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Role of Complement Activation in Allograft Inflammation.

Chun N, Horwitz J, Heeger PS.

Curr Transplant Rep. 2019 Mar;6(1):52-59. doi: 10.1007/s40472-019-0224-2. Epub 2019 Jan 15.


Peritransplant eculizumab does not prevent delayed graft function in deceased donor kidney transplant recipients: Results of two randomized controlled pilot trials.

Schröppel B, Akalin E, Baweja M, Bloom RD, Florman S, Goldstein M, Haydel B, Hricik DE, Kulkarni S, Levine M, Mehrotra A, Patel A, Poggio ED, Ratner L, Shapiro R, Heeger PS.

Am J Transplant. 2019 Aug 26. doi: 10.1111/ajt.15580. [Epub ahead of print]


Absence of evidence that respiratory viral infections influence pediatric lung transplantation outcomes: Results of the CTOTC-03 study.

Sweet SC, Chin H, Conrad C, Hayes D Jr, Heeger PS, Faro A, Goldfarb S, Melicoff-Portillo E, Mohanakumar T, Odim J, Schecter M, Storch GA, Visner G, Williams NM, Kesler K, Danziger-Isakov L.

Am J Transplant. 2019 Jun 19. doi: 10.1111/ajt.15505. [Epub ahead of print]


CD55 Is Essential for CD103+ Dendritic Cell Tolerogenic Responses that Protect against Autoimmunity.

Strainic MG, Liu J, An F, Bailey E, Esposito A, Hamann J, Heeger PS, Medof ME.

Am J Pathol. 2019 Jul;189(7):1386-1401. doi: 10.1016/j.ajpath.2019.04.008. Epub 2019 May 17.


T-cell exhaustion correlates with improved outcomes in kidney transplant recipients.

Fribourg M, Anderson L, Fischman C, Cantarelli C, Perin L, La Manna G, Rahman A, Burrell BE, Heeger PS, Cravedi P.

Kidney Int. 2019 Aug;96(2):436-449. doi: 10.1016/j.kint.2019.01.040. Epub 2019 Feb 27.


Erythropoietin inhibits SGK1-dependent TH17 induction and TH17-dependent kidney disease.

Donadei C, Angeletti A, Cantarelli C, D'Agati VD, La Manna G, Fiaccadori E, Horwitz JK, Xiong H, Guglielmo C, Hartzell S, Madsen JC, Maggiore U, Heeger PS, Cravedi P.

JCI Insight. 2019 Apr 23;5. pii: 127428. doi: 10.1172/jci.insight.127428.


Complement and Transplantation: From New Mechanisms to Potential Biomarkers and Novel Treatment Strategies.

Horwitz JK, Chun NH, Heeger PS.

Clin Lab Med. 2019 Mar;39(1):31-43. doi: 10.1016/j.cll.2018.10.004. Epub 2018 Dec 20. Review.


C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans.

Verghese DA, Chun N, Paz K, Fribourg M, Woodruff TM, Flynn R, Hu Y, Xiong H, Zhang W, Yi Z, Du J, Blazar BR, Heeger PS.

JCI Insight. 2018 Dec 20;3(24). pii: 124646. doi: 10.1172/jci.insight.124646.


Absence of recipient C3aR1 signaling limits expansion and differentiation of alloreactive CD8+ T cell immunity and prolongs murine cardiac allograft survival.

Mathern DR, K Horwitz J, Heeger PS.

Am J Transplant. 2019 Jun;19(6):1628-1640. doi: 10.1111/ajt.15222. Epub 2019 Jan 14.


Early immune biomarkers and intermediate-term outcomes after heart transplantation: Results of Clinical Trials in Organ Transplantation-18.

Stehlik J, Armstrong B, Baran DA, Bridges ND, Chandraker A, Gordon R, De Marco T, Givertz MM, Heroux A, Iklé D, Hunt J, Kfoury AG, Madsen JC, Morrison Y, Feller E, Pinney S, Tripathi S, Heeger PS, Starling RC.

Am J Transplant. 2019 May;19(5):1518-1528. doi: 10.1111/ajt.15218. Epub 2019 Jan 22.


Donor Urinary C5a Levels Independently Correlate With Posttransplant Delayed Graft Function.

Schröppel B, Heeger PS, Thiessen-Philbrook H, Hall IE, Doshi MD, Weng FL, Reese PP, Parikh CR.

Transplantation. 2019 Jan;103(1):e29-e35. doi: 10.1097/TP.0000000000002494.


T follicular helper cells restricted by IRF8 contribute to T cell-mediated inflammation.

Zhang R, Qi CF, Hu Y, Shan Y, Hsieh YP, Xu F, Lu G, Dai J, Gupta M, Cui M, Peng L, Yang J, Xue Q, Chen-Liang R, Chen K, Zhang Y, Fung-Leung WP, Mora JR, Li L, Morse HC 3rd, Ozato K, Heeger PS, Xiong H.

J Autoimmun. 2019 Jan;96:113-122. doi: 10.1016/j.jaut.2018.09.001. Epub 2018 Sep 19.


C5aR1 regulates migration of suppressive myeloid cells required for costimulatory blockade-induced murine allograft survival.

Llaudo I, Fribourg M, Medof ME, Conde P, Ochando J, Heeger PS.

Am J Transplant. 2019 Mar;19(3):633-645. doi: 10.1111/ajt.15072. Epub 2018 Sep 17.


P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes.

D'Addio F, Vergani A, Potena L, Maestroni A, Usuelli V, Ben Nasr M, Bassi R, Tezza S, Dellepiane S, El Essawy B, Iascone M, Iacovoni A, Borgese L, Liu K, Visner G, Dhe-Paganon S, Corradi D, Abdi R, Starling RC, Folli F, Zuccotti GV, Sayegh MH, Heeger PS, Chandraker A, Grigioni F, Fiorina P.

J Clin Invest. 2018 Aug 1;128(8):3490-3503. doi: 10.1172/JCI94524. Epub 2018 Jul 16.


Response to Commentary.

Heeger PS.

Transplantation. 2018 Aug;102(8):e368-e369. doi: 10.1097/TP.0000000000002271. No abstract available.


T Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell (TREG) Generation and TREG-Dependent Cardiac Allograft Survival.

A Verghese D, Demir M, Chun N, Fribourg M, Cravedi P, Llaudo I, Woodruff TM, Yadav P, Lira SA, Medof ME, Heeger PS.

J Immunol. 2018 Mar 15;200(6):2186-2198. doi: 10.4049/jimmunol.1701638. Epub 2018 Feb 7.


Rapid Biolayer Interferometry Measurements of Urinary CXCL9 to Detect Cellular Infiltrates Noninvasively After Kidney Transplantation.

Gandolfini I, Harris C, Abecassis M, Anderson L, Bestard O, Comai G, Cravedi P, Cremaschi E, Duty JA, Florman S, Friedewald J, La Manna G, Maggiore U, Moran T, Piotti G, Purroy C, Jarque M, Nair V, Shapiro R, Reid-Adam J, Heeger PS.

Kidney Int Rep. 2017 Jun 21;2(6):1186-1193. doi: 10.1016/j.ekir.2017.06.010. eCollection 2017 Nov.


Analysis of Biomarkers Within the Initial 2 Years Posttransplant and 5-Year Kidney Transplant Outcomes: Results From Clinical Trials in Organ Transplantation-17.

Faddoul G, Nadkarni GN, Bridges ND, Goebel J, Hricik DE, Formica R, Menon MC, Morrison Y, Murphy B, Newell K, Nickerson P, Poggio ED, Rush D, Heeger PS; CTOT-17 consortium.

Transplantation. 2018 Apr;102(4):673-680. doi: 10.1097/TP.0000000000002026.


Donor SIRP-α polymorphisms: widening the innate-to-adaptive continuum in allograft rejection.

Menon MC, Heeger PS.

Kidney Int. 2017 Dec;92(6):1305-1308. doi: 10.1016/j.kint.2017.10.006.


Analysis of OPTN/UNOS registry suggests the number of HLA matches and not mismatches is a stronger independent predictor of kidney transplant survival.

Yacoub R, Nadkarni GN, Cravedi P, He JC, Delaney VB, Kent R, Chauhan KN, Coca SG, Florman SS, Heeger PS, Murphy B, Menon MC.

Kidney Int. 2018 Feb;93(2):482-490. doi: 10.1016/j.kint.2017.07.016. Epub 2017 Sep 29.


Activation of complement factor B contributes to murine and human myocardial ischemia/reperfusion injury.

Chun N, Haddadin AS, Liu J, Hou Y, Wong KA, Lee D, Rushbrook JI, Gulaya K, Hines R, Hollis T, Nistal Nuno B, Mangi AA, Hashim S, Pekna M, Catalfamo A, Chin HY, Patel F, Rayala S, Shevde K, Heeger PS, Zhang M.

PLoS One. 2017 Jun 29;12(6):e0179450. doi: 10.1371/journal.pone.0179450. eCollection 2017.


Allospecific Memory B Cell Responses Are Dependent on Autophagy.

Fribourg M, Ni J, Nina Papavasiliou F, Yue Z, Heeger PS, Leventhal JS.

Am J Transplant. 2018 Jan;18(1):102-112. doi: 10.1111/ajt.14394. Epub 2017 Jul 24.


TLR-Induced Murine Dendritic Cell (DC) Activation Requires DC-Intrinsic Complement.

Sheen JH, Strainic MG, Liu J, Zhang W, Yi Z, Medof ME, Heeger PS.

J Immunol. 2017 Jul 1;199(1):278-291. doi: 10.4049/jimmunol.1700339. Epub 2017 May 24.


Complement Dependence of Murine Costimulatory Blockade-Resistant Cellular Cardiac Allograft Rejection.

Chun N, Fairchild RL, Li Y, Liu J, Zhang M, Baldwin WM 3rd, Heeger PS.

Am J Transplant. 2017 Nov;17(11):2810-2819. doi: 10.1111/ajt.14328. Epub 2017 May 30.


Correction: The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.

Chorny A, Casas-Recasens S, Sintes J, Shan M, Polentarutti N, García-Escudero R, Walland AC, Yeiser JR, Cassis L, Carrillo J, Puga I, Cunha C, Bastos H, Rodrigues F, Lacerda JF, Morais A, Dieguez-Gonzalez R, Heeger PS, Salvatori G, Carvalho A, Garcia-Sastre A, Blander JM, Mantovani A, Garlanda C, Cerutti A.

J Exp Med. 2017 May 1;214(5):1559. doi: 10.1084/jem.2015028204172017c. Epub 2017 Apr 18. No abstract available.


Erythropoietin Receptor-Mediated Molecular Crosstalk Promotes T Cell Immunoregulation and Transplant Survival.

Purroy C, Fairchild RL, Tanaka T, Baldwin WM 3rd, Manrique J, Madsen JC, Colvin RB, Alessandrini A, Blazar BR, Fribourg M, Donadei C, Maggiore U, Heeger PS, Cravedi P.

J Am Soc Nephrol. 2017 Aug;28(8):2377-2392. doi: 10.1681/ASN.2016101100. Epub 2017 Mar 16.


Moving Biomarkers toward Clinical Implementation in Kidney Transplantation.

Menon MC, Murphy B, Heeger PS.

J Am Soc Nephrol. 2017 Mar;28(3):735-747. doi: 10.1681/ASN.2016080858. Epub 2017 Jan 6. Review.


Role of Circulating MicroRNAs in the Immunopathogenesis of Rejection After Pediatric Lung Transplantation.

Xu Z, Yang W, Steward N, Sweet SC, Danziger-Isakov L, Heeger PS, Mohanakumar T.

Transplantation. 2017 Oct;101(10):2461-2468. doi: 10.1097/TP.0000000000001595.


The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.

Chorny A, Casas-Recasens S, Sintes J, Shan M, Polentarutti N, García-Escudero R, Walland AC, Yeiser JR, Cassis L, Carrillo J, Puga I, Cunha C, Bastos H, Rodrigues F, Lacerda JF, Morais A, Dieguez-Gonzalez R, Heeger PS, Salvatori G, Carvalho A, Garcia-Sastre A, Blander JM, Mantovani A, Garlanda C, Cerutti A.

J Exp Med. 2016 Sep 19;213(10):2167-85. doi: 10.1084/jem.20150282. Epub 2016 Sep 12. Erratum in: J Exp Med. 2017 May 1;214(5):1559.


Blurring the Lines Between Innate and Adaptive Immunity.

Chun N, Heeger PS.

Transplantation. 2016 Sep;100(9):1789-1790. doi: 10.1097/TP.0000000000001429. No abstract available.


Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages.

Stamatiades EG, Tremblay ME, Bohm M, Crozet L, Bisht K, Kao D, Coelho C, Fan X, Yewdell WT, Davidson A, Heeger PS, Diebold S, Nimmerjahn F, Geissmann F.

Cell. 2016 Aug 11;166(4):991-1003. doi: 10.1016/j.cell.2016.06.058. Epub 2016 Jul 28.


What's hot, what's new in basic science: report from the American Transplant Congress 2015.

Heeger PS.

Am J Transplant. 2015 Nov;15(11):2802-7. doi: 10.1111/ajt.13463. Epub 2015 Oct 13.


Peripheral natural killer cell and allo-stimulated T-cell function in kidney transplant recipients associate with cancer risk and immunosuppression-related complications.

Hope CM, Troelnikov A, Hanf W, Jesudason S, Coates PT, Heeger PS, Carroll RP.

Kidney Int. 2015 Dec;88(6):1374-1382. doi: 10.1038/ki.2015.237. Epub 2015 Aug 12.


Multicenter Analysis of Immune Biomarkers and Heart Transplant Outcomes: Results of the Clinical Trials in Organ Transplantation-05 Study.

Starling RC, Stehlik J, Baran DA, Armstrong B, Stone JR, Ikle D, Morrison Y, Bridges ND, Putheti P, Strom TB, Bhasin M, Guleria I, Chandraker A, Sayegh M, Daly KP, Briscoe DM, Heeger PS; CTOT-05 consortium.

Am J Transplant. 2016 Jan;16(1):121-36. doi: 10.1111/ajt.13422. Epub 2015 Aug 10.


Interferon Gamma ELISPOT Testing as a Risk-Stratifying Biomarker for Kidney Transplant Injury: Results From the CTOT-01 Multicenter Study.

Hricik DE, Augustine J, Nickerson P, Formica RN, Poggio ED, Rush D, Newell KA, Goebel J, Gibson IW, Fairchild RL, Spain K, Iklé D, Bridges ND, Heeger PS; CTOT-01 consortium.

Am J Transplant. 2015 Dec;15(12):3166-73. doi: 10.1111/ajt.13401. Epub 2015 Jul 30.


Effects of complement activation on allograft injury.

Sheen JH, Heeger PS.

Curr Opin Organ Transplant. 2015 Aug;20(4):468-75. doi: 10.1097/MOT.0000000000000216. Review.


DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance.

Conde P, Rodriguez M, van der Touw W, Jimenez A, Burns M, Miller J, Brahmachary M, Chen HM, Boros P, Rausell-Palamos F, Yun TJ, Riquelme P, Rastrojo A, Aguado B, Stein-Streilein J, Tanaka M, Zhou L, Zhang J, Lowary TL, Ginhoux F, Park CG, Cheong C, Brody J, Turley SJ, Lira SA, Bronte V, Gordon S, Heeger PS, Merad M, Hutchinson J, Chen SH, Ochando J.

Immunity. 2015 Jun 16;42(6):1143-58. doi: 10.1016/j.immuni.2015.05.009. Epub 2015 Jun 9.


Adverse Outcomes of Tacrolimus Withdrawal in Immune-Quiescent Kidney Transplant Recipients.

Hricik DE, Formica RN, Nickerson P, Rush D, Fairchild RL, Poggio ED, Gibson IW, Wiebe C, Tinckam K, Bunnapradist S, Samaniego-Picota M, Brennan DC, Schröppel B, Gaber O, Armstrong B, Ikle D, Diop H, Bridges ND, Heeger PS; Clinical Trials in Organ Transplantation-09 Consortium.

J Am Soc Nephrol. 2015 Dec;26(12):3114-22. doi: 10.1681/ASN.2014121234. Epub 2015 Apr 29.


Strategies to inhibit alloantibody production in alloprimed murine recipients of hematopoietic stem cell grafts.

Blazar BR, Flynn R, Lee R, Marcucci G, Caliguiri MA, Heeger PS.

Am J Transplant. 2015 Apr;15(4):931-41. doi: 10.1111/ajt.13125. Epub 2015 Mar 11.


Corrigendum. Complement as a multifaceted modulator of kidney transplant injury.

Cravedi P, Heeger PS.

J Clin Invest. 2015 Mar 2;125(3):1365. doi: 10.1172/JCI81182. Epub 2015 Mar 2. No abstract available.


Effect of Absent Immune Cell Expression of Vitamin D Receptor on Cardiac Allograft Survival in Mice.

Gavzy SJ, Heeger PS.

Transplantation. 2015 Jul;99(7):1365-71. doi: 10.1097/TP.0000000000000677.


Molecules Great and Small: The Complement System.

Mathern DR, Heeger PS.

Clin J Am Soc Nephrol. 2015 Sep 4;10(9):1636-50. doi: 10.2215/CJN.06230614. Epub 2015 Jan 7. Review.


Effect of cholecalciferol supplementation on inflammation and cellular alloimmunity in hemodialysis patients: data from a randomized controlled pilot trial.

Li L, Lin M, Krassilnikova M, Ostrow K, Bader A, Radbill B, Uribarri J, Tokita J, Leisman S, Lapsia V, Albrecht RA, García-Sastre A, Branch AD, Heeger PS, Mehrotra A.

PLoS One. 2014 Oct 8;9(10):e109998. doi: 10.1371/journal.pone.0109998. eCollection 2014.


The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma.

Li M, Bolduc AR, Hoda MN, Gamble DN, Dolisca SB, Bolduc AK, Hoang K, Ashley C, McCall D, Rojiani AM, Maria BL, Rixe O, MacDonald TJ, Heeger PS, Mellor AL, Munn DH, Johnson TS.

J Immunother Cancer. 2014 Jul 7;2:21. doi: 10.1186/2051-1426-2-21. eCollection 2014.


Complement as a multifaceted modulator of kidney transplant injury.

Cravedi P, Heeger PS.

J Clin Invest. 2014 Jun;124(6):2348-54. doi: 10.1172/JCI72273. Epub 2014 Jun 2. Review. Erratum in: J Clin Invest. 2015 Mar 2;125(3):1365.


Immunosuppressive effects of erythropoietin on human alloreactive T cells.

Cravedi P, Manrique J, Hanlon KE, Reid-Adam J, Brody J, Prathuangsuk P, Mehrotra A, Heeger PS.

J Am Soc Nephrol. 2014 Sep;25(9):2003-15. doi: 10.1681/ASN.2013090945. Epub 2014 Mar 27.


B cells and kidney transplantation: beyond antibodies.

Mehrotra A, Heeger PS.

J Am Soc Nephrol. 2014 Jul;25(7):1373-4. doi: 10.1681/ASN.2014020132. Epub 2014 Mar 7. No abstract available.


Costimulatory blockade-induced allograft survival requires Beclin1.

Verghese DA, Yadav A, Bizargity P, Murphy B, Heeger PS, Schröppel B.

Am J Transplant. 2014 Mar;14(3):545-53. doi: 10.1111/ajt.12610. Epub 2014 Feb 6.


Transplantation: Complementing donor-specific antibody testing.

Tinckam KJ, Heeger PS.

Nat Rev Nephrol. 2013 Dec;9(12):713-4. doi: 10.1038/nrneph.2013.234. Epub 2013 Nov 5.


Complement regulation of T-cell alloimmunity.

Cravedi P, van der Touw W, Heeger PS.

Semin Nephrol. 2013 Nov;33(6):565-74. doi: 10.1016/j.semnephrol.2013.08.007. Review.

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