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Items: 1 to 50 of 204

1.

Spatially resolved endogenous improved metabolite detection in human osteoarthritis cartilage by matrix assisted laser desorption ionization mass spectrometry imaging.

Eveque-Mourroux MR, Emans PJ, Zautsen RRM, Boonen A, Heeren RMA, Cillero-Pastor B.

Analyst. 2019 Aug 16. doi: 10.1039/c9an00944b. [Epub ahead of print]

PMID:
31418440
2.

Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer's disease on Aβ1-40 peptide early assembly.

Lazzaro S, Ogrinc N, Lamont L, Vecchio G, Pappalardo G, Heeren RMA.

Anal Bioanal Chem. 2019 Sep;411(24):6353-6363. doi: 10.1007/s00216-019-02030-7. Epub 2019 Aug 12.

PMID:
31407050
3.

MALDI-Mass Spectrometry Imaging to Investigate Lipid and Bile Acid Modifications Caused by Lentil Extract Used as a Potential Hypocholesterolemic Treatment.

Genangeli M, Heijens AMM, Rustichelli A, Schuit ND, Micioni Di Bonaventura MV, Cifani C, Vittori S, Siegel TP, Heeren RMA.

J Am Soc Mass Spectrom. 2019 Aug 5. doi: 10.1007/s13361-019-02265-9. [Epub ahead of print]

PMID:
31385259
4.

Enhanced Sensitivity Using MALDI Imaging Coupled with Laser Postionization (MALDI-2) for Pharmaceutical Research.

Barré FPY, Paine MRL, Flinders B, Trevitt AJ, Kelly PD, Ait-Belkacem R, Garcia JP, Creemers LB, Stauber J, Vreeken RJ, Cillero-Pastor B, Ellis SR, Heeren RMA.

Anal Chem. 2019 Aug 20;91(16):10840-10848. doi: 10.1021/acs.analchem.9b02495. Epub 2019 Aug 9.

5.

Precise co-registration of mass spectrometry imaging, histology, and laser microdissection-based omics.

Dewez F, Martin-Lorenzo M, Herfs M, Baiwir D, Mazzucchelli G, De Pauw E, Heeren RMA, Balluff B.

Anal Bioanal Chem. 2019 Sep;411(22):5647-5653. doi: 10.1007/s00216-019-01983-z. Epub 2019 Jul 1.

6.

Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols.

van Gorp C, de Lange IH, Spiller OB, Dewez F, Cillero Pastor B, Heeren RMA, Kessels L, Kloosterboer N, van Gemert WG, Beeton ML, Stock SJ, Jobe AH, Payne MS, Kemp MW, Zimmermann LJ, Kramer BW, Plat J, Wolfs TGAM.

Nutrients. 2019 Apr 27;11(5). pii: E968. doi: 10.3390/nu11050968.

7.

Trends in mass spectrometry imaging for cardiovascular diseases.

Mezger STP, Mingels AMA, Bekers O, Cillero-Pastor B, Heeren RMA.

Anal Bioanal Chem. 2019 Jul;411(17):3709-3720. doi: 10.1007/s00216-019-01780-8. Epub 2019 Apr 12.

8.

A patch-based super resolution algorithm for improving image resolution in clinical mass spectrometry.

Ščupáková K, Terzopoulos V, Jain S, Smeets D, Heeren RMA.

Sci Rep. 2019 Feb 27;9(1):2915. doi: 10.1038/s41598-019-38914-y.

9.

Three-Dimensional Mass Spectrometry Imaging Identifies Lipid Markers of Medulloblastoma Metastasis.

Paine MRL, Liu J, Huang D, Ellis SR, Trede D, Kobarg JH, Heeren RMA, Fernández FM, MacDonald TJ.

Sci Rep. 2019 Feb 18;9(1):2205. doi: 10.1038/s41598-018-38257-0.

10.

Mass Spectrometry-Based Tissue Imaging: The Next Frontier in Clinical Diagnostics?

Leung F, Eberlin LS, Schwamborn K, Heeren RMA, Winograd N, Cooks RG.

Clin Chem. 2019 Apr;65(4):510-513. doi: 10.1373/clinchem.2018.289694. Epub 2019 Feb 8. No abstract available.

PMID:
30737204
11.

Distinguishing core from penumbra by lipid profiles using Mass Spectrometry Imaging in a transgenic mouse model of ischemic stroke.

Mulder IA, Ogrinc Potočnik N, Broos LAM, Prop A, Wermer MJH, Heeren RMA, van den Maagdenberg AMJM.

Sci Rep. 2019 Jan 31;9(1):1090. doi: 10.1038/s41598-018-37612-5.

12.

Rapid Identification of Ischemic Injury in Renal Tissue by Mass-Spectrometry Imaging.

van Smaalen TC, Ellis SR, Mascini NE, Siegel TP, Cillero-Pastor B, Hillen LM, van Heurn LWE, Peutz-Kootstra CJ, Heeren RMA.

Anal Chem. 2019 Mar 5;91(5):3575-3581. doi: 10.1021/acs.analchem.8b05521. Epub 2019 Feb 15.

13.

Increased throughput and ultra-high mass resolution in DESI FT-ICR MS imaging through new-generation external data acquisition system and advanced data processing approaches.

Kooijman PC, Nagornov KO, Kozhinov AN, Kilgour DPA, Tsybin YO, Heeren RMA, Ellis SR.

Sci Rep. 2019 Jan 9;9(1):8. doi: 10.1038/s41598-018-36957-1.

14.

Integrative Clustering in Mass Spectrometry Imaging for Enhanced Patient Stratification.

Balluff B, Buck A, Martin-Lorenzo M, Dewez F, Langer R, McDonnell LA, Walch A, Heeren RMA.

Proteomics Clin Appl. 2019 Jan;13(1):e1800137. doi: 10.1002/prca.201800137. Epub 2019 Jan 4.

15.

Specific Lipid and Metabolic Profiles of R-CHOP-Resistant Diffuse Large B-Cell Lymphoma Elucidated by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and in Vivo Imaging.

Barré FPY, Claes BSR, Dewez F, Peutz-Kootstra C, Munch-Petersen HF, Grønbæk K, Lund AH, Heeren RMA, Côme C, Cillero-Pastor B.

Anal Chem. 2018 Dec 18;90(24):14198-14206. doi: 10.1021/acs.analchem.8b02910. Epub 2018 Dec 4.

16.

Understanding Detrimental and Beneficial Grain Boundary Effects in Halide Perovskites.

Adhyaksa GWP, Brittman S, Āboliņš H, Lof A, Li X, Keelor JD, Luo Y, Duevski T, Heeren RMA, Ellis SR, Fenning DP, Garnett EC.

Adv Mater. 2018 Dec;30(52):e1804792. doi: 10.1002/adma.201804792. Epub 2018 Oct 26.

PMID:
30368936
17.

Targeted Drug and Metabolite Imaging: Desorption Electrospray Ionization Combined with Triple Quadrupole Mass Spectrometry.

Lamont L, Eijkel GB, Jones EA, Flinders B, Ellis SR, Porta Siegel T, Heeren RMA, Vreeken RJ.

Anal Chem. 2018 Nov 20;90(22):13229-13235. doi: 10.1021/acs.analchem.8b03857. Epub 2018 Nov 6.

18.

Strategies for managing multi-patient 3D mass spectrometry imaging data.

Vos DRN, Jansen I, Lucas M, Paine MRL, de Boer OJ, Meijer SL, Savci-Heijink CD, Marquering HA, de Bruin DM, Heeren RMA, Ellis SR, Balluff B.

J Proteomics. 2019 Feb 20;193:184-191. doi: 10.1016/j.jprot.2018.10.008. Epub 2018 Oct 19.

19.

Evaluation of Thin-Layer Chromatography-Laser Desorption Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Imaging for Visualization of Crude Oil Interactions.

Zahraei A, Arisz PWF, van Bavel AP, Heeren RMA.

Energy Fuels. 2018 Jul 19;32(7):7347-7357. doi: 10.1021/acs.energyfuels.8b00639. Epub 2018 Jun 7.

20.

Cross-Species Molecular Imaging of Bile Salts and Lipids in Liver: Identification of Molecular Structural Markers in Health and Disease.

Flinders B, Huizing LRS, van Heerden M, Cuyckens F, Neumann UP, van der Laan LJW, Olde Damink SWM, Heeren RMA, Schaap FG, Vreeken RJ.

Anal Chem. 2018 Oct 16;90(20):11835-11846. doi: 10.1021/acs.analchem.8b01378. Epub 2018 Oct 4.

21.

Digestion-Free Analysis of Peptides from 30-year-old Formalin-Fixed, Paraffin-Embedded Tissue by Mass Spectrometry Imaging.

Paine MRL, Ellis SR, Maloney D, Heeren RMA, Verhaert PDEM.

Anal Chem. 2018 Aug 7;90(15):9272-9280. doi: 10.1021/acs.analchem.8b01838. Epub 2018 Jul 18.

22.

Round robin study of formalin-fixed paraffin-embedded tissues in mass spectrometry imaging.

Buck A, Heijs B, Beine B, Schepers J, Cassese A, Heeren RMA, McDonnell LA, Henkel C, Walch A, Balluff B.

Anal Bioanal Chem. 2018 Sep;410(23):5969-5980. doi: 10.1007/s00216-018-1216-2. Epub 2018 Jul 3.

23.

Identification and High-Resolution Imaging of α-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry.

Bruinen AL, Fisher GL, Balez R, van der Sar AM, Ooi L, Heeren RMA.

J Am Soc Mass Spectrom. 2018 Aug;29(8):1571-1581. doi: 10.1007/s13361-018-1979-x. Epub 2018 Jun 12.

24.

Mass Spectrometry Imaging with Isomeric Resolution Enabled by Ozone-Induced Dissociation.

Paine MRL, Poad BLJ, Eijkel GB, Marshall DL, Blanksby SJ, Heeren RMA, Ellis SR.

Angew Chem Int Ed Engl. 2018 Aug 13;57(33):10530-10534. doi: 10.1002/anie.201802937. Epub 2018 Jun 19.

25.

Automated, parallel mass spectrometry imaging and structural identification of lipids.

Ellis SR, Paine MRL, Eijkel GB, Pauling JK, Husen P, Jervelund MW, Hermansson M, Ejsing CS, Heeren RMA.

Nat Methods. 2018 Jul;15(7):515-518. doi: 10.1038/s41592-018-0010-6. Epub 2018 May 21.

PMID:
29786091
26.

NF-κB-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis.

Remels AHV, Derks WJA, Cillero-Pastor B, Verhees KJP, Kelders MC, Heggermont W, Carai P, Summer G, Ellis SR, de Theije CC, Heeren RMA, Heymans S, Papageorgiou AP, van Bilsen M.

Biochim Biophys Acta Mol Basis Dis. 2018 Aug;1864(8):2579-2589. doi: 10.1016/j.bbadis.2018.04.022. Epub 2018 May 3.

27.

Tumor classification with MALDI-MSI data of tissue microarrays: A case study.

Mascini NE, Teunissen J, Noorlag R, Willems SM, Heeren RMA.

Methods. 2018 Dec 1;151:21-27. doi: 10.1016/j.ymeth.2018.04.004. Epub 2018 Apr 12.

28.

Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity.

Ščupáková K, Soons Z, Ertaylan G, Pierzchalski KA, Eijkel GB, Ellis SR, Greve JW, Driessen A, Verheij J, De Kok TM, Olde Damink SWM, Rensen SS, Heeren RMA.

Anal Chem. 2018 Apr 17;90(8):5130-5138. doi: 10.1021/acs.analchem.7b05215. Epub 2018 Apr 3.

29.

Solvent effects on differentiation of mouse brain tissue using laser microdissection 'cut and drop' sampling with direct mass spectral analysis.

Cahill JF, Kertesz V, Porta T, LeBlanc JCY, Heeren RMA, Van Berkel GJ.

Rapid Commun Mass Spectrom. 2018 Mar 15;32(5):414-422. doi: 10.1002/rcm.8053.

PMID:
29297944
30.

Simultaneous lipidomic and transcriptomic profiling in mouse brain punches of acute epileptic seizure model compared to controls.

Lerner R, Post JM, Ellis SR, Vos DRN, Heeren RMA, Lutz B, Bindila L.

J Lipid Res. 2018 Feb;59(2):283-297. doi: 10.1194/jlr.M080093. Epub 2017 Dec 5.

31.

Host-based lipid inflammation drives pathogenesis in Francisella infection.

Scott AJ, Post JM, Lerner R, Ellis SR, Lieberman J, Shirey KA, Heeren RMA, Bindila L, Ernst RK.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12596-12601. doi: 10.1073/pnas.1712887114. Epub 2017 Nov 6.

32.

Integration of Ion Mobility MSE after Fully Automated, Online, High-Resolution Liquid Extraction Surface Analysis Micro-Liquid Chromatography.

Lamont L, Baumert M, Ogrinc Potočnik N, Allen M, Vreeken R, Heeren RMA, Porta T.

Anal Chem. 2017 Oct 17;89(20):11143-11150. doi: 10.1021/acs.analchem.7b03512. Epub 2017 Oct 6.

33.

The Paradoxical Effects of Chronic Intra-Amniotic Ureaplasma parvum Exposure on Ovine Fetal Brain Development.

Gussenhoven R, Ophelders DRMG, Kemp MW, Payne MS, Spiller OB, Beeton ML, Stock SJ, Cillero-Pastor B, Barré FPY, Heeren RMA, Kessels L, Stevens B, Rutten BP, Kallapur SG, Jobe AH, Kramer BW, Wolfs TGAM.

Dev Neurosci. 2017;39(6):472-486. doi: 10.1159/000479021. Epub 2017 Aug 29.

34.

Optimization of Sample Preparation and Instrumental Parameters for the Rapid Analysis of Drugs of Abuse in Hair samples by MALDI-MS/MS Imaging.

Flinders B, Beasley E, Verlaan RM, Cuypers E, Francese S, Bassindale T, Clench MR, Heeren RMA.

J Am Soc Mass Spectrom. 2017 Nov;28(11):2462-2468. doi: 10.1007/s13361-017-1766-0. Epub 2017 Aug 11.

35.

Sequencing and Identification of Endogenous Neuropeptides with Matrix-Enhanced Secondary Ion Mass Spectrometry Tandem Mass Spectrometry.

Ogrinc Potočnik N, Fisher GL, Prop A, Heeren RMA.

Anal Chem. 2017 Aug 15;89(16):8223-8227. doi: 10.1021/acs.analchem.7b02573. Epub 2017 Aug 3.

36.

Combining Time-of-Flight Secondary Ion Mass Spectrometry Imaging Mass Spectrometry and CARS Microspectroscopy Reveals Lipid Patterns Reminiscent of Gene Expression Patterns in the Wing Imaginal Disc of Drosophila melanogaster.

Marty F, Rago G, Smith DF, Gao X, Eijkel GB, MacAleese L, Bonn M, Brunner E, Basler K, Heeren RMA.

Anal Chem. 2017 Sep 19;89(18):9664-9670. doi: 10.1021/acs.analchem.7b00125. Epub 2017 Aug 29.

37.

Oxygen-Dependent Lipid Profiles of Three-Dimensional Cultured Human Chondrocytes Revealed by MALDI-MSI.

Bakker B, Eijkel GB, Heeren RMA, Karperien M, Post JN, Cillero-Pastor B.

Anal Chem. 2017 Sep 5;89(17):9438-9444. doi: 10.1021/acs.analchem.7b02265. Epub 2017 Aug 14.

38.

Mass spectrometry imaging for clinical research - latest developments, applications, and current limitations.

Vaysse PM, Heeren RMA, Porta T, Balluff B.

Analyst. 2017 Jul 24;142(15):2690-2712. doi: 10.1039/c7an00565b. Review.

PMID:
28642940
39.

Design and Performance of a Novel Interface for Combined Matrix-Assisted Laser Desorption Ionization at Elevated Pressure and Electrospray Ionization with Orbitrap Mass Spectrometry.

Belov ME, Ellis SR, Dilillo M, Paine MRL, Danielson WF, Anderson GA, de Graaf EL, Eijkel GB, Heeren RMA, McDonnell LA.

Anal Chem. 2017 Jul 18;89(14):7493-7501. doi: 10.1021/acs.analchem.7b01168. Epub 2017 Jun 28.

PMID:
28613836
40.

The Composition of Poly(Ethylene Terephthalate) (PET) Surface Precipitates Determined at High Resolving Power by Tandem Mass Spectrometry Imaging.

Fisher GL, Hammond JS, Bryan SR, Larson PE, Heeren RMA.

Microsc Microanal. 2017 Aug;23(4):843-848. doi: 10.1017/S1431927617000654. Epub 2017 Jun 7.

PMID:
28587700
41.

Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids.

Ellis SR, Soltwisch J, Paine MRL, Dreisewerd K, Heeren RMA.

Chem Commun (Camb). 2017 Jun 29;53(53):7246-7249. doi: 10.1039/c7cc02325a.

PMID:
28573274
42.

ToF-SIMS Parallel Imaging MS/MS of Lipid Species in Thin Tissue Sections.

Bruinen AL, Fisher GL, Heeren RMA.

Methods Mol Biol. 2017;1618:165-173. doi: 10.1007/978-1-4939-7051-3_14.

PMID:
28523507
43.

Mass Spectrometry Imaging of Drugs of Abuse in Hair.

Flinders B, Cuypers E, Porta T, Varesio E, Hopfgartner G, Heeren RMA.

Methods Mol Biol. 2017;1618:137-147. doi: 10.1007/978-1-4939-7051-3_12.

PMID:
28523505
44.

Detection of Localized Hepatocellular Amino Acid Kinetics by using Mass Spectrometry Imaging of Stable Isotopes.

Arts M, Soons Z, Ellis SR, Pierzchalski KA, Balluff B, Eijkel GB, Dubois LJ, Lieuwes NG, Agten SM, Hackeng TM, van Loon LJC, Heeren RMA, Olde Damink SWM.

Angew Chem Int Ed Engl. 2017 Jun 12;56(25):7146-7150. doi: 10.1002/anie.201702669. Epub 2017 May 11.

45.

Derivatization Strategies for the Detection of Triamcinolone Acetonide in Cartilage by Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging.

Barré FP, Flinders B, Garcia JP, Jansen I, Huizing LR, Porta T, Creemers LB, Heeren RM, Cillero-Pastor B.

Anal Chem. 2016 Dec 20;88(24):12051-12059. doi: 10.1021/acs.analchem.6b02491. Epub 2016 Dec 2.

PMID:
28193015
46.

Mass Spectrometry Imaging for the Investigation of Intratumor Heterogeneity.

Balluff B, Hanselmann M, Heeren RM.

Adv Cancer Res. 2017;134:201-230. doi: 10.1016/bs.acr.2016.11.008. Epub 2016 Dec 20. Review.

PMID:
28110651
47.

Mass Spectrometry Imaging in Nanomedicine: Unraveling the Potential of MSI for the Detection of Nanoparticles in Neuroscience.

Barre FPY, Heeren RMA, Potocnik NO.

Curr Pharm Des. 2017;23(13):1974-1984. doi: 10.2174/1381612823666170111112550. Review.

PMID:
28078990
48.

Efficient Functionalization of Additives at Supramolecular Material Surfaces.

Goor OJ, Keizer HM, Bruinen AL, Schmitz MG, Versteegen RM, Janssen HM, Heeren RM, Dankers PY.

Adv Mater. 2017 Feb;29(5). doi: 10.1002/adma.201604652. Epub 2016 Nov 29.

PMID:
27896852
49.

Direct Analysis and Quantification of Metaldehyde in Water using Reactive Paper Spray Mass Spectrometry.

Maher S, Jjunju FP, Damon DE, Gorton H, Maher YS, Syed SU, Heeren RM, Young IS, Taylor S, Badu-Tawiah AK.

Sci Rep. 2016 Oct 21;6:35643. doi: 10.1038/srep35643.

50.

Norharmane Matrix Enhances Detection of Endotoxin by MALDI-MS for Simultaneous Profiling of Pathogen, Host, and Vector Systems.

Scott AJ, Flinders B, Cappell J, Liang T, Pelc RS, Tran B, Kilgour DP, Heeren RM, Goodlett DR, Ernst RK.

Pathog Dis. 2016 Sep 19. pii: ftw097. [Epub ahead of print]

PMID:
27650574

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