, Sanders JS, Rip J, Neys SFH, Hendriks RW, Stegeman CA, Heeringa P, Rutgers A, Corneth OBJ.

Rheumatology (Oxford). 2019 Jun 17. pii: kez205. doi: 10.1093/rheumatology/kez205. [Epub ahead of print]

PMID:
31209475
6.

Unraveling the identity of FoxP3+ regulatory T cells in Granulomatosis with Polyangiitis patients.

Reijnders TDY, Stegeman CA, Huitema MG, Rutgers A, Heeringa P, Abdulahad WH.

Sci Rep. 2019 Jun 4;9(1):8273. doi: 10.1038/s41598-019-44636-y.

7.

Lack of IL-17 Receptor A signaling aggravates lymphoproliferation in C57BL/6 lpr mice.

Corneth OBJ, Schaper F, Luk F, Asmawidjaja PS, Mus AMC, Horst G, Heeringa P, Hendriks RW, Westra J, Lubberts E.

Sci Rep. 2019 Mar 11;9(1):4032. doi: 10.1038/s41598-019-39483-w.

8.

Circulating CD24hiCD38hi regulatory B cells correlate inversely with the ThEM17 cell frequency in granulomatosis with polyangiitis patients.

von Borstel A, Lintermans LL, Heeringa P, Rutgers A, Stegeman CA, Sanders JS, Abdulahad WH.

Rheumatology (Oxford). 2019 Jan 10. doi: 10.1093/rheumatology/key412. [Epub ahead of print]

PMID:
30649475
9.

Renal Klotho is Reduced in Septic Patients and Pretreatment With Recombinant Klotho Attenuates Organ Injury in Lipopolysaccharide-Challenged Mice.

Jou-Valencia D, Molema G, Popa E, Aslan A, van Dijk F, Mencke R, Hillebrands JL, Heeringa P, Hoenderop JG, Zijlstra JG, van Meurs M, Moser J.

Crit Care Med. 2018 Dec;46(12):e1196-e1203. doi: 10.1097/CCM.0000000000003427.

10.

Alkylating histone deacetylase inhibitors may have therapeutic value in experimental myeloperoxidase-ANCA vasculitis.

Dooley D, van Timmeren MM, O'Reilly VP, Brady G, O'Brien EC, Fazekas B, Hickey FB, Leacy E, Pusey CD, Tam FWK, Mehrling T, Heeringa P, Little MA.

Kidney Int. 2018 Nov;94(5):926-936. doi: 10.1016/j.kint.2018.05.028. Epub 2018 Aug 26.

11.

Involvement of MicroRNAs in the Aging-Related Decline of CD28 Expression by Human T Cells.

Teteloshvili N, Dekkema G, Boots AM, Heeringa P, Jellema P, de Jong D, Terpstra M, Brouwer E, Pawelec G, Kok K, van den Berg A, Kluiver J, Kroesen BJ.

Front Immunol. 2018 Jun 18;9:1400. doi: 10.3389/fimmu.2018.01400. eCollection 2018.

12.

The net effect of ANCA on neutrophil extracellular trap formation.

Heeringa P, Rutgers A, Kallenberg CGM.

Kidney Int. 2018 Jul;94(1):14-16. doi: 10.1016/j.kint.2018.03.010.

PMID:
29933842
13.

Releasing the complement brakes: is myeloperoxidase the missing link between factor H and C5a in anti-neutrophil cytoplasmic antibody vasculitis?

Heeringa P, Alan Little M.

Rheumatology (Oxford). 2018 Dec 1;57(12):2070-2071. doi: 10.1093/rheumatology/key126. No abstract available.

PMID:
29757426
14.

Positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging of macrophages in large vessel vasculitis: Current status and future prospects.

Jiemy WF, Heeringa P, Kamps JAAM, van der Laken CJ, Slart RHJA, Brouwer E.

Autoimmun Rev. 2018 Jul;17(7):715-726. doi: 10.1016/j.autrev.2018.02.006. Epub 2018 May 3. Review.

15.

Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis?

van der Geest KSM, Sandovici M, van Sleen Y, Sanders JS, Bos NA, Abdulahad WH, Stegeman CA, Heeringa P, Rutgers A, Kallenberg CGM, Boots AMH, Brouwer E.

Arthritis Rheumatol. 2018 Sep;70(9):1366-1376. doi: 10.1002/art.40520. Epub 2018 Jul 30. Review.

16.

Low-Fat Diet With Caloric Restriction Reduces White Matter Microglia Activation During Aging.

Yin Z, Raj DD, Schaafsma W, van der Heijden RA, Kooistra SM, Reijne AC, Zhang X, Moser J, Brouwer N, Heeringa P, Yi CX, van Dijk G, Laman JD, Boddeke EWGM, Eggen BJL.

Front Mol Neurosci. 2018 Mar 12;11:65. doi: 10.3389/fnmol.2018.00065. eCollection 2018.

17.

Checks and Balances in Autoimmune Vasculitis.

Hid Cadena R, Abdulahad WH, Hospers GAP, Wind TT, Boots AMH, Heeringa P, Brouwer E.

Front Immunol. 2018 Feb 22;9:315. doi: 10.3389/fimmu.2018.00315. eCollection 2018. Review.

18.

Urinary and serum soluble CD25 complements urinary soluble CD163 to detect active renal anti-neutrophil cytoplasmic autoantibody-associated vasculitis: a cohort study.

Dekkema GJ, Abdulahad WH, Bijma T, Moran SM, Ryan L, Little MA, Stegeman CA, Heeringa P, Sanders JF.

Nephrol Dial Transplant. 2019 Feb 1;34(2):234-242. doi: 10.1093/ndt/gfy018.

PMID:
29506265
19.

Cellular immune regulation in the pathogenesis of ANCA-associated vasculitides.

von Borstel A, Sanders JS, Rutgers A, Stegeman CA, Heeringa P, Abdulahad WH.

Autoimmun Rev. 2018 Apr;17(4):413-421. doi: 10.1016/j.autrev.2017.12.002. Epub 2018 Feb 9. Review.

20.

Systemic vasculitis developed after immune checkpoint inhibition: comment on the article by Cappelli et al.

Rutgers A, van den Brom RRH, Hospers GAP, Heeringa P, Brouwer E.

Arthritis Care Res (Hoboken). 2018 Aug;70(8):1275. doi: 10.1002/acr.23481. No abstract available.

21.

Towards precision medicine in ANCA-associated vasculitis.

van der Geest KSM, Brouwer E, Sanders JS, Sandovici M, Bos NA, Boots AMH, Abdulahad WH, Stegeman CA, Kallenberg CGM, Heeringa P, Rutgers A.

Rheumatology (Oxford). 2018 Aug 1;57(8):1332-1339. doi: 10.1093/rheumatology/kex367. Review.

PMID:
29045715
22.

Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis.

Land J, Lintermans LL, Stegeman CA, Muñoz-Elías EJ, Tarcha EJ, Iadonato SP, Heeringa P, Rutgers A, Abdulahad WH.

Front Immunol. 2017 Sep 26;8:1205. doi: 10.3389/fimmu.2017.01205. eCollection 2017.

23.

Genetic loci of Staphylococcus aureus associated with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides.

Glasner C, de Goffau MC, van Timmeren MM, Schulze ML, Jansen B, Tavakol M, van Wamel WJB, Stegeman CA, Kallenberg CGM, Arends JP, Rossen JW, Heeringa P, van Dijl JM.

Sci Rep. 2017 Sep 22;7(1):12211. doi: 10.1038/s41598-017-12450-z.

24.

Prospective monitoring of in vitro produced PR3-ANCA does not improve relapse prediction in granulomatosis with polyangiitis.

Land J, Abdulahad WH, Arends S, Sanders JF, Stegeman CA, Heeringa P, Rutgers A.

PLoS One. 2017 Aug 3;12(8):e0182549. doi: 10.1371/journal.pone.0182549. eCollection 2017.

25.

Involvement of Monocyte Subsets in the Immunopathology of Giant Cell Arteritis.

van Sleen Y, Wang Q, van der Geest KSM, Westra J, Abdulahad WH, Heeringa P, Boots AMH, Brouwer E.

Sci Rep. 2017 Jul 26;7(1):6553. doi: 10.1038/s41598-017-06826-4.

26.

Endothelial Interferon Regulatory Factor 1 Regulates Lipopolysaccharide-Induced VCAM-1 Expression Independent of NFκB.

Yan R, van Meurs M, Popa ER, Jongman RM, Zwiers PJ, Niemarkt AE, Kuiper T, Kamps JA, Heeringa P, Zijlstra JG, Molema G, Moser J.

J Innate Immun. 2017;9(6):546-560. doi: 10.1159/000477211. Epub 2017 Jun 29.

27.

Chemokine receptor co-expression reveals aberrantly distributed TH effector memory cells in GPA patients.

Lintermans LL, Rutgers A, Stegeman CA, Heeringa P, Abdulahad WH.

Arthritis Res Ther. 2017 Jun 14;19(1):136. doi: 10.1186/s13075-017-1343-8.

28.

Protective effect of rosiglitazone on kidney function in high-fat challenged human-CRP transgenic mice: a possible role for adiponectin and miR-21?

Morrison MC, Yakala GK, Liang W, Wielinga PY, Salic K, van Koppen A, Tomar T, Kleemann R, Heeringa P, Kooistra T.

Sci Rep. 2017 Jun 6;7(1):2915. doi: 10.1038/s41598-017-02444-2.

29.

M2 macrophage is the predominant phenotype in airways inflammatory lesions in patients with granulomatosis with polyangiitis.

de Souza AWS, van Timmeren M, Sanders JS, Stegeman C, Heeringa P, Kallenberg CGM, Westra J.

Arthritis Res Ther. 2017 May 18;19(1):100. doi: 10.1186/s13075-017-1310-4.

30.

Autoantibodies to box A of high mobility group box 1 in systemic lupus erythematosus.

Schaper F, de Leeuw K, Horst G, Maas F, Bootsma H, Heeringa P, Limburg PC, Westra J.

Clin Exp Immunol. 2017 Jun;188(3):412-419. doi: 10.1111/cei.12951. Epub 2017 Mar 27.

31.

Age-determined severity of anti-myeloperoxidase autoantibody-mediated glomerulonephritis in mice.

Wang Q, van Timmeren MM, Petersen AH, Yuan J, Moser J, Brouwer E, Westra J, Boots AM, Heeringa P.

Nephrol Dial Transplant. 2017 Feb 1;32(2):254-264. doi: 10.1093/ndt/gfw202.

PMID:
28186568
32.

High mobility group box 1 skews macrophage polarization and negatively influences phagocytosis of apoptotic cells.

Schaper F, de Leeuw K, Horst G, Bootsma H, Limburg PC, Heeringa P, Bijl M, Westra J.

Rheumatology (Oxford). 2016 Dec;55(12):2260-2270. Epub 2016 Sep 15.

PMID:
27632996
33.

Effects of Anthocyanin and Flavanol Compounds on Lipid Metabolism and Adipose Tissue Associated Systemic Inflammation in Diet-Induced Obesity.

van der Heijden RA, Morrison MC, Sheedfar F, Mulder P, Schreurs M, Hommelberg PP, Hofker MH, Schalkwijk C, Kleemann R, Tietge UJ, Koonen DP, Heeringa P.

Mediators Inflamm. 2016;2016:2042107. doi: 10.1155/2016/2042107. Epub 2016 Jun 6.

34.

Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin.

Moser J, Heeringa P, Jongman RM, Zwiers PJ, Niemarkt AE, Yan R, de Graaf IA, Li R, Ravasz Regan E, Kümpers P, Aird WC, van Nieuw Amerongen GP, Zijlstra JG, Molema G, van Meurs M.

J Immunol. 2016 Jun 1;196(11):4681-91. doi: 10.4049/jimmunol.1501819. Epub 2016 Apr 29.

35.

Reduced levels of cytosolic DNA sensor AIM2 are associated with impaired cytokine responses in healthy elderly.

Wang Q, Westra J, van der Geest KS, Moser J, Bijzet J, Kuiper T, Lorencetti PG, Joosten LA, Netea MG, Heeringa P, Brouwer E, Boots AM.

Exp Gerontol. 2016 Jun;78:39-46. doi: 10.1016/j.exger.2016.02.016. Epub 2016 Mar 2.

PMID:
26944367
36.

Urinary Soluble CD163 in Active Renal Vasculitis.

O'Reilly VP, Wong L, Kennedy C, Elliot LA, O'Meachair S, Coughlan AM, O'Brien EC, Ryan MM, Sandoval D, Connolly E, Dekkema GJ, Lau J, Abdulahad WH, Sanders JS, Heeringa P, Buckley C, O'Brien C, Finn S, Cohen CD, Lindemeyer MT, Hickey FB, O'Hara PV, Feighery C, Moran SM, Mellotte G, Clarkson MR, Dorman AJ, Murray PT, Little MA.

J Am Soc Nephrol. 2016 Sep;27(9):2906-16. doi: 10.1681/ASN.2015050511. Epub 2016 Mar 3. Erratum in: J Am Soc Nephrol. 2018 Aug;29(8):2255.

37.

Treatment with Anti-HMGB1 Monoclonal Antibody Does Not Affect Lupus Nephritis in MRL/lpr Mice.

Schaper F, van Timmeren MM, Petersen A, Horst G, Bijl M, Limburg PC, Westra J, Heeringa P.

Mol Med. 2016 Sep;22:12-21. doi: 10.2119/molmed.2015.00176. Epub 2016 Jan 13.

38.

Complement system activation in ANCA vasculitis: A translational success story?

Kallenberg CG, Heeringa P.

Mol Immunol. 2015 Nov;68(1):53-6. doi: 10.1016/j.molimm.2015.06.005. Review.

PMID:
26597208
39.

Obesity-induced chronic inflammation in high fat diet challenged C57BL/6J mice is associated with acceleration of age-dependent renal amyloidosis.

van der Heijden RA, Bijzet J, Meijers WC, Yakala GK, Kleemann R, Nguyen TQ, de Boer RA, Schalkwijk CG, Hazenberg BP, Tietge UJ, Heeringa P.

Sci Rep. 2015 Nov 13;5:16474. doi: 10.1038/srep16474.

40.

Toll-like receptor 9 activation enhances B cell activating factor and interleukin-21 induced anti-proteinase 3 autoantibody production in vitro.

Lepse N, Land J, Rutgers A, Kallenberg CG, Stegeman CA, Abdulahad WH, Heeringa P.

Rheumatology (Oxford). 2016 Jan;55(1):162-72. doi: 10.1093/rheumatology/kev293. Epub 2015 Aug 28.

PMID:
26320128
41.

Intermediate monocytes in ANCA vasculitis: increased surface expression of ANCA autoantigens and IL-1β secretion in response to anti-MPO antibodies.

O'Brien EC, Abdulahad WH, Rutgers A, Huitema MG, O'Reilly VP, Coughlan AM, Harrington M, Heeringa P, Little MA, Hickey FB.

Sci Rep. 2015 Jul 7;5:11888. doi: 10.1038/srep11888.

42.

High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice.

van der Heijden RA, Sheedfar F, Morrison MC, Hommelberg PP, Kor D, Kloosterhuis NJ, Gruben N, Youssef SA, de Bruin A, Hofker MH, Kleemann R, Koonen DP, Heeringa P.

Aging (Albany NY). 2015 Apr;7(4):256-68.

43.

Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure.

Glasner C, van Timmeren MM, Stobernack T, Omansen TF, Raangs EC, Rossen JW, de Goffau MC, Arends JP, Kampinga GA, Koedijk DG, Neef J, Buist G, Tavakol M, van Wamel WJ, Rutgers A, Stegeman CA, Kallenberg CG, Heeringa P, van Dijl JM.

Sci Rep. 2015 Feb 2;5:8188. doi: 10.1038/srep08188.

44.

Regulatory and effector B cell cytokine production in patients with relapsing granulomatosis with polyangiitis.

Land J, Abdulahad WH, Sanders JS, Stegeman CA, Heeringa P, Rutgers A.

Arthritis Res Ther. 2016 Apr 4;18:84. doi: 10.1186/s13075-016-0978-1.

45.

Mirtoselect, an anthocyanin-rich bilberry extract, attenuates non-alcoholic steatohepatitis and associated fibrosis in ApoE(∗)3Leiden mice.

Morrison MC, Liang W, Mulder P, Verschuren L, Pieterman E, Toet K, Heeringa P, Wielinga PY, Kooistra T, Kleemann R.

J Hepatol. 2015 May;62(5):1180-6. doi: 10.1016/j.jhep.2014.12.011. Epub 2014 Dec 13.

46.

Genetic analysis of intracapillary glomerular lipoprotein deposits in aging mice.

Noordmans GA, Huang Y, Savage H, van Dijk MC, Schaart G, van den Bergh Weerman MA, Heeringa P, Hillebrands JL, Korstanje R, van Goor H.

PLoS One. 2014 Oct 29;9(10):e111308. doi: 10.1371/journal.pone.0111308. eCollection 2014.

47.

T cells in vascular inflammatory diseases.

Lintermans LL, Stegeman CA, Heeringa P, Abdulahad WH.

Front Immunol. 2014 Oct 14;5:504. doi: 10.3389/fimmu.2014.00504. eCollection 2014. Review.

48.

The renal angiopoietin/Tie2 system in lethal human sepsis.

Aslan A, Jongman RM, Moser J, Stegeman CA, van Goor H, Diepstra A, van den Heuvel MC, Heeringa P, Molema G, Zijlstra JG, van Meurs M.

Crit Care. 2014 Mar 31;18(2):423. doi: 10.1186/cc13806. No abstract available.

49.

Differential expression of granulopoiesis related genes in neutrophil subsets distinguished by membrane expression of CD177.

Hu N, Mora-Jensen H, Theilgaard-Mönch K, Doornbos-van der Meer B, Huitema MG, Stegeman CA, Heeringa P, Kallenberg CG, Westra J.

PLoS One. 2014 Jun 13;9(6):e99671. doi: 10.1371/journal.pone.0099671. eCollection 2014.

50.

In reply to 'rituximab and B-cell return in ANCA-associated vasculitis'.

Kallenberg CG, Stegeman CA, Abdulahad WH, Heeringa P.

Am J Kidney Dis. 2014 Jun;63(6):1066-7. doi: 10.1053/j.ajkd.2014.02.028. No abstract available.

PMID:
24856617

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