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A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly.

Maori E, Navarro IC, Boncristiani H, Seilly DJ, Rudolph KLM, Sapetschnig A, Lin CC, Ladbury JE, Evans JD, Heeney JL, Miska EA.

Mol Cell. 2019 May 2;74(3):598-608.e6. doi: 10.1016/j.molcel.2019.03.010. Epub 2019 Apr 18.


Priming with a Potent HIV-1 DNA Vaccine Frames the Quality of Immune Responses prior to a Poxvirus and Protein Boost.

Asbach B, Kibler KV, Köstler J, Perdiguero B, Yates NL, Stanfield-Oakley S, Tomaras GD, Kao SF, Foulds KE, Roederer M, Seaman MS, Montefiori DC, Parks R, Ferrari G, Forthal DN, Phogat S, Tartaglia J, Barnett SW, Self SG, Gottardo R, Cristillo AD, Weiss DE, Galmin L, Ding S, Heeney JL, Esteban M, Jacobs BL, Pantaleo G, Wagner R.

J Virol. 2019 Jan 17;93(3). pii: e01529-18. doi: 10.1128/JVI.01529-18. Print 2019 Feb 1.


Replication-Competent NYVAC-KC Yields Improved Immunogenicity to HIV-1 Antigens in Rhesus Macaques Compared to Nonreplicating NYVAC.

Kibler KV, Asbach B, Perdiguero B, García-Arriaza J, Yates NL, Parks R, Stanfield-Oakley S, Ferrari G, Montefiori DC, Tomaras GD, Roederer M, Foulds KE, Forthal DN, Seaman MS, Self S, Gottardo R, Phogat S, Tartaglia J, Barnett S, Cristillo AD, Weiss D, Galmin L, Ding S, Heeney JL, Esteban M, Wagner R, Pantaleo G, Jacobs BL.

J Virol. 2019 Jan 17;93(3). pii: e01513-18. doi: 10.1128/JVI.01513-18. Print 2019 Feb 1.


Increased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site.

Bogers WMJM, Barnett SW, Oostermeijer H, Nieuwenhuis IG, Beenhakker N, Mortier D, Mooij P, Koopman G, Remarque E, Martin G, Lai RP, Dey AK, Sun Y, Burke B, Ferrari G, Montefiori D, Martin L, Davis D, Srivastava I, Heeney JL.

J Virol. 2017 Sep 12;91(19). pii: e00811-17. doi: 10.1128/JVI.00811-17. Print 2017 Oct 1.


Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques.

Shen X, Bogers WM, Yates NL, Ferrari G, Dey AK, Williams WT, Jaeger FH, Wiehe K, Sawant S, Alam SM, LaBranche CC, Montefiori DC, Martin L, Srivastava I, Heeney J, Barnett SW, Tomaras GD.

J Virol. 2017 Sep 12;91(19). pii: e00401-17. doi: 10.1128/JVI.00401-17. Print 2017 Oct 1.


HIV/AIDS Vaccine Candidates Based on Replication-Competent Recombinant Poxvirus NYVAC-C-KC Expressing Trimeric gp140 and Gag-Derived Virus-Like Particles or Lacking the Viral Molecule B19 That Inhibits Type I Interferon Activate Relevant HIV-1-Specific B and T Cell Immune Functions in Nonhuman Primates.

García-Arriaza J, Perdiguero B, Heeney JL, Seaman MS, Montefiori DC, Yates NL, Tomaras GD, Ferrari G, Foulds KE, Roederer M, Self SG, Borate B, Gottardo R, Phogat S, Tartaglia J, Barnett SW, Burke B, Cristillo AD, Weiss DE, Lee C, Kibler KV, Jacobs BL, Wagner R, Ding S, Pantaleo G, Esteban M.

J Virol. 2017 Apr 13;91(9). pii: e02182-16. doi: 10.1128/JVI.02182-16. Print 2017 May 1.


Phyloepidemiological Analysis Reveals that Viral Divergence Led to the Paucity of Simian Immunodeficiency Virus SIVmus/gsn/mon Infections in Wild Populations.

Schmidt F, Liegeois F, Greenwood EJD, LeBreton M, Lester J, Deleplancque L, Peeters M, Aghokeng A, Tamoufe U, Diffo JLD, Takuo JM, Wolfe ND, Leroy E, Rouet F, Heeney JL.

J Virol. 2017 Feb 28;91(6). pii: e01884-16. doi: 10.1128/JVI.01884-16. Print 2017 Mar 15.


Is sentinel lymph node biopsy a viable alternative to complete axillary dissection following neoadjuvant chemotherapy in women with node-positive breast cancer at diagnosis? An updated meta-analysis involving 3,398 patients.

El Hage Chehade H, Headon H, El Tokhy O, Heeney J, Kasem A, Mokbel K.

Am J Surg. 2016 Nov;212(5):969-981. doi: 10.1016/j.amjsurg.2016.07.018. Epub 2016 Aug 16. Review.


T- and B-cell responses to multivalent prime-boost DNA and viral vectored vaccine combinations against hepatitis C virus in non-human primates.

Rollier CS, Verschoor EJ, Verstrepen BE, Drexhage JA, Paranhos-Baccala G, Liljeström P, Sutter G, Arribillaga L, Lasarte JJ, Bartosch B, Cosset FL, Inchauspe G, Heeney JL.

Gene Ther. 2016 Oct;23(10):753-759. doi: 10.1038/gt.2016.55. Epub 2016 Jul 14.


Potential To Streamline Heterologous DNA Prime and NYVAC/Protein Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens.

Asbach B, Kliche A, Köstler J, Perdiguero B, Esteban M, Jacobs BL, Montefiori DC, LaBranche CC, Yates NL, Tomaras GD, Ferrari G, Foulds KE, Roederer M, Landucci G, Forthal DN, Seaman MS, Hawkins N, Self SG, Sato A, Gottardo R, Phogat S, Tartaglia J, Barnett SW, Burke B, Cristillo AD, Weiss DE, Francis J, Galmin L, Ding S, Heeney JL, Pantaleo G, Wagner R.

J Virol. 2016 Mar 28;90(8):4133-4149. doi: 10.1128/JVI.03135-15. Print 2016 Apr.


Ebola: Hidden reservoirs.

Heeney JL.

Nature. 2015 Nov 26;527(7579):453-5. doi: 10.1038/527453a. No abstract available.


Simian Immunodeficiency Virus Infection of Chimpanzees (Pan troglodytes) Shares Features of Both Pathogenic and Non-pathogenic Lentiviral Infections.

Greenwood EJ, Schmidt F, Kondova I, Niphuis H, Hodara VL, Clissold L, McLay K, Guerra B, Redrobe S, Giavedoni LD, Lanford RE, Murthy KK, Rouet F, Heeney JL.

PLoS Pathog. 2015 Sep 11;11(9):e1005146. doi: 10.1371/journal.ppat.1005146. eCollection 2015 Sep.


Host Subtraction, Filtering and Assembly Validations for Novel Viral Discovery Using Next Generation Sequencing Data.

Daly GM, Leggett RM, Rowe W, Stubbs S, Wilkinson M, Ramirez-Gonzalez RH, Caccamo M, Bernal W, Heeney JL.

PLoS One. 2015 Jun 22;10(6):e0129059. doi: 10.1371/journal.pone.0129059. eCollection 2015.


Head-to-Head Comparison of Poxvirus NYVAC and ALVAC Vectors Expressing Identical HIV-1 Clade C Immunogens in Prime-Boost Combination with Env Protein in Nonhuman Primates.

García-Arriaza J, Perdiguero B, Heeney J, Seaman M, Montefiori DC, Labranche C, Yates NL, Shen X, Tomaras GD, Ferrari G, Foulds KE, McDermott A, Kao SF, Roederer M, Hawkins N, Self S, Yao J, Farrell P, Phogat S, Tartaglia J, Barnett SW, Burke B, Cristillo A, Weiss D, Lee C, Kibler K, Jacobs B, Asbach B, Wagner R, Ding S, Pantaleo G, Esteban M.

J Virol. 2015 Aug;89(16):8525-39. doi: 10.1128/JVI.01265-15. Epub 2015 Jun 3.


Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance.

Swamy M, Abeler-Dörner L, Chettle J, Mahlakõiv T, Goubau D, Chakravarty P, Ramsay G, Reis E Sousa C, Staeheli P, Blacklaws BA, Heeney JL, Hayday AC.

Nat Commun. 2015 May 19;6:7090. doi: 10.1038/ncomms8090.


Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge.

Sholukh AM, Watkins JD, Vyas HK, Gupta S, Lakhashe SK, Thorat S, Zhou M, Hemashettar G, Bachler BC, Forthal DN, Villinger F, Sattentau QJ, Weiss RA, Agatic G, Corti D, Lanzavecchia A, Heeney JL, Ruprecht RM.

Vaccine. 2015 Apr 21;33(17):2086-95. doi: 10.1016/j.vaccine.2015.02.020. Epub 2015 Mar 11.


Synthetic long peptide booster immunization in rhesus macaques primed with replication-competent NYVAC-C-KC induces a balanced CD4/CD8 T-cell and antibody response against the conserved regions of HIV-1.

Mooij P, Koopman G, Drijfhout JW, Nieuwenhuis IG, Beenhakker N, Koestler J, Bogers WM, Wagner R, Esteban M, Pantaleo G, Heeney JL, Jacobs BL, Melief CJ.

J Gen Virol. 2015 Jun;96(Pt 6):1478-83. doi: 10.1099/vir.0.000074. Epub 2015 Feb 9.


Potent immune responses in rhesus macaques induced by nonviral delivery of a self-amplifying RNA vaccine expressing HIV type 1 envelope with a cationic nanoemulsion.

Bogers WM, Oostermeijer H, Mooij P, Koopman G, Verschoor EJ, Davis D, Ulmer JB, Brito LA, Cu Y, Banerjee K, Otten GR, Burke B, Dey A, Heeney JL, Shen X, Tomaras GD, Labranche C, Montefiori DC, Liao HX, Haynes B, Geall AJ, Barnett SW.

J Infect Dis. 2015 Mar 15;211(6):947-55. doi: 10.1093/infdis/jiu522. Epub 2014 Sep 18.


A helminth-mediated viral awakening.

Veldhoen M, Heeney JL.

Trends Immunol. 2014 Oct;35(10):452-3. doi: 10.1016/ Epub 2014 Aug 28.


Development and immunological assessment of VLP-based immunogens exposing the membrane-proximal region of the HIV-1 gp41 protein.

Benen TD, Tonks P, Kliche A, Kapzan R, Heeney JL, Wagner R.

J Biomed Sci. 2014 Aug 27;21:79. doi: 10.1186/s12929-014-0079-x.


A fusion intermediate gp41 immunogen elicits neutralizing antibodies to HIV-1.

Lai RP, Hock M, Radzimanowski J, Tonks P, Hulsik DL, Effantin G, Seilly DJ, Dreja H, Kliche A, Wagner R, Barnett SW, Tumba N, Morris L, LaBranche CC, Montefiori DC, Seaman MS, Heeney JL, Weissenhorn W.

J Biol Chem. 2014 Oct 24;289(43):29912-26. doi: 10.1074/jbc.M114.569566. Epub 2014 Aug 26.


Full-length genome analyses of two new simian immunodeficiency virus (SIV) strains from mustached monkeys (C. Cephus) in Gabon illustrate a complex evolutionary history among the SIVmus/mon/gsn lineage.

Liégeois F, Schmidt F, Boué V, Butel C, Mouacha F, Ngari P, Ondo BM, Leroy E, Heeney JL, Delaporte E, Peeters M, Rouet F.

Viruses. 2014 Jul 22;6(7):2880-98. doi: 10.3390/v6072880.


Host factors determine differential disease progression after infection with nef-deleted simian immunodeficiency virus.

Sopper S, Mätz-Rensing K, Mühl T, Heeney J, Stahl-Hennig C, Sauermann U.

J Gen Virol. 2014 Oct;95(Pt 10):2273-84. doi: 10.1099/vir.0.066563-0. Epub 2014 Jun 13.


Strong vaccine-induced CD8 T-cell responses have cytolytic function in a chimpanzee clearing HCV infection.

Verstrepen BE, Verschoor EJ, Fagrouch ZC, Mooij P, de Groot NG, Bontrop RE, Bogers WM, Heeney JL, Koopman G.

PLoS One. 2014 Apr 16;9(4):e95103. doi: 10.1371/journal.pone.0095103. eCollection 2014.


Canine hepacivirus is not associated with chronic liver disease in dogs.

Bexfield NH, Watson PJ, Heaney J, Heeney JL, Tiley L.

J Viral Hepat. 2014 Mar;21(3):223-8. doi: 10.1111/jvh.12150. Epub 2013 Aug 12.


Pathology caused by persistent murine norovirus infection.

Shortland A, Chettle J, Archer J, Wood K, Bailey D, Goodfellow I, Blacklaws BA, Heeney JL.

J Gen Virol. 2014 Feb;95(Pt 2):413-22. doi: 10.1099/vir.0.059188-0. Epub 2013 Nov 13.


Loss of memory CD4+ T-cells in semi-wild mandrills (Mandrillus sphinx) naturally infected with species-specific simian immunodeficiency virus SIVmnd-1.

Greenwood EJ, Schmidt F, Liégeois F, Kondova I, Herbert A, Ngoubangoye B, Rouet F, Heeney JL.

J Gen Virol. 2014 Jan;95(Pt 1):201-12. doi: 10.1099/vir.0.059808-0. Epub 2013 Nov 8.


In vitro neutralization of low dose inocula at physiological concentrations of a monoclonal antibody which protects macaques against SHIV challenge.

Davis D, Koornstra W, Fagrouch Z, Verschoor EJ, Heeney JL, Bogers WM.

PLoS One. 2013 Aug 16;8(8):e72702. doi: 10.1371/journal.pone.0072702. eCollection 2013.


Genetic imprint of vaccination on simian/human immunodeficiency virus type 1 transmitted viral genomes in rhesus macaques.

Varela M, Verschoor E, Lai RP, Hughes J, Mooj P, McKinley TJ, Fitzmaurice TJ, Landskron L, Willett BJ, Frost SD, Bogers WM, Heeney JL.

PLoS One. 2013 Aug 14;8(8):e70814. doi: 10.1371/journal.pone.0070814. eCollection 2013.


Metagenomic study of the viruses of African straw-coloured fruit bats: detection of a chiropteran poxvirus and isolation of a novel adenovirus.

Baker KS, Leggett RM, Bexfield NH, Alston M, Daly G, Todd S, Tachedjian M, Holmes CE, Crameri S, Wang LF, Heeney JL, Suu-Ire R, Kellam P, Cunningham AA, Wood JL, Caccamo M, Murcia PR.

Virology. 2013 Jul 5;441(2):95-106. doi: 10.1016/j.virol.2013.03.014. Epub 2013 Apr 4.


DLA class II alleles and haplotypes are associated with risk for and protection from chronic hepatitis in the English Springer spaniel.

Bexfield NH, Watson PJ, Aguirre-Hernandez J, Sargan DR, Tiley L, Heeney JL, Kennedy LJ.

PLoS One. 2012;7(8):e42584. doi: 10.1371/journal.pone.0042584. Epub 2012 Aug 1.


Mixed adjuvant formulations reveal a new combination that elicit antibody response comparable to Freund's adjuvants.

Lai RP, Seaman MS, Tonks P, Wegmann F, Seilly DJ, Frost SD, LaBranche CC, Montefiori DC, Dey AK, Srivastava IK, Sattentau Q, Barnett SW, Heeney JL.

PLoS One. 2012;7(4):e35083. doi: 10.1371/journal.pone.0035083. Epub 2012 Apr 11.


Use of a polyanionic carbomer, Carbopol971P, in combination with MF59, improves antibody responses to HIV-1 envelope glycoprotein.

Dey AK, Burke B, Sun Y, Hartog K, Heeney JL, Montefiori D, Srivastava IK, Barnett SW.

Vaccine. 2012 Apr 5;30(17):2749-59. doi: 10.1016/j.vaccine.2012.02.027. Epub 2012 Feb 22.


Immunization with apoptotic pseudovirus transduced cells induces both cellular and humoral responses: a proof of concept study in macaques.

Koopman G, Beenhakker N, Hofman S, Walther-Jallow L, Mäkitalo B, Mooij P, Anderson J, Verschoor E, Bogers WM, Heeney JL, Spetz AL.

Vaccine. 2012 Mar 28;30(15):2523-34. doi: 10.1016/j.vaccine.2012.01.082. Epub 2012 Feb 5.


Control of simian immunodeficiency virus SIVmnd-1 RNA plasma viremia after coinfection or superinfection with SIVmnd-1 in SIVmnd-2-infected mandrills and vice versa.

Liégeois F, Verrier D, Greenwood E, Schmidt F, Heeney J, Rouet F.

J Virol. 2012 Feb;86(4):2385-6; author reply 2387-8. doi: 10.1128/JVI.06590-11. No abstract available.


Protection in macaques immunized with HIV-1 candidate vaccines can be predicted using the kinetics of their neutralizing antibodies.

Davis D, Koornstra W, Mortier D, Fagrouch Z, Verschoor EJ, Heeney JL, Bogers WM.

PLoS One. 2011;6(12):e28974. doi: 10.1371/journal.pone.0028974. Epub 2011 Dec 28.


A viral discovery methodology for clinical biopsy samples utilising massively parallel next generation sequencing.

Daly GM, Bexfield N, Heaney J, Stubbs S, Mayer AP, Palser A, Kellam P, Drou N, Caccamo M, Tiley L, Alexander GJ, Bernal W, Heeney JL.

PLoS One. 2011;6(12):e28879. doi: 10.1371/journal.pone.0028879. Epub 2011 Dec 21.


Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41.

Lai RP, Yan J, Heeney J, McClure MO, Göttlinger H, Luban J, Pizzato M.

PLoS Pathog. 2011 Dec;7(12):e1002442. doi: 10.1371/journal.ppat.1002442. Epub 2011 Dec 15.


Norovirus regulation of the innate immune response and apoptosis occurs via the product of the alternative open reading frame 4.

McFadden N, Bailey D, Carrara G, Benson A, Chaudhry Y, Shortland A, Heeney J, Yarovinsky F, Simmonds P, Macdonald A, Goodfellow I.

PLoS Pathog. 2011 Dec;7(12):e1002413. doi: 10.1371/journal.ppat.1002413. Epub 2011 Dec 8.


Herpesvirus saimiri infection of rhesus macaques: a model for acute rhadinovirus-induced t-cell transformation and oncogenesis.

Rosenwirth B, Kondova I, Niphuis H, Greenwood EJ, Schmidt F, Verschoor EJ, Wittmann S, Heeney JL, Bogers WM, Fickenscher H, Koopman G.

J Med Virol. 2011 Nov;83(11):1938-50. doi: 10.1002/jmv.22197.


Clearance of genotype 1b hepatitis C virus in chimpanzees in the presence of vaccine-induced E1-neutralizing antibodies.

Verstrepen BE, Depla E, Rollier CS, Mares G, Drexhage JA, Priem S, Verschoor EJ, Koopman G, Granier C, Dreux M, Cosset FL, Maertens G, Heeney JL.

J Infect Dis. 2011 Sep 15;204(6):837-44. doi: 10.1093/infdis/jir423.


Molecular evolution analysis of the human immunodeficiency virus type 1 envelope in simian/human immunodeficiency virus-infected macaques: implications for challenge dose selection.

Varela M, Landskron L, Lai RP, McKinley TJ, Bogers WM, Verschoor EJ, Dubbes R, Barnett SW, Frost SD, Heeney JL.

J Virol. 2011 Oct;85(19):10332-45. doi: 10.1128/JVI.05290-11. Epub 2011 Jul 27.


An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV.

Watkins JD, Siddappa NB, Lakhashe SK, Humbert M, Sholukh A, Hemashettar G, Wong YL, Yoon JK, Wang W, Novembre FJ, Villinger F, Ibegbu C, Patel K, Corti D, Agatic G, Vanzetta F, Bianchi S, Heeney JL, Sallusto F, Lanzavecchia A, Ruprecht RM.

PLoS One. 2011 Mar 31;6(3):e18207. doi: 10.1371/journal.pone.0018207.


No difference in Gag and Env immune-response profiles between vaccinated and non-vaccinated rhesus macaques that control immunodeficiency virus replication.

Nieuwenhuis I, Beenhakker N, Bogers WM, Otting N, Bontrop RE, Dubois P, Mooij P, Heeney JL, Koopman G.

J Gen Virol. 2010 Dec;91(Pt 12):2974-84. doi: 10.1099/vir.0.022772-0. Epub 2010 Sep 8.


CD8+ NK cells are predominant in chimpanzees, characterized by high NCR expression and cytokine production, and preserved in chronic HIV-1 infection.

Rutjens E, Mazza S, Biassoni R, Koopman G, Ugolotti E, Fogli M, Dubbes R, Costa P, Mingari MC, Greenwood EJ, Moretta L, De Maria A, Heeney JL.

Eur J Immunol. 2010 May;40(5):1440-50. doi: 10.1002/eji.200940062. Erratum in: Eur J Immunol. 2010 Jun;40(6):1819. DeMaria, Andrea [corrected to De Maria, Andrea].


Potent adaptive immune responses induced against HIV-1 gp140 and influenza virus HA by a polyanionic carbomer.

Krashias G, Simon AK, Wegmann F, Kok WL, Ho LP, Stevens D, Skehel J, Heeney JL, Moghaddam AE, Sattentau QJ.

Vaccine. 2010 Mar 16;28(13):2482-9. doi: 10.1016/j.vaccine.2010.01.046. Epub 2010 Feb 2.


Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals.

Corti D, Langedijk JP, Hinz A, Seaman MS, Vanzetta F, Fernandez-Rodriguez BM, Silacci C, Pinna D, Jarrossay D, Balla-Jhagjhoorsingh S, Willems B, Zekveld MJ, Dreja H, O'Sullivan E, Pade C, Orkin C, Jeffs SA, Montefiori DC, Davis D, Weissenhorn W, McKnight A, Heeney JL, Sallusto F, Sattentau QJ, Weiss RA, Lanzavecchia A.

PLoS One. 2010 Jan 20;5(1):e8805. doi: 10.1371/journal.pone.0008805.


Viruses as vaccine vectors for infectious diseases and cancer.

Draper SJ, Heeney JL.

Nat Rev Microbiol. 2010 Jan;8(1):62-73. doi: 10.1038/nrmicro2240. Review.


Characterization of novel polyomaviruses from Bornean and Sumatran orang-utans.

Groenewoud MJ, Fagrouch Z, van Gessel S, Niphuis H, Bulavaite A, Warren KS, Heeney JL, Verschoor EJ.

J Gen Virol. 2010 Mar;91(Pt 3):653-8. doi: 10.1099/vir.0.017673-0. Epub 2009 Nov 18.


Infectious diseases: An ill wind for wild chimps?

Weiss RA, Heeney JL.

Nature. 2009 Jul 23;460(7254):470-1. doi: 10.1038/460470a. No abstract available.


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