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Items: 1 to 50 of 164

1.

Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption.

Johann K, Cremer AL, Fischer AW, Heine M, Pensado ER, Resch J, Nock S, Virtue S, Harder L, Oelkrug R, Astiz M, Brabant G, Warner A, Vidal-Puig A, Oster H, Boelen A, López M, Heeren J, Dalley JW, Backes H, Mittag J.

Cell Rep. 2019 Jun 11;27(11):3385-3400.e3. doi: 10.1016/j.celrep.2019.05.054.

PMID:
31189119
2.

PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles.

Fischer AW, Albers K, Schlein C, Sass F, Krott LM, Schmale H, Gordts PLSM, Scheja L, Heeren J.

Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1592-1603. doi: 10.1016/j.bbadis.2019.03.010. Epub 2019 Mar 21.

PMID:
30904610
3.

Scanning transmission X-ray microscopy with efficient X-ray fluorescence detection (STXM-XRF) for biomedical applications in the soft and tender energy range.

Lühl L, Andrianov K, Dierks H, Haidl A, Dehlinger A, Heine M, Heeren J, Nisius T, Wilhein T, Kanngießer B.

J Synchrotron Radiat. 2019 Mar 1;26(Pt 2):430-438. doi: 10.1107/S1600577518016879. Epub 2019 Jan 21.

PMID:
30855252
4.

Effects of Pharmacological Thermogenic Adipocyte Activation on Metabolism and Atherosclerotic Plaque Regression.

Worthmann A, Schlein C, Berbée JFP, Rensen PCN, Heeren J, Bartelt A.

Nutrients. 2019 Feb 23;11(2). pii: E463. doi: 10.3390/nu11020463.

5.

Adenine nucleotides as paracrine mediators and intracellular second messengers in immunity and inflammation.

Fliegert R, Heeren J, Koch-Nolte F, Nikolaev VO, Lohr C, Meier C, Guse AH.

Biochem Soc Trans. 2019 Feb 28;47(1):329-337. doi: 10.1042/BST20180419. Epub 2019 Jan 23. Review.

PMID:
30674608
6.

Intact innervation is essential for diet-induced recruitment of brown adipose tissue.

Fischer AW, Schlein C, Cannon B, Heeren J, Nedergaard J.

Am J Physiol Endocrinol Metab. 2019 Mar 1;316(3):E487-E503. doi: 10.1152/ajpendo.00443.2018. Epub 2018 Dec 21.

7.

Development of the Metabolic Syndrome: Study Design and Baseline Data of the Lufthansa Prevention Study (LUPS), A Prospective Observational Cohort Survey.

Müller-Wieland D, Altenburg C, Becher H, Burchard J, Frisch A, Gebhard J, Haas J, Harth V, Heeren J, Hengelbrock J, von Karais M, Knebel B, Kotzka J, Löwe B, Marx N, Pinnschmidt H, Preisser A, Rose M, Sawitzky-Rose B, Scheja L, Terschüren C, Töller M, Vettorazzi E, Wegscheider K.

Exp Clin Endocrinol Diabetes. 2018 Nov 26. doi: 10.1055/a-0767-6361. [Epub ahead of print]

PMID:
30477037
8.

Abscisic acid stimulates the release of insulin and of GLP-1 in the rat perfused pancreas and intestine.

Booz V, Christiansen CB, Kuhre RE, Saltiel MY, Sociali G, Schaltenberg N, Fischer AW, Heeren J, Zocchi E, Holst JJ, Bruzzone S.

Diabetes Metab Res Rev. 2019 Feb;35(2):e3102. doi: 10.1002/dmrr.3102. Epub 2018 Dec 13.

PMID:
30468287
9.

Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5-dependent and -independent mechanisms.

Treviño-Villarreal JH, Reynolds JS, Bartelt A, Langston PK, MacArthur MR, Arduini A, Tosti V, Veronese N, Bertozzi B, Brace LE, Mejia P, Trocha K, Kajitani GS, Longchamp A, Harputlugil E, Gathungu R, Bird SS, Bullock AD, Figenshau RS, Andriole GL, Thompson A, Heeren J, Ozaki CK, Kristal BS, Fontana L, Mitchell JR.

JCI Insight. 2018 Nov 2;3(21). pii: 99470. doi: 10.1172/jci.insight.99470.

10.

LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat.

Schmidt E, Dhaouadi I, Gaziano I, Oliverio M, Klemm P, Awazawa M, Mitterer G, Fernandez-Rebollo E, Pradas-Juni M, Wagner W, Hammerschmidt P, Loureiro R, Kiefer C, Hansmeier NR, Khani S, Bergami M, Heine M, Ntini E, Frommolt P, Zentis P, Ørom UA, Heeren J, Blüher M, Bilban M, Kornfeld JW.

Nat Commun. 2018 Sep 6;9(1):3622. doi: 10.1038/s41467-018-05933-8.

11.

Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet.

Cairns R, Fischer AW, Blanco-Munoz P, Alvarez-Guaita A, Meneses-Salas E, Egert A, Buechler C, Hoy AJ, Heeren J, Enrich C, Rentero C, Grewal T.

PLoS One. 2018 Aug 15;13(8):e0201310. doi: 10.1371/journal.pone.0201310. eCollection 2018.

12.

The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins.

Fischer AW, Albers K, Krott LM, Hoffzimmer B, Heine M, Schmale H, Scheja L, Gordts PLSM, Heeren J.

Mol Metab. 2018 Oct;16:88-99. doi: 10.1016/j.molmet.2018.07.010. Epub 2018 Jul 30.

13.

Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice.

Heine M, Fischer AW, Schlein C, Jung C, Straub LG, Gottschling K, Mangels N, Yuan Y, Nilsson SK, Liebscher G, Chen O, Schreiber R, Zechner R, Scheja L, Heeren J.

Cell Metab. 2018 Oct 2;28(4):644-655.e4. doi: 10.1016/j.cmet.2018.06.020. Epub 2018 Jul 19.

PMID:
30033199
14.

Effect of sound level on virtual and free-field localization of brief sounds in the anterior median plane.

Marmel F, Marrufo-Pérez MI, Heeren J, Ewert S, Lopez-Poveda EA.

Hear Res. 2018 Aug;365:28-35. doi: 10.1016/j.heares.2018.06.004. Epub 2018 Jun 15.

PMID:
29909353
15.

Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans.

Oldoni F, van Capelleveen JC, Dalila N, Wolters JC, Heeren J, Sinke RJ, Hui DY, Dallinga-Thie GM, Frikke-Schmidt R, Hovingh KG, van de Sluis B, Tybjærg-Hansen A, Kuivenhoven JA.

Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1440-1453. doi: 10.1161/ATVBAHA.117.310309. Epub 2018 May 31.

16.

Neuroimaging abnormalities in individuals exhibiting Parkinson's disease risk markers.

Heldmann M, Heeren J, Klein C, Rauch L, Hagenah J, Münte TF, Kasten M, Brüggemann N.

Mov Disord. 2018 Sep;33(9):1412-1422. doi: 10.1002/mds.27313. Epub 2018 May 14.

PMID:
29756356
17.

Brown adipose tissue and lipid metabolism.

Heeren J, Scheja L.

Curr Opin Lipidol. 2018 Jun;29(3):180-185. doi: 10.1097/MOL.0000000000000504.

PMID:
29718003
18.

Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF-RANKL signaling.

Bartelt A, Behler-Janbeck F, Beil FT, Koehne T, Müller B, Schmidt T, Heine M, Ochs L, Yilmaz T, Dietrich M, Tuckermann JP, Amling M, Herz J, Schinke T, Heeren J, Niemeier A.

Bone Res. 2018 Feb 26;6:4. doi: 10.1038/s41413-017-0006-3. eCollection 2018.

19.

FoxO transcription factors are required for hepatic HDL cholesterol clearance.

Lee SX, Heine M, Schlein C, Ramakrishnan R, Liu J, Belnavis G, Haimi I, Fischer AW, Ginsberg HN, Heeren J, Rinninger F, Haeusler RA.

J Clin Invest. 2018 Apr 2;128(4):1615-1626. doi: 10.1172/JCI94230. Epub 2018 Mar 19.

20.

The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity.

Christoffersen C, Federspiel CK, Borup A, Christensen PM, Madsen AN, Heine M, Nielsen CH, Kjaer A, Holst B, Heeren J, Nielsen LB.

Cell Rep. 2018 Jan 2;22(1):175-188. doi: 10.1016/j.celrep.2017.12.029.

21.

Introduction to the special issue on dietary control of immunometabolism.

Scheja L, Heeren J.

Semin Immunopathol. 2018 Feb;40(2):141-144. doi: 10.1007/s00281-017-0667-4. Epub 2017 Dec 8. No abstract available.

PMID:
29222582
22.

Regulation of immunometabolism in adipose tissue.

Kumari M, Heeren J, Scheja L.

Semin Immunopathol. 2018 Feb;40(2):189-202. doi: 10.1007/s00281-017-0668-3. Epub 2017 Dec 5. Review.

PMID:
29209828
23.

Next-generation in vivo optical imaging with short-wave infrared quantum dots.

Bruns OT, Bischof TS, Harris DK, Franke D, Shi Y, Riedemann L, Bartelt A, Jaworski FB, Carr JA, Rowlands CJ, Wilson MWB, Chen O, Wei H, Hwang GW, Montana DM, Coropceanu I, Achorn OB, Kloepper J, Heeren J, So PTC, Fukumura D, Jensen KF, Jain RK, Bawendi MG.

Nat Biomed Eng. 2017;1. pii: 0056. doi: 10.1038/s41551-017-0056. Epub 2017 Apr 10.

24.

Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men.

Iwen KA, Backhaus J, Cassens M, Waltl M, Hedesan OC, Merkel M, Heeren J, Sina C, Rademacher L, Windjäger A, Haug AR, Kiefer FW, Lehnert H, Schmid SM.

J Clin Endocrinol Metab. 2017 Nov 1;102(11):4226-4234. doi: 10.1210/jc.2017-01250.

PMID:
28945846
25.

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O.

Immunity. 2017 Sep 19;47(3):566-581.e9. doi: 10.1016/j.immuni.2017.08.008.

26.

AMPK Prevents Palmitic Acid-Induced Apoptosis and Lipid Accumulation in Cardiomyocytes.

Adrian L, Lenski M, Tödter K, Heeren J, Böhm M, Laufs U.

Lipids. 2017 Sep;52(9):737-750. doi: 10.1007/s11745-017-4285-7. Epub 2017 Aug 20.

PMID:
28825205
27.

Metabolic Circuit Involving Free Fatty Acids, microRNA 122, and Triglyceride Synthesis in Liver and Muscle Tissues.

Chai C, Rivkin M, Berkovits L, Simerzin A, Zorde-Khvalevsky E, Rosenberg N, Klein S, Yaish D, Durst R, Shpitzen S, Udi S, Tam J, Heeren J, Worthmann A, Schramm C, Kluwe J, Ravid R, Hornstein E, Giladi H, Galun E.

Gastroenterology. 2017 Nov;153(5):1404-1415. doi: 10.1053/j.gastro.2017.08.013. Epub 2017 Aug 9.

PMID:
28802563
28.

Quantitative and qualitative estimation of atherosclerotic plaque burden in vivo at 7T MRI using Gadospin F in comparison to en face preparation evaluated in ApoE KO mice.

Jung C, Christiansen S, Kaul MG, Koziolek E, Reimer R, Heeren J, Adam G, Heine M, Ittrich H.

PLoS One. 2017 Aug 3;12(8):e0180407. doi: 10.1371/journal.pone.0180407. eCollection 2017.

29.

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue.

Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM, Graham MJ, Morton RE, Langefeld CD, Das SK, Rudel LL, Zein N, McCullough AJ, Dasarathy S, Tang WHW, Erokwu BO, Flask CA, Laakso M, Civelek M, Naga Prasad SV, Heeren J, Lusis AJ, Hazen SL, Brown JM.

Cell Rep. 2017 Jul 5;20(1):279. doi: 10.1016/j.celrep.2017.06.053. No abstract available.

30.

Differential effects of Calca-derived peptides in male mice with diet-induced obesity.

Bartelt A, Jeschke A, Müller B, Gaziano I, Morales M, Yorgan T, Heckt T, Heine M, Gagel RF, Emeson RB, Amling M, Niemeier A, Heeren J, Schinke T, Keller J.

PLoS One. 2017 Jun 30;12(6):e0180547. doi: 10.1371/journal.pone.0180547. eCollection 2017.

31.

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue.

Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM, Graham MJ, Morton RE, Langefeld CD, Das SK, Rudel LL, Zein N, McCullough AJ, Dasarathy S, Tang WHW, Erokwu BO, Flask CA, Laakso M, Civelek M, Naga Prasad SV, Heeren J, Lusis AJ, Hazen SL, Brown JM.

Cell Rep. 2017 Jun 20;19(12):2451-2461. doi: 10.1016/j.celrep.2017.05.077. Erratum in: Cell Rep. 2017 Jul 5;20(1):279.

32.

Quantification of Bone Fatty Acid Metabolism and Its Regulation by Adipocyte Lipoprotein Lipase.

Bartelt A, Koehne T, Tödter K, Reimer R, Müller B, Behler-Janbeck F, Heeren J, Scheja L, Niemeier A.

Int J Mol Sci. 2017 Jun 13;18(6). pii: E1264. doi: 10.3390/ijms18061264.

33.

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.

Worthmann A, John C, Rühlemann MC, Baguhl M, Heinsen FA, Schaltenberg N, Heine M, Schlein C, Evangelakos I, Mineo C, Fischer M, Dandri M, Kremoser C, Scheja L, Franke A, Shaul PW, Heeren J.

Nat Med. 2017 Jul;23(7):839-849. doi: 10.1038/nm.4357. Epub 2017 Jun 12.

PMID:
28604703
34.

Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport.

Bartelt A, John C, Schaltenberg N, Berbée JFP, Worthmann A, Cherradi ML, Schlein C, Piepenburg J, Boon MR, Rinninger F, Heine M, Toedter K, Niemeier A, Nilsson SK, Fischer M, Wijers SL, van Marken Lichtenbelt W, Scheja L, Rensen PCN, Heeren J.

Nat Commun. 2017 Apr 19;8:15010. doi: 10.1038/ncomms15010.

35.

Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes.

Kissing S, Rudnik S, Damme M, Lüllmann-Rauch R, Ichihara A, Kornak U, Eskelinen EL, Jabs S, Heeren J, De Brabander JK, Haas A, Saftig P.

Autophagy. 2017 Apr 3;13(4):670-685. doi: 10.1080/15548627.2017.1280216. Epub 2017 Jan 27.

36.

Implications of thermogenic adipose tissues for metabolic health.

Schlein C, Heeren J.

Best Pract Res Clin Endocrinol Metab. 2016 Aug;30(4):487-496. doi: 10.1016/j.beem.2016.08.002. Epub 2016 Aug 13. Review.

PMID:
27697210
37.

Achilles Tendon Properties of Minimalist and Traditionally Shod Runners.

Histen K, Arntsen J, L'Hereux L, Heeren J, Wicki B, Saint S, Aerni G, Denegar CR, Joseph MF.

J Sport Rehabil. 2017 Apr;26(2):159-164. doi: 10.1123/jsr.2016-0006. Epub 2016 Aug 24.

PMID:
27632859
38.

Novel Mouse Models of Methylmalonic Aciduria Recapitulate Phenotypic Traits with a Genetic Dosage Effect.

Forny P, Schumann A, Mustedanagic M, Mathis D, Wulf MA, Nägele N, Langhans CD, Zhakupova A, Heeren J, Scheja L, Fingerhut R, Peters HL, Hornemann T, Thony B, Kölker S, Burda P, Froese DS, Devuyst O, Baumgartner MR.

J Biol Chem. 2016 Sep 23;291(39):20563-73. doi: 10.1074/jbc.M116.747717. Epub 2016 Aug 12.

39.

Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils.

Kozik JH, Trautmann T, Carambia A, Preti M, Lütgehetmann M, Krech T, Wiegard C, Heeren J, Herkel J.

Sci Rep. 2016 Jun 22;6:28556. doi: 10.1038/srep28556.

40.

Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity.

Chen Y, Buyel JJ, Hanssen MJ, Siegel F, Pan R, Naumann J, Schell M, van der Lans A, Schlein C, Froehlich H, Heeren J, Virtanen KA, van Marken Lichtenbelt W, Pfeifer A.

Nat Commun. 2016 Apr 27;7:11420. doi: 10.1038/ncomms11420.

41.

Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis.

Schröder T, Kucharczyk D, Bär F, Pagel R, Derer S, Jendrek ST, Sünderhauf A, Brethack AK, Hirose M, Möller S, Künstner A, Bischof J, Weyers I, Heeren J, Koczan D, Schmid SM, Divanovic S, Giles DA, Adamski J, Fellermann K, Lehnert H, Köhl J, Ibrahim S, Sina C.

Mol Metab. 2016 Feb 2;5(4):283-295. doi: 10.1016/j.molmet.2016.01.010. eCollection 2016 Apr.

42.

Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function.

Oliverio M, Schmidt E, Mauer J, Baitzel C, Hansmeier N, Khani S, Konieczka S, Pradas-Juni M, Brodesser S, Van TM, Bartsch D, Brönneke HS, Heine M, Hilpert H, Tarcitano E, Garinis GA, Frommolt P, Heeren J, Mori MA, Brüning JC, Kornfeld JW.

Nat Cell Biol. 2016 Mar;18(3):328-36. doi: 10.1038/ncb3316. Epub 2016 Feb 22.

PMID:
26900752
43.

Insulin Regulates Hepatic Triglyceride Secretion and Lipid Content via Signaling in the Brain.

Scherer T, Lindtner C, O'Hare J, Hackl M, Zielinski E, Freudenthaler A, Baumgartner-Parzer S, Tödter K, Heeren J, Krššák M, Scheja L, Fürnsinn C, Buettner C.

Diabetes. 2016 Jun;65(6):1511-20. doi: 10.2337/db15-1552. Epub 2016 Feb 9.

44.

FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues.

Schlein C, Talukdar S, Heine M, Fischer AW, Krott LM, Nilsson SK, Brenner MB, Heeren J, Scheja L.

Cell Metab. 2016 Mar 8;23(3):441-53. doi: 10.1016/j.cmet.2016.01.006. Epub 2016 Feb 4.

45.

Metabolic interplay between white, beige, brown adipocytes and the liver.

Scheja L, Heeren J.

J Hepatol. 2016 May;64(5):1176-1186. doi: 10.1016/j.jhep.2016.01.025. Epub 2016 Jan 30. Review.

PMID:
26829204
46.

Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation.

Krott LM, Piscitelli F, Heine M, Borrino S, Scheja L, Silvestri C, Heeren J, Di Marzo V.

J Lipid Res. 2016 Mar;57(3):464-73. doi: 10.1194/jlr.M065227. Epub 2016 Jan 14.

47.

Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity.

Wagner T, Bartelt A, Schlein C, Heeren J.

PLoS One. 2015 Dec 22;10(12):e0145102. doi: 10.1371/journal.pone.0145102. eCollection 2015.

48.

Quantitative Activity Measurements of Brown Adipose Tissue at 7 T Magnetic Resonance Imaging After Application of Triglyceride-Rich Lipoprotein 59Fe-Superparamagnetic Iron Oxide Nanoparticle: Intravenous Versus Intraperitoneal Approach.

Jung CS, Heine M, Freund B, Reimer R, Koziolek EJ, Kaul MG, Kording F, Schumacher U, Weller H, Nielsen P, Adam G, Heeren J, Ittrich H.

Invest Radiol. 2016 Mar;51(3):194-202. doi: 10.1097/RLI.0000000000000235.

PMID:
26674208
49.

Diabetes prevalence in NZO females depends on estrogen action on liver fat content.

Lubura M, Hesse D, Kraemer M, Hallahan N, Schupp M, von Löffelholz C, Kriebel J, Rudovich N, Pfeiffer A, John C, Scheja L, Heeren J, Koliaki C, Roden M, Schürmann A.

Am J Physiol Endocrinol Metab. 2015 Dec 15;309(12):E968-80. doi: 10.1152/ajpendo.00338.2015. Epub 2015 Oct 20.

50.

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure.

Dijk W, Heine M, Vergnes L, Boon MR, Schaart G, Hesselink MK, Reue K, van Marken Lichtenbelt WD, Olivecrona G, Rensen PC, Heeren J, Kersten S.

Elife. 2015 Oct 17;4. pii: e08428. doi: 10.7554/eLife.08428.

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